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MicroRNA: Biogenesis, Function and Role in Cancer

MacFarlane, Leigh-Ann, R. Murphy, Paul·2010·Current Genomics
DOI 10.2174/138920210793175895PMC PMC3048316
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Fig. (1). MicroRNA maturation and function. The miRNA gene is transcribed to generate a primary microRNA (pri-miRNA) precursor molecule that undergoes nuclear cleavage to form a precursor microRNA (pre-miRNA). The pre-miRNA is cleaved in the cytoplasm to create a microRNA duplex (miRNA:miRNA*, passenger strand designated with asterisk) containing the mature miRNA. The duplex unwinds and the mature miRNA assembles into RISC. The miRNA base-pairs with target mRNA to direct gene silencing via mRNA cleavage or translation repression based on the level of complementarity between the miRNA and the mRNA target.
Fig. (1). MicroRNA maturation and function. The miRNA gene is transcribed to generate a primary microRNA (pri-miRNA) precursor molecule that undergoes nuclear cleavage to form a precursor microRNA (pre-miRNA). The pre-miRNA is cleaved in the cytoplasm to create a microRNA duplex (miRNA:miRNA*, passenger strand designated with asterisk) containing the mature miRNA. The duplex unwinds and the mature miRNA assembles into RISC. The miRNA base-pairs with target mRNA to direct gene silencing via mRNA cleavage or translation repression based on the level of complementarity between the miRNA and the mRNA target.CC BY · PubMed Central
Fig. (2). Nuclear component of microRNA biogenesis. Intergenic miRNAs are transcribed by RNA polymerase II or III generating a primary miRNA (pri-miRNA) molecule, which is processed into a precursor miRNA (pre-miRNA) by the microprocessor complex comprised of DGCR8 and Drosha. Pre-miRNAs are exported to the cytoplasm in a nucleocytoplasmic transporter containing Exportin 5 and Ran-GTP. MiRNA within introns are transcribed as part of precursor mRNA (pre-mRNA) by RNA polymerase II. The miRNA sequence is excised from the pre-mRNA by spliceosomal components or the microprocessor to liberate a mirtron or a pre-miRNA that is exported. Alternatively, a primary miRNA (pri-miRNA) is released which undergoes microprocessor cleavage to generate pre-miRNA.
Fig. (2). Nuclear component of microRNA biogenesis. Intergenic miRNAs are transcribed by RNA polymerase II or III generating a primary miRNA (pri-miRNA) molecule, which is processed into a precursor miRNA (pre-miRNA) by the microprocessor complex comprised of DGCR8 and Drosha. Pre-miRNAs are exported to the cytoplasm in a nucleocytoplasmic transporter containing Exportin 5 and Ran-GTP. MiRNA within introns are transcribed as part of precursor mRNA (pre-mRNA) by RNA polymerase II. The miRNA sequence is excised from the pre-mRNA by spliceosomal components or the microprocessor to liberate a mirtron or a pre-miRNA that is exported. Alternatively, a primary miRNA (pri-miRNA) is released which undergoes microprocessor cleavage to generate pre-miRNA.CC BY · PubMed Central
Fig. (3). Cytoplasmic component of microRNA biogenesis. Pre-miRNA is cleaved by Dicer to generate miRNA duplex or by Ago2 to generate an Ago2-cleaved precursor miRNA” (ac-pre-miRNA) that subsequently acts as a substrate for Dicer. The asterisk (*) near a protein symbolizes it is responsible for the cleavage event. The miRNA duplex liberates the mature miRNA to assemble into RISC loading complex comprised of Ago2, TRBP, PACT and Dicer. The mechanism of mature miRNA release is unclear. Possible mechanisms involving RNA Helicase A (RHA), Dicer cleavage, Ago2 cleavage and uncharacterized proteins have been illustrated.
Fig. (3). Cytoplasmic component of microRNA biogenesis. Pre-miRNA is cleaved by Dicer to generate miRNA duplex or by Ago2 to generate an Ago2-cleaved precursor miRNA” (ac-pre-miRNA) that subsequently acts as a substrate for Dicer. The asterisk (*) near a protein symbolizes it is responsible for the cleavage event. The miRNA duplex liberates the mature miRNA to assemble into RISC loading complex comprised of Ago2, TRBP, PACT and Dicer. The mechanism of mature miRNA release is unclear. Possible mechanisms involving RNA Helicase A (RHA), Dicer cleavage, Ago2 cleavage and uncharacterized proteins have been illustrated.CC BY · PubMed Central
Fig. (4). Slicer-dependent microRNA mediated gene silencing. Extensive base-pairing between the miRNA guide and mRNA target permit Ago2 mRNA cleavage. Subsequently, mRNA is deadenylated by protein complexes comprised of Pop2, Ccr4 and Not1. mRNA is then degraded from 3’ to 5’ by the exosome complex or from 5’ to 3’ by the Xrn1p exonuclease following decapping by Dcp enzymes.
Fig. (4). Slicer-dependent microRNA mediated gene silencing. Extensive base-pairing between the miRNA guide and mRNA target permit Ago2 mRNA cleavage. Subsequently, mRNA is deadenylated by protein complexes comprised of Pop2, Ccr4 and Not1. mRNA is then degraded from 3’ to 5’ by the exosome complex or from 5’ to 3’ by the Xrn1p exonuclease following decapping by Dcp enzymes.CC BY · PubMed Central
Fig. (5). Slicer-independent microRNA mediated gene silencing. Limited base-pairing between the miRNA guide and mRNA target create bulges that inhibit Ago2 mRNA cleavage and propels slicer-independent gene silencing mechanisms. MiRNA can repress translation directly pre- or post- translation initiation which is determined by the target mRNA promoter. Alternatively, miRNA can repress translation indirectly by segregating mRNA away from ribosomes to cytoplasmic foci and accelerating deadenylation and decapping processes. Ultimately, mRNA can be isolated for storage or be targeted for decay via Xrn1p or exosome degradation. Stored mRNA can return to active translation or be targeted for degradation.
