The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Parental transmission of type 2 diabetes: the Framingham Offspring Study
Open accessAbstract
Study of parental transmission of diabetes provides insight into the relative contributions of underlying maternal and paternal influences. We estimated risk for type 2 diabetes and milder degrees of glucose intolerance associated with parental diabetes among subjects of the population-based Framingham Offspring Study, in which participants are primarily Caucasian and at relatively low risk for diabetes and for which both parental and offspring phenotypes were ascertained by direct examination. Parental diabetes, assessed over 40 years of biennial follow-up, was defined by use of hypoglycemic drug therapy or a casual plasma glucose level > or = 11.1 mmol/l at any examination. Offspring glucose tolerance, assessed over 20 years of quadrennial follow-up, was defined by fasting plasma glucose levels > or = 7.8 mmol/l at any two examinations, use of hypoglycemic drug therapy at any examination, or with a 75-g oral glucose tolerance test (1980 World Health Organization criteria) at the most recent examination. We calculated odds ratios (ORs) and 95% CIs for offspring glucose tolerance status using generalized estimating equations to account for differential correlations within and between families. The 2,527 offspring came from 1,303 nuclear families, of which 77.6% had two or more siblings per family and in which the prevalence of parental diabetes was 24.6%. The mean offspring age was 54 years (range 26-82), 53% were women, 8.6% had diabetes, 11.4% had impaired glucose tolerance, 76.3% had no parental diabetes, 10.5% had maternal diabetes, 11.5% had paternal diabetes, and 1.7% had bilineal diabetes. Relative to individuals without parental diabetes, the age-adjusted ORs (95% CI) for offspring type 2 diabetes or abnormal glucose tolerance (fasting plasma glucose > or = 6.1 mmol/l or 2-h postchallenge glucose tolerance > or = 7.8 mmol/l) among individuals with maternal diabetes were 3.4 (2.3-4.9) and 2.7 (2.0-3.7), respectively; among individuals with paternal diabetes were 3.5 (2.3-5.2) and 1.7 (1.2-2.4), respectively; and among individuals with bilineal diabetes were 6.1 (2.9-13.0) and 5.2 (2.6-10.5), respectively. Although maternal and paternal diabetes conferred equivalent risk for offspring type 2 diabetes, offspring with maternal diabetes were slightly more likely to have abnormal glucose tolerance compared with those with paternal diabetes (OR 1.6, 95% CI 1.1-2.4). Offspring with maternal diabetes and an age of onset of <50 years had marked increased risk for both type 2 diabetes (9.7, 4.3-22.0) and abnormal glucose tolerance (9.0, 4.2-19.7). We conclude that risk ratios for offspring type 2 diabetes are consistent with a simple additive risk model, where risk when both parents are affected equals the sum of risk when either parent is affected. For maternal diabetes to confer excess risk for mild but not overt glucose intolerance, offspring of diabetic fathers may transit abnormal to impaired glucose tolerance relatively quickly, or diabetic mothers may transmit risk for a mild slowly progressive form of abnormal glucose tolerance in addition to overt diabetes. Very high risk for abnormal glucose homeostasis among offspring with young age-of-onset maternal diabetes is consistent with hypotheses that perinatal exposures increase diabetes risk. Given equivalent risk ratios for type 2 diabetes, fathers may transmit unique paternal genetic factors of similar strength to maternal environmental factors.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Diabetes during pregnancy also predisposes offspring for the development of obesity, T2D and cardiometabolic disease risk factors [33,70,71,72,73,74,75,76,77] (Figure 1).”
From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [33]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Powerful evidence for a genetic component to T2D ( 1 ) has driven extensive efforts to identify genetic variants contributing to risk.”
From β-Cell Failure in Type 2 Diabetes: Postulated Mechanisms and Prospects for Prevention and Treatment (2014) · cites this paper as [1]
The cited source says what the claim attributes to it.
In the citing paper
“maternal diabetes conferred a greater risk of abnormal glucose tolerance in the offspring, when compared to paternal diabetes [33].”
From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [33]
The cited source says what the claim attributes to it.
