Cited by 450Gut microbiota and healthAlzheimer's disease research and treatmentsGastrointestinal motility and disorders

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Altered Gut Microbiota in a Mouse Model of Alzheimer’s Disease

Zhang, Ling, Wang, Ying, Xiayu, Xia, Shi, Changhua, Chen, Wei, Song, Nan, Fu, Xinjing, Zhou, Rui, Xu, Yan-Feng, Huang, Lan, Zhu, Hua, Han, Yunlin, Qin, Chuan·2017·Journal of Alzheimer s Disease

DOI 10.3233/jad-170020

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Abstract

The topic of gut microbiota is currently attracting considerable interest as a potential factor in Alzheimer's disease (AD). However, the extent and time course of alterations in the gut microbiota, and their effects on AD pathology remain uncertain. Herein, we compared the fecal microbiomes and fecal short chain fatty acid composition (SCFAs) between wild-type and AD model mice at different ages under strictly controlled specific pathogen free conditions, and also conducted microscopic investigations of intestinal structures. Our results showed that the microbiota composition and diversity were perturbed and the level of SCFAs was reduced in AD mice, predicting alterations in more than 30 metabolic pathways, which may be associated with amyloid deposition and ultrastructural abnormalities in AD mouse intestine. These findings indicate that AD pathology might not only affect brain function directly, but also exacerbate cognitive deficits through reducing the level of SCFAs via alterations of gut microbiota induced by intestinal amyloid deposition. Our data may support a role of gut microbiota, and suggest a novel route for therapeutic intervention in AD.

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Self-citation

Authors: Zhang, L., Wang, Y., Xiayu, X., Shi, C., Chen, W., Song, N., Fu, X., Zhou, R., Xu, Y.-F., Huang, L., Zhu, H., Han, Y., & Qin, C.
Affiliations: Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Medical Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS), Beijing, China
Corresponding author: Qin, Chuan
ORCID: Zhang, Ling
Wang, Ying
Shi, Changhua
Chen, Wei
Zhou, Rui
Huang, Lan
Zhu, Hua
Han, Yunlin
Qin, Chuan
Venue: Journal of Alzheimer s Disease
Publisher: SAGE Publications
Published: 2017-11-07
Volume: 60
Issue: 4
Pages: 1241-1257
ISSN: 1387-2877 (ISSN-L)
1875-8908
DOI: 10.3233/jad-170020
OpenAlex: W2762048636
Cited by: 449
References: 74
Citations by year: 2026: 18 · 2025: 62 · 2024: 72 · 2023: 76 · 2022: 63 · 2021: 74 · 2020: 45 · 2019: 30 · 2018: 9
FWCI: 9.38
Type: journal article
Language: en
Open access: closed
Locations: Journal of Alzheimer s Disease (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: Alzheimer's disease, gut microbiota
MeSH terms: Gastrointestinal Microbiome, Aging, Alzheimer Disease, Animals, Disease Models, Animal, Fatty Acids, Volatile, Feces, Intestines, Male, Mice, Transgenic, Computational Biology

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Altered Gut Microbiota in a Mouse Model of Alzheimer’s Disease

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