Fig. (5). Slicer-independent microRNA mediated gene silencing. Limited base-pairing between the miRNA guide and mRNA target create bulges that inhibit Ago2 mRNA cleavage and propels slicer-independent gene silencing mechanisms. MiRNA can repress translation directly pre- or post- translation initiation which is determined by the target mRNA promoter. Alternatively, miRNA can repress translation indirectly by segregating mRNA away from ribosomes to cytoplasmic foci and accelerating deadenylation and decapping processes. Ultimately, mRNA can be isolated for storage or be targeted for decay via Xrn1p or exosome degradation. Stored mRNA can return to active translation or be targeted for degradation.CC BY · PubMed Central
Fig. (6). The P-body model. The RISC loading complex containing mature miRNA translocates to a P-body compartment specific for RISC assembly and activation. Upon target recognition the silencing mechanism is determine as slicer -depepndent or –independent, both having distinct functional compartments. Target mRNA will then be redirected for degradation or mRNA storage, which can be later returned to active translation or degraded.
Fig. (6). The P-body model. The RISC loading complex containing mature miRNA translocates to a P-body compartment specific for RISC assembly and activation. Upon target recognition the silencing mechanism is determine as slicer -depepndent or –independent, both having distinct functional compartments. Target mRNA will then be redirected for degradation or mRNA storage, which can be later returned to active translation or degraded.CC BY · PubMed Central
Fig. (7). Proposed microRNA working model. duplexes have mismatched pairs an Ago2 independent bypass mechanism will be employed. I hypothesize that this mechanism uses RNA helicase A to unwind the miRNA duplex which permits Ago2 of the RISC loading complex to load the arm with the least stable 5’end, the miRNA guide. Once the mature miRNA guide is bound to Ago2 additional RISC associated proteins, such as GW182, assemble to form the active miRISC which will seek out and bind its target mRNA.
Fig. (7). Proposed microRNA working model. duplexes have mismatched pairs an Ago2 independent bypass mechanism will be employed. I hypothesize that this mechanism uses RNA helicase A to unwind the miRNA duplex which permits Ago2 of the RISC loading complex to load the arm with the least stable 5’end, the miRNA guide. Once the mature miRNA guide is bound to Ago2 additional RISC associated proteins, such as GW182, assemble to form the active miRISC which will seek out and bind its target mRNA.CC BY · PubMed Central

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  1. [1]Perron MP Provost P Protein interactions and complexes in human microRNA biogenesis and function Front. Biosci 2008 13 2537 2547 17981733 PMC2901379
  2. [4]Rajewsky N L(ou)sy miRNA targets? Nat. Struct. Mol. Biol 2006 13 754 755 16955093
  3. [5]Rajewsky N microRNA target predictions in animals Nat. Genet 2006 38 Suppl S8 13 16736023
  4. [6]Liu W Mao SY Zhu WY Impact of tiny miRNAs on cancers World J. Gastroenterol 2007 13 497 502 17278213 PMC4065969
  5. [7]Berezikov E Guryev V van de Belt J Wienholds E Plasterk RH Cuppen E Phylogenetic shadowing and computational identification of human microRNA genes Cell 2005 120 21 24 15652478
  6. [8]Stanczyk J Pedrioli DM Brentano F Sanchez-Pernaute O Kolling C Gay RE Detmar M Gay S Kyburz D Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis Arthritis Rheum 2008 58 1001 1009 18383392
  7. [9]Griffiths-Jones S miRBase: the microRNA sequence database Methods Mol. Biol 2006 342 129 138 16957372
  8. [10]Griffiths-Jones S The microRNA Registry Nucleic Acids Res 2004 32 D109 111 14681370 PMC308757
  9. [11]Griffiths-Jones S Saini HK van Dongen S Enright AJ miRBase: tools for microRNA genomics Nucleic Acids Res 2008 36 D154 158 17991681 PMC2238936
  10. [12]Cullen BR Transcription and processing of human microRNA precursors Mol. Cell 2004 16 861 865 15610730
  11. [13]Esau C Davis S Murray SF Yu XX Pandey SK Pear M Watts L Booten SL Graham M McKay R Subramaniam A Propp S Lollo BA Freier S Bennett CF Bhanot S Monia BP miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting Cell Metab 2006 3 87 98 16459310
  12. [15]Zhao Y Samal E Srivastava D Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis Nature 2005 436 214 220 15951802
  13. [16]Naguibneva I Ameyar-Zazoua M Polesskaya A Ait-Si-Ali S Groisman R Souidi M Cuvellier S Harel-Bellan A The microRNA miR-181 targets the homeobox protein Hox-A11 during mammalian myoblast differentiation Nat. Cell Biol 2006 8 278 284 16489342
  14. [17]Garzon R Pichiorri F Palumbo T Iuliano R Cimmino A Aqeilan R Volinia S Bhatt D Alder H Marcucci G Calin GA Liu CG Bloomfield CD Andreeff M Croce CM MicroRNA fingerprints during human mega-karyocytopoiesis Proc. Natl. Acad. Sci. USA 2006 103 5078 5083 16549775 PMC1458797
  15. [18]Monticelli S Ansel KM Xiao C Socci ND Krichevsky AM Thai TH Rajewsky N Marks DS Sander C Rajewsky K Rao A Kosik KS MicroRNA profiling of the murine hematopoietic system Genome Biol 2005 6 R71 16086853 PMC1273638
  16. [20]Bartel DP MicroRNAs: genomics, biogenesis, mechanism, and function Cell 2004 116 281 297 14744438
