CoChat
Sign Up
Cited by 418Diabetes Treatment and ManagementDiabetes, Cardiovascular Risks, and LipoproteinsBariatric Surgery and Outcomes

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Very Low-Calorie Diet and 6 Months of Weight Stability in Type 2 Diabetes: Pathophysiological Changes in Responders and Nonresponders

Open access
Steven, Sarah, Hollingsworth, Kieren G., Al-Mrabeh, Ahmad, Avery, Leah, Aribisala, Benjamin, Caslake, Muriel, Taylor, Roy·2016·Diabetes Care
DOI 10.2337/dc15-1942
Open this paper in CoChat — free account

Abstract

OBJECTIVE: Type 2 diabetes mellitus (T2DM) is generally regarded as an irreversible chronic condition. Because a very low-calorie diet (VLCD) can bring about acute return to normal glucose control in some people with T2DM, this study tested the potential durability of this normalization. The underlying mechanisms were defined. RESEARCH DESIGN AND METHODS: People with a T2DM duration of 0.5-23 years (n = 30) followed a VLCD for 8 weeks. All oral agents or insulins were stopped at baseline. Following a stepped return to isocaloric diet, a structured, individualized program of weight maintenance was provided. Glucose control, insulin sensitivity, insulin secretion, and hepatic and pancreas fat content were quantified at baseline, after return to isocaloric diet, and after 6 months to permit the primary comparison of change between post-weight loss and 6 months in responders. Responders were defined as achieving fasting blood glucose <7 mmol/L after return to isocaloric diet. RESULTS: Weight fell (98.0 ± 2.6 to 83.8 ± 2.4 kg) and remained stable over 6 months (84.7 ± 2.5 kg). Twelve of 30 participants achieved fasting plasma glucose <7 mmol/L after return to isocaloric diet (responders), and 13 of 30 after 6 months. Responders had a shorter duration of diabetes and a higher initial fasting plasma insulin level. HbA1c fell from 7.1 ± 0.3 to 5.8 ± 0.2% (55 ± 4 to 40 ± 2 mmol/mol) in responders (P < 0.001) and from 8.4 ± 0.3 to 8.0 ± 0.5% (68 ± 3 to 64 ± 5 mmol/mol) in nonresponders, remaining constant at 6 months (5.9 ± 0.2 and 7.8 ± 0.3% [41 ± 2 and 62 ± 3 mmol/mol], respectively). The responders were characterized by return of first-phase insulin response. CONCLUSIONS: A robust and sustainable weight loss program achieved continuing remission of diabetes for at least 6 months in the 40% who responded to a VLCD by achieving fasting plasma glucose of <7 mmol/L. T2DM is a potentially reversible condition.

Overview

Integrity signals

Registry

Crossref · 10.2337/dc15-1942

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

The text we found for this paper looks like another document, so its claims and self-check weren’t run. The registry and citation checks still apply.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The text we found for this paper looks like another document, so the self-check wasn’t run.

Citations

Cites

Show all 41 references

Research works printed but not linked: 1

  1. Himsworth, 1949, Diet in the aetiology of human diabetes, Proc R Soc Med, 42, 323

Cited by

Sorted by citations

Related

See all

Metadata

Authors
Steven, S., Hollingsworth, K. G., Al-Mrabeh, A., Avery, L., Aribisala, B., Caslake, M., & Taylor, R.
Affiliations
  • Newcastle University (GB)
  • Lagos State University (NG)
  • University of Glasgow (GB)
Corresponding author
Taylor, Roy
ORCID
Venue
Diabetes Care
Publisher
American Diabetes Association
Published
2016-03-21
Volume
39
Issue
5
Pages
808-815
ISSN
  • 0149-5992 (ISSN-L)
  • 1935-5548
DOI
10.2337/dc15-1942
OpenAlex
W2309974746
Cited by
418
References
41
Citations by year
2026: 20 · 2025: 29 · 2024: 37 · 2023: 35 · 2022: 47 · 2021: 51 · 2020: 47 · 2019: 53 · 2018: 36 · 2017: 43 · 2016: 18
FWCI
50.26
Type
journal article
Language
en
Update notices
correction (2018-06-01)
Open access
Licence
Locations
  • Diabetes Care (publishedVersion)
  • PubMed (publishedVersion)
  • Teesside University Research Portal (Teesside University) (submittedVersion, other-oa)
  • Newcastle University ePrints (Newcastle Univesity) (cc-by-nc-nd)
Funders
  • National Institute of Health Research Newcastle Biomedical Research Center Grant
  • Novo Nordisk UK Research Foundation Research Fellowship
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
Keywords
type 2 diabetes, very low calorie diet, weight loss, weight maintenance, diabetes remission, fasting blood glucose, insulin sensitivity, first-phase insulin response, insulin secretion, hepatic fat content, pancreatic fat content, diabetes duration, HbA1c
MeSH terms
Body Weight Maintenance, Adult, Blood Glucose, Body Weight, Diabetes Mellitus, Type 2, Diet, Reducing, Fasting, Female, Humans, Insulin, Longitudinal Studies, Male, Middle Aged, Treatment Outcome, Caloric Restriction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review