HuR function in disease

Interleukin-10 and the Interleukin-10 Receptor

Moore, K. W., de Waal Malefyt, R., Coffman, R. L., & O'Garra, A. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.683 · Cited by 6,737 · see citing works

IL-10 inhibits cytokine production by activated macrophages

Fiorentino, D. F., Zlotnik, A., Mosmann, T. R., Howard, M., & O’Garra, A. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.11.3815 · Cited by 2,888 · see citing works

TGF-β Signaling in Tumor Suppression and Cancer Progression

Derynck, R., Akhurst, R. J., & Balmain, A. (2001) · Nature Genetics · doi:10.1038/ng1001-117 · Cited by 2,275 · see citing works

Control of translation and mRNA degradation by miRNAs and siRNAs: Table 1.

Valencia-Sanchez, M. A., Liu, J., Hannon, G. J., & Parker, R. (2006) · Genes & Development · doi:10.1101/gad.1399806 · Cited by 1,751 · see citing works

Relief of microRNA-Mediated Translational Repression in Human Cells Subjected to Stress

Bhattacharyya, S. N., Habermacher, R., Martiné, U., Closs, E. I., & Filipowicz, W. (2006) · Cell · doi:10.1016/j.cell.2006.04.031 · Cited by 1,332 · see citing works

RNA regulons: coordination of post-transcriptional events

Keene, J. D. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2111 · Cited by 1,321 · see citing works

TGFβ: the molecular Jekyll and Hyde of cancer

Bierie, B., & Moses, H. L. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1926 · Cited by 1,262 · see citing works

Feedback Inhibition of Macrophage Tumor Necrosis Factor-α Production by Tristetraprolin

Carballo, E., Lai, W. S., & Blackshear, P. J. (1998) · Science · doi:10.1126/science.281.5379.1001 · Cited by 1,162 · see citing works

HuR and mRNA stability

Brennan, C. M., & Steitz*, J. A. (2001) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000854 · Cited by 1,095 · see citing works

A Unified Theory of Gene Expression

Orphanides, G., & Reinberg, D. (2002) · Cell · doi:10.1016/s0092-8674(02)00655-4 · Cited by 898 · see citing works

AU Binding Proteins Recruit the Exosome to Degrade ARE-Containing mRNAs

Chen, C.-Y., Gherzi, R., Ong, S.-E., Chan, E. L., Raijmakers, R., Pruijn, G. J. M., Stoecklin, G., Moroni, C., Mann, M., & Karin, M. (2001) · Cell · doi:10.1016/s0092-8674(01)00578-5 · Cited by 865 · see citing works

Evidence that Tristetraprolin Binds to AU-Rich Elements and Promotes the Deadenylation and Destabilization of Tumor Necrosis Factor Alpha mRNA

Lai, W. S., Carballo, E., Strum, J. R., Kennington, E. A., Phillips, R. S., & Blackshear, P. J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.6.4311 · Cited by 730 · see citing works

Cloning and Characterization of HuR, a Ubiquitously Expressed Elav-like Protein

Ma, W.-J., Cheng, S., Campbell, C., Wright, A., & Furneaux, H. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.14.8144 · Cited by 667 · see citing works

Diverse molecular functions of Hu proteins

Hinman, M. N., & Lou, H. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8252-6 · Cited by 587 · see citing works

HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and sex-lethal

Szabo, A., Dalmau, J., Manley, G., Rosenfeld, M., Wong, E., Henson, J., Posner, J. B., & Furneaux, H. M. (1991) · Cell · doi:10.1016/0092-8674(91)90184-z · Cited by 553 · see citing works

HuR recruits let-7/RISC to repress c-Myc expressionPreprint

Kim, H. H., Kuwano, Y., Srikantan, S., Lee, E. K., Martindale, J. L., & Gorospe, M. (2009) · Genes & Development · doi:10.1101/gad.1812509 · Cited by 544 · see citing works

Purification, Characterization, and cDNA Cloning of an AU-Rich Element RNA-Binding Protein, AUF1

Zhang, W., Wagner, B., Ehrenman, K., Schaefer, A., DeMaria, C. T., Crater, D. L., DeHaven, K., Long, L., & Brewer, G. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.12.7652 · Cited by 540 · see citing works

HuR Regulates p21 mRNA Stabilization by UV Light

Wang, W., Furneaux, H., Cheng, H., Caldwell, M. C., Hutter, D., Liu, Y., Holbrook, N. J., & Gorospe, M. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.3.760-769.2000 · Cited by 539 · see citing works

Phosphorylation of HuR by Chk2 Regulates SIRT1 Expression

Abdelmohsen, K., Pullmann, R., Lal, A., Kim, H. H., Galbán, S., Yang, X., Blethrow, J. D., Walker, M., Shubert, J., Gillespie, D. A., et al. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.01.011 · Cited by 527 · see citing works

TIA‐1 is a translational silencer that selectively regulates the expression of TNF‐α

Piecyk, M., Wax, S. D., Beck, A., Kedersha, N., Gupta, M., Maritim, B., Chen, S., Gueydan, C., Kruys, V., Streuli, M., et al. (2000) · The EMBO Journal · doi:10.1093/emboj/19.15.4154 · Cited by 509 · see citing works

Identification of a target RNA motif for RNA-binding protein HuR

de Silanes, I. L., Zhan, M., Lal, A., Yang, X., & Gorospe, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306453101 · Cited by 502 · see citing works

Dual-specificity MAP kinase phosphatases (MKPs) and cancer

Keyse, S. M. (2008) · Cancer and Metastasis Reviews · doi:10.1007/s10555-008-9123-1 · Cited by 492 · see citing works

Inducible Nitric Oxide Synthase Binds, S-Nitrosylates, and Activates Cyclooxygenase-2

Kim, S. F., Huri, D. A., & Snyder, S. H. (2005) · Science · doi:10.1126/science.1119407 · Cited by 484 · see citing works

HNS, a nuclear-cytoplasmic shuttling sequence in HuR

Fan, X. C., & STEITZ, J. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15293 · Cited by 475 · see citing works

Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs

Lal, A., Mazan‐Mamczarz, K., Kawai, T., Yang, X., Martindale, J. L., & Gorospe, M. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600305 · Cited by 461 · see citing works

HuR regulates cyclin A and cyclin B1 mRNA stability during cell proliferation

Wang, W., Caldwell, M. C., Lin, S., Furneaux, H., & Gorospe, M. (2000) · The EMBO Journal · doi:10.1093/emboj/19.10.2340 · Cited by 446 · see citing works

RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation

Mazan-Mamczarz, K., Galbán, S., de Silanes, I. L., Martindale, J. L., Atasoy, U., Keene, J. D., & Gorospe, M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1432104100 · Cited by 445 · see citing works

Altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cells

Dixon, D. A., Tolley, N. D., King, P. H., Nabors, B., McIntyre, T. M., Zimmerman, G. A., & Prescott, S. M. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12973 · Cited by 443 · see citing works

IL-10 Inhibits Inflammation and Attenuates Left Ventricular Remodeling After Myocardial Infarction via Activation of STAT3 and Suppression of HuR

Krishnamurthy, P., Rajasingh, J., Lambers, E., Qin, G., Losordo, D. W., & Kishore, R. (2008) · Circulation Research · doi:10.1161/circresaha.108.188243 · Cited by 423 · see citing works

Posttranscriptional regulation of cancer traits by HuR

Abdelmohsen, K., & Gorospe, M. (2010) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.4 · Cited by 414 · see citing works

Polypyrimidine-tract-binding protein: a multifunctional RNA-binding protein

Sawicka, K., Bushell, M., Spriggs, K. A., & Willis, A. E. (2008) · Biochemical Society Transactions · doi:10.1042/bst0360641 · Cited by 332 · see citing works

ELAV/Hu proteins inhibit p27 translation via an IRES element in the p27 5′UTR

Kullmann, M., Göpfert, U., Siewe, B., & Hengst, L. (2002) · Genes & Development · doi:10.1101/gad.248902 · Cited by 327 · see citing works

HuR, a RNA stability factor, is expressed in malignant brain tumors and binds to adenine- and uridine-rich elements within the 3' untranslated regions of cytokine and angiogenic factor mRNAs.

Nabors, B., Gillespie, G. Y., Harkins, L. E., & King, P. H. (2001) · PubMed · Cited by 315 · see citing works

Role of the RNA-binding protein HuR in colon carcinogenesis

de Silanes, I. L., Fan, J., Yang, X., Zonderman, A. B., Potapova, O., Pizer, E. S., & Gorospe, M. (2003) · Oncogene · doi:10.1038/sj.onc.1206862 · Cited by 280 · see citing works

RNA-Binding Proteins HuR and PTB Promote the Translation of Hypoxia-Inducible Factor 1α

Galbán, S., Kuwano, Y., Pullmann, R., Martindale, J. L., Kim, H. H., Lal, A., Abdelmohsen, K., Yang, X., Dang, Y., Liu, J. O., et al. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00973-07 · Cited by 279 · see citing works

mRNA stability in eukaryotes

Mitchell, P., & Tollervey, D. W. (2000) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00063-0 · Cited by 278 · see citing works

Delineation of mRNA Export Pathways by the Use of Cell-Permeable Peptides

Gallouzi, I., & STEITZ, J. A. (2001) · Science · doi:10.1126/science.1064693 · Cited by 266 · see citing works

Posttranscriptional gene regulation by RNA-binding proteins during oxidative stress: implications for cellular senescence

Abdelmohsen, K., Kuwano, Y., Kim, H. H., & Gorospe, M. (2008) · Biological Chemistry · doi:10.1515/bc.2008.022 · Cited by 258 · see citing works

Posttranscriptional Orchestration of an Anti-Apoptotic Program by HuR

Abdelmohsen, K., Lal, A., Kim, H. H., & Gorospe, M. (2007) · Cell Cycle · doi:10.4161/cc.6.11.4299 · Cited by 244 · see citing works

p38 Mitogen-Activated Protein Kinase- and HuR-Dependent Stabilization of p21 Cip1 mRNA Mediates the G 1 /S Checkpoint

Lafarga, V., Cuadrado, A., de Silanes, I. L., Bengoechea, R., Fernández-Capetillo, Ó., & Nebreda, Á. R. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00210-09 · Cited by 242 · see citing works

The mRNA Binding Proteins HuR and Tristetraprolin Regulate Cyclooxygenase 2 Expression During Colon Carcinogenesis

Young, L. E., Sanduja, S., Bemis–Standoli, K., Peña, E. A., Price, R. L., & Dixon, D. A. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.01.010 · Cited by 237 · see citing works

HuR as a Negative Posttranscriptional Modulator in Inflammation

Katsanou, V., Papadaki, O., Milatos, S., Blackshear, P. J., Anderson, P., Kollias, G. A., & Kontoyiannis, D. L. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.08.007 · Cited by 236 · see citing works

Lipopolysaccharide-induced Methylation of HuR, an mRNA-stabilizing Protein, by CARM1

Li, H., Park, S., Kilburn, B., Jelinek, M. A., Henschen-Edman, A. H., Aswad, D. W., Stallcup, M. R., & Laird‐Offringa, I. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206187200 · Cited by 233 · see citing works

miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels

Abdelmohsen, K., Srikantan, S., Kuwano, Y., & Gorospe, M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809376106 · Cited by 230 · see citing works

Identification and mechanistic characterization of low-molecular-weight inhibitors for HuR

Meisner-Kober, N. C., Hintersteiner, M., Mueller, K., Bauer, R., Seifert, J., Naegeli, H., Ottl, J., Oberer, L., Guenat, C. R., Moss, S., et al. (2007) · Nature Chemical Biology · doi:10.1038/nchembio.2007.14 · Cited by 220 · see citing works

Stabilization of Urokinase and Urokinase Receptor mRNAs by HuR Is Linked to Its Cytoplasmic Accumulation Induced by Activated Mitogen-Activated Protein Kinase-Activated Protein Kinase 2

Tran, H., Maurer, F., & Nagamine, Y. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.20.7177-7188.2003 · Cited by 217 · see citing works

Signalling pathways regulating nucleo-cytoplasmic shuttling of the mRNA-binding protein HuR

Doller, A., Pfeilschifter, J. M., & Eberhardt, W. (2008) · Cellular Signalling · doi:10.1016/j.cellsig.2008.05.007 · Cited by 215 · see citing works

Cytoplasmic HuR Expression Is a Prognostic Factor in Invasive Ductal Breast Carcinoma

Heinonen, M., Bono, P., Narko, K., Chang, S.-H., Lundin, J. E., Joensuu, H., Furneaux, H., Hla, T., Haglund, C. H., & Ristimäki, A. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3765 · Cited by 213 · see citing works

Functional cloning of BRF1, a regulator of ARE‐dependent mRNA turnover

Stoecklin, G., Colombi, M., Raineri, I., Leuenberger, S., Mallaun, M., Schmidlin, M., Gross, B., Lu, M., Kitamura, T., & Moroni, C. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf444 · Cited by 212 · see citing works