  17. [21]Mayr C Hemann MT Bartel DP Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation Science 2007 315 5818 1576 9 17322030 PMC2556962
  18. [22]Lee YS Dutta A The tumor suppressor microRNA let-7 represses the HMGA2 oncogene Genes Dev 2007 21 1025 1030 17437991 PMC1855228
  19. [23]Wang T Zhang X Obijuru L Laser J Aris V Lee P Mittal K Soteropoulos P Wei JJ A micro-RNA signature associated with race tumor size, and target gene activity in human uterine leiomyomas Genes Chromosomes Cancer 2007 46 336 347 17243163
  20. [24]Garzon R Fabbri M Cimmino A Calin GA Croce CM MicroRNA expression and function in cancer Trends Mol. Med 2006 12 580 587 17071139
  21. [25]Nelson PT Wang WX Rajeev BW MicroRNAs (miRNAs) in neurodegenerative diseases Brain Pathol 2008 18 130 138 18226108 PMC2859437
  22. [26]Wang WX Rajeev BW Stromberg AJ Ren N Tang G Huang Q Rigoutsos I Nelson PT The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1 J. Neurosci 2008 28 1213 1223 18234899 PMC2837363
  23. [27]Hansen T Olsen L Lindow M Jakobsen KD Ullum H Jonsson E Andreassen OA Djurovic S Melle I Agartz I Hall H Timm S Wang AG Werge T Brain expressed microRNAs implicated in schizophrenia etiology PLoS ONE 2007 2 e873 17849003 PMC1964806
  24. [28]Jay C Nemunaitis J Chen P Fulgham P Tong AW miRNA profiling for diagnosis and prognosis of human cancer DNA Cell Biol 2007 26 293 300 17504025
  25. [29]Hernando E microRNAs and cancer: role in tumorigenesis, patient classification and therapy Clin. Transl. Oncol 2007 9 155 160 17403626
  26. [30]Barbarotto E Schmittgen TD Calin GA MicroRNAs and cancer: profile, profile, profile Int. J. Cancer 2008 122 969 977 18098138
  27. [31]Lu J Getz G Miska EA Alvarez-Saavedra E Lamb J Peck D Sweet-Cordero A Ebert BL Mak RH Ferrando AA Downing JR Jacks T Horvitz HR Golub TR MicroRNA expression profiles classify human cancers Nature 2005 435 834 838 15944708
  28. [32]Ambros V Bartel B Bartel DP Burge CB Carrington JC Chen X Dreyfuss G Eddy SR Griffiths-Jones S Marshall M Matzke M Ruvkun G Tuschl T A uniform system for microRNA annotation Rna 2003 9 277 279 12592000 PMC1370393
  29. [33]Kim VN MicroRNA biogenesis: coordinated cropping and dicing Nat. Rev. Mol. Cell. Biol 2005 6 376 385 15852042
  30. [34]Kim VN Small RNAs: classification, biogenesis, and function Mol. Cells 2005 19 1 15 15750334
  31. [35]Lagos-Quintana M Rauhut R Meyer J Borkhardt A Tuschl T New microRNAs from mouse and human RNA 2003 9 175 179 12554859 PMC1370382
  32. [36]Rodriguez A Griffiths-Jones S Ashurst JL Bradley A Identification of mammalian microRNA host genes and transcription units Genome Res 2004 14 1902 1910 15364901 PMC524413
  33. [37]Ying SY Chang CP Lin SL Intron-mediated RNA interference intronic microRNAs and applications Methods Mol. Biol 2010 629 205 237 20387152
  34. [38]Saini HK Griffiths-Jones S Enright AJ Genomic analysis of human microRNA transcripts Proc. Natl. Acad. Sci. USA 2007 104 17719 17724 17965236 PMC2077053
  35. [39]Altuvia Y Landgraf P Lithwick G Elefant N Pfeffer S Aravin A Brownstein MJ Tuschl T Margalit H Clustering and conservation patterns of human microRNAs Nucleic Acids Res 2005 33 2697 2706 15891114 PMC1110742
  36. [40]Yu J Wang F Yang GH Wang FL Ma YN Du ZW Zhang JW Human microRNA clusters: genomic organization and expression profile in leukemia cell lines Biochem. Biophys. Res. Commun 2006 349 59 68 16934749
  37. [41]Cullen BR Derivation and function of small interfering RNAs and microRNAs Virus Res 2004 102 3 9 15068874
  38. [42]Lee Y Kim M Han J Yeom KH Lee S Baek SH Kim VN MicroRNA genes are transcribed by RNA polymerase II EMBO J 2004 23 4051 4060 15372072 PMC524334
  39. [43]Cai X Hagedorn CH Cullen BR Human microRNAs are processed from capped polyadenylated transcripts that can also function as mRNAs RNA 2004 10 1957 1966 15525708 PMC1370684
  40. [44]Bartel DP Chen CZ Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs Nat. Rev. Genet 2004 5 396 400 15143321
  41. [45]Cramer P Structure and function of RNA polymerase II Adv. Protein Chem 2004 67 1 42 14969722
  42. [46]Ohkuma Y [Function and structural biology of general transcription factors and RNA polymerase II in eukaryotes] Tanpakushitsu Kakusan Koso 1999 44 438 456 10203998
  43. [47]Woychik NA Young RA RNA polymerase II: subunit structure and function Trends Biochem. Sci 1990 15 347 351 1700503
  44. [48]Goodfellow SJ White RJ Regulation of RNA polymerase III transcription during mammalian cell growth Cell Cycle 2007 6 2323 2326 17938580
  45. [49]Felton-Edkins ZA Kenneth NS Brown TR Daly NL Gomez-Roman N Grandori C Eisenman RN White RJ Direct regulation of RNA polymerase III transcription by RB p53 and c-Myc Cell Cycle 2003 2 181 184 12734418
  46. [50]Scott PH Cairns CA Sutcliffe JE Alzuherri HM McLees A Winter AG White RJ Regulation of RNA polymerase III transcription during cell cycle entry J. Biol. Chem 2001 276 1005 1014 11024049
  47. [51]White RJ Gottlieb TM Downes CS Jackson SP Cell cycle regulation of RNA polymerase III transcription Mol. Cell Biol 1995 15 6653 6662 8524230 PMC230918
  48. [52]Costanzo G Camier S Carlucci P Burderi L Negri R RNA polymerase III transcription complexes on chromosomal 5S rRNA genes in vivo: TFIIIB occupancy and promoter opening Mol. Cell Biol 2001 21 3166 3178 11287621 PMC86947
