Cited by 211Alzheimer's disease research and treatmentsMitochondrial Function and PathologyNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 242 of the 243 references it cites were found in a registry or an index.

Mitochondrial Dysfunction and Synaptic Transmission Failure in Alzheimer’s Disease

Open access

Guo, Lan, Tian, Jing, Du, Heng·2017·Journal of Alzheimer’s Disease

DOI 10.3233/jad-160702PMC PMC5605817

Open this paper in CoChat — free account

Abstract

Alzheimer’s disease (AD) is a chronic neurodegenerative disorder, in which multiple risk factors converge. Despite the complexity of the etiology of the disease, synaptic failure is the pathological basis of cognitive impairment, the cardinal sign of AD. Decreased synaptic density, compromised synaptic transmission, and defected synaptic plasticity are hallmark synaptic pathologies accompanying AD. However, the mechanisms by which synapses are injured in AD-related conditions have not been fully elucidated. Mitochondria are a critical organelle in neurons. The pivotal role of mitochondria in supporting synaptic function and the concomitant occurrence of mitochondrial dysfunction with synaptic stress in postmortem AD brains as well as AD animal models seem to lend the credibility to the hypothesis that mitochondrial defects underlie synaptic failure in AD. This concept is further strengthened by the protective effect of mitochondrial medicine on synaptic function against the toxicity of amyloid-β, a key player in the pathogenesis of AD. In this review, we focus on the association between mitochondrial dysfunction and synaptic transmission deficits in AD. Impaired mitochondrial energy production, deregulated mitochondrial calcium handling, excess mitochondrial reactive oxygen species generation and release play a crucial role in mediating synaptic transmission deregulation in AD. The understanding of the role of mitochondrial dysfunction in synaptic stress may lead to novel therapeutic strategies for the treatment of AD through the protection of synaptic transmission by targeting to mitochondrial deficits.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3233/jad-160702

