The DOI matches its Crossref record; 330 of the 333 references it cites were found in a registry or an index, and 1 are not checked yet.
Sex and gender differences in myocarditis and dilated cardiomyopathy: An update
Open accessAbstract
In the past decade there has been a growing interest in understanding sex and gender differences in myocarditis and dilated cardiomyopathy (DCM), and the purpose of this review is to provide an update on this topic including epidemiology, pathogenesis and clinical presentation, diagnosis and management. Recently, many clinical studies have been conducted examining sex differences in myocarditis. Studies consistently report that myocarditis occurs more often in men than women with a sex ratio ranging from 1:2–4 female to male. Studies reveal that DCM also has a sex ratio of around 1:3 women to men and this is also true for familial/genetic forms of DCM. Animal models have demonstrated that DCM develops after myocarditis in susceptible mouse strains and evidence exists for this progress clinically as well. A consistent finding is that myocarditis occurs primarily in men under 50 years of age, but in women after age 50 or post-menopause. In contrast, DCM typically occurs after age 50, although the age that post-myocarditis DCM occurs has not been investigated. In a small study, more men with myocarditis presented with symptoms of chest pain while women presented with dyspnea. Men with myocarditis have been found to have higher levels of heart failure biomarkers soluble ST2, creatine kinase, myoglobin and T helper 17-associated cytokines while women develop a better regulatory immune response. Studies of the pathogenesis of disease have found that Toll-like receptor (TLR)2 and TLR4 signaling pathways play a central role in increasing inflammation during myocarditis and in promoting remodeling and fibrosis that leads to DCM, and all of these pathways are elevated in males. Management of myocarditis follows heart failure guidelines and there are currently no disease-specific therapies. Research on standard heart failure medications reveal important sex differences. Overall, many advances in our understanding of the effect of biologic sex on myocarditis and DCM have occurred over the past decade, but many gaps in our understanding remain. A better understanding of sex and gender effects are needed to develop disease-targeted and individualized medicine approaches in the future.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Figures
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source doesn’t support the claim as written.
In the citing paper
“Few females progress to DCM in humans or autoimmune/viral myocarditis animal models. 64,124”
From COVID-19, Myocarditis and Pericarditis (2023) · cites this paper as [64]
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Importantly, the findings highlight that myocarditis occurs predominantly in male patients aged 12 to 40 years regardless of whether the cause was due to a virus-like SARS-CoV-2 or associated with a vaccine-a demographic that has been reported before COVID-19.”
From COVID-19, Myocarditis and Pericarditis (2023) · cites this paper as [64]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“We have published previously that upregulation of complement and TLRs including TLR4 are key immune pathways that promote myocarditis in the autoimmune-CVB3 animal model”
From COVID-19, Myocarditis and Pericarditis (2023) · cites this paper as [64]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Myocarditis typically occurs more often in young men aged 16 to 30 years, and the sex ratio for COVID-19 studies is typically observed to be 60% men to 40% women.”
From COVID-19, Myocarditis and Pericarditis (2023) · cites this paper as [64]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“with men developing more scar tissue and dilated cardiomyopathy (DCM) than women. 64,124,131”
From COVID-19, Myocarditis and Pericarditis (2023) · cites this paper as [64]
Experimental — accuracy not yet measured
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“suggesting potential alternative pathogenesis such as autoimmunity, hypersensitivity, or medication usage.”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [150]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Notably, in some cases of lymphocytic myocarditis, these viruses tested negative, while autoantibodies specific to the heart were present”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [150]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Myocarditis is a well-known disease presenting sex differences, with males showing a higher prevalence and mortality rate, observed in both human and animal models. 150”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [150]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Myocarditis pre-COVID is known to occur more often in young men under the age of 50 years, with a sex ratio of 2 to 4:1 men to women”
From COVID-19, Myocarditis and Pericarditis (2023) · cites this paper as [64]
The cited source says what the claim attributes to it.
In the citing paper
“while women are more likely to develop myocarditis after menopause, which is reviewed in previous studies. 64,113-117”
From COVID-19, Myocarditis and Pericarditis (2023) · cites this paper as [64]
The cited source says what the claim attributes to it.
In the citing paper
“Proposed mechanisms include more proinflammatory and profibrotic immune profiles in the heart of males compared with females, potentially attributed to differences in sex hormones. 150”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [150]
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Similar to myocarditis, preCOVID pericarditis occurs more often in young men under the age of 50 years with a sex ratio of around 2:1. 64,95,118”
From COVID-19, Myocarditis and Pericarditis (2023) · cites this paper as [64]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“The accuracy of cMRI depends on the amount of scar tissue present”
From COVID-19, Myocarditis and Pericarditis (2023) · cites this paper as [64]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes
Zinman, B., Wanner, C., Lachin, J. M., Fitchett, D., Bluhmki, E., Hantel, S., Mattheus, M., Devins, T., Johansen, O. E., Woerle, H. J., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1504720 · Cited by 12,315
Ahmed, A., Jorna, T., & Bhandari, S. (2016) · The Nephron journals/Nephron journals · doi:10.1159/000447068 · Cited by 11,782
Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019
Roth, G. A., Mensah, G. A., Johnson, C. O., Addolorato, G., Ammirati, E., Baddour, L. M., Barengo, N. C., Beaton, A. Z., Benjamin, E. J., Benziger, C. P., et al. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.11.010 · Cited by 11,449
