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Intestinal Short Chain Fatty Acids and their Link with Diet and Human Health

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Ríos-Covián, David, Ruas-Madiedo, Patricia, Margolles, Abelardo, Gueimonde, Miguel, de los Reyes-Gavilán, Clara G., Salazar, Nuria·2016·Frontiers in Microbiology
DOI 10.3389/fmicb.2016.00185
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Abstract

The colon is inhabited by a dense population of microorganisms, the so-called "gut microbiota," able to ferment carbohydrates and proteins that escape absorption in the small intestine during digestion. This microbiota produces a wide range of metabolites, including short chain fatty acids (SCFA). These compounds are absorbed in the large bowel and are defined as 1-6 carbon volatile fatty acids which can present straight or branched-chain conformation. Their production is influenced by the pattern of food intake and diet-mediated changes in the gut microbiota. SCFA have distinct physiological effects: they contribute to shaping the gut environment, influence the physiology of the colon, they can be used as energy sources by host cells and the intestinal microbiota and they also participate in different host-signaling mechanisms. We summarize the current knowledge about the production of SCFA, including bacterial cross-feedings interactions, and the biological properties of these metabolites with impact on the human health.

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Research works printed but not linked: 76

  1. Arrieta, 2015, Early infancy microbial and metabolic alterations affect risk of childhood asthma, Sci. Transl. Med., 7, 307r, 10.1126/scitranslmed.aab2271 · DOI · Paper page
  2. Barroso, 2015, Development of human colonic microbiota in the computer-controlled dynamic SIMulator of the GastroIntestinal tract SIMGI, Lwt Food Sci. Technol., 61, 283, 10.1016/j.lwt.2014.12.014 · DOI
  3. Brussow, 2014, You are what you eat, Nat. Biotechnol., 32, 243, 10.1038/nbt.2845 · DOI
  4. Canani, 2011, Potential beneficial effects of butyrate in intestinal and extraintestinal diseases, World J. Gastroenterol., 17, 1519, 10.3748/wjg.v17.i12.1519 · DOI · Paper page
  5. Cardelle-Cobas, 2009, Bifidogenic effect and stimulation of short chain fatty acid production in human faecal slurry cultures by oligosaccharides derived from lactose and lactulose, J. Dairy Res., 76, 317, 10.1017/S0022029909004063 · DOI
  6. Chassard, 2006, H2 and acetate transfers during xylan fermentation between a butyrate-producing xylanolytic species and hydrogenotrophic microorganisms from the human gut, FEMS Microbiol. Lett., 254, 116, 10.1111/j.1574-6968.2005.00016.x · DOI
  7. Chen, 2013, Decreased dietary fiber intake and structural alteration of gut microbiota in patients with advanced colorectal adenoma, Am. J. Clin. Nutr., 97, 1044, 10.3945/ajcn.112.046607 · DOI · Paper page
  8. Costabile, 2015, Effects of orange juice formulation on prebiotic functionality using an in vitro colonic model system, PLoS ONE, 10, e0121955, 10.1371/journal.pone.0121955 · DOI
  9. Counotte, 1981, Role of Megasphaera elsdenii in the Fermentation of dl-[2-C]lactate in the rumen of dairy cattle, Appl. Environ. Microbiol., 42, 649, 10.1128/AEM.42.4.649-655.1981 · DOI · Paper page
  10. Cuervo, 2013, Fiber from a regular diet is directly associated with fecal short-chain fatty acid concentrations in the elderly, Nutr. Res., 33, 811, 10.1016/j.nutres.2013.05.016 · DOI
