Cited by 165Maternal Mental Health During Pregnancy and PostpartumMindfulness and Compassion InterventionsDigital Mental Health Interventions

Effectiveness of Smartphone-Based Mindfulness Training on Maternal Perinatal Depression: Randomized Controlled Trial

Open access
Sun, Yaoyao, Li, Yanyan, Wang, Juan, Chen, Qingyi, Bazzano, Alessandra N, Cao, Fenglin·2021·Journal of Medical Internet Research

Published version of a preprint

Abstract

BACKGROUND Despite potential for benefit, mindfulness remains an emergent area in perinatal mental health care, and evidence of smartphone-based mindfulness training for perinatal depression is especially limited. OBJECTIVE The objective of this study was to evaluate the effectiveness of a smartphone-based mindfulness training intervention during pregnancy on perinatal depression and other mental health problems with a randomized controlled design. METHODS Pregnant adult women who were potentially at risk of perinatal depression were recruited from an obstetrics clinic and randomized to a self-guided 8-week smartphone-based mindfulness training during pregnancy group or attention control group. Mental health indicators were surveyed over five time points through the postpartum period by online self-assessment. The assessor who collected the follow-up data was blind to the assignment. The primary outcome was depression as measured by symptoms, and secondary outcomes were anxiety, stress, affect, sleep, fatigue, memory, and fear. RESULTS A total of 168 participants were randomly allocated to the mindfulness training (n=84) or attention control (n=84) group. The overall dropout rate was 34.5%, and 52.4% of the participants completed the intervention. Mindfulness training participants reported significant improvement of depression (group × time interaction χ24=16.2, P=.003) and secondary outcomes (χ24=13.1, P=.01 for anxiety; χ24=8.4, P=.04 for positive affect) compared to attention control group participants. Medium between-group effect sizes were found on depression and positive affect at postintervention, and on anxiety in late pregnancy (Cohen d=0.47, –0.49, and 0.46, respectively). Mindfulness training participants reported a decreased risk of positive depressive symptom (Edinburgh Postnatal Depression Scale [EPDS] score>9) compared to attention control participants postintervention (odds ratio [OR] 0.391, 95% CI 0.164-0.930) and significantly higher depression symptom remission with different EPDS reduction scores from preintervention to postintervention (OR 3.471-27.986). Parity did not show a significant moderating effect; however, for nulliparous women, mindfulness training participants had significantly improved depression symptoms compared to nulliparous attention control group participants (group × time interaction χ24=18.1, P=.001). CONCLUSIONS Smartphone-based mindfulness training is an effective intervention in improving maternal perinatal depression for those who are potentially at risk of perinatal depression in early pregnancy. Nulliparous women are a promising subgroup who may benefit more from mindfulness training. CLINICALTRIAL Chinese Clinical Trial Registry ChiCTR1900028521; http://www.chictr.org.cn/showproj.aspx?proj=33474

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.2196/23410

Cites

61 of 61 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Prenatal mindfulness interventions have potential benefits for improving perinatal depression.

    “recent pilot studies showed that prenatal mindfulness interventions have potential benefits for improving the emergence of perinatal depression [39,40].”
  • Mindfulness level can be improved by programs based on mindfulness meditation.

    “mindfulness level can be improved by program based on mindfulness meditation.”

    From Acceptance Mindfulness-Trait as a Protective Factor for Post-Natal Depression: A Preliminary Research (2022) · cites this paper as [39]

    The Methods > Intervention section describes a program that includes mindful meditation, but the Methods > Measures and Results sections report depression, anxiety, and positive affect—not participants’ mindfulness levels. Searches for mindfulness level, mindfulness awareness, and trait mindfulness found no passage showing that the program improved mindfulness itself; pages are not specified in our copy. (LLM, conf=0.76)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Sun, Y., Li, Y., Wang, J., Chen, Q., Bazzano, A. N., & Cao, F.
Affiliations
  • Shandong University (CN)
  • Tulane University (US)
Corresponding author
Cao, Fenglin
Venue
Journal of Medical Internet Research
Published
2021-01-27
Volume
23
Issue
1
Pages
e23410
ISSN
1438-8871 (ISSN-L)
OpenAlex
W3124467293
Cited by
165
References
61
Citations by year
2026: 26 · 2025: 35 · 2024: 22 · 2023: 52 · 2022: 22 · 2021: 8
FWCI
22.49
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Journal of Medical Internet Research (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Tulane University
  • Shandong University
  • China Scholarship Council
  • National Social Science Fund of China (17BSH054)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
  • Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
  • Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
Keywords
mindfulness training, perinatal depression, maternal depression, pregnancy, smartphone-based intervention, self-guided intervention, anxiety, positive affect, postpartum depression, nulliparous women, perinatal mental health, digital mental health interventions, Edinburgh Postnatal Depression Scale, sleep and fatigue, stress
MeSH terms
Smartphone, Adult, Depression, Female, Humans, Mental Health, Pregnancy, Surveys and Questionnaires, Telemedicine, Perinatal Care, Mindfulness

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review