Self-citationThe SOLVD Investigators* (1991) · New England Journal of Medicine · doi:10.1056/nejm199108013250501 · Cited by 8,029
Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction
McMurray, J. J. V., Solomon, S. D., Inzucchi, S. E., Køber, L., Kosiborod, M. N., Martinez, F. A., Ponikowski, P., Sabatine, M. S., Anand, I. S., Bělohlávek, J., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1911303 · Cited by 7,140
Angiotensin-neprilysin inhibition versus enalapril in heart failure
McMurray, J. J. V., Packer, M., Desai, A. S., Gong, J., Lefkowitz, M. P., Rizkala, A. R., Rouleau, J. L., Shi, V. C., Solomon, S. D., Swedberg, K., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1409077 · Cited by 6,957
ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012
Authors/Task Force Members, McMurray, J. J. V., Adamopoulos, S., Anker, S. D., Auricchio, A., Böhm, M., Dickstein, K., Falk, V., Filippatos, G., Fonseca, C., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs104 · Cited by 6,879
Effects of Enalapril on Mortality in Severe Congestive Heart Failure
The Consensus Trial Study Group* (1987) · New England Journal of Medicine · doi:10.1056/nejm198706043162301 · Cited by 5,109
Caforio, A. L. P., Pankuweit, S., Arbustini, E., Basso, C., Gimeno-Blanes, J., Felix, S. B., Fu, M., Heliö, T., Heymans, S., Jahns, R., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht210 · Cited by 3,479
Contemporary Definitions and Classification of the Cardiomyopathies
Maron, B. J., Towbin, J. A., Thiene, G., Antzelevitch, C. N., Corrado, D., Arnett, D. K., Moss, A. J., Seidman, C. E., & Young, J. B. (2006) · Circulation · doi:10.1161/circulationaha.106.174287 · Cited by 3,424
The effect of digoxin on mortality and morbidity in patients with heart failure
(1997) · New England Journal of Medicine · doi:10.1056/nejm199702203360801 · Cited by 3,016
Burt, V. L., Whelton, P., Roccella, E. J., Brown, C., Cutler, J. A., Higgins, M., Horan, M. J., & Labarthe, D. (1995) · Hypertension · doi:10.1161/01.hyp.25.3.305 · Cited by 2,998
2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure
Heidenreich, P. A., Bozkurt, B., Aguilar, D., Allen, L. A., Byun, J. J., Colvin, M. M., Deswal, A., Drazner, M. H., Dunlay, S. M., Evers, L. R., et al. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.12.012 · Cited by 2,862
Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase
Yeung, F., Hoberg, J. E., Ramsey, C. S., Keller, M. D., Jones, D. R., Frye, R. A., & Mayo, M. W. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600244 · Cited by 2,750
Mechanisms and Functions of Inflammasomes
Lamkanfi, M., & Dixit, V. M. (2014) · Cell · doi:10.1016/j.cell.2014.04.007 · Cited by 2,579
Angiotensin–Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction
Solomon, S. D., McMurray, J. J. V., Anand, I. S., Ge, J., Lam, C. S. P., Maggioni, A. P., Martinez, F., Packer, M., Pfeffer, M. A., Pieske, B., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1908655 · Cited by 2,430
Sex and Gender Equity in Research: rationale for the SAGER guidelines and recommended use
Heidari, S., Babor, T. F., De Castro, P., Tort, S., & Curno, M. (2016) · Research Integrity and Peer Review · doi:10.1186/s41073-016-0007-6 · Cited by 2,184
Sudden Deaths in Young Competitive Athletes
Maron, B. J., Doerer, J. J., Haas, T. S., Tierney, D. M., & Mueller, F. O. (2009) · Circulation · doi:10.1161/circulationaha.108.804617 · Cited by 2,099
Cardiovascular Magnetic Resonance in Nonischemic Myocardial Inflammation
Ferreira, V. M., Schulz-Menger, J., Holmvang, G., Kramer, C. M., Carbone, I., Sechtem, U., Kindermann, I., Gutberlet, M., Cooper, L. T., Liu, P., et al. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.09.072 · Cited by 2,059
Self-citationGarg, R. (1995) · JAMA · doi:10.1001/jama.273.18.1450 · Cited by 1,993
The complex role of estrogens in inflammation
Straub, R. H. (2007) · Endocrine Reviews · doi:10.1210/er.2007-0001 · Cited by 1,950
Differential Ligand Activation of Estrogen Receptors ERα and ERβ at AP1 Sites
Paech, K., Webb, P., Kuiper, G. G. J. M., Nilsson, S., Gustafsson, J.-Å., Kushner, P. J., & Scanlan, T. S. (1997) · Science · doi:10.1126/science.277.5331.1508 · Cited by 1,861
Cleland, J. G. F. (2003) · European Heart Journal · doi:10.1016/s0195-668x(02)00823-0 · Cited by 1,553
Cooper, L. T. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0800028 · Cited by 1,325
Self-citationA Clinical Trial of Immunosuppressive Therapy for Myocarditis
Mason, J. W., O'Connell, J. B., Herskowitz, A., Rose, N. R., McManus, B. M., Billingham, M. E., & Moon, T. E. (1995) · New England Journal of Medicine · doi:10.1056/nejm199508033330501 · Cited by 1,274
Packer, M., Poole-Wilson, P. A., Armstrong, P. W., Cleland, J. G. F., Horowitz, J. D., Massie, B. M., Rydén, L., Thygesen, K., & Uretsky, B. F. (1999) · Circulation · doi:10.1161/01.cir.100.23.2312 · Cited by 1,244
Myocarditis and inflammatory cardiomyopathy: current evidence and future directions
Tschöpe, C., Ammirati, E., Bozkurt, B., Caforio, A. L. P., Cooper, L. T., Felix, S. B., Hare, J. M., Heidecker, B., Heymans, S., Hübner, N., et al. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-020-00435-x · Cited by 1,217
Self-citationSex Differences in Pharmacokinetics and Pharmacodynamics
Soldin, O. P., & Mattison, D. R. (2009) · Clinical Pharmacokinetics · doi:10.2165/00003088-200948030-00001 · Cited by 1,163
Pinto, Y. M., Elliot, P. M., Arbustini, E., Adler, Y., Anastasakis, A., Böhm, M., Duboc, D., Gimeno, J. R., de Groote, P., Imazio, M., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehv727 · Cited by 1,122
Molecular and Cellular Basis of Cardiovascular Gender Differences
Mendelsohn, M. E., & Karas, R. H. (2005) · Science · doi:10.1126/science.1112062 · Cited by 1,105
Dilated cardiomyopathy: the complexity of a diverse genetic architecture
Hershberger, R. E., Hedges, D. J., & Morales, A. (2013) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2013.105 · Cited by 1,036
Bozkurt, B., Colvin, M. M., Cook, J., Cooper, L. T., Deswal, A. M., Fonarow, G. C., Francis, G. S., Lenihan, D. J., Lewis, E. F., McNamara, D. M., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000455 · Cited by 920
Self-citationSex differences in heart failure
Lam, C. S. P., Arnott, C. G., Beale, A. L., Chandramouli, C., Hilfiker‐Kleiner, D., Kaye, D. M., Ky, B., Santema, B. T., Sliwa, K. S., & Voors, A. A. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehz835 · Cited by 873
Estrogen signaling: a subtle balance between ER alpha and ER beta.
Matthews, J., & Gustafsson, J. (2003) · Molecular Interventions · doi:10.1124/mi.3.5.281 · Cited by 844
Gray, H., Gray, H., & Lewis, W. H. (1918) · Lea & Febiger eBooks · doi:10.5962/bhl.title.20311 · Cited by 839
Report of the WHO/ISFC task force on the definition and classification of cardiomyopathies.