  11. Den Besten, 2015, Short-chain fatty acids protect against high-fat diet-induced obesity via a PPARgamma-Dependent Switch from lipogenesis to fat oxidation, Diabetes, 64, 2398, 10.2337/db14-1213 · DOI · Paper page
  12. Den Besten, 2013a, Gut-derived short-chain fatty acids are vividly assimilated into host carbohydrates and lipids, Am. J. Physiol. Gastrointest. Liver Physiol., 305, G900, 10.1152/ajpgi.00265.2013 · DOI · Paper page
  13. Donohoe, 2014, A gnotobiotic mouse model demonstrates that dietary fiber protects against colorectal tumorigenesis in a microbiota- and butyrate-dependent manner, Cancer Discov., 4, 1387, 10.1158/2159-8290.CD-14-0501 · DOI · Paper page
  14. Duncan, 2002, Acetate utilization and butyryl coenzyme A (CoA):acetate-CoA transferase in butyrate-producing bacteria from the human large intestine, Appl. Environ. Microbiol., 68, 5186, 10.1128/AEM.68.10.5186-5190.2002 · DOI · Paper page
  15. Duncan, 2004a, Contribution of acetate to butyrate formation by human faecal bacteria, Br. J. Nutr., 91, 915, 10.1079/BJN20041150 · DOI · Paper page
  16. Duncan, 2004b, Lactate-utilizing bacteria, isolated from human feces, that produce butyrate as a major fermentation product, Appl. Environ. Microbiol., 70, 5810, 10.1128/AEM.70.10.5810-5817.2004 · DOI · Paper page
  17. El Aidy, 2013, Intestinal colonization: how key microbial players become established in this dynamic process: microbial metabolic activities and the interplay between the host and microbes, Bioessays, 35, 913, 10.1002/bies.201300073 · DOI
  18. El-Semman, 2014, Genome-scale metabolic reconstructions of Bifidobacterium adolescentis L2-32 and Faecalibacterium prausnitzii A2-165 and their interaction, BMC Syst. Biol., 8, 41, 10.1186/1752-0509-8-41 · DOI
  19. Falony, 2006, Cross-feeding between Bifidobacterium longum BB536 and acetate-converting, butyrate-producing colon bacteria during growth on oligofructose, Appl. Environ. Microbiol., 72, 7835, 10.1128/AEM.01296-06 · DOI · Paper page
  20. Fassler, 2006, In vitro fermentability of differently digested resistant starch preparations, Mol. Nutr. Food Res., 50, 1220, 10.1002/mnfr.200600106 · DOI
  21. Fava, 2013, The type and quantity of dietary fat and carbohydrate alter faecal microbiome and short-chain fatty acid excretion in a metabolic syndrome 'at-risk' population, Int. J. Obes. (Lond.), 37, 216, 10.1038/ijo.2012.33 · DOI · Paper page
  22. Fernandes, 2014, Adiposity, gut microbiota and faecal short chain fatty acids are linked in adult humans, Nutr. Diabetes, 4, e121, 10.1038/nutd.2014.23 · DOI · Paper page
  23. Flint, 2007, Interactions and competition within the microbial community of the human colon: links between diet and health, Environ. Microbiol., 9, 1101, 10.1111/j.1462-2920.2007.01281.x · DOI · Paper page
  24. Flint, 2015, Links between diet, gut microbiota composition and gut metabolism, Proc. Nutr. Soc., 74, 13, 10.1017/s0029665114001463 · DOI · Paper page
  25. Francavilla, 2012, Effect of lactose on gut microbiota and metabolome of infants with cow's milk allergy, Pediatr. Allergy Immunol., 23, 420, 10.1111/j.1399-3038.2012.01286.x · DOI
  26. Francois, 2012, Effects of a wheat bran extract containing arabinoxylan oligosaccharides on gastrointestinal health parameters in healthy adult human volunteers: a double-blind, randomised, placebo-controlled, cross-over trial, Br. J. Nutr., 108, 2229, 10.1017/S0007114512000372 · DOI
  27. Frost, 2014, The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism, Nat. Commun., 5, 3611, 10.1038/ncomms4611 · DOI · Paper page