Cites

242 of 242 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359
Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases
Lin, M. T., & Beal, M. F. (2006) · Nature · doi:10.1038/nature05292 · Cited by 6,455
Control of inositol 1,4,5-trisphosphate-induced Ca2+ release by cytosolic Ca2+
Bootman, M. D., Missiaen, L., Parys, J. B., SMEDT, H. D., & Casteels, R. (1995) · Biochemical Journal · doi:10.1042/bj3060445 · Cited by 5,131
Alzheimer’s disease
Querfurth, H. W., & LaFerla, F. M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0909142 · Cited by 4,569
Alzheimer's Disease Is a Synaptic Failure
Selkoe, D. J. (2002) · Science · doi:10.1126/science.1074069 · Cited by 4,420
Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., Hansen, L. A., & Katzman, R. (1991) · Annals of Neurology · doi:10.1002/ana.410300410 · Cited by 4,397
Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles
Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., & LaFerla, F. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00434-3 · Cited by 4,126
Interplay between Cortical Spreading Depolarization and Seizures
Kramer, D. R., Fujii, T., Ohiorhenuan, I. E., & Liu, C. Y. (2017) · Stereotactic and Functional Neurosurgery · doi:10.1159/000452841 · Cited by 3,721
An Energy Budget for Signaling in the Grey Matter of the Brain
Attwell, D., & Laughlin, S. B. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200110000-00001 · Cited by 3,543
Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3
Seth, R. B., Sun, L., Ea, C.-K., & Chen, Z. J. (2005) · Cell · doi:10.1016/j.cell.2005.08.012 · Cited by 3,329
Alzheimer’s disease
Blennow, K., de Leon, M. J., & Zetterberg, H. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69113-7 · Cited by 3,134
THE SYNAPTIC VESICLE CYCLE
Südhof, T. C. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131412 · Cited by 2,491
Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death
Baines, C. P., Kaiser, R. A., Purcell, N. H., Blair, N. S., Osinska, H., Hambleton, M. A., Brunskill, E. W., Sayen, M. R., Gottlieb, R. A., Dorn, G. W., et al. (2005) · Nature · doi:10.1038/nature03434 · Cited by 2,280
The cholinergic hypothesis of Alzheimer’s disease: A review of progress
Francis, P. T., Palmer, A. M., Snape, M., & Wilcock, G. K. (1999) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.66.2.137 · Cited by 2,198
Tyrosine Hydroxylase
Nagatsu, T., Levitt, M., & Udenfriend, S. (1964) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)93832-9 · Cited by 2,067
beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity
Mattson, M. P., Cheng, B., Davis, D. G., Bryant, K., Lieberburg, I. M., & Rydel, R. E. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-02-00376.1992 · Cited by 1,633
Calcium Signaling in Neurons: Molecular Mechanisms and Cellular Consequences
Ghosh, A., & Greenberg, M. E. (1995) · Science · doi:10.1126/science.7716515 · Cited by 1,411
Mitochondrial abnormalities in Alzheimer's disease
Hirai, K., Aliev, G., Nunomura, A., Fujioka, H., Russell, R. L., Atwood, C. S., Johnson, A. B., Kress, Y., Vinters, H. V., Tabaton, M., et al. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-09-03017.2001 · Cited by 1,367
ABAD Directly Links Aß to Mitochondrial Toxicity in Alzheimer's Disease
Lustbader, J. W., Cirilli, M., Lin, C., Xu, H. W., Takuma, K., Wang, N., Caspersen, C., Chen, X., Pollak, S., Chaney, M., et al. (2004) · Science · doi:10.1126/science.1091230 · Cited by 1,303
Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease
Wang, X., Su, B., Lee, H.-G., Li, X., Perry, G., Smith, M. A., & Zhu, X. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1357-09.2009 · Cited by 1,224
Mitochondria are a direct site of Aβ accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression
Manczak, M., Anekonda, T. S., Henson, E., Park, B. S., Quinn, J., & Reddy, P. H. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl066 · Cited by 1,104
S-Nitrosylation of Drp1 Mediates β-Amyloid-Related Mitochondrial Fission and Neuronal Injury
Cho, D.-H., Nakamura, T., Fang, J., Cieplak, P., Godzik, A., Gu, Z., & Lipton, S. A. (2009) · Science · doi:10.1126/science.1171091 · Cited by 1,092
Tyrosine hydroxylase and regulation of dopamine synthesis
Daubner, S. C., Le, T., & Wang, S. (2011) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2010.12.017 · Cited by 1,092
The cholinergic system in aging and neuronal degeneration
Schliebs, R., & Arendt, T. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.11.058 · Cited by 1,047
Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior
Selkoe, D. J. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.02.016 · Cited by 1,038
Amyloid beta, mitochondrial dysfunction and synaptic damage: Implications for cognitive decline in aging and Alzheimer’s disease
Reddy, P. H., & Beal, M. F. (2008) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.12.002 · Cited by 975
Dimers of mitochondrial ATP synthase form the permeability transition pore
Giorgio, V., von Stockum, S., Antoniel, M., Fabbro, A., Fogolari, F., Forte, M. A., Glick, G. D., Petronilli, V., Zoratti, M., Szabó, I., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217823110 · Cited by 973
Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake
Li, S., Hong, S., Shepardson, N. E., Walsh, D. M., Shankar, G. M., & Selkoe, D. (2009) · Neuron · doi:10.1016/j.neuron.2009.05.012 · Cited by 972
The ageing cortical synapse: hallmarks and implications for cognitive decline
Morrison, J. H., & Baxter, M. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3200 · Cited by 965
Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease
Du, H., Guo, L., Fang, F., Chen, D., Sosunov, A. A., McKhann, G. M., Yan, Y., Wang, C., Zhang, H., Molkentin, J. D., et al. (2008) · Nature Medicine · doi:10.1038/nm.1868 · Cited by 950
Self-citation
Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage
Mańczak, M., Calkins, M. J., & Reddy, P. H. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr139 · Cited by 847
Loss of neurons in the nucleus basalis of Meynert in Alzheimer's disease, paralysis agitans and Korsakoff's disease
Arendt, T., Bigl, V., Arendt, A., & Tennstedt, A. (1983) · Acta Neuropathologica · doi:10.1007/bf00697388 · Cited by 817
The Alzheimer’s disease mitochondrial cascade hypothesis: progress and perspectives
Swerdlow, R. H., Burns, J. M., & Khan, S. M. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.09.010 · Cited by 786 · cited 1×
“Mitochondrial cascade hypothesis as an important supplementation to the prevailing A (cid:2) cascade and tauopathy hypotheses has provided us an alternative avenue to understand the pathogenesis of AD, in particular its sporadic form [234].”
Mitochondrial Aβ: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease
Caspersen, C., Wang, N., Yao, J., Sosunov, A., Chen, X., Lustbader, J. W., Xu, H. W., Stern, D., McKhann, G., & Du Yan, S. (2005) · The FASEB Journal · doi:10.1096/fj.05-3735fje · Cited by 738
Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease
Masliah, E., Mallory, M., Alford, M., DeTeresa, R., Hansen, L. A., McKeel, D. W., & Morris, J. C. (2001) · Neurology · doi:10.1212/wnl.56.1.127 · Cited by 720
Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model
Du, H., Guo, L., Yan, S., Sosunov, A. A., McKhann, G. M., & ShiDu Yan, S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006586107 · Cited by 704
Self-citation
Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease
Calkins, M. J., Manczak, M., Mao, P., Shirendeb, U., & Reddy, P. H. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr381 · Cited by 646
Brain fuel metabolism, aging, and Alzheimer’s disease
Cunnane, S. C., Nugent, S., Roy, M., Courchesne‐Loyer, A., Croteau, É., Tremblay, S., Castellano, A., Pifferi, F., Bocti, C., Paquet, N., et al. (2010) · Nutrition · doi:10.1016/j.nut.2010.07.021 · Cited by 633
A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease
Davies, C. A., Mann, D. M. A., Sumpter, P. Q., & Yates, P. O. (1987) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(87)90057-8 · Cited by 628
An uncoupling channel within the c-subunit ring of the F 1 F O ATP synthase is the mitochondrial permeability transition pore
Alavian, K. N., Beutner, G., Lazrove, E., Sacchetti, S., Park, H., Licznerski, P., Li, H., Nabili, P., Hockensmith, K., Graham, M. M., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1401591111 · Cited by 626
Mitochondrial abnormalities in Alzheimer brain: Mechanistic implications
Bubber, P., Haroutunian, V., Fisch, G., Blass, J. P., & Gibson, G. E. (2005) · Annals of Neurology · doi:10.1002/ana.20474 · Cited by 622
Calcium- and activity-dependent synaptic plasticity
Zucker, R. S. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)80045-2 · Cited by 618
Energetic basis of brain activity: implications for neuroimaging
Shulman, R. G., Rothman, D. L., Behar, K. L., & Hyder, F. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.06.005 · Cited by 590
Mitochondria as all‐round players of the calcium game
Rizzuto, R., Bernardi, P., & Pozzan, T. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00037.x · Cited by 562
Loss of the Presynaptic Vesicle Protein Synaptophysin in Hippocampus Correlates with Cognitive Decline in Alzheimer Disease
SZE, C.-I., TRONCOSO, J. C., KAWAS, C., MOUTION, P., PRICE, D. L., & MARTIN, L. J. (1997) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199708000-00011 · Cited by 562 · cited 2×
“Clinical and pathological studies have shown a strong correlation between synaptic deﬁcits and the degree of memory loss in AD [13–16].”
Quasi‐synaptic calcium signal transmission between endoplasmic reticulum and mitochondria
Csordás, G., Thomas, A. P., & Hajnóczky, G. (1999) · The EMBO Journal · doi:10.1093/emboj/18.1.96 · Cited by 550
Cortical Cytochrome Oxidase Activity Is Reduced in Alzheimer's Disease
Mutisya, E. M., Bowling, A. C., & Beal, M. F. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.63062179.x · Cited by 531
Calcium Stores in Hippocampal Synaptic Boutons Mediate Short-Term Plasticity, Store-Operated Ca2+ Entry, and Spontaneous Transmitter Release
Emptage, N. J., Reid, C. A., & Fine, A. (2001) · Neuron · doi:10.1016/s0896-6273(01)00190-8 · Cited by 520
Disease‐specific patterns of locus coeruleus cell loss
German, D. C., Manaye, K. F., White, C. L., Woodward, D. J., McIntire, D. D., Smith, W. K., Kalaria, R. N., & Mann, D. M. A. (1992) · Annals of Neurology · doi:10.1002/ana.410320510 · Cited by 512
Mechanism of Oxidative Stress and Synapse Dysfunction in the Pathogenesis of Alzheimer’s Disease: Understanding the Therapeutics Strategies
Kamat, P. K., Kalani, A., Rai, S., Swarnkar, S., Tota, S., Nath, C., & Tyagi, N. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-9053-6 · Cited by 511
Steroid hormone synthesis in mitochondria
Miller, W. L. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.04.014 · Cited by 510
Electron transport chain defects in Alzheimer's disease brain
Parker, W. D., Parks, J. K., Filley, C. M., & Kleinschmidt-DeMasters, B. K. (1994) · Neurology · doi:10.1212/wnl.44.6.1090 · Cited by 495
A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients
Maurer, I. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00112-3 · Cited by 475
Pyruvate car☐ylase: an astrocyte-specific enzyme implicated in the replenishment of amino acid neurotransmitter pools
Shank, R. P., Bennett, G. S., Freytag, S. O., & Campbell, G. L. (1985) · Brain Research · doi:10.1016/0006-8993(85)90552-9 · Cited by 471
Mitochondria-targeted antioxidants protect against amyloid-β toxicity in Alzheimer's disease neurons
Manczak, M., Mao, P., Calkins, M. J., Cornea, A., Reddy, A. P., Murphy, M. P., Szeto, H. H., Park, B., & Reddy, P. H. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-100564 · Cited by 469
Staging of neurofibrillary pathology in Alzheimer's disease: A study of the BrainNet Europe Consortium
Alafuzoff, I., Arzberger, T., Al‐Sarraj, S., Bodi, I., Bogdanovic, N., Braak, H., Bugiani, O., Del‐Tredici, K., Ferrer, I., Gelpi, E., et al. (2008) · Brain Pathology · doi:10.1111/j.1750-3639.2008.00147.x · Cited by 467
Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage
Mańczak, M., & Reddy, P. H. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds072 · Cited by 467
Glutamate in CNS disorders as a target for drug development: an update
Parsons, C. G., Danysz, W., & Quack, G. (1998) · Drug News & Perspectives · doi:10.1358/dnp.1998.11.9.863689 · Cited by 438
Synapses and Alzheimer's Disease
Sheng, M., Sabatini, B. L., & Sudhof, T. C. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005777 · Cited by 436
Presynaptic Mitochondrial Calcium Sequestration Influences Transmission at Mammalian Central Synapses
Billups, B., & Forsythe, I. D. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-14-05840.2002 · Cited by 414
Correlations of synaptic and pathological markers with cognition of the elderly
Dickson, D. W., Crystal, H. A., Bevona, C., Honer, W., Vincent, I., & Davies, P. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00013-5 · Cited by 410
N-methyl D-aspartate (NMDA) receptor antagonists and memantine treatment for Alzheimer’s disease, vascular dementia and Parkinson’s disease
Olivares, D., K. Deshpande, V., Shi, Y., K. Lahiri, D., H. Greig, N., T. Rogers, J., & Huang, X. (2012) · Current Alzheimer Research · doi:10.2174/156720512801322564 · Cited by 407
Pyruvate Carboxylase Activity in Primary Cultures of Astrocytes and Neurons
Yu, A. C., Drejer, J., Hertz, L., & Schousboe, A. (1983) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1983.tb00849.x · Cited by 406
Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer’s disease: Implications to mitochondria-targeted antioxidant therapeutics
Reddy, P. H., Tripathi, R., Troung, Q., Tirumala, K., Reddy, T. P., Anekonda, V., Shirendeb, U. P., Calkins, M. J., Reddy, A. P., Mao, P., et al. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.10.011 · Cited by 394
Immunohistochemical quantification of the synapse-related protein synaptophysin in Alzheimer disease
Masliah, E., Terry, R. D., DeTeresa, R. M., & Hansen, L. A. (1989) · Neuroscience Letters · doi:10.1016/0304-3940(89)90582-x · Cited by 363
Synthesis, storage and release of [14C]acetylcholine in isolated rat diaphragm muscles
Potter, L. T. (1970) · The Journal of Physiology · doi:10.1113/jphysiol.1970.sp009003 · Cited by 359
Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer’s disease
Manczak, M., & Reddy, P. H. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds360 · Cited by 348
Abnormalities of mitochondrial enzymes in Alzheimer disease
Gibson, G. E., Sheu, K.-F. R., & Blass, J. P. (1998) · Journal of Neural Transmission · doi:10.1007/s007020050099 · Cited by 345
Cellular and Molecular Mechanisms Underlying Perturbed Energy Metabolism and Neuronal Degeneration in Alzheimer's and Parkinson's Diseases
Mattson, M. P., Pedersen, W. A., Duan, W., Culmsee, C., & Camandola, S. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb07824.x · Cited by 343