  49. [53]Young LS Rivier DH Sprague KU Sequences far downstream from the classical tRNA promoter elements bind RNA polymerase III transcription factors Mol. Cell Biol 1991 11 1382 1392 1996100 PMC369409
  50. [54]Besser D Gotz F Schulze-Forster K Wagner H Kroger H Simon D DNA methylation inhibits transcription by RNA polymerase III of a tRNA gene, but not of a 5S rRNA gene FEBS Lett 1990 269 358 362 2401361
  51. [55]Kassavetis GA Riggs DL Negri R Nguyen LH Geiduschek EP Transcription factor IIIB generates extended DNA interactions in RNA polymerase III transcription complexes on tRNA genes Mol. Cell Biol 1989 9 2551 2566 2668737 PMC362328
  52. [56]Chen CZ Li L Lodish HF Bartel DP MicroRNAs modulate hematopoietic lineage differentiation Science 2004 303 83 86 14657504
  53. [57]Borchert GM Lanier W Davidson BL RNA polymerase III transcribes human microRNAs Nat. Struct. Mol. Biol 2006 13 1097 1101 17099701
  54. [58]Hess J Perez-Stable C Wu GJ Weir B Tinoco I Jr. Shen CK End-to-end transcription of an Alu family repeat. A new type of polymerase-III-dependent terminator and its evolutionary implication J. Mol. Biol 1985 184 7 21 2411938
  55. [59]Gu TJ Yi X Zhao XW Zhao Y Yin JQ Alu-directed transcriptional regulation of some novel miRNAs BMC Genomics 2009 10 563 19943974 PMC3087558
  56. [60]Ambros V Lee RC Identification of microRNAs and other tiny noncoding RNAs by cDNA cloning Methods Mol. Biol 2004 265 131 158 15103073
  57. [61]Pillai RS Bhattacharyya SN Filipowicz W Repression of protein synthesis by miRNAs: how many mechanisms? Trends Cell Biol 2007 17 118 126 17197185
  58. [62]Miranda KC Huynh T Tay Y Ang YS Tam WL Thomson AM Lim B Rigoutsos I A pattern-based method for the identification of MicroRNA binding sites and their corresponding heteroduplexes Cell 2006 126 1203 1217 16990141
  59. [63]Davis CD Ross SA Evidence for dietary regulation of microRNA expression in cancer cells Nutr. Rev 2008 66 477 482 18667010
  60. [64]Fiedler SD Carletti MZ Hong X Christenson LK Hormonal regulation of microRNA expression in periovulatory mouse mural granulosa cells Biol. Reprod 2008 79 6 1030 7 18716288 PMC2780477
  61. [65]Kulshreshtha R Ferracin M Negrini M Calin GA Davuluri RV Ivan M Regulation of microRNA expression: the hypoxic component Cell Cycle 2007 6 1426 1431 17582223
  62. [67]O'Donnell KA Wentzel EA Zeller KI Dang CV Mendell JT c-Myc-regulated microRNAs modulate E2F1 expression Nature 2005 435 839 843 15944709
  63. [68]Sylvestre Y De Guire V Querido E Mukhopadhyay UK Bourdeau V Major F Ferbeyre G Chartrand P An E2F/miR-20a autoregulatory feedback loop J. Biol. Chem 2007 282 2135 2143 17135249
  64. [69]Woods K Thomson JM Hammond SM Direct regulation of an oncogenic micro-RNA cluster by E2F transcription factors J. Biol. Chem 2007 282 2130 2134 17135268
  65. [70]Davis BN Hilyard AC Nguyen PH Lagna G Hata A Smad proteins bind a conserved RNA sequence to promote microRNA maturation by Drosha Mol. Cell 2010 39 373 384 20705240 PMC2921543
  66. [71]Michlewski G Guil S Semple CA Caceres JF Posttranscriptional regulation of miRNAs harboring conserved terminal loops Mol. Cell 2008 32 383 393 18995836 PMC2631628
  67. [72]Viswanathan SR Daley GQ Lin28: A microRNA regulator with a macro role Cell 2010 140 445 449 20178735
  68. [73]Han L Witmer PD Casey E Valle D Sukumar S DNA Methylation Regulates MicroRNA Expression Cancer Biol. Ther 2007 6 1284 8 17660710
  69. [74]Yu Z Wang C Wang M Li Z Casimiro MC Liu M Wu K Whittle J Ju X Hyslop T McCue P Pestell RG A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation J. Cell Biol 2008 182 509 517 18695042 PMC2500136
  70. [76]Du T Zamore PD microPrimer: the biogenesis and function of microRNA Development 2005 132 4645 4652 16224044
  71. [77]Gregory RI Yan KP Amuthan G Chendrimada T Doratotaj B Cooch N Shiekhattar R The Microprocessor complex mediates the genesis of microRNAs Nature 2004 432 235 240 15531877
  72. [78]Han J Lee Y Yeom KH Kim YK Jin H Kim VN The Drosha-DGCR8 complex in primary microRNA processing Genes Dev 2004 18 3016 3027 15574589 PMC535913
  73. [79]Hutvagner G McLachlan J Pasquinelli AE Balint E Tuschl T Zamore PD A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA Science 2001 293 834 838 11452083
  74. [80]Lee Y Ahn C Han J Choi H Kim J Yim J Lee J Provost P Radmark O Kim S Kim VN The nuclear RNase III Drosha initiates microRNA processing Nature 2003 425 415 419 14508493
  75. [81]Lee Y Jeon K Lee JT Kim S Kim VN MicroRNA maturation: stepwise processing and subcellular localization EMBO J 2002 21 4663 4670 12198168 PMC126204
  76. [82]Lin SL Kim H Ying SY Intron-mediated RNA interference and microRNA (miRNA) Front. Biosci 2008 13 2216 2230 17981704
  77. [83]Han J Lee Y Yeom KH Nam JW Heo I Rhee JK Sohn SY Cho Y Zhang BT Kim VN Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex Cell 2006 125 887 901 16751099
  78. [84]Abbott AL Alvarez-Saavedra E Miska EA Lau NC Bartel DP Horvitz HR Ambros V The let-7 MicroRNA family members mir-48, mir-84 and mir-241 function together to regulate developmental timing in Caenorhabditis elegans Dev. Cell 2005 9 403 414 16139228 PMC3969732
  79. [85]Zeng Y Cai X Cullen BR Use of RNA polymerase II to transcribe artificial microRNAs Methods Enzymol 2005 392 371 380 15644193