  28. Hernot, 2009, In vitro fermentation profiles, gas production rates, and microbiota modulation as affected by certain fructans, galactooligosaccharides, and polydextrose, J. Agric. Food Chem., 57, 1354, 10.1021/jf802484j · DOI · Paper page
  29. James, 2015, Abnormal fibre usage in UC in remission, Gut, 64, 562, 10.1136/gutjnl-2014-307198 · DOI
  30. Jung, 2015, Butyrate modulates bacterial adherence on LS174T human colorectal cells by stimulating mucin secretion and MAPK signaling pathway, Nutr. Res. Pract., 9, 343, 10.4162/nrp.2015.9.4.343 · DOI · Paper page
  31. Keku, 2015, The gastrointestinal microbiota and colorectal cancer, Am. J. Physiol. Gastrointest. Liver Physiol., 308, G351, 10.1152/ajpgi.00360.2012 · DOI · Paper page
  32. Kim, 2013, Strict vegetarian diet improves the risk factors associated with metabolic diseases by modulating gut microbiota and reducing intestinal inflammation, Environ. Microbiol. Rep., 5, 765, 10.1111/1758-2229.12079 · DOI · Paper page
  33. Le Leu, 2015, Butyrylated starch intake can prevent red meat-induced O6-methyl-2-deoxyguanosine adducts in human rectal tissue: a randomised clinical trial, Br. J. Nutr., 114, 220, 10.1017/S0007114515001750 · DOI
  34. Leonel, 2012, Butyrate: implications for intestinal function, Curr. Opin. Clin. Nutr. Metab. Care, 15, 474, 10.1097/MCO.0b013e32835665fa · DOI · Paper page
  35. Li, 2014, Isolation and characterization of an agaro-oligosaccharide (AO)-hydrolyzing bacterium from the gut microflora of Chinese individuals, PLoS ONE, 9, e91106, 10.1371/journal.pone.0091106 · DOI
  36. Likotrafiti, 2014, An in vitro study of the effect of probiotics, prebiotics and synbiotics on the elderly faecal microbiota, Anaerobe, 27, 50, 10.1016/j.anaerobe.2014.03.009 · DOI
  37. Lin, 2012, Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms, PLoS ONE, 7, e35240, 10.1371/journal.pone.0035240PONE-D-11-22997 · doi:10.1371/journal.pone.0035240pone-d-11-22997
  38. Louis, 2004, Restricted distribution of the butyrate kinase pathway among butyrate-producing bacteria from the human colon, J. Bacteriol., 186, 2099, 10.1128/JB.186.7.2099-2106.2004 · DOI · Paper page
  39. Louis, 2014, The gut microbiota, bacterial metabolites and colorectal cancer, Nat. Rev. Microbiol., 12, 661, 10.1038/nrmicro3344 · DOI · Paper page
  40. Louis, 2007, Understanding the effects of diet on bacterial metabolism in the large intestine, J. Appl. Microbiol., 102, 1197, 10.1111/j.1365-2672.2007.03322.x · DOI · Paper page
  41. Louis, 2010, Diversity of human colonic butyrate-producing bacteria revealed by analysis of the butyryl-CoA:acetate CoA-transferase gene, Environ. Microbiol., 12, 304, 10.1111/j.1462-2920.2009.02066.x · DOI · Paper page
  42. Maathuis, 2012, Galacto-oligosaccharides have prebiotic activity in a dynamic in vitro colon model using a C-13-labeling technique, J. Nutr., 142, 1205, 10.3945/jn.111.157420 · DOI
  43. Machiels, 2014, A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis, Gut, 63, 1275, 10.1136/gutjnl-2013-304833 · DOI · Paper page
  44. Majid, 2011, Faecal microbiota and short-chain fatty acids in patients receiving enteral nutrition with standard or fructo-oligosaccharides and fibre-enriched formulas, J. Hum. Nutr. Diet, 24, 260, 10.1111/j.1365-277X.2011.01154.x · DOI
  45. Makelainen, 2007, The effects of polydextrose and xylitol on microbial community and activity in a 4-stage colon simulator, J. Food Sci., 72, M153, 10.1111/j.1750-3841.2007.00350.x · DOI
