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Cited by 146Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesMemory and Neural MechanismsNeural and Behavioral Psychology Studies

The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.

Neuroimaging in anxiety disorders

Open access
Holzschneider, Kathrin, Mulert, Christoph·2011·Dialogues in Clinical Neuroscience
DOI 10.31887/dcns.2011.13.4/kholzschneiderPMC PMC3263392
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Abstract

Over the last few years, neuroimaging techniques have contributed greatly to the identification of the structural and functional neuroanatomy of anxiety disorders. The amygdala seems to be a crucial structure for fear and anxiety, and has consistently been found to be activated in anxiety-provoking situations. Apart from the amygdala, the insula and anterior cinguiate cortex seem to be critical, and ail three have been referred to as the "fear network." In the present article, we review the main findings from three major lines of research. First, we examine human models of anxiety disorders, including fear conditioning studies and investigations of experimentally induced panic attacks. Then we turn to research in patients with anxiety disorders and take a dose look at post-traumatic stress disorder and obsessive-compulsive disorder. Finally, we review neuroimaging studies investigating neural correlates of successful treatment of anxiety, focusing on exposure-based therapy and several pharmacological treatment options, as well as combinations of both.

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Crossref · 10.31887/dcns.2011.13.4/kholzschneider

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Figures

Figure 1. Activation in the left anterior cingulate cortex (top) and left anterior insula (bottom) during presentation of conditioned (vs neutral) faces. Reproduced from ref 5: Buchel C, Morris J, Dolan RJ, Friston KJ. Brain systems mediating aversive conditioning: an event-related fMRI study. Neuron. 1998;20:947-957. Copyright © Elsevier, 1998
Figure 1. Activation in the left anterior cingulate cortex (top) and left anterior insula (bottom) during presentation of conditioned (vs neutral) faces. Reproduced from ref 5: Buchel C, Morris J, Dolan RJ, Friston KJ. Brain systems mediating aversive conditioning: an event-related fMRI study. Neuron. 1998;20:947-957. Copyright © Elsevier, 1998CC BY-NC-ND · PubMed Central
Figure 2. Activation in the right amygdala is enhanced in post-traumatic stress disorder (PTSD) patients compared with trauma-exposed non-PTSD participants (TENP) during the presentation of emotionally negative pictures. Fix, fixation baseline; Neg, negative; Neut, neutral. Reprinted from ref 43: Brohawn KH, Offringa R, Pfaff DL, Hughes KC, Shin LM. The neural correlates of emotional memory in posttraumatic stress disorder. Biol Psychiatry. 2010;68:1023-1030. Copyright © Elsevier, 2010
Figure 2. Activation in the right amygdala is enhanced in post-traumatic stress disorder (PTSD) patients compared with trauma-exposed non-PTSD participants (TENP) during the presentation of emotionally negative pictures. Fix, fixation baseline; Neg, negative; Neut, neutral. Reprinted from ref 43: Brohawn KH, Offringa R, Pfaff DL, Hughes KC, Shin LM. The neural correlates of emotional memory in posttraumatic stress disorder. Biol Psychiatry. 2010;68:1023-1030. Copyright © Elsevier, 2010CC BY-NC-ND · PubMed Central
Figure 3. Amygdala activation during presentation of pictures of spiders (vs neutral pictures) in spider phobic subjects before and after successful treatment, and in non-phobic control subjects. Reprinted from ref 59: Goossens L, Sunaert S, Peeters R, Griez EJ, Schruers KR. Amygdala hyperfunction in phobic fear normalizes after exposure. Biol Psychiatry. 2007;62:1119-1125. Copyright © Elsevier, 2007
Figure 3. Amygdala activation during presentation of pictures of spiders (vs neutral pictures) in spider phobic subjects before and after successful treatment, and in non-phobic control subjects. Reprinted from ref 59: Goossens L, Sunaert S, Peeters R, Griez EJ, Schruers KR. Amygdala hyperfunction in phobic fear normalizes after exposure. Biol Psychiatry. 2007;62:1119-1125. Copyright © Elsevier, 2007CC BY-NC-ND · PubMed Central

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Research works printed but not linked: 4

  1. American Psychiatric Association., 2000, Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Text Revision. Washington, DC: American Psychiatric Association;
  2. Vermetten E., 2007, Psychopharmacol Bull., 40, 8
  3. Simon D., 2010, Psychophysiology., 47, 728
  4. Bryant RA., 2008, J Psychiatry Neurosci., 33, 142

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Metadata

Authors
Holzschneider, K., & Mulert, C.
Affiliations
University Medical Center Hamburg-Eppendorf (DE)
Corresponding author
Mulert, Christoph
ORCID
Mulert, Christoph
Venue
Dialogues in Clinical Neuroscience
Publisher
Informa UK Limited
Published
2011-12-31
Volume
13
Issue
4
Pages
453-461
ISSN
  • 1294-8322 (ISSN-L)
  • 1958-5969
DOI
10.31887/dcns.2011.13.4/kholzschneider
PMC
PMC3263392
OpenAlex
W4298412747
Cited by
146
References
72
Citations by year
2026: 2 · 2025: 8 · 2024: 7 · 2023: 13 · 2022: 9 · 2021: 12 · 2020: 7 · 2019: 8 · 2018: 6 · 2017: 10 · 2016: 14 · 2015: 14 · 2014: 14 · 2013: 12 · 2012: 9
FWCI
14.43
Type
journal article
Language
en
Open access
Licence
Locations
  • Dialogues in Clinical Neuroscience (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • PubMed
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
anxiety disorders, amygdala, fear network, insula, anterior cingulate cortex, fear conditioning, panic attacks, post-traumatic stress disorder, obsessive-compulsive disorder, exposure therapy, pharmacological treatment of anxiety
MeSH terms
Amygdala, Anxiety Disorders, Humans, Magnetic Resonance Imaging, Tomography, Emission-Computed, Single-Photon, Positron-Emission Tomography

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