Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 214

The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.

Of sound mind and body: depression, disease, and accelerated aging

Open access
M. Wolkowitz, Owen, I. Reus, Victor, H. Mellon, Synthia·2011·Dialogues in Clinical Neuroscience
DOI 10.31887/dcns.2011.13.1/owolkowitz
Open this paper in CoChat — free account

Abstract

Major depressive disorder (MDD) is associated with a high rate of developing serious medical comorbidities such as cardiovascular disease, stroke, dementia, osteoporosis, diabetes, and the metabolic syndrome. These are conditions that typically occur late in life, and it has been suggested that MDD may be associated with "accelerated aging." We review several moderators and mediators that may accompany MDD and that may give rise to these comorbid medical conditions. We first review the moderating effects of psychological styles of coping, genetic predisposition, and epigenetic modifications (eg, secondary to childhood adversity). We then focus on several interlinked mediators occurring in MDD (or at least in subtypes of MDD) that may contribute to the medical comorbidity burden and to accelerated aging: limbic-hypothalamic-pituitary-adrenal axis alterations, diminution in glucocorticoid receptor function, altered glucose tolerance and insulin sensitivity, excitotoxicity, increases in intracellular calcium, oxidative stress, a proinflammatory milieu, lowered levels of "counter-regulatory" neurosteroids (such as allopregnanolone and dehydroepiandrosterone), diminished neurotrophic activity, and accelerated cell aging, manifest as alterations in telomerase activity and as shortening of telomeres, which can lead to apoptosis and cell death. In this model, MDD is characterized by a surfeit of potentially destructive mediators and an insufficiency of protective or restorative ones. These factors interact in increasing the likelihood of physical disease and of accelerated aging at the cellular level. We conclude with suggestions for novel mechanism-based therapeutics based on these mediators.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.31887/dcns.2011.13.1/owolkowitz