Alterations in Expression of Glutamatergic Transporters and Receptors in Sporadic Alzheimer's Disease
Jacob, C. P., Koutsilieri, E., Bartl, J., Neuen-Jacob, E., Arzberger, T., Zander, N., Ravid, R., Roggendorf, W., Riederer, P., & Grünblatt, E. (2007) · Journal of Alzheimer's Disease · doi:10.3233/jad-2007-11113 · Cited by 317
Alzheimer's disease: synapses gone cold
Koffie, R. M., Hyman, B. T., & Spires‐Jones, T. L. (2011) · Molecular Neurodegeneration · doi:10.1186/1750-1326-6-63 · Cited by 316
Abnormal tau, mitochondrial dysfunction, impaired axonal transport of mitochondria, and synaptic deprivation in Alzheimer's disease
Reddy, P. H. (2011) · Brain Research · doi:10.1016/j.brainres.2011.07.052 · Cited by 311
Synaptic mitochondria in synaptic transmission and organization of vesicle pools in health and disease
Vos, M. H. (2010) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2010.00139 · Cited by 307
Brain aging, Alzheimer's disease, and mitochondria
Swerdlow, R. H. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.08.012 · Cited by 306
Cortical and subcortical patterns of synaptophysinlike immunoreactivity in Alzheimer's disease.
Masliah, E., Terry, R. D., Alford, M. F., DeTeresa, R. M., & Hansen, L. A. (1991) · PubMed Central · Cited by 296
Are mitochondria critical in the pathogenesis of Alzheimer's disease?
Reddy, P. H., & Beal, M. F. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.03.004 · Cited by 294
Mitochondria: A therapeutic target in neurodegeneration
Moreira, P. I., Zhu, X., Wang, X., Lee, H., Nunomura, A., Petersen, R. B., Perry, G. L., & Smith, M. A. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.10.007 · Cited by 292
Calcium Secretion Coupling at Calyx of Held Governed by Nonuniform Channel–Vesicle Topography
Meinrenken, C., Borst, J. G., & Sakmann, B. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01648.2002 · Cited by 290
Oxidative Stress in Diabetes and Alzheimer's Disease
Reddy, V. P., Zhu, X., Perry, G. L., & Smith, M. A. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1013 · Cited by 286
Role of the nicotinic acetylcholine receptor in Alzheimer's disease pathology and treatment.
Lombardo, S., & Maskos, U. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.11.018 · Cited by 281
“Is dopamine involved in Alzheimer's disease?”
Martorana, A., & Koch, G. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00252 · Cited by 276
The Glutamatergic System and Alzheimer???s Disease
Butterfield, D. A., & Pocernich, C. B. (2003) · CNS Drugs · doi:10.2165/00023210-200317090-00004 · Cited by 274
The cholinergic hypothesis of Alzheimer's disease: a review of progress
Babić, T., Francis, P. T., Palmer, A. M., SNAPE, M., & WILCOCK, G. K. (1999) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.67.4.558 · Cited by 256
Synthesis, storage and release of acetylcholine by a noradrenergic pheochromocytoma cell line
Greene, L. A., & Rein, G. (1977) · Nature · doi:10.1038/268349a0 · Cited by 253
Amyloid beta impairs mitochondrial anterograde transport and degenerates synapses in Alzheimer's disease neurons
Calkins, M. J., & Reddy, P. H. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.01.007 · Cited by 252
Catecholamines and cholinergic enzymes in pre-senile and senile Alzheimer-type dementia and down's syndrome
Yates, C. M., Simpson, J. A., Gordon, A., Maloney, A. F. J., Allison, Y., Ritchie, I. M., & Urquhart, A. L. (1983) · Brain Research · doi:10.1016/0006-8993(83)91179-4 · Cited by 251
Amyloid-β and Mitochondria in Aging and Alzheimer's Disease: Implications for Synaptic Damage and Cognitive Decline
Reddy, P. H., Mańczak, M., Mao, P., Calkins, M. J., Reddy, A. P., & Shirendeb, U. P. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100504 · Cited by 247
Does Donepezil Treatment Slow the Progression of Hippocampal Atrophy in Patients With Alzheimer’s Disease?
Hashimoto, M., Kazui, H., Matsumoto, K., Nakano, Y., Yasuda, M., & Mori, E. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.4.676 · Cited by 241
Amyloid beta peptides and glutamatergic synaptic dysregulation
Parameshwaran, K., Dhanasekaran, M., & Suppiramaniam, V. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2007.10.008 · Cited by 235
Cyclophilin D deficiency improves mitochondrial function and learning/memory in aging Alzheimer disease mouse model
Du, H., Guo, L., Zhang, W., Rydzewska, M., & Yan, S.-D. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.03.003 · Cited by 234
Self-citation
PKC ε Activation Prevents Synaptic Loss, Aβ Elevation, and Cognitive Deficits in Alzheimer's Disease Transgenic Mice
Hongpaisan, J., Sun, M., & Alkon, D. L. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5209-10.2011 · Cited by 231
Mitochondrial Medicine for Aging and Neurodegenerative Diseases
Reddy, P. H. (2008) · NeuroMolecular Medicine · doi:10.1007/s12017-008-8044-z · Cited by 230
Aβ-Mediated NMDA Receptor Endocytosis in Alzheimer's Disease Involves Ubiquitination of the Tyrosine Phosphatase STEP 61
Kurup, P. K., Zhang, Y., Xu, J., Venkitaramani, D. V., Haroutunian, V. H., Greengard, P., Nairn, A. C., & Lombroso, P. J. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0157-10.2010 · Cited by 228
Release of Adenosine and ATP During Ischemia and Epilepsy
Dale, N., & Frenguelli, B. G. (2009) · Current Neuropharmacology · doi:10.2174/157015909789152146 · Cited by 225
Characteristics and possible functions of mitochondrial Ca2+ transport mechanisms
Gunter, T. E., & Sheu, S. (2009) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2008.12.011 · Cited by 224
Overexpression of SOD-2 reduces hippocampal superoxide and prevents memory deficits in a mouse model of Alzheimer's disease
Massaad, C. A., Washington, T. M., Pautler, R. G., & Klann, E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902714106 · Cited by 223
Mitochondrial Ca2+ Overload Underlies Aβ Oligomers Neurotoxicity Providing an Unexpected Mechanism of Neuroprotection by NSAIDs
Sanz‐Blasco, S., Valero, R. A., Rodríguez‐Crespo, I., Villalobos, C., & Núñez, L. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002718 · Cited by 221
Reduction of oxidative stress, amyloid deposition, and memory deficit by manganese superoxide dismutase overexpression in a transgenic mouse model of Alzheimer's disease
Dumont, M., Wille, E., Stack, C., Calingasan, N. Y., Beal, M. F., & Lin, M. T. (2009) · The FASEB Journal · doi:10.1096/fj.09-132928 · Cited by 221
Amyloid- Peptide Oligomers Disrupt Axonal Transport through an NMDA Receptor-Dependent Mechanism That Is Mediated by Glycogen Synthase Kinase 3 in Primary Cultured Hippocampal Neurons
Decker, H., Lo, K. Y., Unger, S. M., Ferreira, S. T., & Silverman, M. A. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1074-10.2010 · Cited by 221
Impairment of Long-term Potentiation and Associative Memory in Mice That Overexpress Extracellular Superoxide Dismutase
Thiels, E., Urban, N. N., González‐Burgos, G., Kanterewicz, B. I., Barrionuevo, G., Chu, C. T., Oury, T. D., & Klann, E. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-20-07631.2000 · Cited by 214
Mitochondria in Neurodegeneration
Lezi, E., & Swerdlow, R. H. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-2869-1_12 · Cited by 213
Longitudinal 1H MRS changes in mild cognitive impairment and Alzheimer's disease
Kantarci, K., Weigand, S. D., Petersen, R. C., Boeve, B. F., Knopman, D. S., Gunter, J. L., Reyes, D. A., Shiung, M. S., O’Brien, P. C., Smith, G. E., et al. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.06.018 · Cited by 213