  46. Makivuokko, 2005, In vitro effects on polydextrose by colonic bacteria and caco-2 cell cyclooxygenase gene expression, Nutr. Cancer, 52, 94, 10.1207/s15327914nc5201_12 · DOI
  47. Minekus, 1999, A computer-controlled system to simulate conditions of the large intestine with peristaltic mixing, water absorption and absorption of fermentation products, Appl. Microbiol. Biotechnol., 53, 108, 10.1007/s002530051622 · DOI · Paper page
  48. Nistal, 2012, Differences in faecal bacteria populations and faecal bacteria metabolism in healthy adults and celiac disease patients, Biochimie, 94, 1724, 10.1016/j.biochi.2012.03.025 · DOI · Paper page
  49. Ou, 2013, Diet, microbiota, and microbial metabolites in colon cancer risk in rural Africans and African Americans, Am. J. Clin. Nutr., 98, 111, 10.3945/ajcn.112.056689 · DOI · Paper page
  50. Patil, 2012, Molecular analysis of gut microbiota in obesity among Indian individuals, J. Biosci., 37, 647, 10.1007/s12038-012-9244-0 · DOI · Paper page
  51. Pryde, 2002, The microbiology of butyrate formation in the human colon, FEMS Microbiol. Lett., 217, 133, 10.1111/j.1574-6968.2002.tb11467.x · DOI · Paper page
  52. Puertollano, 2014, Biological significance of short-chain fatty acid metabolism by the intestinal microbiome, Curr. Opin. Clin. Nutr. Metab. Care, 17, 139, 10.1097/MCO.0000000000000025 · DOI · Paper page
  53. Rahat-Rozenbloom, 2014, Evidence for greater production of colonic short-chain fatty acids in overweight than lean humans, Int. J. Obes. (Lond.), 38, 1525, 10.1038/ijo.2014.46 · DOI · Paper page
  54. Reichardt, 2014, Phylogenetic distribution of three pathways for propionate production within the human gut microbiota, ISME J., 8, 1323, 10.1038/ismej.2014.14 · DOI · Paper page
  55. Rey, 2010, Dissecting the in vivo metabolic potential of two human gut acetogens, J. Biol. Chem., 285, 22082, 10.1074/jbc.M110.117713 · DOI · Paper page
  56. Rodriguez-Colinas, 2013, Analysis of fermentation selectivity of purified galacto-oligosaccharides by in vitro human faecal fermentation, Appl. Microbiol. Biotechnol., 97, 5743, 10.1007/s00253-013-4892-z · DOI
  57. Ross, 2013, A whole-grain-rich diet reduces urinary excretion of markers of protein catabolism and gut microbiota metabolism in healthy men after one week, J. Nutr., 143, 766, 10.3945/jn.112.172197 · DOI
  58. Rossi, 2005, Fermentation of fructooligosaccharides and inulin by bifidobacteria: a comparative study of pure and fecal cultures, Appl. Environ. Microbiol., 71, 6150, 10.1128/AEM.71.10.6150-6158.2005 · DOI · Paper page
  59. Salazar, 2015, Inulin-type fructans modulate intestinal Bifidobacterium species populations and decrease fecal short-chain fatty acids in obese women, Clin. Nutr., 34, 501, 10.1016/j.clnu.2014.06.001 · DOI · Paper page
  60. Salazar, 2009, Exopolysaccharides produced by Bifidobacterium longum IPLA E44 and Bifidobacterium animalis subsp. lactis IPLA R1 modify the composition and metabolic activity of human faecal microbiota in pH-controlled batch cultures, Int. J. Food Microbiol., 135, 260, 10.1016/j.ijfoodmicro.2009.08.017 · DOI · Paper page
  61. Shoaie, 2015, Quantifying Diet-induced metabolic changes of the human gut microbiome, Cell Metab., 22, 320, 10.1016/j.cmet.2015.07.001 · DOI · Paper page
  62. Sivieri, 2014, Prebiotic effect of Fructooligosaccharide in the Simulator of the Human Intestinal Microbial Ecosystem (SHIME (R) Model), J. Med. Food, 17, 894, 10.1089/jmf.2013.0092 · DOI
  63. Souza, 2014, Prebiotic effects of cassava bagasse in TNO's in vitro model of the colon in lean versus obese microbiota, J. Funct. Foods, 11, 210, 10.1016/j.jff.2014.09.019 · DOI