(1980) · Heart · doi:10.1136/hrt.44.6.672 · Cited by 757
A Fully Magnetically Levitated Circulatory Pump for Advanced Heart Failure
Mehra, M. R., Naka, Y., Uriel, N. Y., Goldstein, D. J., Cleveland, J. C., Colombo, P. C., Walsh, M. N., Milano, C. A., Patel, C. B., Jorde, U. P., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1610426 · Cited by 751
Al‐Khatib, S. M., Stevenson, W. G., Ackerman, M. J., Bryant, W. J., Callans, D. J., Curtis, A. B., Deal, B. J., Dickfeld, T. M., Field, M. E., Fonarow, G. C., et al. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2017.10.035 · Cited by 743
Schultheiss, H.-P., Fairweather, D., Caforio, A. L. P., Escher, F., Hershberger, R. E., Lipshultz, S. E., Liu, P. P., Matsumori, A., Mazzanti, A., McMurray, J., et al. (2019) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0084-1 · Cited by 720
Self-citationKühl, U., Pauschinger, M., Noutsias, M., Seeberg, B., Bock, C. –., Laßner, D., Poller, W. C., Kandolf, R., & Schultheiß, H. (2005) · Circulation · doi:10.1161/01.cir.0000155616.07901.35 · Cited by 710
Repression of the Interleukin-6 Promoter by Estrogen Receptor Is Mediated by NF-κB and C/EBPβ
Stein, B., & Yang, M. X. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.9.4971 · Cited by 702
Sex-Based Differences in the Effect of Digoxin for the Treatment of Heart Failure
Rathore, S. S., Wang, Y., & Krumholz, H. M. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021266 · Cited by 688
Predictors of Outcome in Patients With Suspected Myocarditis
Kindermann, I., Kindermann, M., Kandolf, R., Klingel, K., Bültmann, B. D., Müller, T. M., Lindinger, A., & Böhm, M. (2008) · Circulation · doi:10.1161/circulationaha.108.769489 · Cited by 676
Packer, M. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.03.509 · Cited by 656
Konstam, M. A., Neaton, J. D., Dickstein, K., Drexler, H., Komajda, M., Martinez, F. A., Riegger, G. A., Malbecq, W., Smith, R. D., Guptha, S., et al. (2009) · The Lancet · doi:10.1016/s0140-6736(09)61913-9 · Cited by 646
Codd, M., SUGRUE, D. D., Gersh, B. J., & Melton, L. J. (1989) · Circulation · doi:10.1161/01.cir.80.3.564 · Cited by 638
Shared Genetic Predisposition in Peripartum and Dilated Cardiomyopathies
Ware, J. S., Li, J., Mazaika, E., Yasso, C. M., DeSouza, T., Cappola, T. P., Tsai, E. J., Hilfiker‐Kleiner, D., Kamiya, C., Mazzarotto, F., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1505517 · Cited by 625
Kociol, R. D., Cooper, L. T., Fang, J. C., Moslehi, J. J., Pang, P. S., Sabe, M. A., Shah, R. V., Sims, D. B., Thiene, G., Vardeny, O., et al. (2020) · Circulation · doi:10.1161/cir.0000000000000745 · Cited by 625
Self-citationThe Girl Who Cried Pain: A Bias against Women in the Treatment of Pain
Hoffmann, D. E., & Tarzian, A. J. (2001) · Journal of Law, Medicine & Ethics · doi:10.1111/j.1748-720x.2001.tb00037.x · Cited by 622
Comparison of Omapatrilat and Enalapril in Patients With Chronic Heart Failure
Packer, M., Califf, R. M., Konstam, M. A., Krum, H., McMurray, J. J. V., Rouleau, J. L., & Swedberg, K. B. (2002) · Circulation · doi:10.1161/01.cir.0000029801.86489.50 · Cited by 612
Exploring the Biological Contributions to Human Health: Does Sex Matter?
(2001) · Journal of Women s Health & Gender-Based Medicine · doi:10.1089/152460901300233902 · Cited by 611
Gender differences and aging: Effects on the human heart
Olivetti, G., Giordano, G., Corradi, D., Melissari, M., Lagrasta, C. A. M., Gambert, S. R., & Anversa, P. (1995) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(95)00282-8 · Cited by 580
Johnson, J. L., Greaves, L., & Repta, R. (2009) · International Journal for Equity in Health · doi:10.1186/1475-9276-8-14 · Cited by 534
Oestrogen and inhibition of oxidation of low-density lipoproteins in postmenopausal women
Sack, M. N., Rader, D. J., & Cannon, R. O. (1994) · The Lancet · doi:10.1016/s0140-6736(94)91117-7 · Cited by 525
Stehlik, J., Edwards, L. B., Kucheryavaya, A. Y., Benden, C., Christie, J. D., Dobbels, F., Kirk, R., Rahmel, A. O., & Hertz, M. I. (2011) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2011.08.003 · Cited by 496
Shekelle, P. G., Rich, M. W., Morton, S. C., Atkinson, C. S. W., Tu, W., Maglione, M., Rhodes, S., Barrett, M., Fonarow, G. C., Greenberg, B., et al. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00262-6 · Cited by 492
Truncating FLNC Mutations Are Associated With High-Risk Dilated and Arrhythmogenic Cardiomyopathies
Ortiz-Genga, M., Cuenca, S., Ferro, M. D., Zorio, E., Salgado‐Aranda, R., Climent, V. E., Padrón-Barthe, L., Duro-Aguado, I., Jiménez‐Jáimez, J., Hidalgo-Olivares, V. M., et al. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.09.927 · Cited by 488
Caforio, A. L. P., Calabrese, F., Angelini, A., Tona, F., Vinci, A., Bottaro, S., Ramondo, A. B., Carturan, E., Iliceto, S., Thiene, G., et al. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm076 · Cited by 487
Genetic mutations and mechanisms in dilated cardiomyopathy
McNally, E. M., Golbus, J. R., & Puckelwartz, M. J. (2013) · Journal of Clinical Investigation · doi:10.1172/jci62862 · Cited by 482
Lindberg, M. K., Movérare, S., Skrtic, S., Gao, H., Dahlman‐Wright, K., Gustafsson, J.-Α., & Ohlsson, C. (2003) · Molecular Endocrinology · doi:10.1210/me.2002-0206 · Cited by 479
Shah, A. M., Claggett, B., Sweitzer, N. K., Shah, S. J., Anand, I. S., Liu, L., Pitt, B., Pfeffer, M. A., & Solomon, S. D. (2015) · Circulation · doi:10.1161/circulationaha.115.015884 · Cited by 478
Inflammatory Markers and Incident Heart Failure Risk in Older Adults
Kalogeropoulos, A., Georgiopoulou, V., Psaty, B. M., Rodondi, N., Smith, A. L., Harrison, D. G., Liu, Y., Hoffmann, U., Bauer, D. C., Newman, A. B., et al. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.12.045 · Cited by 478
Estrogen alters thresholds for B cell apoptosis and activation
Grimaldi, C. M., Cleary, J., Dagtas, A. S., Moussai, D., & Diamond, B. (2002) · Journal of Clinical Investigation · doi:10.1172/jci14873 · Cited by 461
Sex differences in primary hypertension
Sandberg, K. L., & Ji, H. (2012) · Biology of Sex Differences · doi:10.1186/2042-6410-3-7 · Cited by 459
Fung, G., Luo, H., Qiu, Y., Yang, D., & McManus, B. (2016) · Circulation Research · doi:10.1161/circresaha.115.306573 · Cited by 444
Estrogen alters thresholds for B cell apoptosis and activation
Grimaldi, C. M., Cleary, J., Dagtas, A. S., Moussai, D., & Diamond, B. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0214873 · Cited by 427
Renin angiotensin system and gender differences in the cardiovascular system