  80. [86]Zeng Y Cullen BR Sequence requirements for micro RNA processing and function in human cells RNA 2003 9 112 123 12554881 PMC1370375
  81. [87]Zeng Y Cullen BR Efficient processing of primary microRNA hairpins by Drosha requires flanking nonstructured RNA sequences J. Biol. Chem 2005 280 27595 27603 15932881
  82. [88]Zhang X Zeng Y The terminal loop region controls microRNA processing by Drosha and Dicer Nucleic Acids Res 2010 [Epub ahead of print] PMC2995066 20660014
  83. [89]Han J Pedersen JS Kwon SC Belair CD Kim YK Yeom KH Yang WY Haussler D Blelloch R Kim VN Posttranscriptional crossregulation between Drosha and DGCR8 Cell 2009 136 75 84 19135890 PMC2680683
  84. [90]Triboulet R Chang HM Lapierre RJ Gregory RI Post-transcriptional control of DGCR8 expression by the Microprocessor RNA 2009 15 1005 1011 19383765 PMC2685516
  85. [92]Gregory RI Shiekhattar R MicroRNA biogenesis and cancer Cancer Res 2005 65 3509 3512 15867338
  86. [93]Zeng Y Yi R Cullen BR MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms Proc. Natl. Acad. Sci. USA 2003 100 9779 9784 12902540 PMC187842
  87. [94]Kim YK Kim VN Processing of intronic microRNAs EMBO J 2007 26 775 783 17255951 PMC1794378
  88. [95]Ying SY Lin SL Intron-derived microRNAs--fine tuning of gene functions Gene 2004 342 25 28 15527961
  89. [96]Lin SL Chang D Wu DY Ying SY A novel RNA splicing-mediated gene silencing mechanism potential for genome evolution Biochem. Biophys. Res. Commun 2003 310 754 760 14550267
  90. [97]Berezikov E Chung WJ Willis J Cuppen E Lai EC Mammalian mirtron genes Mol. Cell 2007 28 328 336 17964270 PMC2763384
  91. [98]Rainer J Ploner C Jesacher S Ploner A Eduardoff M Mansha M Wasim M Panzer-Grumayer R Trajanoski Z Niederegger H Kofler R Glucocorticoid-regulated microRNAs and mirtrons in acute lymphoblastic leukemia Leukemia 2009 23 746 752 19148136
  92. [99]Ruby JG Jan CH Bartel DP Intronic microRNA precursors that bypass Drosha processing Nature 2007 448 83 86 17589500 PMC2475599
  93. [100]Lin SL Miller JD Ying SY Intronic MicroRNA (miRNA) J. Biomed. Biotechnol 2006 2006 26818 17057362 PMC1559912
  94. [101]Bohnsack MT Czaplinski K Gorlich D Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs RNA 2004 10 185 191 14730017 PMC1370530
  95. [102]Lund E Dahlberg JE Substrate Selectivity of Exportin 5 and Dicer in the Biogenesis of MicroRNAs Cold Spring Harb. Symp. Quant. Biol 2006 71 59 66 17381281
  96. [103]Okada C Yamashita E Lee SJ Shibata S Katahira J Nakagawa A Yoneda Y Tsukihara T A high-resolution structure of the pre-microRNA nuclear export machinery Science 2009 326 1275 1279 19965479
  97. [104]Yi R Qin Y Macara IG Cullen BR Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs Genes Dev 2003 17 3011 3016 14681208 PMC305252
  98. [105]Zeng Y Cullen BR Structural requirements for pre-microRNA binding and nuclear export by Exportin 5 Nucleic Acids Res 2004 32 4776 4785 15356295 PMC519115
  99. [106]Okamura K Hagen JW Duan H Tyler DM Lai EC The mirtron pathway generates microRNA-class regulatory RNAs in Drosophila Cell 2007 130 89 100 17599402 PMC2729315
  100. [107]Zhang H Kolb FA Brondani V Billy E Filipowicz W Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP EMBO J 2002 21 5875 5885 12411505 PMC131079
  101. [108]Filipowicz W Jaskiewicz L Kolb FA Pillai RS Post-transcriptional gene silencing by siRNAs and miRNAs Curr. Opin. Struct. Biol 2005 15 331 341 15925505
  102. [109]Haase AD Jaskiewicz L Zhang H Laine S Sack R Gatignol A Filipowicz W TRBP a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing EMBO Rep 2005 6 961 967 16142218 PMC1369185
  103. [110]Jiang F Ye X Liu X Fincher L McKearin D Liu Q Dicer-1 and R3D1-L catalyze microRNA maturation in Drosophila Genes Dev 2005 19 1674 1679 15985611 PMC1176004
  104. [111]Lee YS Nakahara K Pham JW Kim K He Z Sontheimer EJ Carthew RW Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways Cell 2004 117 69 81 15066283
  105. [112]Provost P Dishart D Doucet J Frendewey D Samuelsson B Radmark O Ribonuclease activity and RNA binding of recombinant human Dicer EMBO J 2002 21 5864 5874 12411504 PMC131075
  106. [113]Zhang H Kolb FA Jaskiewicz L Westhof E Filipowicz W Single processing center models for human Dicer and bacterial RNase III Cell 2004 118 57 68 15242644
  107. [114]Song JJ Liu J Tolia NH Schneiderman J Smith SK Martienssen RA Hannon GJ Joshua-Tor L The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes Nat. Struct. Biol 2003 10 1026 1032 14625589
  108. [115]Yan KS Yan S Farooq A Han A Zeng L Zhou MM Structure and conserved RNA binding of the PAZ domain Nature 2003 426 468 474 14615802
  109. [116]Zhang B Pan X Cobb GP Anderson TA microRNAs as oncogenes and tumor suppressors Dev. Biol 2007 302 1 12 16989803
  110. [117]Billy E Brondani V Zhang H Muller U Filipowicz W Specific interference with gene expression induced by long double-stranded RNA in mouse embryonal teratocarcinoma cell lines Proc. Natl. Acad. Sci. USA 2001 98 14428 14433 11724966 PMC64698
  111. [118]Chendrimada TP Gregory RI Kumaraswamy E Norman J Cooch N Nishikura K Shiekhattar R TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing Nature 2005 436 740 744 15973356 PMC2944926