In the citing paper
“maternal and paternal diabetes conferred equivalent risk for offspring T2D”
From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [33]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus* (2002) · Diabetes Care · doi:10.2337/diacare.25.2007.s5 · Cited by 10,325
Longitudinal Data Analysis for Discrete and Continuous Outcomes
Zeger, S. L., & Liang, K. (1986) · Biometrics · doi:10.2307/2531248 · Cited by 7,781
Extension of Multiple Range Tests to Group Means with Unequal Numbers of Replications
Kramer, C. Y. (1956) · Biometrics · doi:10.2307/3001469 · Cited by 3,146
Barker, D. J. P., Hales, C. N., Fall, C. H. D., Osmond, C., Phipps, K., & Clark, P. M. S. (1993) · Diabetologia · doi:10.1007/bf00399095 · Cited by 2,468
DeChiara, T. M., Efstratiadis, A., & Robertsen, E. J. (1990) · Nature · doi:10.1038/345078a0 · Cited by 1,663
AN INVESTIGATION OF CORONARY HEART DISEASE IN FAMILIES
Kannel, W. B., Feinleib, M., McNAMARA, P. M., Garrison, R. J., & Castelli, W. P. (1979) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a112813 · Cited by 1,639
Harris, M. I., Hadden, W. C., Knowler, W. C., & Bennett, P. H. (1987) · Diabetes · doi:10.2337/diab.36.4.523 · Cited by 1,096
Barnett, A. H., Eff, C., Leslie, R. D., & Pyke, D. A. (1981) · Diabetologia · doi:10.1007/bf00262007 · Cited by 966
DIABETES INCIDENCE IN PIMA INDIANS: CONTRIBUTIONS OF OBESITY AND PARENTAL DIABETES1
KNOWLER, W. C., PETTITT, D. J., SAVAGE, P. J., & BENNETT, P. H. (1981) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a113079 · Cited by 561
Congenital susceptibility to NIDDM. Role of intrauterine environment
Pettitt, D. J., Aleck, K. A., Baird, H. R., Carraher, M. J., Bennett, P. H., & Knowler, W. C. (1988) · Diabetes · doi:10.2337/diab.37.5.622 · Cited by 530
Cited by
Sorted by citations
Heart Disease and Stroke Statistics—2020 Update: A Report From the American Heart Association
Virani, S. S., Alonso, A., Benjamin, E. J., Bittencourt, M. S., Callaway, C. W., Carson, A. P., Chamberlain, A. M., Chang, A. R., Cheng, S., Delling, F. N., et al. (2020) · Circulation · doi:10.1161/cir.0000000000000757 · Cited by 9,175
Heart Disease and Stroke Statistics—2019 Update: A Report From the American Heart Association
Benjamin, E. J., Muntner, P., Alonso, A., Bittencourt, M. S., Callaway, C. W., Carson, A. P., Chamberlain, A. M., Chang, A. R., Cheng, S., Das, S. R., et al. (2019) · Circulation · doi:10.1161/cir.0000000000000659 · Cited by 9,036
Heart disease and stroke statistics-2018 update: a report from the american heart association
Benjamin, E. J., Virani, S. S., Callaway, C. W., Chamberlain, A. M., Chang, A. R., Cheng, S., Chiuve, S. E., Cushman, M., Delling, F. N., Deo, R., et al. (2018) · Circulation · doi:10.1161/cir.0000000000000558 · Cited by 7,146
Heart Disease and Stroke Statistics—2023 Update: A Report From the American Heart Association
Tsao, C. W., Aday, A. W., Almarzooq, Z. I., Anderson, C. A. M., Arora, P., Avery, C. L., Baker-Smith, C. M., Beaton, A. Z., Boehme, A. K., Buxton, A. E., et al. (2023) · Circulation · doi:10.1161/cir.0000000000001123 · Cited by 8,300
Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association
Tsao, C. W., Aday, A. W., Almarzooq, Z. I., Alonso, A., Beaton, A. Z., Bittencourt, M. S., Boehme, A. K., Buxton, A. E., Carson, A. P., Commodore-Mensah, Y., et al. (2022) · Circulation · doi:10.1161/cir.0000000000001052 · Cited by 5,987
Heart Disease and Stroke Statistics—2011 Update: A Report From the American Heart Association
Roger, V. L., Go, A. S., Lloyd-Jones, D. M., Adams, R. J., Berry, J. D., Brown, T. M., Carnethon, M. R., Dai, S., de Simone, G., Ford, E. S., et al. (2011) · Circulation · doi:10.1161/cir.0b013e3182009701 · Cited by 6,149
Self-citationHeart Disease and Stroke Statistics—2010 Update: A Report From the American Heart Association
WRITING GROUP MEMBERS, Lloyd-Jones, D., Adams, R. J., Brown, T. M., Carnethon, M., Dai, S., De Simone, G., Ferguson, T. B., Ford, E., Furie, K., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.192667 · Cited by 5,700