Fischer, M. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(01)00479-5 · Cited by 384
Musunuru, K., Hershberger, R. E., Day, S. M., Klinedinst, N. J., Landstrom, A. P., Parikh, V. N., Prakash, S. K., Semsarian, C., & Sturm, A. C. (2020) · Circulation Genomic and Precision Medicine · doi:10.1161/hcg.0000000000000067 · Cited by 382
Gender differences in the cardiovascular effect of sex hormones
Vitale, C., Mendelsohn, M. E., & Rosano, G. M. C. (2009) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2009.105 · Cited by 375
Quaderi, N. A., Schweiger, S., Gaudenz, K., Franco, B., Rugarli, E. I., Berger, W., Feldman, G. J., Volta, M., Andolfi, G., Gilgenkrantz, S., et al. (1997) · Nature Genetics · doi:10.1038/ng1197-285 · Cited by 363
Induction of regulatory T cells by physiological level estrogen
Tai, P., Wang, J., Jin, H., Song, X., Yan, J., Kang, Y., Zhao, L., An, X., Du, X., Chen, X., et al. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21221 · Cited by 359
Baldeviano, G. C., Barin, J. G., Talor, M. V., Srinivasan, S., Bedja, D., Zheng, D., Gabrielson, K., Iwakura, Y., Rose, N. R., & Cihakova, D. (2010) · Circulation Research · doi:10.1161/circresaha.109.213157 · Cited by 334
Regensteiner, J. G., Golden, S., Huebschmann, A. G., Barrett-Connor, E., Chang, A. Y., Chyun, D., Fox, C. S., Kim, C., Mehta, N., Reckelhoff, J. F., et al. (2015) · Circulation · doi:10.1161/cir.0000000000000343 · Cited by 334
From Infection to Autoimmunity
Fairweather, D., Kaya, Z., Shellam, G. R., Lawson, C. M., & Rose, N. R. (2001) · Journal of Autoimmunity · doi:10.1006/jaut.2000.0492 · Cited by 328
Self-citationSex and Gender Differences in Myocarditis and Dilated Cardiomyopathy
Fairweather, D., Cooper, L. T., & Blauwet, L. A. (2013) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2012.07.003 · Cited by 325
Self-citationGender differences in the effects of cardiovascular drugs
Tamargo, J. L., Rosano, G. M. C., Walther, T., Duarte, J., Niessner, A., Kaski, J., Ceconi, C., Drexel, H., Kjeldsen, K. P., Savarese, G., et al. (2016) · European Heart Journal - Cardiovascular Pharmacotherapy · doi:10.1093/ehjcvp/pvw042 · Cited by 325
Sexual dimorphism of humoral immunity with human vaccines
Cook, I. F. (2008) · Vaccine · doi:10.1016/j.vaccine.2008.04.054 · Cited by 320
Hypertension Screening of 1 Million Americans
Stamler, J. (1976) · JAMA · doi:10.1001/jama.1976.03260470017018 · Cited by 295
Adams, K. F., Patterson, J. H., Gattis, W. A., O’Connor, C. M., Lee, C. R., Schwartz, T. A., & Gheorghiade, M. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.02.091 · Cited by 293
Molina, D. K., & DiMaio, V. J. M. (2011) · American Journal of Forensic Medicine & Pathology · doi:10.1097/paf.0b013e31823d29ad · Cited by 292
Wahbi, K., Yaou, R. B., Gandjbakhch, E., Anselme, F., Gossios, T. D., Lakdawala, N. K., Stalens, C., Sacher, F., Babuty, D., Trochu, J., et al. (2019) · Circulation · doi:10.1161/circulationaha.118.039410 · Cited by 292
Gender differences in advanced heart failure: insights from the BEST study
Ghali, J. K., Krause-Steinrauf, H. J., Adams, K. F., Khan, S. S., Rosenberg, Y., Yancy, C. W., Young, J. B., Goldman, S., Peberdy, M. A., & Lindenfeld, J. M. (2003) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.05.012 · Cited by 291
Curtis, L. H., Al‐Khatib, S. M., Shea, A. M., Hammill, B. G., Hernandez, A. F., & Schulman, K. A. (2007) · JAMA · doi:10.1001/jama.298.13.1517 · Cited by 289
Therapeutic implications of the gender-specific aspects of cardiovascular disease
Regitz‐Zagrosek, V. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2032 · Cited by 288
Estradiol Down‐Regulates LPS‐Induced Cytokine Production and NFkB Activation in Murine Macrophages
Deshpande, R. R., Khalili, H., Pergolizzi, R. G., Michael, S. D., & Chang, M.-D. Y. (1997) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.1997.tb00275.x · Cited by 285
Sex Differences in the Prognosis of Congestive Heart Failure
Simon, T., Mary‐Krause, M., Funck‐Brentano, C., & Jaillon, P. (2001) · Circulation · doi:10.1161/01.cir.103.3.375 · Cited by 277
Female-specific aspects in the pharmacotherapy of chronic cardiovascular diseases
Jochmann, N., Stangl, K., Garbe, E., Baumann, G., & Stangl, V. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi397 · Cited by 273
O’Meara, E., Clayton, T. C., McEntegart, M. B., McMurray, J. J. V., Piña, I. L., Granger, C. B., Östergren, J., Michelson, E. L., Solomon, S. D., Pocock, S., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.673442 · Cited by 273
Baumhäkel, M., Müller, U., & Böhm, M. (2009) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfn041 · Cited by 260
The MOGE(S) Classification for a Phenotype–Genotype Nomenclature of Cardiomyopathy
Arbustini, E., Narula, N., Dec, G. W., Reddy, K. S., Greenberg, B., Kushwaha, S. S., Marwick, T. H., Pinney, S., Bellazzi, R., Favalli, V., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.08.1644 · Cited by 260
Santema, B. T., Ouwerkerk, W., Tromp, J., Sama, I. E., Ravera, A., Regitz‐Zagrosek, V., Hillege, H. L., Samani, N. J., Zannad, F. M., Dickstein, K., et al. (2019) · The Lancet · doi:10.1016/s0140-6736(19)31792-1 · Cited by 259
Sex Matters: A Comprehensive Comparison of Female and Male Hearts
Pierre, S. R. S., Peirlinck, M., & Ellen Kuhl, A. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.831179 · Cited by 254
Ito, A., Bebo, B. F., Matejuk, A., Zamora, A., Silverman, M., Fyfe‐Johnson, A. L., & Offner, H. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.1.542 · Cited by 252
González, J. A. G., Moral, F., Elvira, J., García-Gil, D., Guerrero, F., Gavilán, I., & Escobar, L. (2000) · European Journal of Endocrinology · doi:10.1530/eje.0.1430031 · Cited by 251
Chung, A. K., Das, S. R., Leonard, D. S., Peshock, R. M., Kazi, F., Abdullah, S. M., Canham, R. M., Levine, B. D., & Drazner, M. H. (2006) · Circulation · doi:10.1161/circulationaha.105.574400 · Cited by 250
UNCOMMON MYOCARDIAL DISEASES THE NON-CORONARY CARDIOMYOPATHIES*
BRIGDEN, W. (1957) · The Lancet · doi:10.1016/s0140-6736(57)91537-4 · Cited by 246
Huber, S. A., & Pfaeffle, B. (1994) · Journal of Virology · doi:10.1128/jvi.68.8.5126-5132.1994 · Cited by 245
Gender Differences in Left Ventricular Growth
SIMONE, G. D., Devereux, R. B., Daniels, S. R., & Meyer, R. A. (1995) · Hypertension · doi:10.1161/01.hyp.26.6.979 · Cited by 245
Clinical and Demographic Predictors of Outcomes in Recent Onset Dilated Cardiomyopathy
McNamara, D. M., Starling, R. C., Cooper, L. T., BOEHMER, J. P., Mather, P. J., Janosko, K. M., Gorcsan, J., Kip, K. E., & Dec, G. W. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.05.033 · Cited by 243
