Bringing virtual reality from clinical trials to clinical practice for the treatment of eating disorders: An example using virtual reality cue exposure therapy
Open accessAbstract
Novel treatment options for eating disorders (EDs) are critically needed to enhance treatment outcomes and reduce the rates of treatment dropouts. On average, only 50% of individuals receiving evidence-based care remit, whereas 24% drop out before treatment completion. One particularly promising direction involves integrating virtual reality (VR) with existing evidence-based treatments (EBTs) such as cue exposure therapy (CET). Across psychiatric disorders, VR-based interventions are demonstrating at least preliminary efficacy and noninferiority to traditional treatments. Furthermore, VR technology has become increasingly portable, resulting in improved acceptance, increased access, and reductions in cost. However, more efficient research processes may be needed to uncover the potential benefits of these rapid technological advances. This viewpoint paper reviews existing empirical support for integrating VR with EBTs (with a focus on its use with EDs) and proposes key next steps to more rapidly bring this innovative technology-based intervention into real-world clinic settings, as warranted. VR-CET for EDs is used to illustrate a suggested process for developing such treatment enhancements. We recommend following a deployment-focused model of intervention development and testing to enable rapid implementation of robust, practice-ready treatments. In addition, our review highlights the need for a comprehensive clinical protocol that supports clinicians and researchers in the implementation and testing of VR-CET and identifies key missing protocol components with rationale for their inclusion. Ultimately, this work may lead to a more complete understanding of the full potential of the applications and integrations of VR into mental health care globally.
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Systematic reviews have observed that some studies combining immersive virtual reality with cognitive behavioral therapy yielded better results.
“Systematic reviews have observed that some studies have combined IVR with other techniques, such as cognitive behavioral therapy (CBT), yielding better results [15][16][17].”
From Immersive Virtual Reality in Psychotherapeutic Interventions for Youth with Eating Disorders: A Pilot Study in a Rural Context (2025) · cites this paper as [16]
The Introduction reports that three randomized trials found VR-enhanced CBT more effective than CBT alone on some eating-disorder outcomes. But this source calls itself a viewpoint rather than a systematic review, and its Empirical Support section says reviews of VR cue exposure therapy for eating disorders were not yet warranted. It supports the better-results finding, but not the attribution of that finding to systematic reviews. (LLM, conf=0.86)
Experimental — accuracy not yet measuredVR technology can alleviate eating-related anxiety caused by exposure to specific cues, such as virtual food, by modifying dysfunctional thoughts, increasing self-efficacy, and disrupting reconsolidation of adverse food-related memories.
“With the aid of VR technology, eating-related anxiety caused by exposure to specific cues, such as virtual food, can be alleviated by modifying dysfunctional thoughts and by doing so, it would increase self-efficacy, disrupting the reconsolidation of adverse food-related memories (Brown et al., 2020).”
From Virtual reality and psychedelics for the treatment of psychiatric disease: A systematic literature review (2020) · cites this paper as Brown et al., 2020
The Advantages of Virtual Reality–Cue Exposure Therapy section says VR can reduce anxiety during and after virtual-food exposure, helping disrupt reconsolidation of adverse food-related memories. It also says emotional changes may occur partly because of modified dysfunctional thinking and increased self-efficacy. It does not establish the claimed sequence in which modifying thoughts increases self-efficacy and thereby disrupts reconsolidation. (LLM, conf=0.84)
Experimental — accuracy not yet measured
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“…the aid of VR technology, eating-related anxiety caused by exposure to specific cues, such as virtual food, can be alleviated by modifying dysfunctional thoughts and by doing so, it would increase self-efficacy, disrupting the reconsolidation of adverse food-related memories (Brown et al., 2020).”
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- Authors
- Brown, T., Nauman Vogel, E., Adler, S., Bohon, C., Bullock, K., Nameth, K., Riva, G., Safer, D. L., & Runfola, C. D.
- Affiliations
- Stanford University (US)
- Università Cattolica del Sacro Cuore (IT)
- Corresponding author
- Safer, Debra L
- ORCID
- Venue
- Journal of Medical Internet Research
- Publisher
- JMIR Publications Inc.
- Published
- 2020-04-23
- Volume
- 22
- Issue
- 4
- Pages
- e16386
- ISSN
- 1438-8871 (ISSN-L)
- PMC
- PMC7206518
- OpenAlex
- W3020675104
- Cited by
- 49
- References
- 66
- Citations by year
- 2026: 3 · 2025: 16 · 2024: 5 · 2023: 5 · 2022: 9 · 2021: 8 · 2020: 2 · 2018: 1
- FWCI
- 2.40
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Journal of Medical Internet Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Physical Sciences › Computer Science › Human-Computer Interaction › Virtual Reality Applications and Impacts
- Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
- Keywords
- virtual reality, eating disorders, cue exposure therapy, treatment discontinuation, clinical implementation, clinical protocol development
- MeSH terms
- Feeding and Eating Disorders, Humans, Treatment Outcome, Virtual Reality Exposure Therapy
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