  112. [119]Lee Y Hur I Park SY Kim YK Suh MR Kim VN The role of PACT in the RNA silencing pathway EMBO J 2006 25 522 532 16424907 PMC1383527
  113. [120]Diederichs S Haber DA Dual role for argonautes in microRNA processing and posttranscriptional regulation of microRNA expression Cell 2007 131 1097 1108 18083100
  114. [121]Cifuentes D Xue H Taylor DW Patnode H Mishima Y Cheloufi S Ma E Mane S Hannon GJ Lawson ND Wolfe SA Giraldez AJ A novel miRNA processing pathway independent of Dicer requires Argonaute2 catalytic activity Science 2010 328 1694 1698 20448148 PMC3093307
  115. [122]Song JJ Smith SK Hannon GJ Joshua-Tor L Crystal structure of Argonaute and its implications for RISC slicer activity Science 2004 305 1434 1437 15284453
  116. [123]O'Carroll D Mecklenbrauker I Das PP Santana A Koenig U Enright AJ Miska EA Tarakhovsky A A Slicer-independent role for Argonaute 2 in hematopoiesis and the microRNA pathway Genes Dev 2007 21 1999 2004 17626790 PMC1948855
  117. [124]Meister G Landthaler M Patkaniowska A Dorsett Y Teng G Tuschl T Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs Mol. Cell 2004 15 185 197 15260970
  118. [125]Gregory RI Chendrimada TP Cooch N Shiekhattar R Human RISC couples microRNA biogenesis and posttranscriptional gene silencing Cell 2005 123 631 640 16271387
  119. [126]Maniataki E Mourelatos Z A human ATP-independent RISC assembly machine fueled by pre-miRNA Genes Dev 2005 19 2979 2990 16357216 PMC1315402
  120. [127]Rossi JJ Mammalian Dicer finds a partner EMBO Rep 2005 6 927 929 16222240 PMC1369192
  121. [128]Melo SA Ropero S Moutinho C Aaltonen LA Yamamoto H Calin GA Rossi S Fernandez AF Carneiro F Oliveira C Ferreira B Liu CG Villanueva A Capella G Schwartz S Jr Shiekhattar R Esteller M A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function Nat. Genet 2009 41 365 370 19219043 PMC4509508
  122. [129]Daher A Longuet M Dorin D Bois F Segeral E Bannwarth S Battisti PL Purcell DF Benarous R Vaquero C Meurs EF Gatignol A Two dimerization domains in the trans-activation response RNA-binding protein (TRBP) individually reverse the protein kinase R inhibition of HIV-1 long terminal repeat expression J. Biol. Chem 2001 276 33899 33905 11438532
  123. [130]Gupta V Huang X Patel RC The carboxy-terminal M3 motifs of PACT and TRBP have opposite effects on PKR activity Virology 2003 315 283 291 14585331
  124. [131]Peters GA Hartmann R Qin J Sen GC Modular structure of PACT: distinct domains for binding and activating PKR Mol. Cell. Biol 2001 21 1908 1920 11238927 PMC86773
  125. [132]Patel RC Sen GC PACT a protein activator of the interferon-induced protein kinase PKR EMBO J 1998 17 4379 4390 9687506 PMC1170771
  126. [134]Kalai M Suin V Festjens N Meeus A Bernis A Wang XM Saelens X Vandenabeele P The caspase-generated fragments of PKR cooperate to activate full-length PKR and inhibit translation Cell Death Differ 2007 14 1050 1059 17318221
  127. [135]Vattem KM Staschke KA Wek RC Mechanism of activation of the double-stranded-RNA-dependent protein kinase, PKR: role of dimerization and cellular localization in the stimulation of PKR phosphorylation of eukaryotic initiation factor-2 (eIF2) Eur. J. Biochem 2001 268 3674 3684 11432733
  128. [137]Lau NC Lim LP Weinstein EG Bartel DP An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans Science 2001 294 858 862 11679671
  129. [138]Yekta S Shih IH Bartel DP MicroRNA-directed cleavage of HOXB8 mRNA Science 2004 304 594 596 15105502
  130. [139]Matranga C Tomari Y Shin C Bartel DP Zamore PD Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes Cell 2005 123 607 620 16271386
  131. [140]Rand TA Petersen S Du F Wang X Argonaute2 cleaves the anti-guide strand of siRNA during RISC activation Cell 2005 123 621 629 16271385
  132. [141]Khvorova A Reynolds A Jayasena SD Functional siRNAs and miRNAs exhibit strand bias Cell 2003 115 209 216 14567918
  133. [142]Schwarz DS Hutvagner G Du T Xu Z Aronin N Zamore PD Asymmetry in the assembly of the RNAi enzyme complex Cell 2003 115 199 208 14567917
  134. [143]Lagos-Quintana M Rauhut R Lendeckel W Tuschl T Identification of novel genes coding for small expressed RNAs Science 2001 294 853 858 11679670
  135. [144]Mourelatos Z Dostie J Paushkin S Sharma A Charroux B Abel L Rappsilber J Mann M Dreyfuss G miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs Genes Dev 2002 16 720 728 11914277 PMC155365
  136. [145]Zeng Y Cullen BR RNA interference in human cells is restricted to the cytoplasm RNA 2002 8 855 860 12166640 PMC1370302
  137. [146]Tomari Y Zamore PD MicroRNA biogenesis: drosha can't cut it without a partner Curr. Biol 2005 15 R61 64 15668159
  138. [147]Leuschner PJ Ameres SL Kueng S Martinez J Cleavage of the siRNA passenger strand during RISC assembly in human cells EMBO Rep 2006 7 314 320 16439995 PMC1456892
  139. [148]Macrae IJ Ma E Zhou M Robinson CV Doudna JA In vitro reconstitution of the human RISC-loading complex Proc. Natl. Acad. Sci. USA 2008 105 2 512 7 18178619 PMC2206567
  140. [149]Anantharaman V Koonin EV Aravind L Comparative genomics and evolution of proteins involved in RNA metabolism Nucleic Acids Res 2002 30 1427 1464 11917006 PMC101826
  141. [150]Robb GB Rana TM RNA helicase A interacts with RISC in human cells and functions in RISC loading Mol. Cell 2007 26 523 537 17531811