Self-citationPaharkova, V., Maldonado, R., & Kovats, S. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.3.1426 · Cited by 236
Lam, C. S. P., Carson, P. E., Anand, I. S., Rector, T. S., Kuskowski, M. A., Michel Komajda, N., McKelvie, R. S., McMurray, J. J. V., Zile, M. R., Massie, B. M., et al. (2012) · Circulation Heart Failure · doi:10.1161/circheartfailure.112.970061 · Cited by 233
Metoprolol CR/XL in Female Patients With Heart Failure
Ghali, J. K., Piña, I. L., Gottlieb, S. S., DEEDWANIA, P. C., & Wikstrand, J. (2002) · Circulation · doi:10.1161/01.cir.0000012546.20194.33 · Cited by 231
Cardiac myosin-Th17 responses promote heart failure in human myocarditis
Myers, J. M., Cooper, L. T., Kem, D. C., Stavrakis, S., Kosanke, S. D., Shevach, E. M., Fairweather, D., Stoner, J. A., Cox, C. J., & Cunningham, M. W. (2016) · JCI Insight · doi:10.1172/jci.insight.85851 · Cited by 230
Self-citationFairweather, D., Yusung, S., Frisancho, S., Barrett, M., Gatewood, S., Steele, R., & Rose, N. R. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.9.4731 · Cited by 229
Self-citationKayvanpour, E., Sedaghat‐Hamedani, F., Amr, A., Lai, A., Haas, J., Holzer, D. B., Frese, K., Keller, A., Jensen, K., Katus, H. A., et al. (2016) · Clinical Research in Cardiology · doi:10.1007/s00392-016-1033-6 · Cited by 229
Cardiac Autoimmunity: Myocarditis
Bracamonte-Baran, W., & Čiháková, D. (2017) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-57613-8_10 · Cited by 228
Hodgin, J. B., Krege, J. H., Reddick, R. L., Korach, K. S., Smithies, O., & Maeda, N. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11320 · Cited by 221
Cardiac Resynchronization Therapy in Women
Zusterzeel, R., Selzman, K. A., Sanders, W. E., Caños, D., O’Callaghan, K. M., Carpenter, J., Piña, I. L., & Strauss, D. G. (2014) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2014.2717 · Cited by 213
Frisancho-Kiss, S., Davis, S. E., Nyland, J. F., Frisancho, J. A., Cihakova, D., Barrett, M. A., Rose, N. R., & Fairweather, D. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.11.6710 · Cited by 212
Self-citationLi, K., Xu, W., Guo, Q., Jiang, Z., Wang, P., Yue, Y., & Xiong, S. (2009) · Circulation Research · doi:10.1161/circresaha.109.195230 · Cited by 211
Effects of gonadectomy and hormonal replacement on rat hearts.
Scheuer, J., Malhotra, A., Schaible, T., & Capasso, J. M. (1987) · Circulation Research · doi:10.1161/01.res.61.1.12 · Cited by 209
Genetic and hormonal factors in female-biased autoimmunity
Rubtsov, A. V., Rubtsova, K., Kappler, J. W., & Marrack, P. (2010) · Autoimmunity Reviews · doi:10.1016/j.autrev.2010.02.008 · Cited by 207
Merrill, M. E., Sweitzer, N. K., Lindenfeld, J., & Kao, D. P. (2019) · JACC Heart Failure · doi:10.1016/j.jchf.2019.01.003 · Cited by 206
Recent advances in understanding sex differences in cardiac repolarization
James, A. F., Choisy, S. C. M., & Hancox, J. C. (2005) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2005.05.010 · Cited by 205
Souyris, M., Mejía, J. E., Chaumeil, J., & Guéry, J. (2018) · Seminars in Immunopathology · doi:10.1007/s00281-018-0712-y · Cited by 202
Enhanced FoxP3 expression and Treg cell function in pregnant and estrogen-treated mice
Polanczyk, M. J., Hopke, C., Huan, J., Vandenbark, A. A., & Offner, H. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.08.023 · Cited by 200
Fairweather, D., Frisancho-Kiss, S., Yusung, S. A., Barrett, M. A., Davis, S. E., Gatewood, S. J. L., Njoku, D. B., & Rose, N. R. (2004) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63241-5 · Cited by 198
Self-citationA Novel Circulating Noncoding Small RNA for the Detection of Acute Myocarditis
Blanco-Domínguez, R., Sánchez-Díaz, R., de la Fuente, H., Jiménez-Borreguero, L. J., Matesanz-Marín, A., Relaño, M., Jiménez-Alejandre, R., Linillos-Pradillo, B., Tsilingiri, K., Martín-Mariscal, M. L., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2003608 · Cited by 196
Self-citationUNCOMMON MYOCARDIAL DISEASES THE NON-CORONARY CARDIOMYOPATHIES
Brigden, W. (1957) · The Lancet · doi:10.1016/s0140-6736(57)90159-9 · Cited by 196
Magnani, J. W., Danik, H. J. S., Dec, G. W., & DiSalvo, T. G. (2006) · American Heart Journal · doi:10.1016/j.ahj.2005.03.037 · Cited by 195
Dannenberg, A. L., Levy, D. A., & Garrison, R. J. (1989) · The American Journal of Cardiology · doi:10.1016/0002-9149(89)90816-3 · Cited by 194
Burden of Sudden Cardiac Death in Persons Aged 1 to 49 Years
Risgaard, B., Winkel, B. G., Jabbari, R., Behr, E. R., Hansen, O. I., Thomsen, J. L., Ottesen, G. L., Gislason, G., Bundgaard, H., Haunsø, S., et al. (2014) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.113.001421 · Cited by 193
Sex is a potent modifier of the cardiovascular system
Leinwand, L. A. (2003) · Journal of Clinical Investigation · doi:10.1172/jci19429 · Cited by 190
Sex Differences in Heart Failure
Lala, A., Tayal, U., HAMO, C. E., Youmans, Q. R., Al‐Khatib, S. M., Bozkurt, B., Davis, M. B., Januzzi, J. L., Mentz, R. J., Sauer, A. J., et al. (2021) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2021.10.006 · Cited by 189
Akhtar, M. M., Lorenzini, M., Cicerchia, M., Ochoa, J. P., Hey, T. M., Molina, M. S., Restrepo-Córdoba, M. A., Ferro, M. D., Stolfo, D., Johnson, R., et al. (2020) · Circulation Heart Failure · doi:10.1161/circheartfailure.119.006832 · Cited by 187
Sex differences in inflammation, redox biology, mitochondria and autoimmunity
Di Florio, D. N., Sin, J., Coronado, M. J., Atwal, P. S., & Fairweather, D. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101482 · Cited by 185
Self-citationPacker, M., Lam, C. S. P., Lund, L. H., Maurer, M. S., & Borlaug, B. A. (2020) · European Journal of Heart Failure · doi:10.1002/ejhf.1902 · Cited by 185
Rosano, G. M. C., Lewis, B. S., Agewall, S., Waßmann, S., Vitale, C., Schmidt, H. H. H. W., Drexel, H., Patak, A., Torp-Pedersen, C. T., Kjeldsen, K. P., et al. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv161 · Cited by 182
Cardiac fibroblasts mediate IL-17A–driven inflammatory dilated cardiomyopathy
Wu, L., Ong, S., Talor, M. V., Barin, J. G., Baldeviano, G. C., Kass, D. A., Bedja, D., Zhang, H., Sheikh, A., Margolick, J. B., et al. (2014) · Journal of Experimental Medicine · doi:10.1084/jem.20132126 · Cited by 181
The Role of Estrogen Receptors and Androgen Receptors in Sex Steroid Regulation of B Lymphopoiesis
Smithson, G. M., Couse, J. F., Lubahn, D. B., Korach, K. S., & Kincade, P. W. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.1.27 · Cited by 176