Self-citationHeart Disease and Stroke Statistics—2021 Update: A Report From the American Heart Association
Virani, S. S., Alonso, A., Aparicio, H. J., Benjamin, E. J., Bittencourt, M. S., Callaway, C. W., Carson, A. P., Chamberlain, A. M., Cheng, S., Delling, F. N., et al. (2021) · Circulation · doi:10.1161/cir.0000000000000950 · Cited by 5,784
Heart Disease and Stroke Statistics—2009 Update
WRITING GROUP MEMBERS, Lloyd‐Jones, D. M., Adams, R. J., Carnethon, M. R., SIMONE, G. D., Ferguson, T. B., Flegal, K. M., Ford, E. S., Furie, K. L., Go, A. S., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.191259 · Cited by 3,915
Self-citationHeart Disease and Stroke Statistics—2008 Update
Writing Group Members, Rosamond, W. D., Flegal, K. M., Furie, K. L., Go, A. S., Greenlund, K. J., Haase, N., Hailpern, S. M., Ho, M., Howard, V. J., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.187998 · Cited by 3,799
Self-citationRosamond, W., Flegal, K., Friday, G., Furie, K., Go, A., Greenlund, K., Haase, N., Ho, M., Howard, V., Kissela, B., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.179918 · Cited by 3,277
Self-citationWRITING GROUP MEMBERS, Lloyd-Jones, D., Adams, R., Carnethon, M., De Simone, G., Ferguson, T. B., Flegal, K., Ford, E., Furie, K., Go, A., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.191261 · Cited by 3,140
Self-citationMartin, S. S., Aday, A. W., Almarzooq, Z. I., Anderson, C. A. M., Arora, P., Avery, C. L., Baker-Smith, C. M., Barone Gibbs, B., Beaton, A. Z., Boehme, A. K., et al. (2024) · Circulation · doi:10.1161/cir.0000000000001209 · Cited by 2,800
Mahajan, A., Taliun, D., Thurner, M., Robertson, N. R., Torres, J. M., Rayner, N. W., Payne, A. J., Steinthorsdottir, V., Scott, R. A., Grarup, N., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0241-6 · Cited by 1,744
Martin, S. S., Aday, A. W., Allen, N. B., Almarzooq, Z., Anderson, C. A. M., Arora, P. K., Avery, C. L., Baker-Smith, C. M., Bansal, N., Beaton, A., et al. (2025) · Circulation · doi:10.1161/cir.0000000000001303 · Cited by 1,284
Body Mass Index, Metabolic Syndrome, and Risk of Type 2 Diabetes or Cardiovascular Disease
Meigs, J. B., Wilson, P. W. F., Fox, C. S., Vasan, R. S., Nathan, D. M., SULLIVAN, L. M., & D’Agostino, R. B. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0594 · Cited by 1,088
Self-citationAnimal models of obesity and diabetes mellitus
Kleinert, M., Clemmensen, C., Hofmann, S. M., Moore, M. C., Renner, S., Woods, S. C., Huypens, P., Beckers, J., de Angelis, M. H., Schürmann, A., et al. (2018) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.161 · Cited by 893
Genotype score in addition to common risk factors for prediction of type 2 diabetes
Meigs, J. B., Shrader, P., Sullivan, L. M., McAteer, J. B., Fox, C. S., Dupuis, J., Manning, A. K., Florez, J. C., Wilson, P. W. F., D'Agostino, R. B., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0804742 · Cited by 759
Self-citationGestational diabetes mellitus: mechanisms, treatment, and complications
Johns, E. C., Denison, F. C., Norman, J. E., & Reynolds, R. M. (2018) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2018.09.004 · Cited by 828
Ruegsegger, G. N., & Booth, F. W. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a029694 · Cited by 690
β-Cell Failure in Type 2 Diabetes: Postulated Mechanisms and Prospects for Prevention and Treatment
Halban, P. A., Polonsky, K. S., Bowden, D. W., Hawkins, M. A., Ling, C., Mather, K. J., Powers, A. C., Rhodes, C. J., Sussel, L., & Weir, G. C. (2014) · Diabetes Care · doi:10.2337/dc14-0396 · Cited by 460
“Powerful evidence for a genetic component to T2D (1) has driven extensive efforts to identify genetic variants con-”
BackgroundGenetics of Type 2 Diabetes—Pitfalls and Possibilities
Prasad, R., & Groop, L. (2015) · Genes · doi:10.3390/genes6010087 · Cited by 458
Tsao, C. W., & Vasan, R. S. (2015) · International Journal of Epidemiology · doi:10.1093/ije/dyv337 · Cited by 457
Drake, A. J., & Walker, B. (2004) · Journal of Endocrinology · doi:10.1677/joe.0.1800001 · Cited by 434
Risk factors for type 2 diabetes mellitus.