  64. Valdés, 2015, The relationship between phenolic compounds from diet and microbiota: impact on human health, Food Funct., 6, 2424, 10.1039/c5fo00322a · DOI · Paper page
  65. Van Den Abbeele, 2013a, Butyrate-producing Clostridium cluster XIVa species specifically colonize mucins in an in vitro gut model, ISME J., 7, 949, 10.1038/ismej.2012.158 · DOI · Paper page
  66. Van Den Abbeele, 2010, Microbial community development in a dynamic gut model is reproducible, colon region specific, and selective for Bacteroidetes and Clostridium cluster IX, Appl. Environ. Microbiol., 76, 5237, 10.1128/AEM.00759-10 · DOI · Paper page
  67. Van Den Abbeele, 2013b, Different human gut models reveal the distinct fermentation patterns of Arabinoxylan versus inulin, J. Agric. Food Chem., 61, 9819, 10.1021/jf4021784 · DOI
  68. Van Zanten, 2012, The effect of selected synbiotics on microbial composition and short-chain fatty acid production in a model system of the human colon, PLoS ONE, 7, e47212, 10.1371/journal.pone.0047212 · DOI
  69. Veiga, 2014, Changes of the human gut microbiome induced by a fermented milk product, Sci. Rep., 4, 6328, 10.1038/srep06328 · DOI · Paper page
  70. West, 2013, Butyrylated starch increases colonic butyrate concentration but has limited effects on immunity in healthy physically active individuals, Exerc. Immunol. Rev., 19, 102
  71. Wrzosek, 2013, Bacteroides thetaiotaomicron and Faecalibacterium prausnitzii influence the production of mucus glycans and the development of goblet cells in the colonic epithelium of a gnotobiotic model rodent, BMC Biol., 11, 61, 10.1186/1741-7007-11-61 · DOI · Paper page
  72. Wu, 2011, Linking long-term dietary patterns with gut microbial enterotypes, Science, 334, 105, 10.1126/science.1208344 · DOI · Paper page
  73. Yang, 2013, Impact of dietary fiber fermentation from cereal grains on metabolite production by the fecal microbiota from normal weight and obese individuals, J. Med. Food, 16, 862, 10.1089/jmf.2012.0292 · DOI
  74. Yang, 2014, Long-term dietary pattern of fecal donor correlates with butyrate production and markers of protein fermentation during in vitro fecal fermentation, Nutr. Res., 34, 749, 10.1016/j.nutres.2014.08.006 · DOI
  75. Zhang, 2010, Butyrate induces cell apoptosis through activation of JNK MAP kinase pathway in human colon cancer RKO cells, Chem. Biol. Interact., 185, 174, 10.1016/j.cbi.2010.03.035 · DOI
  76. Zhou, 2013, Starch structure modulates metabolic activity and gut microbiota profile, Anaerobe, 24, 71, 10.1016/j.anaerobe.2013.09.012 · DOI

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Metadata

Authors
Ríos-Covián, D., Ruas-Madiedo, P., Margolles, A., Gueimonde, M., de los Reyes-Gavilán, C. G., & Salazar, N.
Venue
Frontiers in Microbiology
Publisher
Frontiers Media SA
Published
2016-02-17
Volume
7
Pages
185-185
ISSN
1664-302X (ISSN-L)
DOI
10.3389/fmicb.2016.00185
OpenAlex
W2274927794
Cited by
2,179
References
19
FWCI
77.50
Type
journal article
Language
en
Open access
gold
Funders
  • Ministerio de Economía y Competitividad (AGL2013-43770-R)
  • Plan Regional de Investigación del Principado de Asturias (GRUPIN14-043)

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Ríos-Covián, D., Ruas-Madiedo, P., Margolles, A., Gueimonde, M., de los Reyes-Gavilán, C. G., & Salazar, N. (2016). Intestinal Short Chain Fatty Acids and their Link with Diet and Human Health. Frontiers in Microbiology. https://doi.org/10.3389/fmicb.2016.00185

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