Afanasyeva, M., Wang, Y., Kaya, Z., Park, S., Zilliox, M. J., Schofield, B. H., Hill, S. L., & Rose, N. R. (2001) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)61685-9 · Cited by 175
Rettew, J. A., Huet, Y. M., & Marriott, I. (2009) · Endocrinology · doi:10.1210/en.2009-0098 · Cited by 175
Androgen Receptor Expression Is Greater in Macrophages From Male Than From Female Donors
McCrohon, J. A., Death, A. K., Nakhla, S., Jessup, W., Handelsman, D. J., Stanley, K. K., & Celermajer, D. S. (2000) · Circulation · doi:10.1161/01.cir.101.3.224 · Cited by 173
Sex Differences in Inflammation during Atherosclerosis
Fairweather, D. (2014) · Clinical Medicine Insights Cardiology · doi:10.4137/cmc.s17068 · Cited by 172
Self-citationIn Vivo Effects of Sex Steroids on Lymphocyte Responsiveness and Immunoglobulin Levels in Humans
Giltay, E. J., Fonk, J. C. M., Blomberg, B. M. E. V., Drexhage, H. A., Schalkwijk, C., & Gooren, L. J. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.4.6562 · Cited by 170
INTERMACS Analysis of Stroke During Support With Continuous-Flow Left Ventricular Assist Devices
Acharya, D., Loyaga‐Rendon, R. Y., Morgan, C. J., Sands, K. A., Pamboukian, S. V., Rajapreyar, I. N., Holman, W. L., Kirklin, J. K., & Tallaj, J. A. (2017) · JACC Heart Failure · doi:10.1016/j.jchf.2017.06.014 · Cited by 170
Sex in basic research: concepts in the cardiovascular field
Ventura‐Clapier, R., Dworatzek, E., Seeland, U., Kararigas, G., Arnal, J., Brunelleschi, S., Carpenter, T., Erdmann, J., Franconi, F., Giannetta, E., et al. (2017) · Cardiovascular Research · doi:10.1093/cvr/cvx066 · Cited by 169
Santangeli, P., Pelargonio, G., Russo, A. D., Casella, M., Bisceglia, C., Bartoletti, S., Santarelli, P., Biase, L. D., & Natale, A. (2010) · Heart Rhythm · doi:10.1016/j.hrthm.2010.03.042 · Cited by 167
Interferon-γ levels are upregulated by 17-β-estradiol and diethylstilbestrol
Karpuzoglu-Sahin, E., Hissong, B. D., & Ahmed, S. A. (2001) · Journal of Reproductive Immunology · doi:10.1016/s0165-0378(01)00117-6 · Cited by 167
Estrogen inhibition of EAE involves effects on dendritic cell function
Liu, H. Y., Buenafe, A. C., Matejuk, A., Ito, A., Zamora, A., Dwyer, J. M., Vandenbark, A. A., & Offner, H. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10409 · Cited by 166
Update on coxsackievirus B3 myocarditis
Fairweather, D., Stafford, K. A., & Sung, Y. K. (2012) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e328353372d · Cited by 165
Self-citationReciprocal Antagonism Between Estrogen Receptor and NF-κB Activity In Vivo
Evans, M. J., Eckert, A., Lai, K., Adelman, S. J., & Harnish, D. C. (2001) · Circulation Research · doi:10.1161/hh2101.098543 · Cited by 164
Sex is a potent modifier of the cardiovascular system
Leinwand, L. A. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319429 · Cited by 161
Gender-Specific Differences in Major Cardiac Events and Mortality in Lamin A/C Mutation Carriers
van Rijsingen, I. A. W., Nannenberg, E. A., Arbustini, E., Elliot, P. M., Mogensen, J., Ast, J. F. H.-V., van der Kooi, A. J., van Tintelen, J. P., van den Berg, M. P., Grasso, M., et al. (2012) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfs191 · Cited by 151
Sex-Related Differences in Heart Failure With Preserved Ejection Fraction
Dewan, P., Rørth, R., Raparelli, V., Campbell, R. T., Shen, L., Jhund, P. S., Petrie, M. C., Anand, I. S., Carson, P. E., Desai, A. S., et al. (2019) · Circulation Heart Failure · doi:10.1161/circheartfailure.119.006539 · Cited by 151
Acute Myocarditis Associated With Desmosomal Gene Variants
Ammirati, E., Raimondi, F., Piriou, N., Sardo Infirri, L., Mohiddin, S. A., Mazzanti, A., Shenoy, C., Cavallari, U. A., Imazio, M., Aquaro, G. D., et al. (2022) · JACC: Heart Failure · doi:10.1016/j.jchf.2022.06.013 · Cited by 150
Self-citationPetrie, M. C., Dawson, N., Murdoch, D. R., Davie, A. P., & McMurray, J. J. V. (1999) · Circulation · doi:10.1161/01.cir.99.17.2334 · Cited by 150
Varshney, A. S., Berg, D. D., Katz, J. N., Baird-Zars, V. M., Bohula, E. A., Carnicelli, A., Chaudhry, S., Guo, J., Lawler, P. R., Nativi-Nicolau, J. N., et al. (2020) · JAMA Cardiology · doi:10.1001/jamacardio.2020.0692 · Cited by 150
Braunwald, E. (2017) · Circulation Research · doi:10.1161/circresaha.117.311812 · Cited by 150
Sex- and Age-Based Differences in the Natural History and Outcome of Dilated Cardiomyopathy
Halliday, B. P., Gulati, A., Ali, A., Newsome, S., Lota, A. S., Tayal, U., Vassiliou, V. S., Aržanauskaitė, M., İzgi, C., Krishnathasan, K., et al. (2018) · European Journal of Heart Failure · doi:10.1002/ejhf.1216 · Cited by 148
Sex-based Biology and the Rational Design of Influenza Vaccination Strategies
Klein, S. L., & Pekosz, A. S. (2014) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiu066 · Cited by 144
Frisancho-Kiss, S., Coronado, M. J., Frisancho, J. A., Lau, V. M., Rose, N. R., Klein, S. L., & Fairweather, D. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2008.12.002 · Cited by 143
Self-citationLambert, K. C., Curran, E. M., Judy, B. M., Milligan, G. N., Lubahn, D. B., & Estes, D. M. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.9.5716 · Cited by 142
Cavasin, M. A., Tao, Z.-Y., Yu, A.-L., & Yang, X.-P. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01121.2005 · Cited by 141
Genetics of Myocarditis in Arrhythmogenic Right Ventricular Dysplasia
Lopez-Ayala, J. M., Pastor-Quirante, F., Gonzalez-Carrillo, J., Lopez-Cuenca, D., Sanchez-Munoz, J. J., Oliva-Sandoval, M. J., & Gimeno, J. R. (2015) · Heart Rhythm · doi:10.1016/j.hrthm.2015.01.001 · Cited by 140
Molina, D. K., & DiMaio, V. J. M. (2011) · American Journal of Forensic Medicine & Pathology · doi:10.1097/paf.0b013e31823d298b · Cited by 139
Chadwick, C. C., Chippari, S. M., Matelan, E. M., Borges-Marcucci, L., Eckert, A. M., Keith, J. C., Albert, L. M., Leathurby, Y., Harris, H. A., Bhat, R. A., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405841102 · Cited by 137
Distinct Patterns of Sirtuin Expression During Progression of Alzheimer’s Disease
Lutz, M. I., Milenković, I., Regelsberger, G., & Kovács, G. G. (2014) · NeuroMolecular Medicine · doi:10.1007/s12017-014-8288-8 · Cited by 134
Fairweather, D., Frisancho-Kiss, S., Yusung, S. A., Barrett, M. A., Davis, S. E., Steele, R. A., Gatewood, S. J. L., & Rose, N. R. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.1.261 · Cited by 133
Self-citationMolina, D. K., & DiMaio, V. J. M. (2015) · American Journal of Forensic Medicine & Pathology · doi:10.1097/paf.0000000000000174 · Cited by 133