Fletcher, B., Gulanick, M., & Lamendola, C. (2002) · Journal of Cardiovascular Nursing · doi:10.1097/00005082-200201000-00003 · Cited by 423
Hu, C., & Jia, W. (2017) · Diabetes · doi:10.2337/dbi17-0013 · Cited by 386
Epigenetic germline inheritance of diet-induced obesity and insulin resistance
Huypens, P., Sass, S., Wu, M., Dyckhoff, D., Tschöp, M., Theis, F., Marschall, S., de Angelis, M. H., & Beckers, J. (2016) · Nature Genetics · doi:10.1038/ng.3527 · Cited by 366
Lyssenko, V., Almgren, P., Anevski, D., Perfekt, R., Lahti, K., Nissén, M., Isomaa, B., Forsen, B., Homström, N., Saloranta, C., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.1.166 · Cited by 362
Murea, M., Ma, L., & Freedman, B. I. (2012) · The Review of Diabetic Studies · doi:10.1900/rds.2012.9.6 · Cited by 380
Ali, O. (2013) · World Journal of Diabetes · doi:10.4239/wjd.v4.i4.114 · Cited by 350
The InterAct Consortium (614230) (2012) · Diabetologia · doi:10.1007/s00125-012-2715-x · Cited by 355
Association of risk factors with type 2 diabetes: A systematic review
Ismail, L., Materwala, H., & Alkaabi, J. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.03.003 · Cited by 416
Epigenetic Regulation of the DLK1-MEG3 MicroRNA Cluster in Human Type 2 Diabetic Islets
Kameswaran, V., Bramswig, N. C., McKenna, L. B., Penn, M. M. C., Schug, J., Hand, N. J., Chen, Y., Choi, I., Vourekas, A., Won, K., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.11.016 · Cited by 324
Family History in Public Health Practice: A Genomic Tool for Disease Prevention and Health Promotion
Valdez, R. A., Yoon, P. W., Qureshi, N., Green, R. F., & Khoury, M. J. (2010) · Annual Review of Public Health · doi:10.1146/annurev.publhealth.012809.103621 · Cited by 311
Consequences of Fetal Exposure to Maternal Diabetes in Offspring
Fetita, L.-S., Sobngwi, E., Serradas, P., Calvo, F., & Gautier, J.-F. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0624 · Cited by 299
Rayanagoudar, G., Hashi, A. A., Zamora, J., Khan, K. S., Hitman, G. A., & Thangaratinam, S. (2016) · Diabetologia · doi:10.1007/s00125-016-3927-2 · Cited by 292
Almind, K., Manieri, M., Sivitz, W. I., Cinti, S., & Kahn, C. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610416104 · Cited by 286
Diabetes Mellitus and Risk of Developing Alzheimer Disease
Akomolafe, A., Beiser, A., Meigs, J. B., Au, R., Green, R. C., Farrer, L. A., Wolf, P. A., & Seshadri, S. S. (2006) · Archives of Neurology · doi:10.1001/archneur.63.11.1551 · Cited by 287
Self-citationPopulation-Based Incidence Rates and Risk Factors for Type 2 Diabetes in White Individuals
Bonora, E., Kiechl, S. J., Willeit, J., Oberhollenzer, F., Egger, G., Meigs, J. B., Bonadonna, R. C., & Muggeo, M. (2004) · Diabetes · doi:10.2337/diabetes.53.7.1782 · Cited by 272
Self-citationPalaniappan, L. P., Allen, N. B., Almarzooq, Z., Anderson, C. A. M., Arora, P. K., Avery, C. L., Baker-Smith, C. M., Bansal, N., Currie, M. E., Earlie, R. S., et al. (2026) · Circulation · doi:10.1161/cir.0000000000001412 · Cited by 343
Barroso, I. (2005) · Diabetic Medicine · doi:10.1111/j.1464-5491.2005.01550.x · Cited by 268
