Effectiveness of Smartphone-Based Mindfulness Training on Maternal Perinatal Depression: Randomized Controlled Trial
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Abstract
BACKGROUND Despite potential for benefit, mindfulness remains an emergent area in perinatal mental health care, and evidence of smartphone-based mindfulness training for perinatal depression is especially limited. OBJECTIVE The objective of this study was to evaluate the effectiveness of a smartphone-based mindfulness training intervention during pregnancy on perinatal depression and other mental health problems with a randomized controlled design. METHODS Pregnant adult women who were potentially at risk of perinatal depression were recruited from an obstetrics clinic and randomized to a self-guided 8-week smartphone-based mindfulness training during pregnancy group or attention control group. Mental health indicators were surveyed over five time points through the postpartum period by online self-assessment. The assessor who collected the follow-up data was blind to the assignment. The primary outcome was depression as measured by symptoms, and secondary outcomes were anxiety, stress, affect, sleep, fatigue, memory, and fear. RESULTS A total of 168 participants were randomly allocated to the mindfulness training (n=84) or attention control (n=84) group. The overall dropout rate was 34.5%, and 52.4% of the participants completed the intervention. Mindfulness training participants reported significant improvement of depression (group × time interaction χ24=16.2, P=.003) and secondary outcomes (χ24=13.1, P=.01 for anxiety; χ24=8.4, P=.04 for positive affect) compared to attention control group participants. Medium between-group effect sizes were found on depression and positive affect at postintervention, and on anxiety in late pregnancy (Cohen d=0.47, –0.49, and 0.46, respectively). Mindfulness training participants reported a decreased risk of positive depressive symptom (Edinburgh Postnatal Depression Scale [EPDS] score>9) compared to attention control participants postintervention (odds ratio [OR] 0.391, 95% CI 0.164-0.930) and significantly higher depression symptom remission with different EPDS reduction scores from preintervention to postintervention (OR 3.471-27.986). Parity did not show a significant moderating effect; however, for nulliparous women, mindfulness training participants had significantly improved depression symptoms compared to nulliparous attention control group participants (group × time interaction χ24=18.1, P=.001). CONCLUSIONS Smartphone-based mindfulness training is an effective intervention in improving maternal perinatal depression for those who are potentially at risk of perinatal depression in early pregnancy. Nulliparous women are a promising subgroup who may benefit more from mindfulness training. CLINICALTRIAL Chinese Clinical Trial Registry ChiCTR1900028521; http://www.chictr.org.cn/showproj.aspx?proj=33474
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Prenatal mindfulness interventions have potential benefits for improving perinatal depression.
“recent pilot studies showed that prenatal mindfulness interventions have potential benefits for improving the emergence of perinatal depression [39,40].”
From Acceptance Mindfulness-Trait as a Protective Factor for Post-Natal Depression: A Preliminary Research (2022) · cites this paper as [39]
Mindfulness level can be improved by programs based on mindfulness meditation.
“mindfulness level can be improved by program based on mindfulness meditation.”
From Acceptance Mindfulness-Trait as a Protective Factor for Post-Natal Depression: A Preliminary Research (2022) · cites this paper as [39]
The Methods > Intervention section describes a program that includes mindful meditation, but the Methods > Measures and Results sections report depression, anxiety, and positive affect—not participants’ mindfulness levels. Searches for mindfulness level, mindfulness awareness, and trait mindfulness found no passage showing that the program improved mindfulness itself; pages are not specified in our copy. (LLM, conf=0.76)
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- Authors
- Sun, Y., Li, Y., Wang, J., Chen, Q., Bazzano, A. N., & Cao, F.
- Affiliations
- Shandong University (CN)
- Tulane University (US)
- Corresponding author
- Cao, Fenglin
- Venue
- Journal of Medical Internet Research
- Publisher
- JMIR Publications Inc.
- Published
- 2021-01-27
- Volume
- 23
- Issue
- 1
- Pages
- e23410
- ISSN
- 1438-8871 (ISSN-L)
- PMC
- PMC7875700
- OpenAlex
- W3124467293
- Cited by
- 165
- References
- 61
- Citations by year
- 2026: 26 · 2025: 35 · 2024: 22 · 2023: 52 · 2022: 22 · 2021: 8
- FWCI
- 22.49
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Journal of Medical Internet Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Tulane University
- Shandong University
- China Scholarship Council
- National Social Science Fund of China (17BSH054)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
- Keywords
- mindfulness training, perinatal depression, maternal depression, pregnancy, smartphone-based intervention, self-guided intervention, anxiety, positive affect, postpartum depression, nulliparous women, perinatal mental health, digital mental health interventions, Edinburgh Postnatal Depression Scale, sleep and fatigue, stress
- MeSH terms
- Smartphone, Adult, Depression, Female, Humans, Mental Health, Pregnancy, Surveys and Questionnaires, Telemedicine, Perinatal Care, Mindfulness
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