Calcium/calmodulin-dependent kinase II and Alzheimer’s disease
Ghosh, A., & Giese, K. P. (2015) · Molecular Brain · doi:10.1186/s13041-015-0166-2 · Cited by 205
Altered brain energetics induces mitochondrial fission arrest in Alzheimer’s Disease
Zhang, L., Trushin, S., Christensen, T. A., Bachmeier, B. V., Gateno, B., Schroeder, A., Yao, J., Itoh, K., Sesaki, H., Poon, W. W., et al. (2016) · Scientific Reports · doi:10.1038/srep18725 · Cited by 201
Emanuel Miller. M.A. Cantab., F.R.C.P., D.P.M.
Cantab, M. A. (1970) · PubMed · Cited by 197
Frontotemporal dementia and early Alzheimer disease: differentiation with frontal lobe H-1 MR spectroscopy.
Ernst, T., Chang, L., Melchor, R., & Mehringer, C. M. (1997) · Radiology · doi:10.1148/radiology.203.3.9169712 · Cited by 192
Role of Mitochondria in Neurodegenerative Diseases: Mitochondria as a Therapeutic Target in Alzheimer's Disease
Reddy, P. H. (2009) · CNS Spectrums · doi:10.1017/s1092852900024901 · Cited by 192
Mitochondrial Ca2+ uptake prevents desynchronization of quantal release and minimizes depletion during repetitive stimulation of mouse motor nerve terminals
David, G., & Barrett, E. F. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.035196 · Cited by 182
β-Amyloid Causes Depletion of Synaptic Vesicles Leading to Neurotransmission Failure
Parodí, J., Sepúlveda, F. J., Roa, J., Opazo, C., Inestrosa, N. C., & Aguayo, L. G. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.030023 · Cited by 181
Deregulation of mitochondrial F1FO-ATP synthase via OSCP in Alzheimer’s disease
Beck, S. J., Guo, L., Phensy, A. J., Tian, J., Wang, L., Tandon, N., Gauba, E., Lu, L., Pascual, J. M., Kroener, S., et al. (2016) · Nature Communications · doi:10.1038/ncomms11483 · Cited by 175
Self-citation
Mitochondrial Fatty Acid Synthesis Type II: More than Just Fatty Acids
Hiltunen, J. K., Schonauer, M. S., Autio, K. J., Mittelmeier, T. M., Kastaniotis, A. J., & Dieckmann, C. L. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.r800068200 · Cited by 174
Is the neuronal basis of Alzheimer's disease cholinergic or glutamatergic?
Palmer, A. M., & Gershon, S. (1990) · The FASEB Journal · doi:10.1096/fasebj.4.10.2165009 · Cited by 172
The loading of neurotransmitters into synaptic vesicles
Gasnier, B. (2000) · Biochimie · doi:10.1016/s0300-9084(00)00221-2 · Cited by 171
Increased glutamate in CSF and plasma of patients with HIV dementia
Ferrarese, C., Aliprandi, A., Tremolizzo, L., Stanzani, L., Micheli, A., Dolara, A., & Frattola, L. (2001) · Neurology · doi:10.1212/wnl.57.4.671 · Cited by 168
Selective regional loss of exocytotic presynaptic vesicle proteins in Alzheimer’s disease brains
Sze, C., Bi, H., Kleinschmidt-DeMasters, B. K., Filley, C. M., & Martin, L. J. (2000) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(00)00285-9 · Cited by 166
The Role of Mitochondria in Presynaptic Calcium Handling at a Ribbon Synapse
Zenisek, D., & Matthews, G. (2000) · Neuron · doi:10.1016/s0896-6273(00)80885-5 · Cited by 164
Prologue
Braak, H., & Tredici, K. D. (2014) · Advances in anatomy, embryology and cell biology · doi:10.1007/978-3-319-12679-1_1 · Cited by 164
Synaptic pathology in alzheimer's disease: Immunological data for markers of synaptic and large dense-core vesicles
Lassmann, H., Weiler, R., Fischer, P. A., Bancher, C., Jellinger, K. A., Floor, E., Danielczyk, W., SEITELBERGER, F., & Winkler, H. J. S. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90003-k · Cited by 161
Impaired platelet mitochondrial activity in Alzheimer's disease and mild cognitive impairment
Valla, J., Schneider, L., Niedzielko, T., Coon, K. D., Caselli, R., Sabbagh, M. N., Ahern, G. L., Baxter, L., Alexander, G., Walker, D. G., et al. (2006) · Mitochondrion · doi:10.1016/j.mito.2006.10.004 · Cited by 159
Neuroanatomy and pathology of sporadic Alzheimer's disease.
Braak, H., & Trecidi, K. D. (2014) · Advances in Anatomy, Embryology and Cell Biology · doi:10.1007/978-3-319-12679-1 · Cited by 158
Alzheimer's disease, amnestic mild cognitive impairment, and age-associated memory impairment: current understanding and progress toward integrative prevention.
Kidd, P. M. (2008) · PubMed · Cited by 158
Glutamate forward and reverse transport: From molecular mechanism to transporter‐mediated release after ischemia
Grewer, C. T., Gameiro, A. M., Zhang, Z., Tao, Z., Braams, S., & Rauen, T. (2008) · IUBMB Life · doi:10.1002/iub.98 · Cited by 157
FAMILIAR ABBREVIATIONS
ROBERT, E. (1973) · The Lancet · doi:10.1016/s0140-6736(73)90900-8 · Cited by 157
The glutamatergic system and neurodegeneration in dementia: preventive strategies in Alzheimer's disease
Cacabelos, R., Takeda, M., & Winblad, B. G. (1999) · International Journal of Geriatric Psychiatry · doi:10.1002/(sici)1099-1166(199901)14:1 · Cited by 156
Synaptic Mitochondrial Pathology in Alzheimer's Disease
Du, H., Guo, L., & Yan, S. S. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4277 · Cited by 154
Self-citation
Increased Autophagic Degradation of Mitochondria in Alzheimer Disease
Moreira, P. I., Siedlak, S. L., Wang, X., Santos, M. S., Oliveira, C. R., Tabaton, M., Nunomura, A., Szweda, L. I., Aliev, G. M., Smith, M. A., et al. (2007) · Autophagy · doi:10.4161/auto.4872 · Cited by 150
Vulnerability of Select Neuronal Types to Alzheimer's Disease
BRAAK, H., DEL TREDICI, K., SCHULTZ, C., & BRAAK, E. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb05560.x · Cited by 150
Dopamine Modulates Cholinergic Cortical Excitability in Alzheimer's Disease Patients
Martorana, A., Mori, F., Esposito, Z., Kusayanagi, H., Monteleone, F., Codecà, C., Sancesario, G., Bernardi, G., & Koch, G. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.60 · Cited by 148
Amyloid β-Induced Impairments in Hippocampal Synaptic Plasticity Are Rescued by Decreasing Mitochondrial Superoxide
Ma, T., Hoeffer, C. A., Wong, H., Massaad, C. A., Zhou, P., Iadecola, C., Murphy, M. P., Pautler, R. G., & Klann, E. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6566-10.2011 · Cited by 147
M1 muscarinic acetylcholine receptor in Alzheimer’s disease
Jiang, S., Li, Y., Zhang, C., Zhao, Y., Bu, G., Xu, H., & Zhang, Y. (2014) · Neuroscience Bulletin · doi:10.1007/s12264-013-1406-z · Cited by 147
Cytochrome C Oxidase in Alzheimer's Disease Brain: Purification and Characterization
Parker, W. D., & Parks, J. K. (1995) · Neurology · doi:10.1212/wnl.45.3.482 · Cited by 142
Amyloid β: linking synaptic plasticity failure to memory disruption in Alzheimer’s disease
Ma, T., & Klann, E. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07506.x · Cited by 140
A novel mechanism for GABA synthesis and packaging into synaptic vesicles
Buddhala, C., Hsu, C., & Wu, J. (2009) · Neurochemistry International · doi:10.1016/j.neuint.2009.01.020 · Cited by 138
NADPH oxidase is required for NMDA receptor‐dependent activation of ERK in hippocampal area CA1
Kishida, K. T., Pao, M., Holland, S. M., & Klann, E. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03189.x · Cited by 136
Pathology of presynaptic proteins in Alzheimer's disease: more than simple loss of terminals
Honer, W. (2003) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.04.005 · Cited by 135
Damage to dopamine systems differs between parkinson's disease and alzheimer's disease with parkinsonism
Murray, A. M., Weihmueller, F. B., Marshall, J. F., Hurtig, H. I., Gottleib, G. L., & Joyce, J. N. (1995) · Annals of Neurology · doi:10.1002/ana.410370306 · Cited by 135