MKP-1 mRNA Stabilization and Translational Control by RNA-Binding Proteins HuR and NF90

Kuwano, Y., Kim, H. H., Abdelmohsen, K., Pullmann, R., Martindale, J. L., Yang, X., & Gorospe, M. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00165-08 · Cited by 209 · see citing works

AMP-Activated Kinase Regulates Cytoplasmic HuR

Wang, W., Fan, J., Yang, X., Fürer-Galbán, S., de Silanes, I. L., von Kobbe, C., Guo, J., Georas, S. N., Foufelle, F., Hardie, D. G., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.10.3425-3436.2002 · Cited by 208 · see citing works

MiR‐34a attenuates paclitaxel‐resistance of hormone‐refractory prostate cancer PC3 cells through direct and indirect mechanisms

Kojima, K., Fujita, Y., Nozawa, Y., Deguchi, T., & Ito, M. (2010) · The Prostate · doi:10.1002/pros.21185 · Cited by 205 · see citing works

Nuclear HuR accumulation through phosphorylation by Cdk1Preprint

Kim, H. H., Abdelmohsen, K., Lal, A., Pullmann, R., Yang, X., Galbán, S., Srikantan, S., Martindale, J. L., Blethrow, J. D., Shokat, K. M., et al. (2008) · Genes & Development · doi:10.1101/gad.1645808 · Cited by 202 · see citing works

Involvement of KSRP in the post-transcriptional regulation of human iNOS expression-complex interplay of KSRP with TTP and HuR

Linker, K., Pautz, A., Fechir, M., Hubrich, T., Greeve, J. C., & Kleinert, H. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki797 · Cited by 200 · see citing works

Analysis of Turnover and Translation Regulatory RNA-Binding Protein Expression through Binding to Cognate mRNAs

Pullmann, R., Kim, H. H., Abdelmohsen, K., Lal, A., Martindale, J. L., Yang, X., & Gorospe, M. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00500-07 · Cited by 199 · see citing works

MicroRNA-125a represses cell growth by targeting HuR in breast cancer

Guo, X., Wu, Y., & Hartley, R. S. (2009) · RNA Biology · doi:10.4161/rna.6.5.10079 · Cited by 197 · see citing works

Essential role of the RNA-binding protein HuR in progenitor cell survival in mice

Ghosh, M., Aguila, H. L., Michaud, J. E., Ai, Y., Wu, M.-T., Hemmes, A., Ristimaki, A. P., Guo, C., Furneaux, H., & Hla, T. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38263 · Cited by 196 · see citing works

Role of HuR in Skeletal Myogenesis through Coordinate Regulation of Muscle Differentiation Genes

Figueroa, A., Cuadrado, A., Fan, J., Atasoy, U., Muscat, G. E. O., Muñoz‐Cánoves, P., Gorospe, M., & Múñoz, A. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.14.4991-5004.2003 · Cited by 193 · see citing works

Protein Kinase Cα-dependent Phosphorylation of the mRNA-stabilizing Factor HuR: Implications for Posttranscriptional Regulation of Cyclooxygenase-2

Doller, A., Huwiler, A., Müller, R., Radeke, H. H., Pfeilschifter, J. M., & Eberhardt, W. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-09-0850 · Cited by 191 · see citing works

Translational Control of Cytochrome c by RNA-Binding Proteins TIA-1 and HuR

Kawai, T., Lal, A., Yang, X., Galbán, S., Mazan-Mamczarz, K., & Gorospe, M. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.8.3295-3307.2006 · Cited by 187 · see citing works

Posttranslational Modification of the AU-Rich Element Binding Protein HuR by Protein Kinase Cδ Elicits Angiotensin II-Induced Stabilization and Nuclear Export of Cyclooxygenase 2 mRNA

Doller, A., Akool, E., Huwiler, A., Müller, R., Radeke, H. H., Pfeilschifter, J. M., & Eberhardt, W. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01530-07 · Cited by 187 · see citing works

Purification, Characterization, and cDNA Cloning of an AU-Rich Element RNA-Binding Protein, AUF1

Zhang, W., Wagner, B. J., Ehrenman, K., et al. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.12.7652-7665.1993 · Cited by 182 · see citing works

The Role of HuR in Gemcitabine Efficacy in Pancreatic Cancer: HuR Up-regulates the Expression of the Gemcitabine Metabolizing Enzyme Deoxycytidine Kinase

Costantino, C. L., Witkiewicz, A. K., Kuwano, Y., Cozzitorto, J. A., Kennedy, E. P., Dasgupta, A., Keen, J. C., Yeo, C. J., Gorospe, M., & Brody, J. R. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-0371 · Cited by 181 · see citing works

Natural antisense transcript stabilizes inducible nitric oxide synthase messenger RNA in rat hepatocytes

Matsui, K., Nishizawa, M., Ozaki, T., Kimura, T., Hashimoto, I., Yamada, M., Kaibori, M., Kamiyama, Y., Ito, S., & Okumura, T. (2007) · Hepatology · doi:10.1002/hep.22036 · Cited by 168 · see citing works

The RNA-binding Protein HuR Regulates the Expression of Cyclooxygenase-2

Sengupta, S., Jang, B., Wu, M.-T., Paik, J., Furneaux, H., & Hla, T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301813200 · Cited by 163 · see citing works

Antiapoptotic function of RNA‐binding protein HuR effected through prothymosin α

Lal, A., Kawai, T., Yang, X., Mazan-Mamczarz, K., & Gorospe, M. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600661 · Cited by 161 · see citing works

Overexpression of the Embryonic-Lethal Abnormal Vision-like Protein HuR in Ovarian Carcinoma Is a Prognostic Factor and Is Associated with Increased Cyclooxygenase 2 Expression

Denkert, C., Weichert, W., Pest, S., Koch, I., Licht, D., Köbel, M., Reles, A., Sehouli, J., Dietel, M., & Hauptmann, S. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-1987 · Cited by 159 · see citing works

Ubiquitin‐mediated proteolysis of HuR by heat shock

Abdelmohsen, K., Srikantan, S., Yang, X., Lal, A., Kim, H. H., Kuwano, Y., Galbán, S., Becker, K. G., Kamara, D. F., de Cabo, R., et al. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.67 · Cited by 158 · see citing works

Defining a neuron: neuronal ELAV proteins

Pascale, A., Amadio, M., & Quattrone, A. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7017-y · Cited by 158 · see citing works