Autosomal Recessive Cardiomyopathy Presenting as Acute Myocarditis
Belkaya, S., Kontorovich, A., Byun, M., Mulero‐Navarro, S., Bajolle, F., Cobat, A., Josowitz, R., Itan, Y., Quint, R., Lorenzo, L., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.01.043 · Cited by 132
Bazett, H. C. (1920) · The Journal of Physiology · doi:10.1113/jphysiol.1920.sp001881 · Cited by 127
Sex Differences in Advanced Heart Failure Therapies
Hsich, E. (2019) · Circulation · doi:10.1161/circulationaha.118.037369 · Cited by 127
The effects of gender and age on occurrence of clinically suspected myocarditis in adulthood
Kytö, V., Sipilä, J., & Rautava, P. (2013) · Heart · doi:10.1136/heartjnl-2013-304449 · Cited by 124
Estrogen, natriuretic peptides and the renin-angiotensin system.
Kuroski de Bold, M. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(98)00324-1 · Cited by 122
Carreras, E., Turner, S., Paharkova, V., Mao, A., Dascher, C. C., & Kovats, S. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.2.727 · Cited by 122
Sobolewska, A., Gajewska, M., Zarzynska, J. M., Gajkowska, B., & Motyl, T. (2008) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2008.09.004 · Cited by 121
Editorial policies for sex and gender analysis
Schiebinger, L. L., Leopold, S. S., & Miller, V. M. (2016) · The Lancet · doi:10.1016/s0140-6736(16)32392-3 · Cited by 118
Hudson, M., Rahme, E., Behlouli, H., Sheppard, R. J., & Pilote, L. (2007) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2007.02.001 · Cited by 117
Coronado, M. J., Brandt, J. E., Kim, E., Bucek, A., Bedja, D., Abston, E. D., Shin, J., Gabrielson, K. L., Mitzner, W., & Fairweather, D. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00783.2011 · Cited by 116
Self-citationFairweather, D., Frisancho-Kiss, S., Gatewood, S., Njoku, D., Steele, R., Barrett, M., & Rose, N. R. (2004) · Autoimmunity · doi:10.1080/0891693042000196200 · Cited by 115
Self-citationCocker, M. S., Abdel-Aty, H., Strohm, O., & Friedrich, M. G. (2009) · Heart · doi:10.1136/hrt.2008.164061 · Cited by 115
Atherosclerosis and sex hormones: current concepts.
Villablanca, A., Jayachandran, M., & Banka, C. (2010) · Clinical science · doi:10.1042/cs20100248 · Cited by 115
DeFilippis, E. M., Truby, L., Garan, A. R., Givens, R. C., Takeda, K., Takayama, H., Naka, Y., Haythe, J. H., FARR, M. A., & Topkara, V. K. (2019) · JACC Heart Failure · doi:10.1016/j.jchf.2019.01.008 · Cited by 112
Age and Gender Effects on Cardiomyocyte Apoptosis in the Normal Human Heart
Mallat, Z., Fornés, P., Costagliola, R., Esposito, B., Belmin, J., Lecomte, D., & Tedgui, A. (2001) · The Journals of Gerontology Series A · doi:10.1093/gerona/56.11.m719 · Cited by 111
Douin‐Echinard, V., Laffont, S., Seillet, C., Delpy, L., Krust, A., Chambon, P., Gourdy, P., Arnal, J., & Guéry, J. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.6.3661 · Cited by 109
Wang, J. M., Irwin, R. W., & Brinton, R. D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608128103 · Cited by 104
Robinson, D. P., Huber, S. A., Moussawi, M., Roberts, B., Teuscher, C., Watkins, R., Arnold, A. P., & Klein, S. L. (2011) · Biology of Sex Differences · doi:10.1186/2042-6410-2-8 · Cited by 102
Sex- and estrogen-dependent regulation of a miRNA network in the healthy and hypertrophied heart
Queirós, A. M., Eschen, C., Fliegner, D., Kararigas, G., Dworatzek, E., Westphal, C., Sanchez‐Ruderisch, H., & Regitz‐Zagrosek, V. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.09.002 · Cited by 102
The Pathogenesis and Long-Term Consequences of COVID-19 Cardiac Injury
Siripanthong, B., Asatryan, B., Hanff, T. C., Chatha, S., Khanji, M. Y., Ricci, F., Muser, D., Ferrari, V. A., Nazarian, S., Santangeli, P., et al. (2022) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2021.10.011 · Cited by 102
Self-citationMolina, D. K., & DiMaio, V. J. M. (2015) · American Journal of Forensic Medicine & Pathology · doi:10.1097/paf.0000000000000175 · Cited by 102
Extracellular vesicles as personalized medicine
Beetler, D. J., Di Florio, D. N., Bruno, K. A., Ikezu, T., March, K. L., Cooper, L. T., Wolfram, J., & Fairweather, D. (2023) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2022.101155 · Cited by 101
Self-citationManagement of patients with heart failure in clinical practice: differences between men and women
Lenzen, M. J., Rosengren, A., Reimer, W. J. M. S. O., Folláth, F., Boersma, E. H., Simoons, M. L., Cleland, J. G. F., & Michel Komajda, N. (2007) · Heart · doi:10.1136/hrt.2006.099523 · Cited by 100
Eosinophil-derived IL-4 drives progression of myocarditis to inflammatory dilated cardiomyopathy
Diny, N. L., Baldeviano, G. C., Talor, M. V., Barin, J. G., Ong, S., Bedja, D., Hays, A. G., Gilotra, N. A., Coppens, I., Rose, N. R., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20161702 · Cited by 99
Elevated Sera sST2 Is Associated With Heart Failure in Men ≤50 Years Old With Myocarditis
Coronado, M. J., Bruno, K. A., Blauwet, L. A., Tschöpe, C., Cunningham, M. W., Pankuweit, S., van Linthout, S., Jeon, E., McNamara, D. M., Krejčí, J., et al. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.118.008968 · Cited by 99
Self-citationEffects of aging on cardiac extracellular matrix in men and women
Dworatzek, E., Baczkó, I., & Kararigas, G. (2015) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201500031 · Cited by 99
Bogaev, R. C., Pamboukian, S. V., Moore, S. A., Chen, L., John, R., Boyle, A. J., Sundareswaran, K. S., Farrar, D. J., & Frazier, O. H. (2011) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2010.12.009 · Cited by 98
Lyden, D. C., Olszewski, J., Feran, M., Job, L. P., & Huber, S. A. (1987) · PubMed Central · Cited by 97
Hey, T. M., Rasmussen, T. B., Madsen, T., Aagaard, M. M., Harbo, M., Mølgaard, H., Møller, J. E., Eiskjær, H., & Mogensen, J. (2019) · Circulation Heart Failure · doi:10.1161/circheartfailure.118.005700 · Cited by 96
Myopathic Cardiac Genotypes Increase Risk for Myocarditis
Kontorovich, A. R., Patel, N., Moscati, A., Richter, F., Peter, I., Purevjav, E., Selejan, S. R., Kindermann, I., Towbin, J. A., Bohm, M., et al. (2021) · JACC: Basic to Translational Science · doi:10.1016/j.jacbts.2021.06.001 · Cited by 95
Abston, E. D., Coronado, M. J., Bucek, A., Bedja, D., Shin, J., Kim, J. B., Kim, E., Gabrielson, K. L., Georgakopoulos, D., Mitzner, W., et al. (2012) · Clinical and Developmental Immunology · doi:10.1155/2012/129486 · Cited by 94
Self-citationAnimal models for autoimmune myocarditis and autoimmune thyroiditis.