The molecular machinery of synaptic vesicle exocytosis
Li, L., & Chin, L. (2003) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-2240-7 · Cited by 129
Brain Glutamate Levels Are Decreased in Alzheimer’s Disease: A Magnetic Resonance Spectroscopy Study
Fayed, N., Modrego, P. J., Rojas-Salinas, G., & Aguilar, K. (2011) · American Journal of Alzheimer's Disease & Other Dementias® · doi:10.1177/1533317511421780 · Cited by 128
Mitochondria in Alzheimer's disease
Swerdlow, R. H., & Kish, S. J. (2002) · International review of neurobiology · doi:10.1016/s0074-7742(02)53013-0 · Cited by 126
Alzheimer's disease and aging: Effects on perforant pathway perikarya and synapses
Lippa, C. F., Hamos, J. E., Pulaski-Salo, D., DeGennaro, L. J., & Drachman, D. A. (1992) · Neurobiology of Aging · doi:10.1016/0197-4580(92)90115-e · Cited by 123
Synapses and Dendritic Spines as Pathogenic Targets in Alzheimer’s Disease
Yu, W., & Lu, B. (2012) · Neural Plasticity · doi:10.1155/2012/247150 · Cited by 123
Treatment Options in Alzheimer´s Disease: The GABA Story
Solas, M., Puerta, E., & Ramírez, M. J. (2015) · Current Pharmaceutical Design · doi:10.2174/1381612821666150914121149 · Cited by 122
Amyloid β-Peptide Promotes Permeability Transition Pore in Brain Mitochondria
Moreira, P. I., Santos, M. S., Moreno, A. J., & Oliveira, C. R. (2001) · Bioscience Reports · doi:10.1023/a:1015536808304 · Cited by 122
Active Transport of Acetylcholine by the Human Vesicular Acetylcholine Transporter
Varoqui, H., & Erickson, J. D. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.44.27229 · Cited by 121
The contribution of intracellular calcium stores to mEPSCs recorded in layer II neurones of rat barrel cortex
Simkus, C. R. L., & Stricker, C. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.022103 · Cited by 121
Effect of amyloid β‐peptide on permeability transition pore: A comparative study
Moreira, P. I., Santos, M. S., Moreno, A. J., Rego, A. C., & Oliveira, C. R. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10282 · Cited by 120
Allosteric modulation of the M1 muscarinic acetylcholine receptor: improving cognition and a potential treatment for schizophrenia and Alzheimer's disease
Melancon, B. J., Tarr, J. C., Panarese, J. D., Wood, M. R., & Lindsley, C. W. (2013) · Drug Discovery Today · doi:10.1016/j.drudis.2013.09.005 · Cited by 120
Immunocytochemical Examination of Neural Rat and Mouse Primary Cultures Using Monoclonal Antibodies Raised Against Pyruvate Carboxylase
Cesar, M., & Hamprecht, B. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.64052312.x · Cited by 120
Cyclophilin D Deficiency Rescues Axonal Mitochondrial Transport in Alzheimer’s Neurons
Guo, L., Du, H., Yan, S., Wu, X., McKhann, G. M., Chen, J. X., & Yan, S. S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054914 · Cited by 118
Self-citation
Neurodegeneration mediated by glutamate and β-amyloid peptide: a comparison and possible interaction
Gray, C. W., & Patel, A. J. (1995) · Brain Research · doi:10.1016/0006-8993(95)00669-h · Cited by 117
Structural mechanisms of cyclophilin D-dependent control of the mitochondrial permeability transition pore
Gutiérrez‐Aguilar, M., & Baines, C. P. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2014.11.009 · Cited by 110
Mitochondria and Neurotransmission: Evacuating the Synapse
Hollenbeck, P. J. (2005) · Neuron · doi:10.1016/j.neuron.2005.07.017 · Cited by 107
Neurotransmitter amino acids in cerebrospinal fluid of patients with Alzheimer's disease
Jiménez‐Jiménez, F. J., Molina, J. A., Gómez, P. A., Vargas, C., de Bustos, F., Benito‐León, J., Tallón-Barranco, A., Pareja, M. O., Gasalla, T., & Arenas, J. (1998) · Journal of Neural Transmission · doi:10.1007/s007020050056 · Cited by 98
Prolonged Activation of Mitochondrial Conductances During Synaptic Transmission
Jonas, E. A., Buchanan, J., & Kaczmarek, L. K. (1999) · Science · doi:10.1126/science.286.5443.1347 · Cited by 94
Electrical synapses, a personal perspective (or history)
Bennett, M. V. L. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00065-x · Cited by 94
ER vesicles and mitochondria move and communicate at synapses
Mironov, S. L., & Symonchuk, N. (2006) · Journal of Cell Science · doi:10.1242/jcs.03254 · Cited by 93
Synaptosomal Mitochondrial Dysfunction in 5xFAD Mouse Model of Alzheimer's Disease
Wang, L., Guo, L., Lu, L., Sun, H., Shao, M., Beck, S. J., Lin, L., Ramachandran, J., Du, Y., & Du, H. (2016) · PLoS ONE · doi:10.1371/journal.pone.0150441 · Cited by 90
Self-citation
Oxidative metabolism deficiencies in brains of patients with Alzheimer's disease
Hoyer, S. (1996) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1996.tb05868.x · Cited by 88
Cyclophilin D deficiency rescues Aβ-impaired PKA/CREB signaling and alleviates synaptic degeneration
Du, H., Guo, L., Wu, X., Sosunov, A. A., McKhann, G. M., Chen, J. X., & Yan, S. S. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.03.004 · Cited by 87
Self-citation
Synaptic Physiology and Mitochondrial Function in Crayfish Tonic and Phasic Motor Neurons
Nguyen, P., Marin, L., & Atwood, H. L. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.78.1.281 · Cited by 87
Decreased Brain Protein Levels of Cytochrome Oxidase Subunits in Alzheimer's Disease and in Hereditary Spinocerebella Ataxia Disorders
Kish, S. J., Mastrogiacomo, F., Guttman, M., Furukawa, Y., Taanman, J., Dozic, S., Pandolfo, M., Lamarche, J. B., DiStefano, L. M., & Chang, L. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0720700.x · Cited by 85
Regulation of axonal mitochondrial transport and its impact on synaptic transmission
Cai, Q., Davis, M. L., & Sheng, Z. (2011) · Neuroscience Research · doi:10.1016/j.neures.2011.02.005 · Cited by 85
Loading and recycling of synaptic vesicles in the Torpedo electric organ and the vertebrate neuromuscular junction
der Kloot, W. V. (2003) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2003.10.003 · Cited by 84
Synaptic plasticity disruption by amyloid β protein: modulation by potential Alzheimer's disease modifying therapies
Rowan, M. J., Klyubin, I. V., Wang, Q., & Anwyl, R. (2005) · Biochemical Society Transactions · doi:10.1042/bst0330563 · Cited by 83
Mitochondrial medicine for neurodegenerative diseases
Du, H., & Yan, S. S. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.01.004 · Cited by 82
Self-citation
Mitochondrial Respiration in the Platelets of Patients with Alzheimer’s Disease
Fišar, Z., Hroudová, J., Hansíková, H., Křížová, J., Lelková, P., Wenchich, L., Jirák, R., Zvěřová, M., Zeman, J., Pavel Martasek, E., et al. (2016) · Current Alzheimer Research · doi:10.2174/1567205013666160314150856 · Cited by 82
Correlated Calcium Uptake and Release by Mitochondria and Endoplasmic Reticulum of CA3 Hippocampal Dendrites after Afferent Synaptic Stimulation
Pivovarova, N. B., Pozzo‐Miller, L. D., Hongpaisan, J., & Andrews, S. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-24-10653.2002 · Cited by 81
The expression of calcium/calmodulin-dependent protein kinase II-α in the hippocampus of patients with Alzheimer's disease and its links with AD-related pathology
Wang, Y., Chen, G.-H., Hu, X., Lu, Y.-P., Zhou, J., & Liu, R. (2004) · Brain Research · doi:10.1016/j.brainres.2004.10.061 · Cited by 80
Putative amino acid transmitters in lumbar cerebrospinal fluid of patients with histologically verified Alzheimer's dementia.
Smith, C., Bowen, D. M., Francis, P. T., Snowden, J. S., & Neary, D. (1985) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.48.5.469 · Cited by 75