Cites

47 of 47 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 47 references

Research works printed but not linked: 111

  1. 10.1016/S0378-5122(02)00012-9 · DOI · Paper page
  2. 10.3109/10401230701653377 · doi:10.3109/10401230701653377
  3. 10.1016/j.biopsych.2005.05.001 · DOI · Paper page
  4. 10.1001/archinte.160.12.1761 · DOI · Paper page
  5. 10.1080/15622970701875601 · DOI
  6. 10.14310/horm.2002.1217 · DOI · Paper page
  7. 10.1016/j.psyneuen.2005.08.011 · DOI · Paper page
  8. 10.3109/15622970109026799 · DOI
  9. SelyeH.The Stress of Life. New York, NY: McGraw-Hill.1956
  10. 10.1016/S0893-133X(99)00129-3 · DOI · Paper page
  11. 10.1073/pnas.97.1.325 · DOI · Paper page
  12. 10.1016/j.yfrne.2008.11.002 · DOI · Paper page
  13. 10.1176/appi.ajp.160.9.1554 · DOI · Paper page
  14. 10.1037/0022-3514.50.5.992 · DOI · Paper page
  15. 10.1023/A:1010630801589 · DOI
  16. 10.1073/pnas.0914568107 · DOI
  17. 10.1037/0022-3514.95.1.197 · DOI · Paper page
  18. 10.1001/archpsyc.1988.01800350021003 · DOI · Paper page
  19. 10.1016/j.jad.2003.12.013 · DOI · Paper page
  20. 10.1590/S1516-44462008000100012 · DOI · Paper page
  21. 10.1002/syn.20637 · DOI
  22. BarnesSK.OzanneSE.Pathways linking the early environment to longterm health and lifespan.Prog Biophys Mol Biol. In press.
  23. 10.1016/j.brainresbull.2005.09.015 · DOI
  24. 10.1016/j.biopsych.2009.08.014 · DOI · Paper page
  25. 10.1038/nn1276 · DOI · Paper page
  26. 10.1176/appi.ajp.2009.10030434 · DOI · Paper page
  27. 10.1385/ENDO:28:3:263 · DOI
  28. 10.1097/YCO.0b013e32833d16c1 · DOI
  29. 10.1523/JNEUROSCI.4214-09.2010 · DOI · Paper page
  30. 10.1016/j.biopsych.2009.05.012 · DOI · Paper page
  31. KargK.BurmeisterM.SheddenK.SenS.The Serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation.Arch Gen Psychiatry. In press.
  32. 10.1016/j.biopsych.2005.10.026 · DOI · Paper page
  33. 10.1016/j.psyneuen.2005.04.006 · DOI · Paper page
  34. 10.1016/j.biopsych.2006.11.033 · DOI · Paper page
  35. MillerAH.Letter to the Editor Re: An inflammatory review of glucocorticoids in the CNS. Sorrells SF, Sapolsky RM.Brain Behavior Immun.200721259272988989; author reply 990.
  36. 10.1016/j.bbi.2006.11.006 · DOI · Paper page
  37. 10.1001/archpsyc.1987.01800210013002 · DOI
  38. 10.1176/ajp.152.2.265 · DOI
  39. BelanoffJ.SchatzbergAF.Glucocorticoid antagonists.Neuropsychopharmacology.200023S56
  40. 10.1097/00006842-199909000-00011 · DOI · Paper page
  41. 10.1002/14651858.CD005168.pub2 · DOI
  42. 10.1016/0166-2236(95)93942-Q · DOI · Paper page
  43. 10.1111/j.1749-6632.2009.04980.x · DOI · Paper page
  44. 10.1016/0165-1781(85)90088-5 · DOI
  45. 10.1016/j.biopsych.2006.02.013 · DOI · Paper page
  46. 10.1016/S0306-4530(99)00035-9 · DOI · Paper page
  47. 10.1073/pnas.95.6.3239 · DOI · Paper page
  48. 10.1016/S0006-3223(98)00070-5 · DOI
  49. 10.1159/000156467 · DOI
  50. 10.1111/j.1582-4934.2008.00493.x · DOI
  51. 10.2174/156720507783018262 · DOI
  52. 10.1016/S0006-3223(98)00328-X · DOI · Paper page
  53. 10.1080/15622970310029901 · DOI
  54. 10.1016/S0074-7742(01)46065-X · DOI · Paper page
  55. 10.1677/joe.0.1580121 · DOI
  56. 10.1016/0306-4522(94)90330-1 · DOI · Paper page
  57. 10.1172/JCI119261 · DOI
  58. 10.1073/pnas.051628598 · DOI · Paper page
  59. 10.1016/j.biopsycho.2005.02.007 · DOI
  60. 10.1016/S0029-7844(97)00417-1 · DOI · Paper page
  61. 10.1055/s-0029-1237361 · DOI
  62. 10.1097/00006842-200203000-00010 · DOI · Paper page
  63. 10.1016/j.psyneuen.2006.11.009 · DOI · Paper page
  64. de LeonMJ.McRaeT.RusinekH.et al.Cortisol reduces hippocampal glucose metabolism in normal elderly, but not in Alzheimer's disease.J Clin Endocrinol Metab.199782325132599329348
  65. 10.1517/14656566.7.10.1305 · DOI
  66. 10.1016/j.neurobiolaging.2005.09.004 · DOI
  67. 10.1007/s00424-009-0721-8 · DOI
  68. 10.1161/01.CIR.0000163550.70487.0B · DOI · Paper page
  69. 10.1038/oby.2010.22 · DOI · Paper page
  70. 10.1093/jn/136.12.3022 · DOI · Paper page
  71. 10.1111/j.1749-6632.2008.03966.x · DOI · Paper page
  72. 10.1016/S0022-3999(02)00309-4 · DOI · Paper page
  73. 10.1016/j.jpsychires.2009.05.010 · DOI · Paper page
  74. 10.1016/j.biopsych.2009.09.033 · DOI · Paper page
  75. 10.1016/j.yjmcc.2006.08.005 · DOI
  76. 10.1016/S0079-6123(07)63020-9 · DOI · Paper page
  77. 10.1111/j.1365-2796.2007.01890.x · DOI · Paper page
  78. 10.1016/j.jpsychires.2005.01.009 · DOI
  79. 10.1007/s11064-005-6967-4 · DOI
  80. 10.1097/01.psy.0000195780.37277.2a · DOI · Paper page
  81. 10.1111/j.1440-1797.2006.00697.x · DOI
  82. 10.1002/pmic.200300924 · DOI
  83. 10.1038/sj.mp.4002075 · DOI · Paper page
  84. 10.1016/S0006-3223(01)01083-6 · DOI · Paper page
  85. 10.3109/15622971003611319 · DOI · Paper page
  86. 10.1038/npp.2010.114 · DOI · Paper page
  87. 10.1016/j.bbr.2009.03.040 · DOI
  88. 10.1097/00001756-200405190-00016 · DOI
  89. 10.1523/JNEUROSCI.22-24-10710.2002 · DOI
  90. 10.1007/s00125-007-0706-0 · DOI
  91. 10.1038/nm1006-1133 · DOI · Paper page
  92. 10.1097/YPG.0b013e32808374f6 · DOI
  93. 10.1002/da.20749 · DOI · Paper page
  94. 10.18632/aging.100007 · DOI · Paper page
  95. 10.4049/jimmunol.179.6.4249 · DOI · Paper page
  96. WolkowitzOM.MellonSH.EpelES.et al.Resting leukocyte telomerase activity is elevated in major depression and predicts treatment response.Mol Psychiatry. In press.2011
  97. 10.1016/j.bbi.2007.12.004 · DOI · Paper page
  98. 10.1016/j.arr.2010.03.002 · DOI
  99. 10.1602/neurorx.1.1.111 · DOI
  100. 10.1111/j.1742-4658.2005.04677.x · DOI
  101. 10.1007/s11011-008-9118-1 · DOI · Paper page
  102. 10.1038/nrd2462 · DOI · Paper page
  103. 10.1002/hup.186 · DOI
  104. 10.2174/187152809789352221 · DOI
  105. 10.1016/S0006-8993(00)03108-5 · DOI · Paper page
  106. 10.1016/j.exger.2006.11.005 · DOI
  107. HarleyCB.LiuW.BlascoM.et al.A natural product telomerase activator as part of a health maintenance program.Rejuvenation Res. In press.
  108. 10.1001/jama.1983.03330250034024 · DOI · Paper page
  109. 10.1016/j.ceb.2010.04.011 · DOI
  110. 10.1016/j.ejphar.2007.12.032 · DOI · Paper page
  111. 10.1542/peds.65.4.862 · DOI

Cited by

See all 214

Metadata

Authors
M. Wolkowitz, O., I. Reus, V., & H. Mellon, S.
Venue
Dialogues in Clinical Neuroscience
Publisher
Informa UK Limited
Published
2011-03-31
Volume
13
Issue
1
Pages
25-39
ISSN
  • 1294-8322 (ISSN-L)
  • 1958-5969
DOI
10.31887/dcns.2011.13.1/owolkowitz
OpenAlex
W1659146612
Cited by
214
References
47
FWCI
6.94
Type
journal article
Language
en
Open access
diamond
Licence
creativecommons.org/licenses/by-nc-nd/3.0/ (vor)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Of sound mind and body: depression, disease, and accelerated aging. https://app.cochat.ai/papers/10.31887/dcns.2011.13.1/owolkowitz
The paper
M. Wolkowitz, O., I. Reus, V., & H. Mellon, S. (2011). Of sound mind and body: depression, disease, and accelerated aging. Dialogues in Clinical Neuroscience. https://doi.org/10.31887/dcns.2011.13.1/owolkowitz

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.