Translational Repression by RNA-Binding Protein TIAR

Mazan-Mamczarz, K., Lal, A., Martindale, J. L., Kawai, T., & Gorospe, M. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.7.2716-2727.2006 · Cited by 158 · see citing works

Hu Antigen R (HuR) Functions as an Alternative Pre-mRNA Splicing Regulator of Fas Apoptosis-promoting Receptor on Exon Definition

Izquierdo, J. M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800017200 · Cited by 156 · see citing works

NF-κB-Mediated MyoD Decay during Muscle Wasting Requires Nitric Oxide Synthase mRNA Stabilization, HuR Protein, and Nitric Oxide Release

Marco, S. D., Mazrouï, R., Dallaire, P., Chittur, S. V., Tenenbaum, S. A., Radzioch, D., Marette, A., & Gallouzi, I. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.15.6533-6545.2005 · Cited by 154 · see citing works

Interleukin-4, Interleukin-13, Signal Transducer and Activator of Transcription Factor 6, and Allergic Asthma

Kuperman, D. A., & Schleimer, R. P. (2008) · Current Molecular Medicine · doi:10.2174/156652408785161032 · Cited by 153 · see citing works

Transportins 1 and 2 are redundant nuclear import factors for hnRNP A1 and HuR

Rebane, A., Aab, A., & STEITZ, J. A. (2004) · RNA · doi:10.1261/rna.5224304 · Cited by 150 · see citing works

IL‐10‐induced TNF‐alpha mRNA destabilization is mediated via IL‐10 suppression of p38 MAP kinase activation and inhibition of HuR expression

Rajasingh, J., Bord, E., Luedemann, C., Asai, J., Hamada, H., Thorne, T. E., Qin, G., Goukassian, D. A., Zhu, Y., Losordo, D. W., et al. (2006) · The FASEB Journal · doi:10.1096/fj.06-6084fje · Cited by 150 · see citing works

Regulation of innate immune response by MAP kinase phosphatase-1

Wang, X., & Liu, Y. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.03.013 · Cited by 149 · see citing works

miR-519 suppresses tumor growth by reducing HuR levels

Abdelmohsen, K., Kim, M. M., Srikantan, S., Mercken, E. M., Brennan, S. E., Wilson, G. M., de Cabo, R., & Gorospe, M. (2010) · Cell Cycle · doi:10.4161/cc.9.7.11164 · Cited by 146 · see citing works

Cyclooxygenase-2 Is an Independent Prognostic Factor in Gastric Cancer and Its Expression Is Regulated by the Messenger RNA Stability Factor HuR

Mrena, J., Wiksten, J., Thiel, A., Kokkola, A., Pohjola, L. K., Lundin, J. E., Nordling, S., Ristimäki, A., & Haglund, C. H. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-0764 · Cited by 145 · see citing works

Cytoplasmic HuR expression correlates with poor outcome and with cyclooxygenase 2 expression in serous ovarian carcinoma.

Erkinheimo, T.-L., Lassus, H. J., Sivula, A., Sengupta, S., Furneaux, H., Hla, T., Haglund, C. H., Bützow, R. C., & Ristimaki, A. P. (2003) · PubMed · Cited by 145 · see citing works

The Proximal Region of the 3′-Untranslated Region of Cyclooxygenase-2 is Recognized by a Multimeric Protein Complex Containing HuR, TIA-1, TIAR, and the Heterogeneous Nuclear Ribonucleoprotein U

Cok, S. J., Acton, S. J., & Morrison, A. R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302547200 · Cited by 136 · see citing works

MicroRNA profiling in human diploid fibroblasts uncovers miR-519 role in replicative senescence

Marasa, B. S., Srikantan, S., Martindale, J. L., Kim, M. M., Lee, E. K., Gorospe, M., & Abdelmohsen, K. (2010) · Aging · doi:10.18632/aging.100159 · Cited by 132 · see citing works

NF-κB Activates Transcription of the RNA-Binding Factor HuR, via PI3K-AKT Signaling, to Promote Gastric Tumorigenesis

Kang, M. J., Ryu, B., Lee, M., Han, J., Lee, J., Ha, T., Byun, D., Chae, K. S., Lee, B., Chun, H. S., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.08.009 · Cited by 130 · see citing works

Polyamine Depletion Increases Cytoplasmic Levels of RNA-binding Protein HuR Leading to Stabilization of Nucleophosmin and p53 mRNAs

Zou, T., Mazan-Mamczarz, K., Rao, J. N., Liu, L., Marasa, B. S., Zhang, A., Xiao, L., Pullmann, R., Gorospe, M., & Wang, J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602344200 · Cited by 128 · see citing works

Caspase-mediated cleavage of HuR in the cytoplasm contributes to pp32/PHAP-I regulation of apoptosis

Mazrouï, R., Marco, S. D., Clair, E., von Roretz, C., Tenenbaum, S. A., Keene, J. D., Saleh, M., & Gallouzi, I. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200709030 · Cited by 126 · see citing works

Distinct Domains of AU-Rich Elements Exert Different Functions in mRNA Destabilization and Stabilization by p38 Mitogen-Activated Protein Kinase or HuR

Winzen, R., Gowrishankar, G., Bollig, F., Redich, N., Resch, K., & Holtmann, H. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.11.4835-4847.2004 · Cited by 126 · see citing works

RNAi-mediated HuR Depletion Leads to the Inhibition of Muscle Cell Differentiation

van der Giessen, K., Marco, S. D., Clair, E., & Gallouzi, I. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308889200 · Cited by 125 · see citing works

Regulation of Eotaxin Gene Expression by TNF-α and IL-4 Through mRNA Stabilization: Involvement of the RNA-Binding Protein HuR

Atasoy, U., Curry, S. L., de Silanes, I. L., Shyu, A., Casolaro, V., Gorospe, M., & Stellato, C. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.8.4369 · Cited by 122 · see citing works

The RNA‐binding protein HuD: a regulator of neuronal differentiation, maintenance and plasticity

Deschênes‐Furry, J., Perrone‐Bizzozero, N. I., & Jasmin, B. J. (2006) · BioEssays · doi:10.1002/bies.20449 · Cited by 116 · see citing works

The 3′-Untranslated Region of p21WAF1 mRNA Is a Composite cis-Acting Sequence Bound by RNA-binding Proteins from Breast Cancer Cells, Including HuR and Poly(C)-binding Protein

Giles, K. M., Daly, J. M., Beveridge, D. J., Thomson, A. M., Voon, D. C., Furneaux, H. M., Jazayeri, J. A., & Leedman, P. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208439200 · Cited by 114 · see citing works

Transportin2 functions as importin and mediates nuclear import of HuR

Güttinger, S., Mühlhäusser, P., Koller-Eichhorn, R., Brennecke, J., & Kutay, U. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400342101 · Cited by 112 · see citing works

The PKCβ/HuR/VEGF pathway in diabetic retinopathy

Amadio, M., Bucolo, C., Leggio, G. M., Drago, F., Govoni, S. M., & Pascale, A. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.06.033 · Cited by 112 · see citing works

Sindbis Virus Usurps the Cellular HuR Protein to Stabilize Its Transcripts and Promote Productive Infections in Mammalian and Mosquito Cells

Sokoloski, K. J., Dickson, A., Chaskey, E. L., Garneau, N. L., Wilusz, C. J., & Wilusz, J. (2010) · Cell Host & Microbe · doi:10.1016/j.chom.2010.07.003 · Cited by 112 · see citing works

Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotype

Mazan-Mamczarz, K., Hagner, P. R., Corl, S., Srikantan, S., Wood, W. H., Becker, K. G., Gorospe, M., Keene, J. D., Levenson, A. S., & Gartenhaus, R. B. (2008) · Oncogene · doi:10.1038/onc.2008.215 · Cited by 110 · see citing works

Alternative polyadenylation variants of the RNA binding protein, HuR: abundance, role of AU-rich elements and auto-Regulation

Al‐Ahmadi, W., Alghamdi, M. A., Al‐Haj, L., Al‐Saif, M., & Khabar, K. S. A. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp223 · Cited by 110 · see citing works

Prognostic Role of HuR in Hereditary Breast Cancer

Heinonen, M., Fagerholm, R., Aaltonen, K., Kilpivaara, O., Aittomäki, K., BLOMQVIST, C. P., Heikkilä, P., Haglund, C. H., Nevanlinna, H. A., & Ristimaki, A. P. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1432 · Cited by 106 · see citing works

The role of 3′-untranslated region (3′-UTR) mediated mRNA stability in cardiovascular pathophysiology

Misquitta, C., Iyer, V. R., Werstiuk, E. S., & Grover, A. K. (2001) · Molecular and Cellular Biochemistry · doi:10.1023/a:1011982932645 · Cited by 104 · see citing works

Role of TGF-? in immune-evasion of cancer

Beck, C., Schreiber, H. W., & Rowley, D. A. (2001) · Microscopy Research and Technique · doi:10.1002/1097-0029(20010215)52:4 · Cited by 103 · see citing works

Stability of Eukaryotic Translation Initiation Factor 4E mRNA Is Regulated by HuR, and This Activity Is Dysregulated in Cancer

Topisirović, I., Siddiqui, N., Orolicki, S., Skrabanek, L. A., Tremblay, M. R., Hoang, T., & Borden, K. L. B. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01532-08 · Cited by 100 · see citing works

IL-1? induces stabilization of IL-8 mRNA in malignant breast cancer cellsvia the 3? untranslated region: Involvement of divergent RNA-binding factors HuR, KSRP and TIAR

Suswam, E. A., Nabors, B., Huang, Y., Yang, X., & King, P. H. (2004) · International Journal of Cancer · doi:10.1002/ijc.20675 · Cited by 100 · see citing works

HuR Contributes to Cyclin E1 Deregulation in MCF-7 Breast Cancer Cells

Guo, X., & Hartley, R. S. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4362 · Cited by 99 · see citing works

Tandem Phosphorylation of Serines 221 and 318 by Protein Kinase Cδ Coordinates mRNA Binding and Nucleocytoplasmic Shuttling of HuR

Doller, A., Schlepckow, K., Schwalbe, H., Pfeilschifter, J. M., & Eberhardt, W. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01373-09 · Cited by 98 · see citing works

HuR Status is a Powerful Marker for Prognosis and Response to Gemcitabine-Based Chemotherapy for Resected Pancreatic Ductal Adenocarcinoma Patients

Richards, N. G., Rittenhouse, D. W., Freydin, B., Cozzitorto, J. A., Grenda, D. R., Rui, H., Gonye, G., Kennedy, E. P., Yeo, C. J., Brody, J. R., et al. (2010) · Annals of Surgery · doi:10.1097/sla.0b013e3181f1fd44 · Cited by 97 · see citing works

RNA-binding protein HuR mediates cytoprotection through stimulation of XIAP translation

Durie, D., Lewis, S. M., Liwak, U., Kisilewicz, M., Gorospe, M., & Holčı́k, M. (2010) · Oncogene · doi:10.1038/onc.2010.527 · Cited by 97 · see citing works

Regulation of Bcl-2 Expression by HuR in HL60 Leukemia Cells and A431 Carcinoma Cells

Ishimaru, D., Ramalingam, S., Sengupta, T. K., Bandyopadhyay, S., Dellis, S., Tholanikunnel, B. G., Fernandes, D., & Spicer, E. K. (2009) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-08-0476 · Cited by 95 · see citing works

Control of Thymic T Cell Maturation, Deletion and Egress by the RNA-Binding Protein HuR

Papadaki, O., Milatos, S., Grammenoudi, S., Mukherjee, N., Keene, J. D., & Kontoyiannis, D. L. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900377 · Cited by 94 · see citing works

Wnt-5a mRNA translation is suppressed by the Elav-like protein HuR in human breast epithelial cells

Leandersson, K., Riesbeck, K., & Andersson, T. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl571 · Cited by 92 · see citing works

p38 Mitogen-activated protein kinase stabilizes SMN mRNA through RNA binding protein HuR

Farooq, F., Balabanian, S., Liu, X., Holčı́k, M., & MacKenzie, A. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp352 · Cited by 92 · see citing works

The Expression of RNA-Binding Protein HuR in Non-Small Cell Lung Cancer Correlates with Vascular Endothelial Growth Factor-C Expression and Lymph Node Metastasis

Wang, J., Zhao, W., Guo, Y., Zhang, B., Xie, Q., Xiang, D., Gao, J., Wang, B., & Chen, Z. (2009) · Oncology · doi:10.1159/000216837 · Cited by 87 · see citing works

Mutant Cu/Zn-Superoxide Dismutase Associated with Amyotrophic Lateral Sclerosis Destabilizes Vascular Endothelial Growth Factor mRNA and Downregulates Its Expression

Lu, L., Zheng, L., Viera, L., Suswam, E. A., Li, Y., Li, X., Estévez, Á. G., & King, P. H. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1877-07.2007 · Cited by 87 · see citing works

Chemical inhibitors destabilize HuR binding to the AU-rich element of TNF-α mRNA

Chae, M.-J., Sung, H. Y., Kim, E., et al. (2009) · Experimental & Molecular Medicine · doi:10.3858/emm.2009.41.11.088 · Cited by 87 · see citing works

Coordinated posttranscriptional mRNA population dynamics during T‐cell activation

Mukherjee, N., Lager, P. J., Friedersdorf, M. B., Thompson, M. A., & Keene, J. D. (2009) · Molecular Systems Biology · doi:10.1038/msb.2009.44 · Cited by 86 · see citing works

LFA-1-Dependent HuR Nuclear Export and Cytokine mRNA Stabilization in T Cell Activation

Wang, J. G., Collinge, M., Ramgolam, V. S., Ayalon, O., Fan, X. C., Pardi, R., & Bender, J. R. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.4.2105 · Cited by 85 · see citing works

Phosphorylated HuR shuttles in cycles

Kim, H. H., & Gorospe, M. (2008) · Cell Cycle · doi:10.4161/cc.7.20.6884 · Cited by 84 · see citing works

HuR Knockdown Changes the Oncogenic Potential of Oral Cancer Cells

Kakuguchi, W., Kitamura, T., Kuroshima, T., Ishikawa, M., Kitagawa, Y., Totsuka, Y., Shindoh, M., & Higashino, F. (2010) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0367 · Cited by 84 · see citing works

Inhibition of HuR and MMP-9 expression in macrophage-differentiated HL-60 myeloid leukemia cells by green tea polyphenol EGCg

Annabi, B., Currie, J.-C., Moghrabi, A., & Béliveau, R. (2006) · Leukemia Research · doi:10.1016/j.leukres.2006.10.001 · Cited by 81 · see citing works

The Role of Human Antigen R, an RNA-binding Protein, in Mediating the Stabilization of Toll-Like Receptor 4 mRNA Induced by Endotoxin

Lin, F., Chen, Y., Lin, Y., Tsai, J.-S., Chen, J., Wang, H.-J., Chen, Y., Li, C., & Lin, S. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000246779.78003.cf · Cited by 80 · see citing works

Reduced nuclear export of HuR mRNA by HuR is linked to the loss of HuR in replicative senescence

Yi, J., Chang, N., Liu, X., Guo, G., Xue, L., Tong, T., Gorospe, M., & Wang, W. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp1114 · Cited by 79 · see citing works

HuR, a Protein Implicated in Oncogene and Growth Factor mRNA Decay, Binds to the 3′ Ends of Hepatitis C Virus RNA of Both Polarities

Spångberg, K., Wiklund, L., & Schwartz, S. (2000) · Virology · doi:10.1006/viro.2000.0461 · Cited by 78 · see citing works

HIV protease inhibitors increase TNF-α and IL-6 expression in macrophages: Involvement of the RNA-binding protein HuR

Zhou, H., Brimson, S. J., Gurley, E. C., Chen, L., Ding, H., Studer, E. J., Pandak, W. M., Hu, W., Zou, T., Wang, J., et al. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.04.008 · Cited by 77 · see citing works

Trichostatin A and 5 Aza-2′ deoxycytidine decrease estrogen receptor mRNA stability in ER positive MCF7 cells through modulation of HuR

Pryzbylkowski, P., Obajimi, O., & Keen, J. C. (2007) · Breast Cancer Research and Treatment · doi:10.1007/s10549-007-9751-0 · Cited by 76 · see citing works

Molecular Cloning and Characterization of a Translational Inhibitory Protein That Binds to Coding Sequences of Human Acid β-Glucosidase and Other mRNAs

Xu, Y.-H., & Grabowski, G. A. (1999) · Molecular Genetics and Metabolism · doi:10.1006/mgme.1999.2934 · Cited by 76 · see citing works

Enhanced Proliferation of Cultured Human Vascular Smooth Muscle Cells Linked to Increased Function of RNA-binding Protein HuR

Pullmann, R., Juhaszova, M., de Silanes, I. L., Kawai, T., Mazan-Mamczarz, K., Halushka, M. K., & Gorospe, M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501106200 · Cited by 73 · see citing works

Expression of the ELAV-like protein HuR in human prostate carcinoma is an indicator of disease relapse and linked to COX-2 expression

Niesporek, S., Kristiansen, G., Thoma, A., et al. (2008) · International Journal of Oncology · doi:10.3892/ijo.32.2.341 · Cited by 72 · see citing works

Hu Antigen Specificities of ANNA-I Autoantibodies in Paraneoplastic Neurological Disease

King, P. H., Redden, D. T., Palmgren, J. S., Nabors, B., & Lennon, V. A. (1999) · Journal of Autoimmunity · doi:10.1006/jaut.1999.0337 · Cited by 71 · see citing works

Androgens regulate the binding of endogenous HuR to the AU-rich 3′UTRs of HIF-1α and EGF mRNA

Sheflin, L. G., Zou, A.-P., & Spaulding, S. W. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.07.173 · Cited by 71 · see citing works

Modification at HuR(S242) alters HuR localization and proliferative influence

Kim, H. H., Yang, X., Kuwano, Y., & Gorospe, M. (2008) · Cell Cycle · doi:10.4161/cc.7.21.6895 · Cited by 70 · see citing works

Hyaluronic Acid or TNF-α Plus Fibronectin Triggers Granulocyte Macrophage-Colony-Stimulating Factor mRNA Stabilization in Eosinophils Yet Engages Differential Intracellular Pathways and mRNA Binding Proteins

Esnault, S. J., & Malter, J. S. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.12.6780 · Cited by 68 · see citing works

TIP30 Induces Apoptosis under Oxidative Stress through Stabilization of p53 Messenger RNA in Human Hepatocellular Carcinoma

Zhao, J., Chen, J., Lü, B., Dong, L., Wang, H., Bi, C., Wu, G., Guo, H., Wu, M., & Guo, Y. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0432 · Cited by 68 · see citing works

Increased blood vessel density provides the mole rat physiological tolerance to its hypoxic subterranean habitat

Avivi, A., Shams, I., Joel, A., Lache, O., Levy, A. P., & Nevo, E. (2005) · The FASEB Journal · doi:10.1096/fj.04-3414fje · Cited by 68 · see citing works

Posttranscriptional regulation of IL-13 in T cells: Role of the RNA-binding protein HuR

Casolaro, V., Fang, X., Tancowny, B. P., Fan, J., Wu, F., Srikantan, S., Asaki, S. Y., Fanis, U. D., Huang, S. K., Gorospe, M., et al. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.12.1166 · Cited by 67 · see citing works

Gastrin-Mediated Interleukin-8 and Cyclooxygenase-2 Gene Expression: Differential Transcriptional and Posttranscriptional Mechanisms

Subramaniam, D., Ramalingam, S., May, R. J., Dieckgraefe, B. K., Berg, D. E., Pothoulakis, C., Houchen, C. W., Wang, T. C., & Anant, S. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.01.040 · Cited by 67 · see citing works

Stabilization of Snail by HuR in the process of hydrogen peroxide induced cell migration

Dong, R., Lu, J., Wang, Q., He, X., Chu, Y.-K., & Ma, Q.-J. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.02.145 · Cited by 66 · see citing works

Purification and Characterization of β-Adrenergic Receptor mRNA-binding Proteins

Blaxall, B. C., Pellett, A. C., Wu, S. C., Pende, A., & Port, J. D. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.6.4290 · Cited by 65 · see citing works

Kaposin-B Enhances the PROX1 mRNA Stability during Lymphatic Reprogramming of Vascular Endothelial Cells by Kaposi's Sarcoma Herpes Virus

Yoo, J., Kang, J., Lee, H. N., Aguilar, B., Kafka, D., Lee, S., Choi, I., Lee, J., Ramu, S., Haas, J., et al. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001046 · Cited by 64 · see citing works

Il-19 reduces VSMC activation by regulation of mRNA regulatory factor HuR and reduction of mRNA stability

Cuneo, A. A., Herrick, D. J., & Autieri, M. V. (2010) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2010.04.016 · Cited by 63 · see citing works

Overexpression of ELAV-like Protein HuR is Associated with Increased COX-2 Expression in Atrophy, High-grade Prostatic Intraepithelial Neoplasia, and Incidental Prostate Cancer in Cystoprostatectomies

Barbisan, F., Mazzucchelli, R., Santinelli, A., et al. (2008) · European Urology · doi:10.1016/j.eururo.2008.04.043 · Cited by 62 · see citing works

Protein Kinase RNA/FADD/Caspase-8 Pathway Mediates the Proapoptotic Activity of the RNA-binding Protein Human Antigen R (HuR)

von Roretz, C., & Gallouzi, I. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.087320 · Cited by 60 · see citing works

The cleavage of HuR interferes with its transportin-2-mediated nuclear import and promotes muscle fiber formation

Beauchamp, P., Nassif, C., Hillock, S., van der Giessen, K., von Roretz, C., Jasmin, B. J., & Gallouzi, I. (2010) · Cell Death and Differentiation · doi:10.1038/cdd.2010.34 · Cited by 56 · see citing works

Early Exposure to IL-4 Stabilizes IL-4 mRNA in CD4+ T Cells via RNA-Binding Protein HuR

Yarovinsky, T. O., Butler, N. S., Monick, M. M., & Hunninghake, G. W. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.7.4426 · Cited by 55 · see citing works

Transcriptional and Posttranscriptional Down-Regulation of the Imprinted Tumor Suppressor Gene ARHI (DRAS3) in Ovarian Cancer

Lü, Z., Luo, R. Z.-T., Peng, H., Rosen, D. G., Atkinson, E. N., Warneke, C. L., Huang, M., Nishmoto, A., Liu, J., Liao, W. S. ‐., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1036 · Cited by 53 · see citing works

Alterations in RNA‐binding activities of IRES‐regulatory proteins as a mechanism for physiological variability and pathological dysregulation of IGF‐IR translational control in human breast tumor cells

Meng, Z., Jackson, N. L., Choi, H., et al. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21486 · Cited by 52 · see citing works

Posttranscriptional Regulation of the Breast Cancer Susceptibility Gene BRCA1 by the RNA Binding Protein HuR

Saunus, J. M., French, J. D., Edwards, S. L., Beveridge, D. J., Hatchell, E. C., Wagner, S. A., Stein, S. R., Davidson, A. D., Simpson, K. J., Francis, G. D., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1159 · Cited by 50 · see citing works

HuR and the bioenergetic signature of breast cancer: a low tumor expression of the RNA-binding protein predicts a higher risk of disease recurrence

Ortega, A. D., Sala, S., Espinosa, E., González-Barón, M., & Cuezva, J. M. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn185 · Cited by 50 · see citing works

Promotion of exon 6 inclusion in HuD pre-mRNA by Hu protein family members

Wang, H., Molfenter, J., Zhu, H., & Lou, H. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq028 · Cited by 49 · see citing works

Prognostic significance of cyclin A in gastric cancer

Mrena, J., Wiksten, J., Kokkola, A., Nordling, S., Haglund, C. H., & Ristimaki, A. P. (2006) · International Journal of Cancer · doi:10.1002/ijc.21944 · Cited by 48 · see citing works

Expression of vascular endothelial growth factor-A and mRNA stability factor HuR in human meningiomas

Sakuma, T., Nakagawa, T., Ido, K., et al. (2008) · Journal of Neuro-Oncology · doi:10.1007/s11060-008-9559-8 · Cited by 48 · see citing works

Posttranscriptional Suppression of Interleukin-6 Production by Human Cytomegalovirus

Gealy, C., Denson, M., Humphreys, C., et al. (2004) · Journal of Virology · doi:10.1128/jvi.79.1.472-485.2005 · Cited by 46 · see citing works

HuR is exported to the cytoplasm in oral cancer cells in a different manner from that of normal cells

Hasegawa, H., Kakuguchi, W., Kuroshima, T., Kitamura, T., Tanaka, S., Kitagawa, Y., Totsuka, Y., Shindoh, M., & Higashino, F. (2009) · British Journal of Cancer · doi:10.1038/sj.bjc.6605084 · Cited by 45 · see citing works

HuR interacts with human immunodeficiency virus type 1 reverse transcriptase, and modulates reverse transcription in infected cells

Lemay, J., Maidou-Peindara, P., Bader, T., Ennifar, E., Rain, J., Bénarous, R., & Liu, L. X. (2008) · Retrovirology · doi:10.1186/1742-4690-5-47 · Cited by 45 · see citing works

RNA-binding Protein HuR Interacts with Thrombomodulin 5′Untranslated Region and Represses Internal Ribosome Entry Site–mediated Translation under IL-1β Treatment

Yeh, C.-H., Hung, L., Hsu, C., Le, S., Lee, P.-T., Liao, W.-L., Lin, Y.-T., Chang, W., & Tseng, J. T.-C. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-09-0962 · Cited by 45 · see citing works

HETEs enhance IL-1-mediated COX-2 expression via augmentation of message stability in human colonic myofibroblasts

Mari, J. F. D., Saada, J. I., Mifflin, R. C., Valentich, J. D., & Powell, D. W. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00117.2007 · Cited by 43 · see citing works

Altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cells

Dixon, D. A., Tolley, N. D., King, P. H., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200112973 · Cited by 43 · see citing works

Mutant copper‐zinc superoxide dismutase associated with amyotrophic lateral sclerosis binds to adenine/uridine‐rich stability elements in the vascular endothelial growth factor 3′‐untranslated region

Li, X., Lu, L., Bush, D. J., Zhang, X., Zheng, L., Suswam, E. A., & King, P. H. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05856.x · Cited by 39 · see citing works

Oxidative Stress Impairs Vasorelaxation Induced by the Soluble Guanylyl Cyclase Activator BAY 41-2272 in Spontaneously Hypertensive Rats

Priviero, F. B. M., Zemse, S. M., Teixeira, C. E. G., et al. (2009) · American Journal of Hypertension · doi:10.1038/ajh.2009.18 · Cited by 39 · see citing works

Human-Antigen R (HuR) Expression in Hypertension

Klöß, S., Rodenbach, D., Bordel, R., & Mülsch, A. (2005) · Hypertension · doi:10.1161/01.hyp.0000165674.58470.8f · Cited by 39 · see citing works

von Hippel-Lindau tumor suppressor gene-dependent mRNA stabilization of the survival factor parathyroid hormone-related protein in human renal cell carcinoma by the RNA-binding protein HuR

Danilin, S., Sourbier, C., Thomas, L., Rothhut, S., Lindner, V., Helwig, J., Didier Jacqmin, D., Lang, H., & Massfelder, T. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn275 · Cited by 38 · see citing works

Analysis of Nitric Oxide-Stabilized mRNAs in Human Fibroblasts Reveals HuR-Dependent Heme Oxygenase 1 Upregulation

Kuwano, Y., Rabinovic, A., Srikantan, S., Gorospe, M., & Demple, B. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01495-08 · Cited by 38 · see citing works

Expression of vascular endothelial growth factor‐A and mRNA stability factor HuR in human astrocytic tumors

Ido, K., Nakagawa, T., Sakuma, T., et al. (2008) · Neuropathology · doi:10.1111/j.1440-1789.2008.00926.x · Cited by 37 · see citing works

Expression of the RNA-stabilizing protein HuR in ischemia-reperfusion injury of rat kidney

Ayupova, D. A., Singh, M., Leonard, E. C., Basile, D. P., & Lee, B. S. (2009) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.90632.2008 · Cited by 35 · see citing works

Regulation of non-AU-rich element containing c-fms proto-oncogene expression by HuR in breast cancer

Woo, H.-H., Zhou, Y., Yi, X., David, C. L., Zheng, W., Gilmore-Hebert, M., Kluger, H. M., Ulukus, E. C., Baker, T., Stoffer, J. B., et al. (2009) · Oncogene · doi:10.1038/onc.2008.469 · Cited by 34 · see citing works

Altered VEGF mRNA Stability following Treatments with Immunosuppressive Agents

Basu, A., Datta, D. B., Zurakowski, D., & Pal, S. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.119446 · Cited by 34 · see citing works

HuR, a novel target of anti-Hu antibodies, is expressed in non-neural tissues

Nabors, B., Furneaux, H. M., & King, P. H. (1998) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(98)00196-9 · Cited by 34 · see citing works

7-Ketocholesterol Upregulates Interleukin-6 via Mechanisms That Are Distinct from Those of Tumor Necrosis Factor-α, in Vascular Smooth Muscle Cells

Sung, S.-C., Kim, K., Lee, K.-A., et al. (2008) · Journal of Vascular Research · doi:10.1159/000135663 · Cited by 32 · see citing works

Regulation of soluble guanylyl cyclase-α1 expression in chronic hypoxia-induced pulmonary hypertension: role of NFATc3 and HuR

de Frutos, S., Nitta, C. H., Caldwell, E., Friedman, J. K., & Bosc, L. V. G. (2009) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00060.2009 · Cited by 32 · see citing works

Overexpression of cyclooxygenase‐2 correlates with cytoplasmic HuR expression in salivary mucoepidermoid carcinoma but not in pleomorphic adenoma

Cho, N., Han, H., Soh, Y., et al. (2007) · Journal of Oral Pathology and Medicine · doi:10.1111/j.1600-0714.2007.00526.x · Cited by 28 · see citing works

The RNA-binding protein HuR regulates GATA3 mRNA stability in human breast cancer cell lines

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Transcriptional Control of Human Antigen R by Bone Morphogenetic Protein

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Tumor Antigen HuR Binds Specifically to One of Five Protein-Binding Segments in the 3′-Untranslated Region of the Neurofibromin Messenger RNA

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Expression of HuR in Merkel cell carcinoma and in normal skin

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Aurothiomalate inhibits COX-2 expression in chondrocytes and in human cartilage possibly through its effects on COX-2 mRNA stability

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Effects of infliximab therapy on gene expression levels of tumor necrosis factor α, tristetraprolin, T cell intracellular antigen 1, and Hu antigen R in patients with rheumatoid arthritis

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Expression of TNF-α, tristetraprolin, T-cell intracellular antigen-1 and Hu antigen R genes in synovium of patients with rheumatoid arthritis

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Expression of the SH2D1A gene is regulated by a combination of transcriptional and post‐transcriptional mechanisms

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Inhibition of MMP-9 secretion by the anti-metastatic PSP94-derived peptide PCK3145 requires cell surface laminin receptor signaling

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RNA-binding protein HuR regulates RGS4 mRNA stability in rabbit colonic smooth muscle cells

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LPL-mediated lipolysis of VLDL induces an upregulation of AU-rich mRNAs and an activation of HuR in endothelial cells

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PMA induces stabilization of oncostatin M mRNA in human lymphoma U937 cells

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Messenger RNA degradation may be inhibited in sporadic inclusion body myositis

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Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by <i>CircPABPN1</i>

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The neurogenetics of alternative splicing

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Rbfox1 Regulates Synaptic Transmission through the Inhibitory Neuron-Specific vSNARE Vamp1

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Temporally defined neocortical translation and polysome assembly are determined by the RNA-binding protein Hu antigen R

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mRNPs : Structure and role in development

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Reversible inhibition of translation by Xenopus oocyte-specific proteins

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Mechanisms of translational regulation in Drosophila

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The RNA-binding protein Y14 inhibits mRNA decapping and modulates processing body formation

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The coupled and uncoupled mechanisms by which trans-acting factors regulate mRNA stability and translation

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