Elucidation of the quantitative significance of pyruvate carboxylation in cultured cerebellar neurons and astrocytes
Waagepetersen, H. S., Qu, H., Schousboe, A., & Sonnewald, U. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.10061 · Cited by 74
Do Cholinesterase Inhibitors Have Disease-Modifying Effects in Alzheimer??s Disease?
Giacobini, E. (2001) · CNS Drugs · doi:10.2165/00023210-200115020-00001 · Cited by 72
Mitochondria-Targeted Antioxidant SS31 Prevents Amyloid Beta-Induced Mitochondrial Abnormalities and Synaptic Degeneration in Alzheimer’s Disease
Calkins, M. J., Mańczak, M., & Reddy, P. (2012) · Pharmaceuticals · doi:10.3390/ph5101103 · Cited by 71
The effects of botulinum toxin on the synthesis, storage and release of acetylcholine
Gundersen, C. B. (1980) · Progress in Neurobiology · doi:10.1016/0301-0082(80)90019-2 · Cited by 67
Linking Mitochondria to Synapses: New Insights for Stress-Related Neuropsychiatric Disorders
Jeanneteau, F. D., & Arango-Lievano, M. (2016) · Neural Plasticity · doi:10.1155/2016/3985063 · Cited by 66
Cerebrospinal Fluid Concentrations of Functionally Important Amino Acids and Metabolic Compounds in Patients with Mild Cognitive Impairment and Alzheimer’s Disease
Kaiser, E., Schoenknecht, P., Kassner, S. S., Hildebrandt, W., Kinscherf, R., & Schröeder, J. (2010) · Neurodegenerative Diseases · doi:10.1159/000287953 · Cited by 65
Clinical Studies of the Cholinergic Deficit in Alzheimer's Disease
Davis, B. M., Mohs, R. C., GREENWALD, B. S., Mathé, A. A., Johns, C. A., Horvath, T., & Davis, K. L. (1985) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1985.tb04184.x · Cited by 64
DOPAMINE IN ALZHEIMER'S DISEASE AND SENILE DEMENTIA
Yates, C., Allison, Y., Simpson, J., Maloney, A. F. J., & Gordon, A. (1979) · The Lancet · doi:10.1016/s0140-6736(79)92202-5 · Cited by 62
Synaptic Alterations in the Vestibulocerebellar System in Alzheimer's Disease - A Golgi and Electron Microscope Study
Stavros J. Baloyannis, S. L. M. (2000) · Acta Oto-Laryngologica · doi:10.1080/000164800750001026 · Cited by 61
Clinical Management of Diabetic Neuropathy.
WATKINS, P. (1999) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.67.4.558a · Cited by 60
The Mitochondrial Monoamine Oxidase−Aldehyde Dehydrogenase Pathway: A Potential Site of Action of Daidzin
Rooke, N., Li, D.-J., Li, J., & Keung, W. M. (2000) · Journal of Medicinal Chemistry · doi:10.1021/jm990614i · Cited by 59
Topographical distribution of synaptic-associated proteins in the neuritic plaques of Alzheimer's disease hippocampus
Masliah, E., Honer, W. G., Mallory, M. E., Voigt, M., Kushner, P. D., Hansen, L. A., & Terry, R. D. (1994) · Acta Neuropathologica · doi:10.1007/bf00296182 · Cited by 56
CHOLINE THERAPY IN ALZHEIMER'S DISEASE
Smith, C. M., Swash, M., Exton‐Smith, A. N., Phillips, M. J., Overstall, P. W., Piper, M. E., & Bailey, M. R. (1978) · The Lancet · doi:10.1016/s0140-6736(78)91721-x · Cited by 56
Protein Kinase C Activation as a Potential Therapeutic Strategy in Alzheimer's Disease: Is there a Role for Embryonic Lethal Abnormal Vision-like Proteins?
Talman, V., Pascale, A., Jäntti, M., Amadio, M., & Tuominen, R. (2016) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.12581 · Cited by 56
Oxidative Damage and Alzheimer's Disease: Are Antioxidant Therapies Useful?
Moreira, P. I., Smith, M. A., Zhu, X., Honda, K., Lee, H., Aliev, G. M., & Perry, G. L. (2005) · Drug News & Perspectives · doi:10.1358/dnp.2005.18.1.877164 · Cited by 54
Fatty acid synthesis in rat liver: Relative contributions of the mitochondrial, microsomal and non-particulate systems
Donaldson, W. E., Wit-Peeters, E. M., & Scholte, H. R. (1970) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(70)90215-8 · Cited by 53
Alzheimer neurofibrillary lesions: Molecular nature and potential roles of different components
Yen, S.-H. C., Liu, W.-K., Hall, F. L., Yan, S., Stern, D. M., & Dickson, D. W. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00022-7 · Cited by 53
Neurotransmitter measures in the cerebrospinal fluid of patients with Alzheimer's disease: a review.
Štrac, D. Š., Mück‐Šeler, D., & Pivac, N. (2015) · PubMed · Cited by 51
Neurotransmitter amino acids in cerebrospinal fluid of patients with Parkinson's disease
Jiménez‐Jiménez, F. J., Molina, J., Vargas, C., Gómez, P., Navarro, J. A., Benito‐León, J., Pareja, M. O., Gasalla, T., Cisneros, E., & Arenas, J. (1996) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(96)00115-3 · Cited by 51
Neurotransmitters and Novelty: A Systematic Review
Rangel‐Gomez, M., & Meeter, M. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881115612238 · Cited by 51
Effect of beta-Amyloid Peptide Fragment 25-35 on Nonselective Permeability of Mitochondria
Shevtzova, E. F., Kireeva, E. G., & Бачурин, С. О. (2001) · Bulletin of Experimental Biology and Medicine · doi:10.1023/a:1014559331402 · Cited by 50
Early Selective Vulnerability of Synapses and Synaptic Mitochondria in the Hippocampal CA1 Region of the Tg2576 Mouse Model of Alzheimer's Disease
Balietti, M., Giorgetti, B., Casoli, T., Solazzi, M., Tamagnini, F., Burattini, C., Aicardi, G., & Fattoretti, P. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-121711 · Cited by 50
Decreased levels of ARPP-19 and PKA in brains of Down syndrome and Alzheimer’s disease
Kim, S. H., Nairn, A. C., Cairns, N. J., & Lübec, G. (2001) · Springer eBooks · doi:10.1007/978-3-7091-6262-0_21 · Cited by 49
Memory loss caused by β-amyloid protein is rescued by a β3-adrenoceptor agonist
Gibbs, M. E., Maksel, D., Gibbs, Z., Hou, X., Summers, R. J., & Small, D. H. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.05.018 · Cited by 49
Ca2+ signaling pathways linked to glutamate receptor activation in the somatic and dendritic regions of cultured cerebellar purkinje neurons
Gruol, D. L., Netzeband, J. G., & Parsons, K. L. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.76.5.3325 · Cited by 48
Memantine in Patients with Moderate to Severe Alzheimer's Disease: Meta-Analyses Using Realistic Definitions of Response
Wilkinson, D. G., Wirth, Y., & Goebel, C. (2013) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000353801 · Cited by 47
The choline-leakage hypothesis for the loss of acetylcholine in Alzheimer's disease
Ehrenstein, G., Galdzicki, Z., & Lange, G. D. (1997) · Biophysical Journal · doi:10.1016/s0006-3495(97)78160-8 · Cited by 46
Hippocampal memory and plasticity in superoxide dismutase mutant mice
Thiels, E., & Klann, E. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00900-9 · Cited by 44
Chronic treatment with the α2-adrenoceptor antagonist fluparoxan prevents age-related deficits in spatial working memory in APP×PS1 transgenic mice without altering β-amyloid plaque load or astrocytosis
Scullion, G. A., Kendall, D. A., Marsden, C. A., Sunter, D., & Pardon, M. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.09.002 · Cited by 44
Loss of Dopamine D2 Receptors in Alzheimer's Disease with Parkinsonism But Not Parkinson's or Alzheimer's Disease
Joyce, J., Murray, A., Hurtig, H., Gottlieb, G., & Trojanowski, J. (1998) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00044-x · Cited by 43
Acetylcholine Transport: Fundamental Properties and Effects of Pharmacologic Agentsa
Parsons, S. M., Bahr, B. A., Gracz, L. M., Kaufman, R., Kornreich, W. D., NILSSON, L., & Rogers, G. A. (1987) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1987.tb27203.x · Cited by 43

