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Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans
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Fasting induces ANGPTL4 expression in tissues other than adipose, including liver and some oxidative tissues.
“fasting induces ANGPTL4 expression in tissues other than adipose, including liver and some oxidative tissues (40, 46, 47, 72).”
From Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8 (2021) · cites this paper as [40]
Angptl4 is expressed in several tissues including liver, heart, intestine, and skeletal muscle.
“Although Angptl4 is most highly expressed in adipose, it is also expressed in several other tissues including liver, heart, intestine, and skeletal muscle (40, 46, 47, 72).”
From Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8 (2021) · cites this paper as [40]
Single nucleotide polymorphisms in ANGPTL5 are associated with plasma triglyceride levels in humans.
“Single nucleotide polymorphisms (SNPs) in ANGPTL5 are associated with plasma triglyceride levels in humans (40).”
From Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8 (2021) · cites this paper as [40]
ANGPTL4 loss-of-function mutations in humans are associated with lower plasma triglycerides.
“ANGPTL4 loss-of-function mutations in humans are associated with lower plasma triglycerides (40, 56–58).”
From Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8 (2021) · cites this paper as [40]
In humans, ANGPTL5 is expressed in several tissues, including high expression in adipose tissue.
“In humans, ANGPTL5 is expressed in several tissues, including high expression in adipose tissue (40).”
From Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8 (2021) · cites this paper as [40]
ANGPTL6 does not appear to modulate plasma TG levels.
“However, despite these marked changes, ANGPTL6 does not appear to modulate plasma TG levels (40, 41).”
From Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8 (2021) · cites this paper as [40]
In humans, loss of functional ANGPTL3 protein leads to decreased triglyceride levels.
“In humans, loss of functional ANGPTL3 protein also leads to decreased triglyceride levels (40, 108–110).”
From Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8 (2021) · cites this paper as [40]
ANGPTL3 is expressed in and secreted from the liver and circulates in the bloodstream.
“ANGPTL3 is expressed in and secreted from the liver and circulates in the bloodstream (15, 40, 72, 103).”
From Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8 (2021) · cites this paper as [40]
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Cites
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“Both ANGPTL3 and ANGPTL4 inhibit LPL activity in vitro and in vivo (4–6), and mice lacking Angptl3 or Angptl4 have increased LPL activity and reduced levels of plasma TG (7, 8).”
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“ANGPTL4 associated with low plasma triglycerides [9,10], which is substantiated by the finding that mice lacking ANGPTL4 have low concentrations of triglycerides in plasma and increased LPL activity [11].”
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Metadata
- Authors
- Romeo, S., Yin, W., Kozlitina, J., Pennacchio, L. A., Boerwinkle, E., Hobbs, H. H., & Cohen, J. C.
- Venue
- Journal of Clinical Investigation
- Published
- 2008-12-15
- ISSN
- 0021-9738
- Cited by
- 58
- References
- 4
- Language
- en
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