Cited by 260Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsGut microbiota and health

Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice: Role of microbiome

Abraham, Dora, Feher, Janos, Scuderi, Gian Luca, Szabo, Dora, Dobolyi, Arpad, Cservenak, Melinda, Juhasz, Janos, Ligeti, Balazs +7 more·2019·Experimental Gerontology

Abstract

It has been suggested that exercise training and probiotic supplementation could decelerate the progress of functional and biochemical deterioration in APP/PS1 transgenic mice (APP/PS1 TG). APP/PS1 TG mice were subjected to exercise training and probiotic treatments and functional, biochemical and microbiome markers were analyzed. Under these conditions the mice significantly outperformed controls on The Morris Maze Test, and the number of beta-amyloid plaques decreased in the hippocampus. B. thetaiotaomicron levels correlated highly with the results of the Morris Maze Test (p < 0.05), and this group of bacteria was significantly elevated in the microbiome of the APP/PS1 TG mice compared to the wild type. L. johnsonii levels positively correlated with the beta amyloid content and area. Data revealed that exercise and probiotic treatment can decrease the progress of Alzheimer's Disease and the beneficial effects could be partly mediated by alteration of the microbiome.

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Crossref · 10.1016/j.exger.2018.12.005

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Authors
Abraham, D., Feher, J., Scuderi, G. L., Szabo, D., Dobolyi, A., Cservenak, M., Juhasz, J., Ligeti, B., Pongor, S., Gomez-Cabrera, M. C., Vina, J., Higuchi, M., Suzuki, K., Boldogh, I., & Radak, Z.
Affiliations
  • Waseda University (JP)
  • The University of Texas Medical Branch at Galveston (US)
Corresponding author
Radak, Zsolt
Venue
Experimental Gerontology
Publisher
Elsevier BV
Published
2019-01
Volume
115
Pages
122-131
ISSN
0531-5565 (ISSN-L)
OpenAlex
W2905037443
Cited by
260
References
55
Citations by year
2026: 17 · 2025: 38 · 2024: 36 · 2023: 45 · 2022: 43 · 2021: 44 · 2020: 27 · 2019: 10
FWCI
13.83
Type
journal article
Language
en
Open access
closed
Locations
  • Experimental Gerontology (publishedVersion)
  • PubMed (publishedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Funders
  • OTKA (112810)
  • National Excellence Program (126823)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords
Alzheimer's disease, exercise training, probiotics, gut microbiota, APP/PS1 mice, Bacteroides thetaiotaomicron, amyloid plaques, hippocampus, spatial learning and memory, neuroprotection
MeSH terms
Alzheimer Disease, Animals, Disease Models, Animal, Hippocampus, Male, Mice, Transgenic, Physical Conditioning, Animal, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Probiotics, Mice, Presenilin-1, Plaque, Amyloid, Microbiota

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