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Cited by 26Mangiferin and Mango ExtractsNatural Compound Pharmacology StudiesPharmacology and Nanomedicine Research

From Nature to Nanotechnology: The Bioactivities of Mangiferin Explored

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Al-Madhagi, Haitham·2025·Nanotechnology, Science and Applications
DOI 10.2147/nsa.s525423PMC PMC12258238
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Abstract

Abstract: Mangiferin, a naturally occurring C-glucosylxanthone derived from various parts of the mango tree ( Mangifera indica ), has gained significant attention for its diverse pharmacological properties, including antioxidant, anti-inflammatory, antimicrobial, anticancer, and anti-diabetic activities. This mini-review provides an updated overview of the phytochemistry, pharmacokinetics, and medicinal properties of mangiferin. However, the low solubility (0.111 mg/mL) and oral bioavailability (less than 2%) of mangiferin pose significant challenges for its clinical application. To address these issues, the development of nanoformulations such as nanoparticles, micelles, and liposomes has been explored, which was proven to improve mangiferin’s solubility, stability, and targeted delivery. These nanocarriers enhance the bioavailability and therapeutic efficacy of mangiferin, making it a promising candidate for various therapeutic applications. The review ends with the discussion of the safety of mangiferin and its formulations in addition to the potential for clinical translation. Keywords: mangiferin, phytochemistry, anticancer, antioxidant, inflammation, neurodegenerative diseases

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  1. [1]Dar A, Faizi S, Naqvi S, et al. Analgesic and antioxidant activity of mangiferin and its derivatives: the structure activity relationship. Biol Pharm Bull. 2005; 28: 596– 600. doi: 10.1248/bpb.28.596 15802793 · DOI · Paper page
  2. [2]Ali A, Asgher Z, Cottrell JJ, Dunshea FR. Screening and characterization of phenolic compounds from selected unripe fruits and their antioxidant potential. Molecules. 2023; 29: 167. doi: 10.3390/molecules29010167 38202750 PMC10779760 · DOI
  3. [3]Matkowski A, Kus P, Goralska E, Wozniak D. Mangiferin – a bioactive xanthonoid, not only from mango and not just antioxidant. Mini Reviews in Med Chem. 2013; 13: 439– 455. doi: 10.2174/138955713804999838 23190031 · DOI · Paper page
  4. [4]Ahmad R, Alqathama A, Aldholmi M, et al. Antidiabetic and anticancer potentials of Mangifera indica L. from different geographical origins. Pharmaceuticals. 2023; 16(350): 350. doi: 10.3390/ph16030350 36986450 PMC10055559 · DOI
  5. [5]Lebaka VR, Wee Y-J, Ye W, Korivi M. Nutritional composition and bioactive compounds in three different parts of mango fruit. IJERPH. 2021; 18(741): 741. doi: 10.3390/ijerph18020741 33467139 PMC7830918 · DOI
  6. [6]Tacias-Pascacio VG, Castañeda-Valbuena D, Fernandez-Lafuente R, et al. Phenolic compounds in mango fruit: a review. Food Meas. 2022; 16: 619– 636. doi: 10.1007/s11694-021-01192-2 · DOI
  7. [7]Thangsiri S, Suttisansanee U, Koirala P, et al. Phenolic content of Thai Bao mango peel and its in-vitro antioxidant, anti-cholinesterase, and antidiabetic activities. Saudi J Biol Sci. 2024; 31: 104033. doi: 10.1016/j.sjbs.2024.104033 38946846 PMC11214510 · DOI
  8. [8]Castro-Vargas HI, Ballesteros Vivas D, Ortega Barbosa J, Morantes Medina SJ, Aristizabal Gutiérrez F, Parada-Alfonso F. Bioactive phenolic compounds from the agroindustrial waste of Colombian mango cultivars “sugar mango” and ‘tommy atkins’-an alternative for their use and valorization. Antioxidants. 2019; 8: 41. doi: 10.3390/antiox8020041 30781395 PMC6406469 · DOI
  9. [9]Castro-Muñoz R, Cabezas R, Plata-Gryl M. Mangiferin: a comprehensive review on its extraction, purification and uses in food systems. Adv. Colloid InterfaceSci. 2024; 329: 103188. doi: 10.1016/j.cis.2024.103188 38761602 · DOI · Paper page
  10. [11]Ehianeta TS, Laval S, Yu B. Bio- and chemical syntheses of mangiferin and congeners. BioFactors. 2016; 42: 445– 458. doi: 10.1002/biof.1279 27774668 · DOI · Paper page
  11. [12]López-Cárdenas FG, Pérez-Jiménez J, Mateos-Briz R, Zamora-Gasga VM, Sánchez-Burgos JA, Sáyago-Ayerdi SG. Advances in mangiferin: biosynthetic pathways, bioavailability and bioactivity. In: Xiao J, editor. ISBN 978-3-030-94753-8. Handbook of Dietary Flavonoids. Cham: Springer International Publishing; 2023: 1– 37.
  12. [13]Kaur P, Pandey DK, Gupta RC, et al. Biotechnological interventions and genetic diversity assessment in swertia sp.: a myriad source of valuable secondary metabolites. Appl Microbiol Biotechnol. 2021; 105: 4427– 4451. doi: 10.1007/s00253-021-11345-4 34037841 · DOI
  13. [14]Kumar M, Saurabh V, Tomar M, et al. Mango (Mangifera indica L.) leaves: nutritional composition, phytochemical profile, and health-promoting bioactivities. Antioxidants. 2021; 10: 299. doi: 10.3390/antiox10020299 33669341 PMC7920260 · DOI · Paper page
  14. [15]Dutta T, Das T, Gopalakrishnan AV, et al. Mangiferin: the miraculous xanthone with diverse pharmacological properties. Naunyn-Schmiedeberg’s Arch Pharmacol. 2023; 396: 851– 863. doi: 10.1007/s00210-022-02373-6 36656353 · DOI
  15. [16]Ma H, Chen H, Sun L, Tong L, Zhang T. Improving permeability and oral absorption of mangiferin by phospholipid complexation. Fitoterapia. 2014; 93: 54– 61. doi: 10.1016/j.fitote.2013.10.016 24220727 · DOI · Paper page
  16. [19]Lin H, Teng H, Wu W, et al. Pharmacokinetic and metabolomic analyses of mangiferin calcium salt in rat models of type 2 diabetes and non-alcoholic fatty liver disease. BMC Pharmacol Toxicol. 2020; 21: 59. doi: 10.1186/s40360-020-00438-x 32762728 PMC7409647 · DOI
  17. [20]Sarwar AR, Iqbal FM, Jamil MA, Abbas K. Nanocrystals of mangiferin using design expert: preparation, characterization, and pharmacokinetic evaluation. Molecules. 2023; 28: 5918. doi: 10.3390/molecules28155918 37570887 PMC10420877 · DOI
  18. [21]Tian X, Xu Z, Li Z, et al. Pharmacokinetics of mangiferin and its metabolite—norathyriol, part 2: influence of UGT, CYP450, P‐gp, and enterobacteria and the potential interaction in rhizoma anemarrhenae decoction with timosaponin b2 as the major contributor. BioFactors. 2016; 42: 545– 555. doi: 10.1002/biof.1290 27151461 · DOI
  19. [22]Kaurav M, Kanoujia J, Gupta M, et al. In-depth analysis of the chemical composition, pharmacological effects, pharmacokinetics, and patent history of mangiferin. Phytomedicine Plus. 2023; 3: 100445. doi: 10.1016/j.phyplu.2023.100445 · DOI
  20. [23]Aswal S, Kumar A, Chauhan A, Semwal RB, Kumar A, Semwal DK. A molecular approach on the protective effects of mangiferin against diabetes and diabetes-related complications. Current Diabetes Rev. 2020; 16: 690– 698. doi: 10.2174/1573399815666191004112023 31584372 · DOI
  21. [24]Mittal S, Iqubal MK, Iqbal B, Gupta MM, Ali J, Baboota S. A pervasive scientific overview on mangiferin in the prevention and treatment of various diseases with preclinical and clinical updates. J Complement Integr Med. 2021; 18: 9– 21. doi: 10.1515/jcim-2019-0250 32427121 · DOI
  22. [25]Yehia RS, Altwaim SA. An insight into in vitro antioxidant, antimicrobial, cytotoxic, and apoptosis induction potential of mangiferin, a bioactive compound derived from Mangifera indica. Plants. 2023; 12: 1539. doi: 10.3390/plants12071539 37050165 PMC10096949 · DOI · Paper page
  23. [26]Chaudhary P, Janmeda P, Docea AO, et al. Oxidative stress, free radicals and antioxidants: potential crosstalk in the pathophysiology of human diseases. Front Chem. 2023; 11: 1158198. doi: 10.3389/fchem.2023.1158198 37234200 PMC10206224 · DOI
  24. [27]Jo Y-J, Cho H-S, Chun J-Y. Antioxidant activity of β-cyclodextrin inclusion complexes containing trans-cinnamaldehyde by DPPH, ABTS and FRAP. Food Sci Biotechnol. 2021; 30: 807– 814. doi: 10.1007/s10068-021-00914-y 34249386 PMC8225751 · DOI
  25. [28]Lee JY, Kim H, Moon Y, et al. Enhancement of the water solubility and antioxidant capacities of mangiferin by transglucosylation using a cyclodextrin glycosyltransferase. Enzyme Microb Technol. 2022; 159: 110065. doi: 10.1016/j.enzmictec.2022.110065 35567857 · DOI
  26. [29]Medina Ramírez N, Monteiro Farias L, Apolonio Santana F, et al. Extraction of mangiferin and chemical characterization and sensorial analysis of teas from Mangifera indica L. leaves of the ubá variety. Beverages. 2016; 2(33): 33. doi: 10.3390/beverages2040033 · DOI
  27. [30]Da Veiga AAS, De Jesus Chaves Neto AM, Da Silva ABF, Herculano AM, Oliveira KRM, Dos Santos Borges R. Sugar moiety has a synergistic effect on hydroxylated xanthone for better antioxidant activity of mangiferin. Med Chem Res. 2018; 27: 1276– 1282. doi: 10.1007/s00044-018-2147-3 · DOI
  28. [32]Phuong NTN, Ha MT, Nguyen DXT, et al. Development and antioxidant evaluation of mango leaf (Mangifera Indica L.) extract loaded silk fibroin nanoparticles. Front Mater. 2024; 11: 1419697. doi: 10.3389/fmats.2024.1419697 · DOI
  29. [33]Samadarsi R, Mishra D, Dutta D. Mangiferin nanoparticles fortified dairy beverage as a low glycemic food product: its quality attributes and antioxidant properties. Int J of Food Sci Tech. 2020; 55: 589– 600. doi: 10.1111/ijfs.14310 · DOI
  30. [34]Liang Q, Ren X, Chalamaiah M, Ma H. Simulated gastrointestinal digests of corn protein hydrolysate alleviate inflammation in caco-2 cells and a mouse model of colitis. J Food Sci Technol. 2020; 57: 2079– 2088. doi: 10.1007/s13197-020-04242-7 32431334 PMC7230093 · DOI
  31. [38]Lee YT, Tan YJ, Oon CE. Molecular targeted therapy: treating cancer with specificity. Eur J Pharmacol. 2018; 834: 188– 196. doi: 10.1016/j.ejphar.2018.07.034 30031797 · DOI
  32. [39]Mei S, Ma H, Chen X. Anticancer and anti-inflammatory properties of mangiferin: a review of its molecular mechanisms. Food and Chemical Toxicology. 2021; 149: 111997. doi: 10.1016/j.fct.2021.111997 33465461 · DOI
  33. [40]Siswanto S, Arozal W, Juniantito V, Grace A, Agustini FD. Nafrialdi the effect of mangiferin against brain damage caused by oxidative stress and inflammation induced by doxorubicin. HAYATI J Biosci. 2016; 23: 51– 55. doi: 10.1016/j.hjb.2016.02.001 · DOI
  34. [41]Zeng Z, Lin C, Wang S, et al. Suppressive activities of mangiferin on human epithelial ovarian cancer. Phytomedicine. 2020; 76: 153267. doi: 10.1016/j.phymed.2020.153267 32570111 · DOI
  35. [42]Szandruk M, Merwid-Ląd A, Szeląg A. The impact of mangiferin from belamcanda chinensis on experimental colitis in rats. Inflammopharmacol. 2018; 26: 571– 581. doi: 10.1007/s10787-017-0337-0 PMC5859701 28337639 · DOI
  36. [43]Li Y, Wu Y, Jiang K, et al. Mangiferin prevents TBHP-induced apoptosis and ECM degradation in mouse osteoarthritic chondrocytes via restoring autophagy and ameliorates murine osteoarthritis. Oxid Med Cell Longev. 2019; 2019: 1– 17. doi: 10.1155/2019/8783197 PMC6815628 31885823 · DOI
  37. [44]Li M, Wu C, Guo H, Chu C, Hu M, Zhou C. Mangiferin improves hepatic damage-associated molecular patterns, lipid metabolic disorder and mitochondrial dysfunction in alcohol hepatitis rats. Food Funct. 2019; 10: 3514– 3534. doi: 10.1039/C9FO00153K 31144698 · DOI
  38. [45]Toledo RCL, Brito LF, Caetano MMM, et al. Acute treatment with Mangifera indica L. leaf extract attenuates liver inflammation in rats fed a cafeteria diet. Food Funct. 2019; 10: 4861– 4867. doi: 10.1039/C9FO00651F 31334539 · DOI
  39. [46]Jia L, Sun P, Gao H, et al. Mangiferin attenuates bleomycin-induced pulmonary fibrosis in mice through inhibiting TLR4/P65 and TGF-Β1/Smad2/3 Pathway. J Pharm Pharmacol. 2019; 71: 1017– 1028. doi: 10.1111/jphp.13077 30847938 · DOI
  40. [47]Wang H, Shao W, Lu X, et al. Characterization, and in vitro anti-tumor activity studies of the hyaluronic acid-mangiferin-methotrexate nanodrug targeted delivery system. Int J Biol Macromol. 2023; 239: 124208. doi: 10.1016/j.ijbiomac.2023.124208 36972827 · DOI
  41. [48]Razura-Carmona FF, Herrera-Martínez M, Sáyago-Ayerdi SG, et al. Nanoparticles of two ZnO precursors as an encapsulating matrix of mangiferin: associated studies to cytotoxic effects on liver cancer cells Hep-G2 and healthy lung cell beas-2B. J Clust Sci. 2022; 33: 163– 171. doi: 10.1007/s10876-020-01957-7 · DOI
  42. [50]Al-Yasiri AY, Khoobchandani M, Cutler CS, et al. Mangiferin functionalized radioactive gold nanoparticles (MGF-198 AuNPs) in prostate tumor therapy: green nanotechnology for production, in vivo tumor retention and evaluation of therapeutic efficacy. Dalton Trans. 2017; 46: 14561– 14571. doi: 10.1039/C7DT00383H 28440368 · DOI
  43. [51]Khoobchandani M, Katti KK, Karikachery AR, et al. New approaches in breast cancer therapy through green nanotechnology and nano-ayurvedic medicine – pre-clinical and pilot human clinical investigations. IJN. 2020; 15: 181– 197. doi: 10.2147/IJN.S219042 32021173 PMC6970107 · DOI
  44. [52]Khoobchandani M, Khan A, Katti KK, et al. Green nanotechnology of MGF-AuNPs for immunomodulatory intervention in prostate cancer therapy. Sci Rep. 2021; 11: 16797. doi: 10.1038/s41598-021-96224-8 34408231 PMC8373987 · DOI
  45. [53]Ge X-H, Shao L, Zhu G-J. Oxymatrine attenuates brain hypoxic-ischemic injury from apoptosis and oxidative stress: role of p-Akt/GSK3β/HO-1/Nrf-2 signaling pathway. Metab Brain Dis. 2018; 33: 1869– 1875. doi: 10.1007/s11011-018-0293-4 30032345 · DOI
  46. [54]Avila JA, Kiprowska M, Jean‐Louis T, Rockwell P, Figueiredo‐Pereira ME, Serrano PA. PACAP27 mitigates an age‐dependent hippocampal vulnerability to PGJ2‐induced spatial learning deficits and neuroinflammation in mice. Brain and Behavior. 2020; 10: e01465. doi: 10.1002/brb3.1465 31769222 PMC6955932 · DOI
  47. [55]Alberdi E, Sánchez-Gómez MV, Ruiz A, et al. Mangiferin and Morin attenuate oxidative stress, mitochondrial dysfunction, and neurocytotoxicity, induced by amyloid beta oligomers. Oxid Med Cell Longev. 2018; 2018: 1– 13. doi: 10.1155/2018/2856063 PMC6022276 30013719 · DOI
  48. [56]Agarwala S, B NR, Mudholkar K, Bhuwania R, Satish Rao BS. Mangiferin, a dietary xanthone protects against mercury‐induced Toxicity in HepG2 cells. Environ. Toxicol. 2012; 27: 117– 127. doi: 10.1002/tox.20620 20629087 PMC3483531 · DOI
  49. [57]Levi S, Ripamonti M, Moro AS, Cozzi A. Iron Imbalance in Neurodegeneration. Mol Psychiatry. 2024; 29: 1139– 1152. doi: 10.1038/s41380-023-02399-z 38212377 PMC11176077 · DOI
  50. [60]Infante-Garcia C, Ramos-Rodriguez JJ, Delgado-Olmos I, et al. Long-term mangiferin extract treatment improves central pathology and cognitive deficits in APP/PS1 Mice. Mol Neurobiol. 2017; 54: 4696– 4704. doi: 10.1007/s12035-016-0015-z 27443159 · DOI
  51. [61]Amazzal L, Lapôtre A, Quignon F, Bagrel D. Mangiferin protects against 1-Methyl-4-phenylpyridinium toxicity mediated by oxidative stress in N2A Cells. Neurosci Lett. 2007; 418: 159– 164. doi: 10.1016/j.neulet.2007.03.025 17433543 · DOI
  52. [63]Rao VS, Carvalho AC, Trevisan MTS, et al. Mangiferin ameliorates 6-hydroxydopamineinduced cytotoxicity and oxidative stress in ketamine model of schizophrenia. Pharmacol Rep. 2012; 64(4): 848– 856. doi: 10.1016/s1734-1140(12)70879-4 23087136 · DOI
  53. [64]Cao C, Su M, Zhou F. Mangiferin Inhibits Hippocampal NLRP3 Inflammasome and exerts antidepressant effects in a chronic mild stress mice model. Behav Pharmacol. 2017; 28: 356– 364. doi: 10.1097/FBP.0000000000000305 28410265 · DOI
  54. [65]Luo G-Q, Liu L, Gao Q-W, Wu X-N, Xiang W, Deng W-T. Mangiferin prevents corticosterone-induced behavioural deficits via alleviation of oxido-nitrosative stress and down-regulation of indoleamine 2,3-Dioxygenase (IDO) activity. Neurol Res. 2017; 39: 709– 718. doi: 10.1080/01616412.2017.1310705 28403684 · DOI
  55. [66]Feng S-T, Wang -Z-Z, Yuan Y-H, Sun H-M, Chen N-H, Zhang Y. Mangiferin: a multipotent natural product preventing neurodegeneration in alzheimer’s and parkinson’s disease models. Pharmacol Res. 2019; 146: 104336. doi: 10.1016/j.phrs.2019.104336 31271846 · DOI · Paper page
  56. [67]Ahmad N, Khan MF, Ullah Z, et al. Development and evaluation of polysorbate-80 coated mangiferin PLGA nanoparticles used in the treatment of cerebral ischemia. Polym Bull. 2024; 81: 7035– 7069. doi: 10.1007/s00289-023-05030-x · DOI
  57. [70]Sekar V, Mani S, Malarvizhi R, Barathidasan R, Vasanthi HR. positive interaction of mangiferin with selected oral hypoglycemic drugs: a therapeutic strategy to alleviate diabetic nephropathy in experimental rats. Mol Biol Rep. 2020; 47: 4465– 4475. doi: 10.1007/s11033-020-05517-0 32451927 · DOI
  58. [71]Wu Y, Liu W, Yang T, et al. Oral administration of mangiferin ameliorates diabetes in animal models: a meta-analysis and systematic review. Nutr Res. 2021; 87: 57– 69. doi: 10.1016/j.nutres.2020.12.017 33601215 · DOI
  59. [73]Wang M, Zhang Z, Huo Q, et al. Targeted polymeric nanoparticles based on mangiferin for enhanced protection of pancreatic β-cells and type 1 diabetes mellitus efficacy. ACS Appl. Mater. Interfaces. 2022; 14: 11092– 11103. doi: 10.1021/acsami.1c22964 35199981 · DOI
  60. [74]Górniak I, Bartoszewski R, Króliczewski J. Comprehensive review of antimicrobial activities of plant flavonoids. Phytochem Rev. 2019; 18: 241– 272. doi: 10.1007/s11101-018-9591-z · DOI
  61. [76]Singh SK, Tiwari RM, Sinha SK, Danta CC, Prasad SK. Antimicrobial evaluation of mangiferin and its synthesized analogues. Asian Pac J Trop Biomed. 2012; 2: S884– S887. doi: 10.1016/S2221-1691(12)60329-3 · DOI
  62. [77]Rechenchoski DZ, Agostinho KF, Faccin-Galhardi LC, et al. Mangiferin: a promising natural xanthone from Mangifera indica for the control of acyclovir – resistant herpes simplex virus 1 infection. Bioorg. Med. Chem. 2020; 28: 115304. doi: 10.1016/j.bmc.2020.115304 31956052 · DOI
  63. [78]de Oliveira CS, Falcão-Silva VDS, Siqueira JP, et al. Drug resistance modulation in staphylococcus aureus, a new biological activity for mesoionic hydrochloride compounds. Molecules. 2011; 16: 2023– 2031. doi: 10.3390/molecules16032023 21358591 PMC6259633 · DOI
  64. [79]Jiamboonsri P, Pithayanukul P, Bavovada R, Chomnawang MT. The inhibitory potential of Thai mango seed kernel extract against methicillin-resistant staphylococcus aureus. Molecules. 2011; 16: 6255– 6270. doi: 10.3390/molecules16086255 21788933 PMC6264745 · DOI
  65. [80]Diso SU, Ali M, Mukhtar SI, Garba M. Antibacterial activity and phytochemical screening of Mangifera indica (mango) stem and leaf extracts on clinical isolates of methicillin resistant staphylococcus aureus. J Adv Med Pharm Sci. 2017: 1– 6. doi: 10.9734/JAMPS/2017/31127 · DOI
  66. [81]Al Bshabshe A, Joseph MRP, Awad El-Gied AA, Fadul AN, Chandramoorthy HC, Hamid ME. Clinical relevance and antimicrobial profiling of Methicillin-Resistant Staphylococcus Aureus (MRSA) on routine antibiotics and ethanol extract of mango kernel (Mangifera Indica L.). Biomed Res Int. 2020; 2020: 4150678. doi: 10.1155/2020/4150678 32149104 PMC7049837 · DOI
  67. [82]Prabhu K, Prasathkumar M, Sivaraman J, et al. Phytochemical Characterization, antibacterial, and anti-biofilm efficacy of Mangifera indica seed kernel: a preliminary study using in vitro and in silico approaches. J King Saud Univ Sci. 2023; 35: 102688. doi: 10.1016/j.jksus.2023.102688 · DOI
  68. [83]Sicurella M, Sguizzato M, Cortesi R, et al. Mangiferin-loaded smart gels for HSV-1 Treatment. Pharmaceutics. 2021; 13: 1323. doi: 10.3390/pharmaceutics13091323 34575399 PMC8465222 · DOI
  69. [84]Athipornchai A, Pabunrueang P, Trakulsujaritchok T. Mangiferin loaded carrageenan/chitosan core-shell hydrogel beads: preparation, characterization and proposed application. Food Hydrocoll. 2024; 147: 109394. doi: 10.1016/j.foodhyd.2023.109394 · DOI
  70. [85]Samadarsi R, Dutta D. Design and characterization of mangiferin nanoparticles for oral delivery. Journal of Food Engineering. 2019; 247: 80– 94. doi: 10.1016/j.jfoodeng.2018.11.020 · DOI
  71. [86]Wisutthathum S, Kamkaew N, Inchan A, et al. Extract of aquilaria crassna leaves and mangiferin are vasodilators while showing no cytotoxicity. J Traditional Complementary Med. 2019; 9: 237– 242. doi: 10.1016/j.jtcme.2018.09.002 PMC6701956 31453117 · DOI
  72. [87]Rodeiro I, Hernandez S, Morffi J, et al. Evaluation of genotoxicity and DNA protective effects of mangiferin, a glucosylxanthone isolated from Mangifera indica L. stem bark extract. Food and Chemical Toxicology. 2012; 50: 3360– 3366. doi: 10.1016/j.fct.2012.06.032 22749943 · DOI
  73. [88]Mei S, Perumal M, Battino M, et al. Mangiferin: a review of dietary sources, absorption, metabolism, bioavailability, and safety. Crit. Rev. Food Sci. Nutr. 2023; 63: 3046– 3064. doi: 10.1080/10408398.2021.1983767 34606395 · DOI · Paper page
  74. [89]Reddeman RA, Glávits R, Endres JR, et al. A toxicological evaluation of mango leaf extract (Mangifera indica) containing 60% mangiferin. J Toxicol. 2019; 2019: 1– 14. doi: 10.1155/2019/4763015 PMC6699309 31467524 · DOI · Paper page
  75. [90]Villas Boas GR, Rodrigues Lemos JM, De Oliveira MW, et al. Preclinical safety evaluation of the aqueous extract from Mangifera indica Linn. (Anacardiaceae): genotoxic, clastogenic and cytotoxic assessment in experimental models of genotoxicity in rats to predict potential human risks. J Ethnopharmacol. 2019; 243: 112086. doi: 10.1016/j.jep.2019.112086 31310830 · DOI
  76. [91]Razura-Carmona FF, Díaz-Reséndiz KJG, Covantes-Rosales CE, et al. Toxicity of hybrid particles (PLGA-ZnO) loaded with lupeol and mangiferina: ex vivo model of peripheral cells. ACS Food Sci Technol. 2023; 3: 675– 682. doi: 10.1021/acsfoodscitech.2c00417 · DOI
  77. [92]Jamwal D, Saini P, Tomar PC, Ghosh A. Perspectives on the Potential of Mangiferin as a Nutraceutical: a Review. NFS. 2023; 53: 249– 264. doi: 10.1108/NFS-01-2022-0013 · DOI

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Authors
Al-Madhagi, H.
ORCID
Al-Madhagi, Haitham
Venue
Nanotechnology, Science and Applications
Publisher
Informa UK Limited
Published
2025-07
Volume
Volume 18
Pages
277-294
ISSN
1177-8903 (ISSN-L)
DOI
10.2147/nsa.s525423
PMC
PMC12258238
OpenAlex
W4412156367
Cited by
26
References
14
Citations by year
2026: 21 · 2025: 5
FWCI
5.76
Type
journal article
Language
en
Open access
Licence
Locations
  • Nanotechnology Science and Applications (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Natural Compound Pharmacology Studies
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Pharmacology and Nanomedicine Research
Keywords
mangiferin, mango, xanthones, phytochemistry, pharmacokinetics, bioavailability, solubility, nanoformulations, nanoparticles, micelles, liposomes, targeted drug delivery, antioxidant activity, anti-inflammatory activity, antimicrobial activity, anticancer activity, antidiabetic activity, neurodegenerative diseases, safety, clinical translation

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