Cited by 79Virtual Reality Applications and ImpactsDigital Mental Health InterventionsAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Deterioration rates in Virtual Reality Therapy: An individual patient data level meta-analysis

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Fernández-Álvarez, Javier, Rozental, Alexander, Carlbring, Per, Colombo, Desirée, Riva, Giuseppe, Anderson, Page L., Baños, Rosa María, Benbow, Amanda A. +18 more·2019·Journal of Anxiety Disorders

Abstract

Ample evidence supports the use of Virtual Reality (VR) for anxiety disorders. Nonetheless, currently there is no evidence about moderators or potential negative effects of VR treatment strategies. An Individual Patient Data (IPD) approach was employed with 15 retrieved datasets. The current study sample was composed of 810 patients. Randomized control trials (RCTs) for each primary outcome measure were performed, in addition to moderator analyses of the socio-demographic variables. Deterioration rates were 14 patients (4.0%) in VR, 8 (2.8%) in active control conditions, and 27 (15%) in the WL condition. With regard to receiving treatment, patients in a waiting list control condition had greater odds of deteriorating than in the two active conditions, odds ratios (ORs) 4.87, 95% confidence interval (CI) [0.05, 0.67]. In the case of the socio-demographic variables, none of them were associated with higher or lower odds of deterioration, with the exception of marital status in the WL condition; married people presented a significantly lower probability of deterioration, OR 0.19, 95% CI [0.05, 0.67]. Finally, when comparing pooled effects of VR versus all control conditions, the OR was 0.61 (95% CI 0.31-1.23) in favor of VR, although this result was not statistically significant. This study provides evidence about the deterioration rates of a therapeutic VR approach, showing that the number of deteriorated patients coincides with other therapeutic approaches, and that deterioration is less likely to occur, compared to patients in WL control groups.

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Crossref · 10.1016/j.janxdis.2018.06.005

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Authors
Fernández-Álvarez, J., Rozental, A., Carlbring, P., Colombo, D., Riva, G., Anderson, P. L., Baños, R. M., Benbow, A. A., Bouchard, S., Bretón-López, J. M., Cárdenas, G., Difede, J., Emmelkamp, P., García-Palacios, A., Guillén, V., Hoffman, H., Kampann, I., Moldovan, R., Mühlberger, A., North, M., Pauli, P., Peñate Castro, W., Quero, S., Tortella-Feliu, M., Wyka, K., & Botella, C.
Affiliations
  • Karolinska Institutet (SE)
  • Stockholm University (SE)
  • Universitat Jaume I (ES)
  • Università Cattolica del Sacro Cuore (IT)
  • Georgia State University (US)
  • Universitat de València (ES)
  • Université du Québec en Outaouais (CA)
  • Cornell University (US)
  • University of Amsterdam (NL)
  • University of Washington (US)
  • Babeș-Bolyai University (RO)
  • University of Regensburg (DE)
  • Kennesaw State University (US)
  • University of Würzburg (DE)
Venue
Journal of Anxiety Disorders
Publisher
Elsevier BV
Published
2019-01
Volume
61
Pages
3-17
ISSN
0887-6185 (ISSN-L)
OpenAlex
W2884586559
Cited by
79
References
143
Citations by year
2026: 2 · 2025: 4 · 2024: 5 · 2023: 17 · 2022: 14 · 2021: 10 · 2020: 17 · 2019: 8 · 2018: 2
FWCI
9.20
Type
journal article
Language
en
Open access
Locations
  • Journal of Anxiety Disorders (publishedVersion)
  • PubMed (publishedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
  • Research Explorer (The University of Manchester) (publishedVersion)
  • Repositori UJI (Universitat Jaume I) (submittedVersion, cc-by-nc-nd)
  • DigitalCommons - Kennesaw State University (Kennesaw State University) (submittedVersion)
  • University of Regensburg Publication Server (University of Regensburg) (submittedVersion)
  • Repository of Digital Objects for Teaching Research and Culture (University of Valencia) (submittedVersion, cc-by-nc)
  • Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, cc-by)
  • Greater South Information System
Funders
  • Marie Skłodowska-Curie Innovative Training Network AffecTech
  • European Commission H2020
Topics
  • Physical Sciences › Computer Science › Human-Computer Interaction › Virtual Reality Applications and Impacts
  • Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
virtual reality therapy, anxiety disorders, treatment deterioration, waitlist control, active control, sociodemographic moderators, marital status
MeSH terms
Adolescent, Adult, Aged, Anxiety Disorders, Female, Humans, Male, Middle Aged, Odds Ratio, Young Adult, Virtual Reality Exposure Therapy

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