Gestational Glucose Tolerance and Risk of Type 2 Diabetes in Young Pima Indian Offspring
Franks, P. W., Looker, H. C., Kobes, S., Touger, L., Tataranni, P. A., Hanson, R. L., & Knowler, W. C. (2006) · Diabetes · doi:10.2337/diabetes.55.02.06.db05-0823 · Cited by 253
Clair, C., Rigotti, N. A., Porneala, B., Fox, C. S., D’Agostino, R. B., Pencina, M. J., & Meigs, J. B. (2013) · JAMA · doi:10.1001/jama.2013.1644 · Cited by 255
Self-citationGenome-wide association studies in type 2 diabetes
McCarthy, M. I., & Zeggini, E. (2009) · Current Diabetes Reports · doi:10.1007/s11892-009-0027-4 · Cited by 235
Amabile, N., Cheng, S. C., Renard, J. M., Larson, M. G., Ghorbani, A., McCabe, E. L., Griffin, G. K., Guérin, C. L., Ho, J. E., Shaw, S. Y., et al. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu153 · Cited by 231
β-Cell Failure in Type 2 Diabetes: Postulated Mechanisms and Prospects for Prevention and Treatment
Halban, P. A., Polonsky, K. S., Bowden, D. W., Hawkins, M. A., Ling, C., Mather, K. J., Powers, A. C., Rhodes, C. J., Sussel, L., & Weir, G. C. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1425 · Cited by 242
Recent progress in genetic and epigenetic research on type 2 diabetes
Kwak, S. H., & Park, K. S. (2016) · Experimental & Molecular Medicine · doi:10.1038/emm.2016.7 · Cited by 228
Association of Oxidative Stress, Insulin Resistance, and Diabetes Risk Phenotypes
Meigs, J. B., Larson, M. G., Fox, C. S., Keaney, J. F., Vasan, R. S., & Benjamin, E. J. (2007) · Diabetes Care · doi:10.2337/dc07-0817 · Cited by 220
Self-citationThe genetic and epigenetic basis of type 2 diabetes and obesity
Drong, A. W., Lindgren, C. M., & McCarthy, M. I. (2012) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2012.149 · Cited by 212
Cupples, L. A., Arruda, H. T., Benjamin, E. J., D’Agostino, R. B., Demissie, S., DeStefano, A. L., Dupuis, J., Falls, K. M., Fox, C. S., Gottlieb, D. J., et al. (2007) · BMC Medical Genetics · doi:10.1186/1471-2350-8-s1-s1 · Cited by 213
Self-citationRevised Framingham Stroke Risk Profile to Reflect Temporal Trends
Dufouil, C., Beiser, A., McClure, L. A., Wolf, P. A., Tzourio, C., Howard, V. J., Westwood, A. J., Himali, J. J., SULLIVAN, L. M., Aparicio, H. J., et al. (2017) · Circulation · doi:10.1161/circulationaha.115.021275 · Cited by 217
Family history of diabetes as a potential public health tool
Harrison, T. A., Hindorff, L. A., Kim, H., Wines, R. C. M., Bowen, D. J., McGrath, B. B., & Edwards, K. L. (2003) · American Journal of Preventive Medicine · doi:10.1016/s0749-3797(02)00588-3 · Cited by 335
Epigenetics as a mechanism linking developmental exposures to long-term toxicity
Barouki, R., Melén, E., Herceg, Z., Beckers, J., Chen, J., Karagas, M. R., Puga, A., Xia, Y., Chadwick, L. H., Yan, W., et al. (2018) · Environment International · doi:10.1016/j.envint.2018.02.014 · Cited by 216
Family History and Prevalence of Diabetes in the U.S. Population
Valdez, R. A., Yoon, P. W., Liu, T., & Khoury, M. J. (2007) · Diabetes Care · doi:10.2337/dc07-0720 · Cited by 208
McPherson, N. O., Owens, J. A., Fullston, T., & Lane, M. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00013.2015 · Cited by 199