  142. [151]Abdelhaleem M Maltais L Wain H The human DDX and DHX gene families of putative RNA helicases Genomics 2003 81 618 622 12782131
  143. [152]Lee CG Hurwitz J A new RNA helicase isolated from HeLa cells that catalytically translocates in the 3 to 5 direction J. Biol. Chem 1992 267 4398 4407 1537828
  144. [153]Friedemann J Grosse F Zhang S Nuclear DNA helicase II (RNA helicase A) interacts with Werner syndrome helicase and stimulates its exonuclease activity J. Biol. Chem 2005 280 31303 31313 15995249
  145. [154]Meister G Landthaler M Peters L Chen PY Urlaub H Luhrmann R Tuschl T Identification of novel argonaute-associated proteins Curr. Biol 2005 15 2149 2155 16289642
  146. [155]Yoda M Kawamata T Paroo Z Ye X Iwasaki S Liu Q Tomari Y ATP-dependent human RISC assembly pathways Nat. Struct. Mol. Biol 2010 17 17 23 19966796 PMC2915567
  147. [156]Brennecke J Stark A Russell RB Cohen SM Principles of microRNA-target recognition PLoS Biol 2005 3 e85 15723116 PMC1043860
  148. [157]Doench JG Sharp PA Specificity of microRNA target selection in translational repression Genes Dev 2004 18 504 511 15014042 PMC374233
  149. [159]Lewis BP Shih IH Jones-Rhoades MW Bartel DP Burge CB Prediction of mammalian microRNA targets Cell 2003 115 787 798 14697198
  150. [160]Doench JG Petersen CP Sharp PA siRNAs can function as miRNAs Genes Dev 2003 17 438 442 12600936 PMC195999
  151. [161]Saxena S Jonsson ZO Dutta A Small RNAs with imperfect match to endogenous mRNA repress translation. Implications for off-target activity of small inhibitory RNA in mammalian cells J. Biol. Chem 2003 278 44312 44319 12952966
  152. [162]Stark A Brennecke J Russell RB Cohen SM Identification of Drosophila MicroRNA targets PLoS Biol 2003 1 E60 14691535 PMC270017
  153. [163]Enright AJ John B Gaul U Tuschl T Sander C Marks DS MicroRNA targets in Drosophila Genome Biol 2003 5 R1 14709173 PMC395733
  154. [164]Cougot N Babajko S Seraphin B Cytoplasmic foci are sites of mRNA decay in human cells J. Cell Biol 2004 165 31 40 15067023 PMC2172085
  155. [165]Brengues M Teixeira D Parker R Movement of eukaryotic mRNAs between polysomes and cytoplasmic processing bodies Science 2005 310 486 489 16141371 PMC1863069
  156. [166]Sheth U Parker R Decapping and decay of messenger RNA occur in cytoplasmic processing bodies Science 2003 300 805 808 12730603 PMC1876714
  157. [167]Eystathioy T Chan EK Mahler M Luft LM Fritzler ML Fritzler MJ A panel of monoclonal antibodies to cytoplasmic GW bodies and the mRNA binding protein GW182 Hybrid Hybridomics 2003 22 79 86 12831532
  158. [168]Eystathioy T Jakymiw A Chan EK Seraphin B Cougot N Fritzler MJ The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies RNA 2003 9 1171 1173 13130130 PMC1370480
  159. [169]Wu L Fan J Belasco JG MicroRNAs direct rapid deadenylation of mRNA Proc. Natl. Acad. Sci. USA 2006 103 4034 4039 16495412 PMC1449641
  160. [170]van Dijk E Cougot N Meyer S Babajko S Wahle E Seraphin B Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures EMBO J 2002 21 6915 6924 12486012 PMC139098
  161. [171]Coller J Parker R General translational repression by activators of mRNA decapping Cell 2005 122 875 886 16179257 PMC1853273
  162. [172]Liu J Carmell MA Rivas FV Marsden CG Thomson JM Song JJ Hammond SM Joshua-Tor L Hannon GJ Argonaute2 is the catalytic engine of mammalian RNAi Science 2004 305 1437 1441 15284456
  163. [173]Meister G Landthaler M Dorsett Y Tuschl T Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing RNA 2004 10 544 550 14970398 PMC1370948
  164. [175]Maroney PA Yu Y Fisher J Nilsen TW Evidence that microRNAs are associated with translating messenger RNAs in human cells Nat. Struct. Mol. Biol 2006 13 1102 1107 17128271
  165. [176]Maroney PA Yu Y Nilsen TW MicroRNAs mRNAs and Translation Cold Spring Harb. Symp. Quant. Biol 2006 71 531 535 17381336
  166. [177]Nottrott S Simard MJ Richter JD Human let-7a miRNA blocks protein production on actively translating polyribosomes Nat. Struct. Mol. Biol 2006 13 1108 1114 17128272
  167. [178]Mallory AC Reinhart BJ Jones-Rhoades MW Tang G Zamore PD Barton MK Bartel DP MicroRNA control of PHABULOSA in leaf development: importance of pairing to the microRNA 5' region EMBO J 2004 23 3356 3364 15282547 PMC514513
  168. [179]Mallory AC Vaucheret H MicroRNAs: something important between the genes Curr. Opin. Plant. Biol 2004 7 120 125 15003210
  169. [180]Kiriakidou M Nelson PT Kouranov A Fitziev P Bouyioukos C Mourelatos Z Hatzigeorgiou A A combined computational-experimental approach predicts human microRNA targets Genes Dev 2004 18 1165 1178 15131085 PMC415641
  170. [181]Parker R Song H The enzymes and control of eukaryotic mRNA turnover Nat. Struct. Mol. Biol 2004 11 121 127 14749774
  171. [182]Coller J Parker R Eukaryotic mRNA decapping Annu. Rev. Biochem 2004 73 861 890 15189161
  172. [183]Pillai RS MicroRNA function: multiple mechanisms for a tiny RNA? RNA 2005 11 1753 1761 16314451 PMC1370863
  173. [184]Pillai RS Bhattacharyya SN Artus CG Zoller T Cougot N Basyuk E Bertrand E Filipowicz W Inhibition of translational initiation by Let-7 MicroRNA in human cells Science 2005 309 1573 1576 16081698