Čiháková, D., Sharma, R. B., Fairweather, D., Afanasyeva, M., & Rose, N. (2004) · Methods in Molecular Medicine · doi:10.1385/1-59259-805-6:175 · Cited by 94
Self-citationSex-Specific Mortality Risk by QRS Morphology and Duration in Patients Receiving CRT
Zusterzeel, R., Curtis, J. P., Caños, D., Sanders, W. E., Selzman, K. A., Piña, I. L., Spatz, E. S., Bao, H., Ponirakis, A., Varosy, P. D., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.06.1162 · Cited by 93
Baritussio, A., Schiavo, A., Basso, C., Giordani, A. S., Cheng, C., Pontara, E., Cattini, M. G., Bison, E., Gallo, N., De Gaspari, M., et al. (2022) · European Journal of Heart Failure · doi:10.1002/ejhf.2496 · Cited by 90
Lynge, T. H., Nielsen, T. S., Winkel, B. G., Tfelt-Hansen, J., & Banner, J. (2019) · Forensic Sciences Research · doi:10.1080/20961790.2019.1595352 · Cited by 90
Frisancho-Kiss, S., Nyland, J. F., Davis, S. E., Augusto Frisancho, J., Barrett, M. A., Rose, N. R., & Fairweather, D. (2006) · Brain Research · doi:10.1016/j.brainres.2006.08.003 · Cited by 90
Self-citationHuber, S. A., Kupperman, J., & Newell, M. K. (1999) · Lupus · doi:10.1177/096120339900800511 · Cited by 90
Russo, A. M., Daugherty, S. L., Masoudi, F. A., Wang, Y., Curtis, J. P., & Lampert, R. J. (2015) · American Heart Journal · doi:10.1016/j.ahj.2015.02.025 · Cited by 86
Sex Differences in Cardiomyopathies
Meyer, S., van der Meer, P., van Tintelen, J. P., & van den Berg, M. P. (2014) · European Journal of Heart Failure · doi:10.1002/ejhf.15 · Cited by 86
Research works printed but not linked: 4
- 2015, Consideration of Sex as a Biological Variable in NIH-funded Research.
- 2022, Sex/Gender-Specific COVID-19 Outcomes and Management Relevant for Heart, Lung, Blood, and Sleep Disorders: From Bench to Bedside.
- 2012, What a Difference Sex and Gender Make: A Gender, Sex and Health Research Casebook.
- Nakaya, 2003, Estrogenic compounds suppressed interferon-gamma production in mouse splenocytes through direct cell-cell interaction., In Vitro Cell Dev Biol Anim., 39, 383, 10.1290/1543-706X(2003)039<0383:ECSIPI>2.0.CO;2 · DOI
Cited by
Sorted by citations
COVID-19, Myocarditis and Pericarditis
Fairweather, D., Beetler, D. J., Di Florio, D. N., Musigk, N., Heidecker, B., & Cooper, L. T. (2023) · Circulation Research · doi:10.1161/circresaha.123.321878 · Cited by 194
Self-citationMechanisms underlying sex differences in autoimmunity
Fairweather, D., Beetler, D. J., McCabe, E. J., & Lieberman, S. M. (2024) · Journal of Clinical Investigation · doi:10.1172/jci180076 · Cited by 121
Self-citationClinical Characteristics and Mechanisms of Acute Myocarditis
Heymans, S. R. B., Linthout, S. V., Kraus, S., Cooper, L. T., & Ntusi, N. (2024) · Circulation Research · doi:10.1161/circresaha.124.324674 · Cited by 52
Self-citationAutoimmune Myocarditis, Old Dogs and New Tricks.
Won, T., Song, E. J., Kalinoski, H. M., Moslehi, J. J., & Čiháková, D. (2024) · Circulation Research · doi:10.1161/circresaha.124.323816 · Cited by 51
Sex- and gender-related disparities in chest pain syndromes: the feminine mystique of chest pain
Angeli, F., Ricci, F., Moscucci, F., Sciomer, S., Bucciarelli, V., Bianco, F., Mattioli, A. V., Pizzi, C., & Gallina, S. (2024) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2024.102457 · Cited by 36
Metadata
- Authors
- Fairweather, D., Beetler, D. J., Musigk, N., Heidecker, B., Lyle, M. A., Cooper, L. T., & Bruno, K. A.
- Affiliations
- Mayo Clinic (US)
- Humboldt-Universität zu Berlin (DE)
- Corresponding author
- Fairweather, DeLisa
- ORCID
- Venue
- Frontiers in Cardiovascular Medicine
- Publisher
- Frontiers Media SA
- Published
- 2023-03-02
- Volume
- 10
- Pages
- 1129348-1129348
- ISSN
- 2297-055X (ISSN-L)
- PMC
- PMC10017519
- OpenAlex
- W4322773336
- Cited by
- 124
- References
- 333
- Citations by year
- 2026: 29 · 2025: 32 · 2024: 44 · 2023: 19
- FWCI
- 6.60
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Cardiovascular Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health (R01 HL164520, R21 AI145356, R21 AI152318, R21 AI154927, TL1 TR002380, R21 AI163302, R01 HL135165)
- American Heart Association (20TPA35490415)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Immunology Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
- Keywords
- sex differences, gender differences, myocarditis, dilated cardiomyopathy, sex ratio, postmenopausal women, heart failure biomarkers, soluble ST2, Toll-like receptor signaling, cardiac remodeling, heart failure treatment, personalized medicine
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