Gestational diabetes: risks, management, and treatment options
Kim, C. (2010) · International Journal of Women s Health · doi:10.2147/ijwh.s13333 · Cited by 200
Cardiovascular Disease Risk Factors, Type 2 Diabetes Mellitus, and the Framingham Heart Study
Fox, C. S. (2010) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2010.08.001 · Cited by 198
Offspring of diabetic pregnancy: Long-term outcomes
Siméoni, U., & Barker, D. J. P. (2009) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2009.01.002 · Cited by 191
Vasiliu, O., Cameron, L. L., Gardiner, J. C., DeGuire, P., & Karmaus, W. (2006) · Epidemiology · doi:10.1097/01.ede.0000220553.84350.c5 · Cited by 190
Latent Autoimmune Diabetes in Adults
Naik, R. G., Brooks-Worrell, B. M., & Palmer, J. P. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1120 · Cited by 249
Meigs, J. B., Panhuysen, C. I. M., Myers, R. H., Wilson, P. W. F., & Cupples, L. A. (2002) · Diabetes · doi:10.2337/diabetes.51.3.833 · Cited by 185
Self-citationHemostatic Markers of Endothelial Dysfunction and Risk of Incident Type 2 Diabetes
Meigs, J. B., O’Donnell, C. J., Tofler, G. H., Benjamin, E. J., Fox, C. S., Lipinska, I., Nathan, D. M., SULLIVAN, L. M., D’Agostino, R. B., & Wilson, P. W. F. (2006) · Diabetes · doi:10.2337/diabetes.55.02.06.db05-1041 · Cited by 184
Self-citationA Susceptibility Gene for Psoriatic Arthritis Maps to Chromosome 16q: Evidence for Imprinting
Kárason, A., Gudjonsson, J. E., Upmanyu, R., Antonsdóttir, A. A., Hauksson, V. B., Rúnarsdóttir, E. H., Jónsson, H. H., Gudbjartsson, D. F., Frigge, M. L., Kong, A., et al. (2003) · The American Journal of Human Genetics · doi:10.1086/345646 · Cited by 180
Ge, T., Irvin, M. R., Patki, A., Srinivasasainagendra, V., Lin, K., Tiwari, H. K., Armstrong, N. D., Benoit, B., Chen, C., Choi, K. W., et al. (2022) · Genome Medicine · doi:10.1186/s13073-022-01074-2 · Cited by 178
Self-citationWhy are Indians more prone to diabetes?
Mohan, V. (2004) · PubMed · Cited by 165
Ukropcova, B., Sereda, O., de Jonge, L., Bogacka, I., Nguyen, T., Xie, H., Bray, G. A., & Smith, S. R. (2007) · Diabetes · doi:10.2337/db06-0521 · Cited by 165
Insulin signaling and glucose transport in insulin resistant human skeletal muscle
Karlsson, H. K. R., & Zierath, J. R. (2007) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-007-0030-9 · Cited by 159
Familial Risks for Type 2 Diabetes in Sweden
Hemminki, K., Li, X., Sundquist, K., & Sundquist, J. (2009) · Diabetes Care · doi:10.2337/dc09-0947 · Cited by 174
Annis, A., Caulder, M. S., Cook, M. L., & Duquette, D. A. (2005) · PubMed Central · Cited by 162
Walaszczyk, E., Luijten, M., Spijkerman, A. M. W., Bonder, M. J., Lutgers, H. L., Snieder, H., Wolffenbuttel, B. H. R., & van Vliet‐Ostaptchouk, J. V. (2017) · Diabetologia · doi:10.1007/s00125-017-4497-7 · Cited by 165
Polygenic Type 2 Diabetes Prediction at the Limit of Common Variant Detection
Vassy, J. L., Hivert, M., Porneala, B., Dauriz, M., Florez, J. C., Dupuis, J., Siscovick, D. S., Fornage, M., Rasmussen‐Torvik, L. J., Bouchard, C., et al. (2014) · Diabetes · doi:10.2337/db13-1663 · Cited by 153
Self-citationThe Genetic Basis of Type 2 Diabetes.
Das, S. K., & Elbein, S. C. (2006) · PubMed · doi:10.1901/jaba.2006.2-100 · Cited by 153
Vilas‐Boas, E. A., de Almeida, D. C., Roma, L. P., Ortis, F., & Carpinelli, Â. R. (2021) · Cells · doi:10.3390/cells10123328 · Cited by 163
The changing face of diabetes in youth: lessons learned from studies of type 2 diabetes
Hannon, T. S., & Arslanian, S. A. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12939 · Cited by 137
Bowden Davies, K. A., Sprung, V. S., Norman, J. A., Thompson, A., Mitchell, K. L., Halford, J. C. G., Harrold, J. A., Wilding, J. P. H., Kemp, G. J., & Cuthbertson, D. J. (2018) · Diabetologia · doi:10.1007/s00125-018-4603-5 · Cited by 138
Altered Glucose Metabolism in Mouse and Humans Conceived by IVF
Chen, M.-X., Wu, L., Zhao, J., Wu, F., Davies, M., Wittert, G., Norman, R., Robker, R., & Heilbronn, L. (2014) · Diabetes · doi:10.2337/db14-0103 · Cited by 141
Hyperandrogenic origins of polycystic ovary syndrome-Implications for Pathophysiology and Therapy
Abbott, D. H., Dumesic, D. A., & Levine, J. E. (2019) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2019.1576522 · Cited by 131
Developing Family Healthware, a family history screening tool to prevent common chronic diseases.
Yoon, P. W., Scheuner, M. T., Jorgensen, C. M., & Khoury, M. J. (2009) · PubMed Central · Cited by 131
Double diabetes: a distinct high-risk group?
Kietsiriroje, N., Pearson, S., Campbell, M., Ariëns, R. A. S., & Ajjan, R. A. (2019) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.13848 · Cited by 123
Pathophysiology of Type 2 Diabetes in Children and Adolescents
Valaiyapathi, B., Gower, B. A., & Ashraf, A. P. (2019) · Current Diabetes Reviews · doi:10.2174/1573399814666180608074510 · Cited by 160
Valdez, R., Yoon, P. W., Liu, T., & Khoury, M. J. (2007) · Diabetes · doi:10.2337/db07-0720x · Cited by 121
Lifestyle and Genetics in Obesity and type 2 Diabetes
Temelkova-Kurktschiev, T. S., & Stefanov, T. (2011) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0031-1285832 · Cited by 124
Family health history: underused for actionable risk assessment
Ginsburg, G. S., Wu, R. R., & Orlando, L. A. (2019) · The Lancet · doi:10.1016/s0140-6736(19)31275-9 · Cited by 105
Stride, A., Shepherd, M. H., Frayling, T. M., Bulman, M. P., Ellard, S., & Hattersley, A. T. (2002) · Diabetes Care · doi:10.2337/diacare.25.12.2287 · Cited by 110
Niiranen, T., McCabe, E. L., Larson, M. G., Henglin, M., Lakdawala, N. K., Vasan, R. S., & Cheng, S. C. (2017) · BMJ · doi:10.1136/bmj.j1949 · Cited by 116
Genetics of Type 2 Diabetes: Implications from Large-Scale Studies
DeForest, N., & Majithia, A. R. (2022) · Current Diabetes Reports · doi:10.1007/s11892-022-01462-3 · Cited by 112
Plastino, M., Fava, A., Pirritano, D., Cotronei, P., Sacco, N., Sperlì, T., Spano, A. L., Gallo, D., Mungari, P., Consoli, D., et al. (2009) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2009.09.022 · Cited by 107
Cornelis, M. C., & Hu, F. B. (2012) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071811-150648 · Cited by 107
Systematic review: family history in risk assessment for common diseases.
Wilson, B. J., Qureshi, N., Santaguida, P. L., Little, J., Carroll, J. C., Allanson, J. E., & Raina, P. S. (2009) · PubMed · doi:10.7326/0003-4819-151-12-200912150-00177 · Cited by 106
Obesity, energy balance and spermatogenesis
Oliveira, P. F., Sousa, M., Silva, B. M., Monteiro, M. P., & Alves, M. G. (2017) · Reproduction · doi:10.1530/rep-17-0018 · Cited by 109
Risk of diabetes in siblings of index cases with Type 2 diabetes: implications for genetic studies
Weijnen, C. F., Rich, S. S., Meigs, J. B., Królewski, A. S., & Warram, J. H. (2002) · Diabetic Medicine · doi:10.1046/j.1464-5491.2002.00624.x · Cited by 104
Self-citationEarly determinants of type-2 diabetes
Berends, L. M., & Ozanne, S. E. (2012) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2012.03.002 · Cited by 101
Genetic predisposition to type 2 diabetes among Asian Indians.
Radha, V., & Mohan, V. (2007) · PubMed · Cited by 101
Racialized Genetics and the Study of Complex Diseases: The Thrifty Genotype Revisited
Paradies, Y., Montoya, M. J., & Fullerton, S. M. (2007) · Perspectives in biology and medicine · doi:10.1353/pbm.2007.0020 · Cited by 98
Systematic Review: Family History in Risk Assessment for Common Diseases
Wilson, B. J., Qureshi, N., Santaguida, P., Little, J., Carroll, J. C., Allanson, J., & Raina, P. (2009) · Annals of Internal Medicine · doi:10.7326/0000605-200912150-00177 · Cited by 117
A 100K Genome-Wide Association Scan for Diabetes and Related Traits in the Framingham Heart Study
Florez, J. C., Manning, A. K., Dupuis, J., McAteer, J. B., Irenze, K., Gianniny, L., Mirel, D. B., Fox, C. S., Cupples, L. A., & Meigs, J. B. (2007) · Diabetes · doi:10.2337/db07-0451 · Cited by 95
Self-citationDiagnosis, treatment and prevention of type 2 diabetes mellitus in children and adolescents
Serbis, A., Giapros, V. I., Kotanidou, E. P., Galli‐Τsinopoulou, A., & Siomou, E. C. (2021) · World Journal of Diabetes · doi:10.4239/wjd.v12.i4.344 · Cited by 111
Genome-wide association with diabetes-related traits in the Framingham Heart Study
Meigs, J. B., Manning, A. K., Fox, C. S., Florez, J. C., Liu, C., Cupples, L. A., & Dupuis, J. (2007) · BMC Medical Genetics · doi:10.1186/1471-2350-8-s1-s16 · Cited by 94
Self-citationEkpenyong, C. E., Akpan, U. P., Ibu, J. O., & Daniel, N. E. (2012) · Diabetologia Croatica · Cited by 90
Epigenetic changes in diabetes
Keating, S. T., & El‐Osta, A. (2013) · Clinical Genetics · doi:10.1111/cge.12121 · Cited by 90
Metadata
- Authors
- Meigs, J. B., Cupples, L. A., & Wilson, P. W.
- Affiliations
- Harvard University (US)
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2000-12-01
- Volume
- 49
- Issue
- 12
- Pages
- 2201-2207
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W1989797259
- Cited by
- 666
- References
- 37
- Citations by year
- 2026: 15 · 2025: 17 · 2024: 27 · 2023: 29 · 2022: 44 · 2021: 40 · 2020: 37 · 2019: 37 · 2018: 31 · 2017: 32 · 2016: 26 · 2015: 41 · 2014: 36 · 2013: 44 · 2012: 28
- FWCI
- 2.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Diabetes Association
- National Institutes of Health
- National Heart, Lung, and Blood Institute (N01-HC-38083)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Keywords
- type 2 diabetes, parental diabetes, familial aggregation, maternal diabetes, paternal diabetes, impaired glucose tolerance, diabetes risk, Framingham Offspring Study
- MeSH terms
- Adult, Aged, Aged, 80 and over, Blood Glucose, Diabetes Mellitus, Type 2, Fathers, Female, Glucose Tolerance Test, Humans, Hypoglycemic Agents, Insulin Resistance, Male, Middle Aged, Mothers, Cohort Studies, Prevalence, Odds Ratio, Randomized Controlled Trials as Topic, Genetic Predisposition to Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