  174. [185]Pillai RS Artus CG Filipowicz W Tethering of human Ago proteins to mRNA mimics the miRNA-mediated repression of protein synthesis RNA 2004 10 1518 1525 15337849 PMC1370638
  175. [186]Richter D Isono K The mechanism of protein synthesis-initiation elongation and termination in translation of genetic messeges Curr. Top. Microbiol. Immunol 1977 76 83 125 334484
  176. [187]Petersen CP Bordeleau ME Pelletier J Sharp PA Short RNAs repress translation after initiation in mammalian cells Mol. Cell 2006 21 533 542 16483934
  177. [188]Kong YW Cannell IG de Moor CH Hill K Garside PG Hamilton TL Meijer HA Dobbyn HC Stoneley M Spriggs KA Willis AE Bushell M The mechanism of micro-RNA-mediated translation repression is determined by the promoter of the target gene Proc. Natl. Acad. Sci. USA 2008 105 8866 8871 18579786 PMC2449332
  178. [189]Liu J Valencia-Sanchez MA Hannon GJ Parker R MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies Nat. Cell Biol 2005 7 719 723 15937477 PMC1855297
  179. [190]Liu J Rivas FV Wohlschlegel J Yates J. R 3rd Parker R Hannon GJ A role for the P-body component GW182 in microRNA function Nat. Cell Biol 2005 7 1261 1266 16284623 PMC1804202
  180. [191]Kedersha N Stoecklin G Ayodele M Yacono P Lykke-Andersen J Fritzler MJ Scheuner D Kaufman RJ Golan DE Anderson P Stress granules and processing bodies are dynamically linked sites of mRNP remodeling J. Cell Biol 2005 169 871 884 15967811 PMC2171635
  181. [192]Andrei MA Ingelfinger D Heintzmann R Achsel T Rivera-Pomar R Luhrmann R A role for eIF4E and eIF4E-transporter in targeting mRNPs to mammalian processing bodies RNA 2005 11 717 727 15840819 PMC1370757
  182. [193]Anderson P Kedersha N RNA granules J. Cell Biol 2006 172 803 808 16520386 PMC2063724
  183. [194]Teixeira D Sheth U Valencia-Sanchez MA Brengues M Parker R Processing bodies require RNA for assembly and contain nontranslating mRNAs RNA 2005 11 371 382 15703442 PMC1370727
  184. [195]Bagga S Bracht J Hunter S Massirer K Holtz J Eachus R Pasquinelli AE Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation Cell 2005 122 553 563 16122423
  185. [196]Fischer N Weis K The DEAD box protein Dhh1 stimulates the decapping enzyme Dcp1 EMBO J 2002 21 2788 2797 12032091 PMC126031
  186. [197]Coller JM Tucker M Sheth U Valencia-Sanchez MA Parker R The DEAD box helicase Dhh1p functions in mRNA decapping and interacts with both the decapping and deadenylase complexes RNA 2001 7 1717 1727 11780629 PMC1370212
  187. [198]Gibbings DJ Ciaudo C Erhardt M Voinnet O Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity Nat. Cell Biol 2009 11 1143 1149 19684575
  188. [199]Kedersha N Anderson P Mammalian stress granules and processing bodies Methods Enzymol 2007 431 61 81 17923231
  189. [200]Kedersha NL Gupta M Li W Miller I Anderson P RNA-binding proteins TIA-1 and TIAR link the phosphory-lation of eIF-2 alpha to the assembly of mammalian stress granules J. Cell Biol 1999 147 1431 1442 10613902 PMC2174242
  190. [201]Chan SP Slack FJ microRNA-Mediated Silencing Inside P-Bodies RNA Biol 2006 3 97 100 17179742
  191. [202]Parker R Sheth U P bodies and the control of mRNA translation and degradation Mol. Cell 2007 25 635 646 17349952
  192. [203]Jakymiw A Lian S Eystathioy T Li S Satoh M Hamel JC Fritzler MJ Chan EK Disruption of GW bodies impairs mammalian RNA interference Nat. Cell Biol 2005 7 1267 1274 16284622
  193. [204]Jakymiw A Pauley KM Li S Ikeda K Lian S Eystathioy T Satoh M Fritzler MJ Chan EK The role of GW/P-bodies in RNA processing and silencing J. Cell Sci 2007 120 1317 1323 17401112
  194. [205]Pauley KM Eystathioy T Jakymiw A Hamel JC Fritzler MJ Chan EK Formation of GW bodies is a consequence of microRNA genesis EMBO Rep 2006 7 904 910 16906129 PMC1559661
  195. [206]Sen GL Blau HM Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies Nat. Cell Biol 2005 7 633 636 15908945
  196. [207]Yang Z Jakymiw A Wood MR Eystathioy T Rubin RL Fritzler MJ Chan EK GW182 is critical for the stability of GW bodies expressed during the cell cycle and cell proliferation J. Cell Sci 2004 117 5567 5578 15494374
  197. [208]Eystathioy T Chan EK Tenenbaum SA Keene JD Griffith K Fritzler MJ A phosphorylated cytoplasmic autoantigen GW182 associates with a unique population of human mRNAs within novel cytoplasmic speckles Mol. Biol. Cell 2002 13 1338 1351 11950943 PMC102273
  198. [209]Behm-Ansmant I Rehwinkel J Doerks T Stark A Bork P Izaurralde E mRNA degradation by miRNAs and GW182 requires both CCR4: NOT deadenylase and DCP1:DCP2 decapping complexes Genes Dev 2006 20 1885 1898 16815998 PMC1522082
  199. [210]Behm-Ansmant I Rehwinkel J Izaurralde E MicroRNAs Silence Gene Expression by Repressing Protein Expression and/or by Promoting mRNA Decay Cold Spring Harb. Symp. Quant. Biol 2006 71 523 530 17381335
  200. [211]Ding L Han M GW182 family proteins are crucial for microRNA-mediated gene silencing Trends Cell Biol 2007 17 411 416 17766119

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Metadata

Authors
MacFarlane, L.-A., & R. Murphy, P.
Venue
Current Genomics
Publisher
Bentham Science Publishers Ltd.
Published
2010-11-01
Volume
11
Issue
7
Pages
537-561
ISSN
1389-2029
DOI
10.2174/138920210793175895
PMC
PMC3048316
Cited by
1,584
References
20
Language
en

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