Cited by 215Cannabis and Cannabinoid ResearchNeuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

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Effects of endocannabinoid system modulation on cognitive and emotional behavior

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Zanettini, Claudio·2011·Frontiers in Behavioral Neuroscience

DOI 10.3389/fnbeh.2011.00057PMC PMC3171696

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Abstract

Cannabis has long been known to produce cognitive and emotional effects. Research has shown that cannabinoid drugs produce these effects by driving the brain's endogenous cannabinoid system and that this system plays a modulatory role in many cognitive and emotional processes. This review focuses on the effects of endocannabinoid system modulation in animal models of cognition (learning and memory) and emotion (anxiety and depression). We review studies in which natural or synthetic cannabinoid agonists were administered to directly stimulate cannabinoid receptors or, conversely, where cannabinoid antagonists were administered to inhibit the activity of cannabinoid receptors. In addition, studies are reviewed that involved genetic disruption of cannabinoid receptors or genetic or pharmacological manipulation of the endocannabinoid-degrading enzyme, fatty acid amide hydrolase (FAAH). Endocannabinoids affect the function of many neurotransmitter systems, some of which play opposing roles. The diversity of cannabinoid roles and the complexity of task-dependent activation of neuronal circuits may lead to the effects of endocannabinoid system modulation being strongly dependent on environmental conditions. Recent findings are reviewed that raise the possibility that endocannabinoid signaling may change the impact of environmental influences on emotional and cognitive behavior rather than selectively affecting any specific behavior.

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Umathe S. N. Manna S. S. Jain N. S. (2011). Involvement of endocannabinoids in antidepressant and anti-compulsive effect of fluoxetine in mice. Behav. Brain Res. 223, 125– 134 10.1016/j.bbr.2011.04.031 21549765 · DOI

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Authors: Zanettini, C.
Affiliations: National Institutes of Health (US)
Corresponding author: Zanettini, Claudio
ORCID: Zanettini, Claudio
Venue: Frontiers in Behavioral Neuroscience
Publisher: Frontiers Media SA
Published: 2011
Volume: 5
Pages: 57-57
ISSN: 1662-5153 (ISSN-L)
DOI: 10.3389/fnbeh.2011.00057
PMC: PMC3171696
OpenAlex: W2071835207
Cited by: 214
References: 161
Citations by year: 2026: 7 · 2025: 10 · 2024: 7 · 2023: 9 · 2022: 18 · 2021: 13 · 2020: 14 · 2019: 15 · 2018: 13 · 2017: 10 · 2016: 22 · 2015: 24 · 2014: 13 · 2013: 15 · 2012: 22
FWCI: 11.95
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Behavioral Neuroscience (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: U.S. Department of Health and Human Services
Johns Hopkins University
National Institutes of Health
National Institute on Drug Abuse
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: endocannabinoid system, cognitive behavior, emotional behavior, learning and memory, anxiety, depression, cannabinoid receptor agonists, cannabinoid receptor antagonists, cannabinoid receptors, fatty acid amide hydrolase, neurotransmitter systems, environmental influences on behavior

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Effects of endocannabinoid system modulation on cognitive and emotional behavior

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