Flagged first, then by citations

1 of the 243 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

10.1007/s007020050073 · DOI

Sorted by citations

Amyloid β-based therapy for Alzheimer’s disease: Challenges, successes and future
Zhang, Y., Chen, H., Li, R., Sterling, K., & Song, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01484-7 · Cited by 988
“Mitochondria are essential for the glutamate synthesis, synaptic transmission and calcium regulation.(193,194) Disrupted energy metabolism has been found in early AD and precedes the disease development, suggesting the core role of mitochondria dysfunction in Alzheimer’s pathogenesis.”
Background
Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease
Khan, S., Barve, K. H., & Kumar, M. S. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200528142429 · Cited by 820
“Apart from this, Aβ induces hypersensitivity of NMDA receptors and also disrupts the regulatory control of NMDA activity causing excitotoxicity [12].”
Background
Mitochondria: It is all about energy
Casanova, A., Wevers, A., Ledesma, S. N., & Pruimboom, L. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1114231 · Cited by 350
The Association of Tau With Mitochondrial Dysfunction in Alzheimer’s Disease
Cheng, Y., & Bai, F. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00163 · Cited by 239
Dysfunctional Mitochondria and Mitophagy as Drivers of Alzheimer’s Disease Pathogenesis
Chakravorty, A., Jetto, C. T., & Manjithaya, R. R. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00311 · Cited by 225

See all 211

Authors: Guo, L., Tian, J., & Du, H.
Affiliations: The University of Texas at Dallas (US)
Shandong University (CN)
Corresponding author: Du, Heng
ORCID: Guo, Lan
Tian, Jing
Du, Heng
Venue: Journal of Alzheimer’s Disease
Publisher: SAGE Publications
Published: 2016-09-20
Volume: 57
Issue: 4
Pages: 1071-1086
ISSN: 1387-2877 (ISSN-L)
1875-8908
DOI: 10.3233/jad-160702
PMC: PMC5605817
OpenAlex: W2522744939
Cited by: 211
References: 243
Citations by year: 2026: 26 · 2025: 31 · 2024: 29 · 2023: 31 · 2022: 22 · 2021: 22 · 2020: 28 · 2019: 17 · 2018: 3 · 2017: 2
FWCI: 0.86
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Journal of Alzheimer s Disease (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (R00AG037716, R01AG053588)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: Alzheimer's disease, mitochondrial dysfunction
MeSH terms: Alzheimer Disease, Animals, Humans, Mitochondria, Synaptic Transmission, Mitochondrial Diseases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Mitochondrial Dysfunction and Synaptic Transmission Failure in Alzheimer’s Disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks