The DOI matches its Crossref record; 82 of the 82 references it cites were found in a registry or an index; 22 of the 62 sources its claims cite were checked for support.
Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates
Open accessAbstract
The superior longitudinal fasciculus (SLF) is part of the longitudinal association fiber system, which lays connections between the frontal lobe and other areas of the ipsilateral hemisphere. As a dominant association fiber bundle, it should correspond to a well-defined structure with a clear anatomical definition. However, this is not the case, and a lot of confusion and overlap surrounds this entity. In this review/opinion study, we survey relevant current literature on the topic and try to clarify the definition of SLF in each hemisphere. After a comparison of postmortem dissections and data obtained from diffusion MRI studies, we discuss the specifics of this bundle regarding its anatomical landmarks, differences in lateralization, as well as individual variability. We also discuss the confusion regarding the arcuate fasciculus in relation to the SLF. Finally, we recommend a nomenclature based on the findings exposed in this review and finalize with a discussion on relevant functional correlates of the structure.
Overview
AI snapshot
Written from the paper’s full text.
TL;DR
This review/opinion argues that the superior longitudinal fasciculus (SLF) remains anatomically and nomenclaturally controversial, despite being a major association fiber system. It recommends distinguishing the SLF from the arcuate fasciculus, questioning SLF I as separate from the cingulum, and recognizing asymmetric SLF II/III functional roles.
Key findings
- The SLF is best defined as a fronto-parietal tract, whereas the arcuate fasciculus (AF) is a fronto-temporal tract; classifications that include the AF as part of the SLF are described as misleading.
- SLF I, connecting parietal precuneus to superior frontal gyrus, appears assimilable to the cingulum, so its existence and role are unclear; SLF II and SLF III are described as distinct and asymmetric, with left-sided SLF II/III implicated in speech processing and right-sided SLF II/III in visuospatial functioning.
- Wang et al.’s combined dMRI (\(n=10\)) and dissection (\(n=5\)) study found SLF II represented about 66% of total SLF volume and SLF III about 33%; left SLF II connectivity was linked to motor planning of language and/or syntax, right SLF II to attention regulation in spatial orientation.
- The review highlights dMRI validation problems: 63–90% of white matter volume is estimated to contain crossing fibers, and in an international tractography competition most tractograms contained more invalid than valid bundles.
Methods
- Narrative review/opinion based on a literature survey of SLF anatomy, nomenclature, lateralization, individual variability, AF relationship, and functional correlates.
- The authors compare postmortem dissection and diffusion MRI/tractography studies and summarize studies reporting 2, 3, 3 plus AF, and 5 SLF divisions in a table.
- No original cohort is analyzed; illustrative figures use open-source MRI images and the Imeka test tractogram, with segmentation methods derived from Wakana et al. and Fitzgerald et al.
Limitations
- The authors state that inter- and intra-individual variability is greater than previously suspected and recommend larger cohorts; they also note that cited studies often have low subject numbers.
- The authors discuss dMRI pitfalls including false positives, poor inter-protocol segmentation agreement, and orientation errors up to 90° at gray-white matter transitions; postmortem dissection cannot resolve crossing fibers or distal terminations and is biased toward elderly brains and fixation effects.
- Evident from the text: as a review/opinion without a systematic search or quantitative synthesis, its nomenclature recommendations are expert opinion rather than empirically tested consensus.
Model-written summary. Check it against the paper before relying on it.
Integrity signals
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Claims the paper makes
28 Own interpretation · 18 No full text of the sources · 6 Supported so far · 5 Partly supported · 4 Supported · 3 Couldn’t confirm · 2 Own result · 2 No basis given · 1 Mixed support · 1 Not supported · accuracy not yet measured
At least one cited source doesn’t support this claim or points to a different paper, and none confirmed it — see the verdicts below.
In the paper
“However, there is one domain where histological postmortem studies have shown a consistent failure of dMRI, which is in regions of transition between white and gray matter, where orientation errors of as much as 90° have been observed (49, 50).”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Introduction > Anatomical Description Derived From Diffusion MRI Studies
What the sources say
- Not checked — no full text of the sourcecites [49] Dyrby, 2007, Validation of in vitro probabilistic tractography, Neuroimage source
- Disputedcites [50] Seehaus, 2015, Histological validation of high-resolution DTI in human post mortem tissue, Front Neuroanat sourceExperimental — accuracy not yet measured
The Results (Orientation differences) say that at the white-to-gray-matter transition, orientation differences often remained small despite reduced FA. The near-90° differences were instead found mostly in bands within gray matter, at intermediate cortical depths (Discussion, Orientations). Thus the paper does not describe a consistent failure at the transition. (LLM, conf=0.88)
Checked by a reasoning model — may be wrong.
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“Postmortem factors, such as the interval between death and fixation, as well as the known effects of the fixative on the tissue can also alter results (18–21).”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Introduction > Anatomical Description Derived From Postmortem Dissections
What the sources say
- Not checked — no full text of the sourcecites [18] Chu, 2005, Ultrasound-accelerated formalin fixation of tissue improves morphology, antigen and mRNA preservation, Mod Pathol source
- Supportedcites [19] Schmierer, 2008, Quantitative magnetic resonance of postmortem multiple sclerosis brain before and after fixation, Magnetic Resonance in Medicine source
The Introduction says short postmortem delays are desirable to avoid structural damage from autolysis. The Discussion reports significant changes in quantitative MR measures following fixation. The Results found no confounding from the measured death-to-retrieval or death-to-MRI intervals in this sample, but that does not contradict the claim that postmortem factors can alter results. (LLM, conf=0.85)
- Not checked — no full text of the sourcecites [20] Stüber, 2014, Myelin and iron concentration in the human brain: a quantitative study of MRI contrast, NeuroImage source
- Not checked — no full text of the sourcecites [21] van Duijn, 2011, artifacts in human brain tissue after prolonged formalin storage, Magnetic Resonance in Medicine source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Every source the paper cites for this claim was checked and supports it.
In the paper
“Indeed, they found that most tractograms produced in this competition were made up of more invalid than valid bundles (52).”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Introduction > Anatomical Description Derived From Diffusion MRI Studies
What the sources say
- Supportedcites [52] Maier-Hein, 2017, The challenge of mapping the human connectome based on diffusion tractography, Nat Commun source
The Results section, “Tractograms contained more invalid than valid bundles,” reports an average of 88 invalid bundles per submission, more than four times the average number of valid bundles. It also reports that 69 submissions with at least 23 valid bundles had no fewer than 37 invalid bundles, supporting the claim about most competition tractograms. (LLM, conf=0.94)
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Supported
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“overall, the right-sided SLF as a whole appears more voluminous than on the left (3, 55).”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Lateralization
What the sources say
- Not checked — no full text of the sourcecites [3] Martino, 2013, Analysis of the subcomponents and cortical terminations of the perisylvian superior longitudinal fasciculus: a fiber dissection and DTI tractography study, Brain Struct Funct source
- Supportedcites [55] Hecht, 2015, Virtual dissection and comparative connectivity of the superior longitudinal fasciculus in chimpanzees and humans, Neuroimage source
The Results (§3.4) report that the SLF was right-lateralized as a whole across the chimpanzees and humans studied, supporting the statement that the right-sided SLF appears more voluminous overall. (LLM, conf=0.94)
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Every source the paper cites for this claim was checked and supports it.
In the paper
“One of them was that current state-of-the-art tractography algorithms do not control for false positives.”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Introduction > Anatomical Description Derived From Diffusion MRI Studies
What the sources say
- Supportedcites [52] Maier-Hein, 2017, The challenge of mapping the human connectome based on diffusion tractography, Nat Commun source
The Introduction reports that most of the 96 evaluated tractography pipelines produced large numbers of false-positive bundles. The Discussion adds that current pipelines produced substantial false-positive bundles even when tracking ground-truth fiber orientations, supporting the claim about their inability to control false positives in this evaluation. (LLM, conf=0.91)
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Supported
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“Even when given the same set of underlying streamlines, variability across protocols for bundle segmentation was found to be greater than all other sources of potential unevenness.”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Introduction > Anatomical Description Derived From Diffusion MRI Studies
What the sources say
- Partly supportedcites [69] Schilling, 2021, Tractography dissection variability: what happens when 42 groups dissect 14 white matter bundles on the same dataset?, Neuroimage sourceExperimental — accuracy not yet measured
The Discussion (page unavailable) says that, using the same underlying streamlines, variability across segmentation protocols exceeded variability within protocols, including acquisition, registration, reconstruction, and streamline-generation effects. But it describes inter-protocol variability as “similar to (or greater than)” inter-subject variability, not greater than every other source. The Results for the corticospinal tract also show that the comparison depends on the measure used. (LLM, conf=0.88)
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Partly supported
Every source the paper cites for this claim was checked and supports it.
In the paper
“In terms of validation, ex vivo dMRI in cadaveric samples appears ideally suited to the study of normal anatomy as it can be obtained with maximal quality.”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Introduction > Anatomical Description Derived From Diffusion MRI Studies
What the sources say
- Supportedcites [53] Takahashi, 2013, Detection of postmortem human cerebellar cortex and white matter pathways using high angular resolution diffusion tractography: a feasibility study, Neuroimage source
The Introduction says ex vivo imaging avoids motion and permits very high resolution and adequate signal-to-noise for HARDI. The Discussion describes high-resolution, high-signal-to-noise postmortem imaging as a way to reveal cerebellar pathways, while the validation section connects the findings to understanding cerebellar organization in healthy individuals. The claim is a reasonable paraphrase of those advantages, though the study specifically examines the cerebellum. (LLM, conf=0.88)
hedgeddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Supported
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“This variability can be observed at different levels such as in cortical morphology, cytoarchitecture, task-evoked activation, or in dMRI connectivity pattern (65–68).”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Individual Variability
What the sources say
- Not checked — no full text of the sourcecites [65] Amunts, 2004, Analysis of neural mechanisms underlying verbal fluency in cytoarchitectonically defined stereotaxic space - The roles of Brodmann areas 44 and 45, Neuroimage source
- Partly supportedcites [66] Baldassarre, 2012, Individual variability in functional connectivity predicts performance of a perceptual task, Proc Natl Acad Sci U S A sourceExperimental — accuracy not yet measured
The Discussion (page unavailable) proposes individual variability in structural connectivity as a possible explanation for its functional-connectivity findings. It does not establish the claimed anatomical variability across cortical morphology, cytoarchitecture, task-evoked activation, and dMRI connectivity patterns; the study measured resting-state functional connectivity, not dMRI connectivity. (LLM, conf=0.79)
- Not checked — no full text of the sourcecites [67] Good, 2001, voxel-based morphometric study of ageing in 465 normal adult human brains, Neuroimage source
- Partly supportedcites [68] Hill, 2010, Similar patterns of cortical expansion during human development and evolution, PNAS sourceExperimental — accuracy not yet measured
The Results (page not available) show differences in cortical surface area among individuals within each age group, supporting variability in cortical morphology. The Abstract discusses regional differences in cellular structure, not cytoarchitectural differences between individuals. The cited passages do not establish individual variability in task-evoked activation or dMRI connectivity patterns. (LLM, conf=0.85)
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Every source the paper cites for this claim was checked and supports it.
In the paper
“If we are to still consider the SLF I as part of the SLF, then this trunk appears to be distributed symmetrically between the right and left hemispheres (9).”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Lateralization
What the sources say
- Supportedcites [9] Thiebaut de Schotten, 2011, A lateralized brain network for visuospatial attention, Nat Neurosci source
The 'Asymmetry of Parieto-Frontal Spatial Networks' section treats SLF I as one of the three branches of the SLF and reports a symmetrical distribution between the left and right hemispheres. This directly supports the attributed claim. (LLM, conf=0.94)
hedged- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Supported
The cited sources that could be checked couldn’t confirm or dispute this claim.
In the paper
“from one individual to another, the volume of the SLF appears different.”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Individual Variability
What the sources say
- Not checked — no full text of the sourcecites [67] Good, 2001, voxel-based morphometric study of ageing in 465 normal adult human brains, Neuroimage source
- Could not verifycites [68] Hill, 2010, Similar patterns of cortical expansion during human development and evolution, PNAS sourceExperimental — accuracy not yet measured
The Results describe differences in cortical surface area among individuals, not differences in superior longitudinal fasciculus (SLF) volume. A search for SLF and superior longitudinal fasciculus found no passage in our copy addressing its volume across individuals; the Discussion's reference to white-matter volume concerns postnatal maturation instead. (LLM, conf=0.76)
hedged- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Probably not a substantial claim. 24
- It may state two separate claims as one. 19
Some cited sources support this claim and some don’t — read each source’s verdict below.
In the paper
“Indeed, some studies even describe a fifth division of the SLF comprised of a distinct fasciculus (61–63) that would connect the superior temporal gyrus to the superior parietal.”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Introduction > Anatomical Description Derived From Diffusion MRI Studies
What the sources say
- Not checked — no full text of the sourcecites [61] Frey, 2008, Dissociating the human language pathways with high angular resolution diffusion fiber tractography, J Neurosci source
- Disputedcites [62] Makris, 2009, Delineation of the middle longitudinal fascicle in humans: A quantitative, in vivo, DT-MRI study, Cerebral Cortex sourceExperimental — accuracy not yet measured
The Abstract and Discussion identify the tract as the middle longitudinal fascicle, connecting the superior temporal gyrus to the angular gyrus of the inferior parietal lobule—not the superior parietal region. The Discussion also explicitly describes it as distinct from the SLF, rather than a fifth division of it. (LLM, conf=0.89)
Checked by a reasoning model — may be wrong.
- Partly supportedcites [63] Zhang, 2010, Atlas-guided tract reconstruction for automated and comprehensive examination of the white matter anatomy, Neuroimage sourceExperimental — accuracy not yet measured
The Results (Comparison between the automated and manual methods; page unavailable) describe a separately reconstructed SLF segment connecting the parietal and temporal lobes. They do not call it a fifth division or identify its endpoints as the superior temporal gyrus and superior parietal region; the parietal regions specified are the angular and supramarginal gyri. (LLM, conf=0.85)
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“Classical DTI postmortem histological validation studies have shown that fiber orientation is correctly represented in large unidirectional fiber bundles, but fails in complex regions with fiber crossings and low anisotropy (44–46).”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Introduction > Anatomical Description Derived From Diffusion MRI Studies
What the sources say
- Not checked — no full text of the sourcecites [44] Dauguet, 2007, Comparison of fiber tracts derived from in-vivo DTI tractography with 3D histological neural tract tracer reconstruction on a macaque brain, Neuroimage source
- Partly supportedcites [45] Kaufman, 2005, Anatomical analysis of an aye-aye brain (Daubentonia madagascariensis, primates: prosimii) combining histology, structural magnetic resonance imaging, and diffusion-tensor imaging, Anat Rec A Discov Mol Cell Evol Biol sourceExperimental — accuracy not yet measured
The Diffusion-Tensor Imaging section (page unavailable) reports good correspondence between DTI and histological measurements in the cingulum bundle, supporting the claim for coherent fibers. It also finds broader fiber-orientation distributions where anisotropy is low, but does not show that DTI fails there or test regions with crossing fibers. (LLM, conf=0.88)
- Not checked — no full text of the sourcecites [46] Fernandez-Miranda, 2008, Three-dimensional microsurgical and tractographic anatomy of the white matter of the human brain, Neurosurgery source
boosteddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“A great many studies clearly distinguish the 2 bundles as distinct entities, both anatomically and functionally (56, 59, 70, 71, 75, 76).”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Is The AF Part of the SLF?
What the sources say
- Not checked — no full text of the sourcecites [56] Thiebaut de Schotten, 2011, Monkey to human comparative anatomy of the frontal lobe association tracts, Cortex source
- Partly supportedcites [59] Cabeen, 2016, Kernel regression estimation of fiber orientation mixtures in diffusion MRI, Neuroimage sourceExperimental — accuracy not yet measured
The Results (§5.5; page unavailable) describe the arcuate fasciculus and three portions of the superior longitudinal fasciculus separately, supporting an anatomical distinction. The paper does not address whether they are functionally distinct or establish that a great many studies distinguish them on both grounds. (LLM, conf=0.84)
- Not checked — no full text of the sourcecites [70] Catani, 2012, Atlas of Human Brain Connections source
boosted- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
The cited sources that could be checked couldn’t confirm or dispute this claim.
In the paper
“This variability is a correlate of the phenotypic variability in general, determined by the genetic substrates and the environmental exposure that shapes this diversity for any trait, including the brain's anatomy, (68)”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Individual Variability
What the sources say
- Could not verifycites [68] Hill, 2010, Similar patterns of cortical expansion during human development and evolution, PNAS sourceExperimental — accuracy not yet measured
The Discussion considers intrinsic and extrinsic signals in the maturation of cortical areas and suggests that postnatal experience may contribute to development in some regions. It does not address whether genetic substrates and environmental exposure determine variability among individuals or phenotypic variability across traits (searched: individual variability, genetics, environment, and phenotype). (LLM, conf=0.72)
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
- Could not verify
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“the SLF is in its essence a fronto-parietal tract, hence connecting the frontal and parietal cortices”
- Also stated in: § Functional Correlates of SLF · plain
“The SLF is a massive bundle connecting widespread areas of the frontal and the parietal lobes.”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Is The AF Part of the SLF?
What the sources say
- Supportedcites [55] Hecht, 2015, Virtual dissection and comparative connectivity of the superior longitudinal fasciculus in chimpanzees and humans, Neuroimage source
The Introduction defines the SLF as direct fronto-parietal connections. The Results (§3.2) describe SLF tracts connecting frontal and parietal cortical regions, supporting the verbatim citing sentence. (LLM, conf=0.94)
- Not checked — no full text of the sourcecites [56] Thiebaut de Schotten, 2011, Monkey to human comparative anatomy of the frontal lobe association tracts, Cortex source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Also stated in: § Functional Correlates of SLF · plain
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“the AF is recognized as a distinctive bundle with connection areas and a trajectory different from that of the SLF”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Is The AF Part of the SLF?
What the sources say
- Supportedcites [55] Hecht, 2015, Virtual dissection and comparative connectivity of the superior longitudinal fasciculus in chimpanzees and humans, Neuroimage source
The Introduction distinguishes the arcuate fasciculus (AF) as a fronto-temporal bundle from the fronto-parietal SLF. Discussion §4.1 adds that the AF travels beneath the SLF without terminating in parietal cortex, supporting the claimed differences in connections and trajectory. The paper notes that naming conventions vary, but adopts this distinction. (LLM, conf=0.92)
- Not checked — no full text of the sourcecites [56] Thiebaut de Schotten, 2011, Monkey to human comparative anatomy of the frontal lobe association tracts, Cortex source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Supported
The cited sources that could be checked couldn’t confirm or dispute this claim.
In the paper
“Fractional anisotropy of SLF also varies between individuals, but less importantly, than volume (67, 68).”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Individual Variability
What the sources say
- Not checked — no full text of the sourcecites [67] Good, 2001, voxel-based morphometric study of ageing in 465 normal adult human brains, Neuroimage source
- Could not verifycites [68] Hill, 2010, Similar patterns of cortical expansion during human development and evolution, PNAS sourceExperimental — accuracy not yet measured
The Results and Materials and Methods passages discuss individual differences in cortical surface area and patterns of cortical expansion, not the superior longitudinal fasciculus (SLF). Searches for SLF fractional anisotropy and its variability relative to volume found no passage addressing the claim. (LLM, conf=0.76)
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“whereas the AF is a fronto-temporal tract that passes through the parietal white matter beneath the SLF (55, 56).”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Is The AF Part of the SLF?
What the sources say
- Supportedcites [55] Hecht, 2015, Virtual dissection and comparative connectivity of the superior longitudinal fasciculus in chimpanzees and humans, Neuroimage source
Section 4.1 (page not provided) describes the arcuate fasciculus as a fronto-temporal tract that travels through parietal white matter beneath the SLF. The authors explicitly adopt this anatomical distinction, although they did not track the arcuate fasciculus in this study. (LLM, conf=0.95)
- Not checked — no full text of the sourcecites [56] Thiebaut de Schotten, 2011, Monkey to human comparative anatomy of the frontal lobe association tracts, Cortex source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Supported
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“a lot of the prior work which has made its way in the literature and anatomy textbooks is based on non-human primates, which present a rather different connectivity anatomy, thus steering the nomenclature toward a biased pattern (5, 56).”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Nomenclature
What the sources say
- Supportedcites [5] Mandonnet, 2018, The nomenclature of human white matter association pathways: proposal for a systematic taxonomic anatomical classification, Front Neuroanat source
In the Introduction, under “The Current Status of WM Terminology,” the paper says that extensive monkey tracing work was used as a basis for classifying human white-matter pathways, calling this a “drift.” The same section explains that macaque pathways cannot be treated as the ground truth of human neuroanatomy and that interspecies analogy has made bundle names confusing. (LLM, conf=0.91)
- Not checked — no full text of the sourcecites [56] Thiebaut de Schotten, 2011, Monkey to human comparative anatomy of the frontal lobe association tracts, Cortex source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Supported
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“As such, this fiber bundle is likely to be one of the most affected whenever we undertake a surgery for an intrinsic brain tumor.”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Introduction
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. The paper may give no reason why it holds.
- Rests on an assumption: The SLF is part of the longitudinal association fiber system, which lays connections between the frontal lobe and other areas of the ipsilateral hemisphere.
- Rests on an assumption: The SLF connects the perisylvian areas in the hemisphere (frontal, temporal, and parietal).
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“However, this is not the case, and a lot of confusion and overlap surrounds this entity.”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Abstract
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“It stands to reason that there would be asymmetric findings between both SLF.”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Lateralization
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
- Rests on an assumption: There is a clear asymmetry in speech function (left-sided characteristically) and visuospatial functioning (right-sided characteristically).
In the paper
“In this diffusion tensor imaging study, the SLF of 12 normal right-handed participants was assessed to find that projection to Broca's area was minimal or absent in the majority of cases.”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Introduction > Anatomical Description Derived From Diffusion MRI Studies
What the sources say
- Not checked — no full text of the sourcecites [57] Bernal, 2010, The connectivity of the superior longitudinal fasciculus: A tractography DTI study, Magn Reson Imaging source
plainn = 12- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Hence, they consider the SLF as only composed of a dorsal (SLF II) and a ventral (SLF III) segment.”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Introduction > Anatomical Description Derived From Diffusion MRI Studies
What the sources say
- Not checked — no full text of the sourcecites [7] Wang, 2016, Subcomponents and connectivity of the superior longitudinal fasciculus in the human brain, Brain Struct Funct source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Wang et al., on the other hand, found a slight asymmetric difference in all SLF sub-component with a tendency toward right-hemispheric dominance (7).”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Lateralization
What the sources say
- Not checked — no full text of the sourcecites [7] Wang, 2016, Subcomponents and connectivity of the superior longitudinal fasciculus in the human brain, Brain Struct Funct source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
In the paper
“In this construct, the SLF II represents 66% of the total volume, whereas the SLF III about 33%.”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Introduction > Anatomical Description Derived From Diffusion MRI Studies
What the sources say
- Not checked — no full text of the sourcecites [7] Wang, 2016, Subcomponents and connectivity of the superior longitudinal fasciculus in the human brain, Brain Struct Funct source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
In the paper
“The first conclusion is that there is a high discrepancy between the simian and human anatomy; hence, all conclusions derived from the study of the former cannot be applied to the latter.”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Introduction > Anatomical Description Derived From Diffusion MRI Studies
What the sources say
- Not checked — no full text of the sourcecites [7] Wang, 2016, Subcomponents and connectivity of the superior longitudinal fasciculus in the human brain, Brain Struct Funct source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“There is no such thing as a singular brain blueprint!”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Individual Variability
plain- Asserted: passes — The authors put it forward as true.
- Checkable: fails — It may be too vague to check against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. It may be too vague to check against evidence.
- Rests on an assumption: Some areas and connectivity routes are highly conserved amongst individuals (such as primary areas and large projection bundles), while others are more variable.
- Rests on an assumption: The brain connectivity pattern of an individual is constantly changing, and the density of white matter changes during the development of the individual.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“However, the inclusion of the AF as the 4th component of the SLF is far from unanimous and remains a subject of controversy in the nomenclature that is addressed in a later section of this study.”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Introduction > Anatomical Description Derived From Diffusion MRI Studies
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“other researchers found the SLF II subcomponents' lateralization to be dominant in the left hemisphere (7, 56, 72).”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Lateralization
What the sources say
- Not checked — no full text of the sourcecites [7] Wang, 2016, Subcomponents and connectivity of the superior longitudinal fasciculus in the human brain, Brain Struct Funct source
- Not checked — no full text of the sourcecites [56] Thiebaut de Schotten, 2011, Monkey to human comparative anatomy of the frontal lobe association tracts, Cortex source
- Not checked — no full text of the sourcecites [72] Vernooij, 2007, Fiber density asymmetry of the arcuate fasciculus in relation to functional hemispheric language lateralization in both right- and left-handed healthy subjects: a combined fMRI and DTI study, Neuroimage source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“This is an illustration of the poor consensus on the precise anatomical definition of white matter bundles.”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Introduction > Anatomical Description Derived From Diffusion MRI Studies
plain- Asserted: passes — The authors put it forward as true.
- Checkable: fails — It may be too vague to check against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. It may be too vague to check against evidence.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“some difference in connectivity is expected.”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Lateralization
hedged- Asserted: passes — The authors put it forward as true.
- Checkable: fails — It may be too vague to check against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. It may be too vague to check against evidence. The paper’s conclusions may not depend on it.
- Rests on an assumption: There is a clear asymmetry in speech function (left-sided characteristically) and visuospatial functioning (right-sided characteristically).
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The first three SLF subdivisions are usually reported alike in most studies, except for a few minor differences (Figure 2).”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Introduction > Anatomical Description Derived From Diffusion MRI Studies
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Their findings are rather provocative, differing from the rest of the literature and challenging the current knowledge on the SLF.”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Introduction > Anatomical Description Derived From Diffusion MRI Studies
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“This would functionally be related to its role in language.”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Lateralization
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“This finding contradicts the preconceived SLF structure and role, and does not represent the dominant consensus.”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Introduction > Anatomical Description Derived From Diffusion MRI Studies
plainn = 12- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Martino et al. used dMRI and cortex-sparing fiber dissection and came to the conclusion that there were two segments to the SLF, an anterior and a posterior segment, much like Martino et al. and Wang et al. (3, 7).”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Introduction > Anatomical Description Derived From Diffusion MRI Studies
What the sources say
- Not checked — no full text of the sourcecites [3] Martino, 2013, Analysis of the subcomponents and cortical terminations of the perisylvian superior longitudinal fasciculus: a fiber dissection and DTI tractography study, Brain Struct Funct source
- Not checked — no full text of the sourcecites [7] Wang, 2016, Subcomponents and connectivity of the superior longitudinal fasciculus in the human brain, Brain Struct Funct source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“these long associative axons comprise only 2% of the total intrahemispheric cortico-cortical fibers and that 98% of the fibers are short U-fibers (74).”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Individual Variability
What the sources say
- Not checked — no full text of the sourcecites [74] Duffau, 2012 source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Other authors also support the idea that the SLF is indeed comprised of two main divisions.”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Introduction > Anatomical Description Derived From Diffusion MRI Studies
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“This would be in keeping with a role for the left SLF II in motor planning of speech and/or syntax processing.”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Functional Correlates of SLF
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“As the bundle depicts clear asymmetry between both hemispheres, this must translate into obvious functional implications.”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Functional Correlates of SLF
boosteddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. The paper may give no reason why it holds.
- Rests on an assumption: There is a clear asymmetry in speech function (left-sided characteristically) and visuospatial functioning (right-sided characteristically).
In the paper
“the anterior segment of the AF appears to somehow correspond to the SLF III, and the two terms are used interchangeably.”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Is The AF Part of the SLF?
What the sources say
- Not checked — no full text of the sourcecites [70] Catani, 2012, Atlas of Human Brain Connections source
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The SLF II and III are clearly defined as distinct entities that are asymmetrical in their function as well as presumably in their role”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Conclusion
boostedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“According to some authors, this connectivity pattern is probably involved in spatial awareness functioning (7).”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Functional Correlates of SLF
What the sources say
- Not checked — no full text of the sourcecites [7] Wang, 2016, Subcomponents and connectivity of the superior longitudinal fasciculus in the human brain, Brain Struct Funct source
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“the SLF itself in its current definition is not a consensual entity.”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Conclusion
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
- Rests on an assumption: Individual variability had been underestimated in the past.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“the very definition of the SLF, connecting the frontal to the parietal lobe, allows a clear distinction with the AF, connecting the frontal lobe to the temporal lobe.”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Conclusion
boosteddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“its existence, as well as its role is unclear at this time.”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Conclusion
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
The paper relies on this without support.
The SLF is part of the longitudinal association fiber system, which lays connections between the frontal lobe and other areas of the ipsilateral hemisphere.
“The superior longitudinal fasciculus (SLF) is part of the longitudinal association fiber system, which lays connections between the frontal lobe and other areas of the ipsilateral hemisphere.”
The paper relies on this without support.
The SLF connects the perisylvian areas in the hemisphere (frontal, temporal, and parietal).
“To put it simply, it connects the perisylvian areas in the hemisphere (frontal, temporal, and parietal).”
The paper relies on this without support.
There is a clear asymmetry in speech function (left-sided characteristically) and visuospatial functioning (right-sided characteristically).
“As there is a clear asymmetry in speech function (left-sided characteristically) and visuospatial functioning (right-sided characteristically)”
The paper relies on this without support.
Some areas and connectivity routes are highly conserved amongst individuals (such as primary areas and large projection bundles), while others are more variable.
“Although some areas and connectivity routes are highly conserved amongst individuals (such as primary areas and large projection bundles), others are more variable.”
The paper relies on this without support.
The brain connectivity pattern of an individual is constantly changing, and the density of white matter changes during the development of the individual.
“the brain connectivity pattern of an individual is constantly changing, and the density of white matter has been shown to change during the development of the individual.”
The paper relies on this without support.
Individual variability had been underestimated in the past.
“the individual variability had been underestimated in the past.”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Rated major: it would touch a result — a value a result rests on, reported and recomputed p-values on opposite sides of the significance level, two passages that conflict with no sign which is right, or a cited work retracted before this paper was published.
In the paper
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Introduction > Anatomical Description Derived From Diffusion MRI Studies
“In the left hemisphere, the connectivity pattern was in keeping with a predominant functional role in speech (connections between the supramarginal gyrus with the dorsal precentral gyrus and caudal middle frontal gyrus).”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Introduction > Anatomical Description Derived From Diffusion MRI Studies
“Dorsal segment (SLF II) in the left hemisphere | Angular gyrus, Brodmann Areas (BA) 39 | Caudal middle frontal gyrus and dorsal precentral gyrus”
Rated minor: it would not touch a result — a value no result rests on, a p-value that stays on the same side of the significance level, or a conflict that is clerical, resolved elsewhere in the paper, or outside its own findings.
In the paper
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Lateralization
“other researchers found the SLF II subcomponents' lateralization to be dominant in the left hemisphere (7, 56, 72).”
§ Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates > Lateralization
“Wang et al., on the other hand, found a slight asymmetric difference in all SLF sub-component with a tendency toward right-hemispheric dominance (7).”
Citations
Cites
Spin Diffusion Measurements: Spin Echoes in the Presence of a Time-Dependent Field Gradient
Stejskal, E. O., & Tanner, J. E. (1965) · The Journal of Chemical Physics · doi:10.1063/1.1695690 · Cited by 8,239
The basis of anisotropic water diffusion in the nervous system—A technical review.
Beaulieu, C. (2002) · NMR in Biomedicine · doi:10.1002/nbm.782 · Cited by 4,628
A Voxel-Based Morphometric Study of Ageing in 465 Normal Adult Human Brains
Good, C. D., Johnsrude, I. S., Ashburner, J., Henson, R. N. A., Friston, K. J., & Frackowiak, R. S. J. (2001) · NeuroImage · doi:10.1006/nimg.2001.0786 · Cited by 4,561
Diffusion tensor imaging of the brain
Alexander, A. L., Lee, J. E., Lazar, M., & Field, A. S. (2007) · Neurotherapeutics · doi:10.1016/j.nurt.2007.05.011 · Cited by 2,747
Diffusion tensor MR imaging of the human brain
Pierpaoli, C., Jezzard, P., Basser, P. J., Barnett, A., & Di Chiro, G. (1996) · Radiology · doi:10.1148/radiology.201.3.8939209 · Cited by 2,664
Jensen, J. H., Helpern, J. A., Ramani, A., Lu, H., & Kaczynski, K. (2005) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20508 · Cited by 2,488
Tuch, D. S. (2004) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20279 · Cited by 1,880
Network structure of cerebral cortex shapes functional connectivity on multiple time scales
Honey, C. J., Kötter, R., Breakspear, M. J., & Sporns, O. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701519104 · Cited by 1,727
Reproducibility of quantitative tractography methods applied to cerebral white matter
Wakana, S., Caprihan, A., Panzenboeck, M. M., Fallon, J. H., Perry, M., Gollub, R. L., Hua, K., Zhang, J., Jiang, H., Dubey, P., et al. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.02.049 · Cited by 1,686
Tractography-based connectomes are dominated by false-positive connections
Maier-Hein, K. H., Neher, P., Houde, J.-C., Côté, M.-A., Garyfallidis, E., Zhong, J., Chamberland, M., Yeh, F.-C., Lin, Y.-C., Ji, Q., et al. (2016) · doi:10.1101/084137 · Cited by 1,376
Research works printed but not linked: 2
- Descoteaux, 2015, Wiley Encyclopedia of Electrical and Electronics Engineering (EEEE), High Angular Resolution Diffusion Imaging (HARDI)
- Rheault, 2016, MI-Brain, a Software to Handle Tractograms and Perform Interactive Virtual Dissection
Cited by
Sorted by citations
The Cortical and Subcortical Neural Control of Swallowing: A Narrative Review
Wei, K., Wang, T., & Hsiao, M. (2023) · Dysphagia · doi:10.1007/s00455-023-10613-x · Cited by 50
“The SLF is an association tract connecting the frontal, occipital, parietal, and temporal lobes and transmitting cortical neural signals across long and short distances [107].”
Bayoumi, A., Hasan, K. M., Thomas, J. A., Yazdani, A., & Lincoln, J. A. (2024) · Multiple Sclerosis Journal · doi:10.1177/13524585241280842 · Cited by 37
“44 Our decision to use the average of left and right DTI-ALPS-indices was guided by a previous study that showed higher reproducibility with bilateral measurements.”
The shared genetic architecture and evolution of human language and musical rhythm
Alagöz, G., Eising, E., Mekki, Y., Bignardi, G., Fontanillas, P., Aslibekyan, S. W., Auton, A., Babalola, E., Bell, R. K., Bielenberg, J., et al. (2024) · Nature Human Behaviour · doi:10.1038/s41562-024-02051-y · Cited by 42
“To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/ Response to reviewers’ comments for Nature Human Behaviour manuscript NATHUMBEHAV-23103300-T titled “The shared genetic architecture and evolution of human language and musical rhythm” - Author responses are in blue.”
InfluentialZhao, J., Huang, C., Zhang, Y., Liu, Y., Tsai, S., Lin, C., & Lo, C. Z. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02520-4 · Cited by 33
“In addition, the superior longitudinal fasciculus is a prominent associative fiber bundle connecting wide areas of the frontal and parietal cortex, which is related to language function, motor regulation and visuospatial processing [55].”
BackgroundSecondary neurodegeneration following Stroke: what can blood biomarkers tell us?
Brunelli, S., Giannella, E., Bizzaglia, M., Angelis, D. D., & Sancesario, G. M. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1198216 · Cited by 30
Imaging of the superficial white matter in health and disease
Dyken, P. C. V., KHAN, A. R., & Palaniyappan, L. K. (2024) · Imaging Neuroscience · doi:10.1162/imag_a_00221 · Cited by 24
“This proposal has been disputed in other work ( Janelle et al., 2022).”
Resultde Rezende, T. J. R., Petit, E., Park, Y. W., du Montcel, S. T., Joers, J. M., DuBois, J. M., Arnold, H. M., Považan, M., Banan, G., Valabrègue, R., et al. (2024) · Movement Disorders · doi:10.1002/mds.29934 · Cited by 25
“61 Visuospatial impairment was noted in later-stage SCA3, 62 and our fi nding motivates assessment of visuospatial de fi cits in early disease.”
Blasi, V., Rapisarda, L., Cacciatore, D. M., Palumbo, E., Tella, S. D., Borgnis, F., & Baglio, F. (2025) · Journal of Neurology · doi:10.1007/s00415-025-13048-6 · Cited by 23
Çini, N., Pennisi, M., Genç, S., Spandidos, D. A., Falzone, L., Mitsias, P., Tsatsakis, A., & Taghizadehghalehjoughi, A. (2024) · Oncology Report · doi:10.3892/or.2024.8798 · Cited by 17
“However, some studies in the literature are not concordant indicating that SLF is greater on the right side than on the left side (47,51), while other studies have claimed that SLF II is dominant on the left side through multiple components (49,52).”
BackgroundResultWhole-brain white matter variation across childhood environments
Carozza, S., Kletenik, I., Astle, D. E., Schwamm, L. H., & Dhand, A. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2409985122 · Cited by 20
“The SLF is the largest association tract of the brain, linking the frontal lobe to numerous ipsilateral regions (29); the SF connects the frontal lobe and basal ganglia by way of striatum (30).”
Gong, Z., Bilgel, M., An, Y., Bergeron, C. M., Bergeron, J., Zukley, L. M., Ferrucci, L., Resnick, S. M., & Bouhrara, M. (2024) · Brain Communications · doi:10.1093/braincomms/fcae412 · Cited by 17
Baj, J., Kowalska, B., Flieger, W., et al. (2023) · Nutrients · doi:10.3390/nu15122799 · Cited by 15
“The superior longitudinal fasciculus is the largest associative fiber bundle system in the brain that connects large areas of the frontal and parietal lobes [54].”
BackgroundHumanBrainAtlas: an in vivo MRI dataset for detailed segmentations
Schira, M. M., Isherwood, Z. J., Kassem, M. S., Barth, M., Shaw, T. B., Roberts, M. M., & Paxinos, G. (2023) · Brain Structure and Function · doi:10.1007/s00429-023-02653-8 · Cited by 17
“Directional information reveals their borders where blue identifies a dorsal–ventral direction of fibres, into the superior frontal gyrus (slf I) and green, anterior–posterior (slf II), into the medial frontal gyrus (Janelle et al. 2022).”
BackgroundDiffusion along the perivascular space influenced by handedness and language lateralisation
Perlaki, G., Dudás, B., Horváth, R. A., Orsi, G., Darnai, G., Arató, Á., Nagy, S. A., Doczi, T. P., Komoly, S., Kovács, N., et al. (2025) · Brain Communications · doi:10.1093/braincomms/fcaf252 · Cited by 16
“41,42 Unfortunately, due to the close proximity and the potential spatial overlap of SLF and AF 43 and because their names are often used interchangeably in the literature, previous studies may represent results mixed from both tracts.”
Computational memory capacity predicts aging and cognitive decline
Mijalkov, M., Storm, L., Gerbolés, B. Z., Veréb, D., Xu, Z., Canal-García, A., Sun, J., Chang, Y.-W., Zhao, H., Gómez-Ruiz, E., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-57995-0 · Cited by 14
“The manuscript is well-structured and effectively presents the authors' excellent research.”
The right hemisphere’s capacity for language: evidence from primary progressive aphasia
Neophytou, K., Wiley, R. W., Litovsky, C. P., Tsapkini, K., & Rapp, B. C. (2023) · Cerebral Cortex · doi:10.1093/cercor/bhad258 · Cited by 12
Burnett, J., Cobden, A. L., Burmester, A., Akhlaghi, H., D, J. F. D., & Caeyenberghs, K. (2025) · Cortex · doi:10.1016/j.cortex.2025.04.011 · Cited by 12
“Moreover, segmentation of the SLF in prior studies has often relied on anatomical landmarks that can vary across individuals, potentially introducing variability in tract identification (Janelle et al., 2022).”
Cheng, X., Wang, W., Sun, C., Sun, Y., & Zhou, C. (2023) · Journal of Obesity · doi:10.1155/2023/7966540 · Cited by 10
Wu, L., Wang, Z., Zhou, X., Kong, Q., Zhang, Y., Xu, S., Huang, H., & Luo, X. (2023) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.29121 · Cited by 10
“36,37 It interconnects nearly all cortical areas of the lateral cerebral hemisphere and is associated with higher cognitive function and motor function.”
Zhao, H., Rong, B., Gao, G., Zhou, M., Huang, J., Tu, N., Bu, L., Xiao, L., & Wang, G. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1364786 · Cited by 10
“A recent study focusing on the SLF proposed that the SLF might play different roles in different hemispheres: the left SLF has a greater involvement in processing language, while the right SLF is closely related to visual spatial processing (41).”
BackgroundEarly life adversity and white matter microstructural organization—a systematic review
Mitchell, O., Roddy, D. W., & Connaughton, M. (2025) · Brain Imaging and Behavior · doi:10.1007/s11682-025-01007-8 · Cited by 11
“The SLF, regarded as part of the visuospatial attention network, is important in the initiation of movement and higher order control of body-centered action (Naidich et al., 2013), as well as being involved in the control of eye movement and attention (Janelle et al., 2022).”
White matter tracts contribute selectively to cognitive functioning in patients with glioma
Andreoli, M., Mackie, M., Aaby, D., & Tate, M. C. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1221753 · Cited by 10
“The SLF is considered to be the largest association bundle in the human brain and is composed of three segments that connect widespread regions of the frontal and parietal lobe (42).”
Ronderos, J., Zuk, J., Hernández, A. E., & Vaughn, K. A. (2024) · Human Brain Mapping · doi:10.1002/hbm.26608 · Cited by 12
“…(Glauche & Abel, 2008; Middlebrooks et al., 2017), processing complex syntactic structures (Friederici, 2012; Wilson et al., 2011), and supporting phonological planning and processing for language and reading processing (Janelle et al., 2022; Middlebrooks et al., 2017; Wandell & Yeatman, 2013).”
BackgroundStructural brain networks correlating with poststroke cognition
Brownsett, S. L. E., Carey, L. M., Copland, D. A., Walsh, A., & Sihvonen, A. J. (2024) · Human Brain Mapping · doi:10.1002/hbm.26665 · Cited by 11
“It connects perisylvian regions, and is largely asymmetrical, with the left being implicated in language processes (Janelle et al., 2022), and the right with executive tasks with visuospatial processing (De Schotten et al., 2011; Ribeiro et al., 2023).”
BackgroundMatsuhashi, K., Itahashi, T., Aoki, R., & Hashimoto, R. (2023) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2023.110827 · Cited by 10
“FC revealed cerebellum It is also agreed that the SLF-II shows strong u r n e - r o o leftward lateralization (Janelle et al., 2022; Wang et al., 2016), with the parietal origin extending into the supramarginal cortex only in the left hemisphere (Wang et al., 2016).”
BackgroundTaghvaei, M., Mechanic-Hamilton, D. J., Sadaghiani, S., Shakibajahromi, B., Dolui, S., Das, S. R., Brown, C. D., Tackett, W., Khandelwal, P., Cook, P. A., et al. (2023) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2023.10.012 · Cited by 13
Gunatilake, N., Boyes, A., Elwyn, R., Brunet, A., Hermens, D. F., & Driver, C. (2025) · Adolescent Research Review · doi:10.1007/s40894-025-00263-5 · Cited by 13
“These long-ranging tracts are involved in several vital cognitive, emotional and motor functions such visual integration, somatosensory processing, processing of language, social cognition and motor planning for complex movements (Hodgdon et al., 2022; Janelle et al., 2022).”
Gerritsen, J. K. W., Karschnia, P., Bello, L., Hervey‐Jumper, S. L., Young, J., Seidel, K., Satoer, D., Schnell, O., Parsons, M. W., Nahed, B. V., et al. (2025) · The Lancet Oncology · doi:10.1016/s1470-2045(25)00531-5 · Cited by 10
Mamah, D. T., Chen, S., Shimony, J. S., & Harms, M. P. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1240502 · Cited by 9
“The SLF is the largest associative fi ber bundle system in the brain, and connects the frontal, temporal, and parietal lobes within the same hemisphere (74, 75).”
Backgroundwang, X., Yi, Y., Wang, X., Xu, G., Tian, J., & Ma, X. (2024) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2024.105500 · Cited by 8
Lindberg, P. G., AmirShemiraniha, N., Krewer, C., et al. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1375152 · Cited by 8
“…in sensorimotor integration: the longitudinal superior fasciculus has been shown to be important for visuomotor integration during manual tasks (59, 60), and larger white matter lesions affecting sub-cortical structures (basal ganglia) have been shown to be detrimental to post-stroke dual-task…”
BackgroundUnderstanding vigilance and its decrement: theoretical, contextual, and neural insights
Hemmerich, K., Luna, F. G., Martín‐Arévalo, E., & Lupiáñez, J. (2025) · Frontiers in Cognition · doi:10.3389/fcogn.2025.1617561 · Cited by 14
Chylińska, M., Karaszewski, B., Komendziński, J., Wyszomirski, A., Hałas, M., Szurowska, E., & Sabisz, A. (2023) · Neurological Sciences · doi:10.1007/s10072-023-06817-6 · Cited by 9
Wei, Y., Kung, Y., Lin, C., Chen, C., Lin, C., Tseng, R.-Y., Chen, Y.-L., Huang, W., Chen, P., Chong, S. T., et al. (2024) · Behavioral and Brain Functions · doi:10.1186/s12993-024-00238-x · Cited by 10
England-Mason, G., Reardon, A. J. F., Reynolds, J. E., Grohs, M. N., MacDonald, A. M., Kinniburgh, D. W., Martin, J. W., Lebel, C. A., & Dewey, D. (2024) · Environmental Research · doi:10.1016/j.envres.2024.120638 · Cited by 10
Driver, C., Boyes, A., Mohamed, A. Z., Levenstein, J. M., Parker, M. J., & Hermens, D. F. (2024) · Journal of Youth and Adolescence · doi:10.1007/s10964-024-01939-2 · Cited by 7
“The SLF is one of the largest association fi ber bundle systems, connecting frontal, temporal, and parietal areas ipsilaterally (Janelle et al., 2022), and is thought to be responsible for language function, motor planning (left hemisphere), and spatial orientation (mainly right hemisphere) (Janelle…”
BackgroundCai, J. C., Xie, M., Zhao, L., Li, X., Liang, S., Deng, W., Guo, W., Ma, X., Sham, P. C., Wang, Q., et al. (2023) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2023.103482 · Cited by 7
Bell, T., Ansari, M., Joyce, J. M., et al. (2024) · American Journal of Neuroradiology · doi:10.3174/ajnr.a8454 · Cited by 7
Cheng, Y., Lin, L., Jiang, S., Pei-lin, H., Zhang, J., Xin, J., Xu, H., Wang, Y., & Pan, X. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14586 · Cited by 6
The trait-specific timing of accelerated genomic change in the human lineage
Kun, E., Sohail, M., & Narasimhan, V. M. (2025) · Cell Genomics · doi:10.1016/j.xgen.2024.100740 · Cited by 7
“61 In support of this finding, previous studies by Alagoz et al. and Tilot et al. also examined heritability enrichment of these same fetal and adult HGEPs in the brain and found significant heritability enrichment in HGEPs at 7 p.c.w. for the cortical surface area of the pars orbi-talis, a region…”
InfluentialXie, Z., Chen, Z., Jiang, Y., Yao, J., Zhang, P., Lei, H., & Tang, W. (2024) · Medicine · doi:10.1097/md.0000000000040090 · Cited by 6
“[38] Previous research has confirmed that the SLF is associated with the generation of motor hyperactivity.”
BackgroundLan, L., He, H., & Zhang, J. (2024) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2024.107921 · Cited by 5
Topographic Axes of Wiring Space Converge to Genetic Topography in Shaping the Human Cortical Layout
Li, D., Wang, Y., Ma, L., Wang, Y., Cheng, L., Liu, Y., Shi, W., Lu, Y., Wang, H., Gao, C., et al. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.1510-24.2024 · Cited by 5
Derome, M., Amir, S., Sprüngli‐Toffel, E., Salaminios, G., Fonseca‐Pedrero, E., & Debbané, M. (2025) · Schizophrenia Bulletin · doi:10.1093/schbul/sbad147 · Cited by 5
“38 Reinforcing our hypothesis, research has showed that FA in the slf predicted improvement of response to therapeutic interactions such as social skills training and cognitive remediation in schizophrenia patients.”
Functional and structural brain asymmetries in language processing
Trettenbrein, P. C., & Friederici, A. D. (2025) · Handbook of clinical neurology · doi:10.1016/b978-0-443-15646-5.00020-8 · Cited by 4
Thurston, L. T., Rodkong, A., Saokhieo, P., Supindham, T., Kaewthip, O., Wantanajittikul, K., Skorska, M. N., Lai, M., Chariyalertsak, S., Saekho, S., et al. (2025) · Human Brain Mapping · doi:10.1002/hbm.70188 · Cited by 5
Basic knowledge on neuroanatomy and neurophysiology of the central nervous system
Konstantopoulos, K., & Giakoumettis, D. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-823875-2.00004-9 · Cited by 5
Unraveling the Thread of Aphasia Rehabilitation: A Translational Cognitive Perspective
Papageorgiou, G., Kasselimis, D. S., Laskaris, N., & Potagas, C. M. (2023) · Biomedicines · doi:10.3390/biomedicines11102856 · Cited by 5
“For example, the third branch of the superior longitudinal fasciculus which connects prefrontal, premotor and parietal areas (SLF III) is involved in phonological processing, but it is also assumed to control orofacial action, even in non-verbal tasks [13].”
BackgroundParlatini, V., Raduà, J., Naianna, R., Lintas, A., Atuk, E., Dell’Acqua, F., de Schotten, M. T., & Murphy, D. (2024) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-024-01927-4 · Cited by 6
van Velzen, L. S., Čolić, L., Ceja, Z., Dauvermann, M. R., Villa, L. M., Savage, H. S., Toenders, Y. J., Dehestani, N., Zhu, A. H., Campos, A. I., et al. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03602-1 · Cited by 7
The neurobiology of motivational anhedonia in patients with depression
Breit, S., Denier, N., Mertse, N., Walther, S., Soravia, L. M., Federspiel, A., Wiest, R., & Bracht, T. (2025) · Brain Imaging and Behavior · doi:10.1007/s11682-025-00999-7 · Cited by 8
“Our results suggest a functional disturbance in a region that is in close proximity to the SLF, a pathway that is crucial for integrating information of distinct modalities and for goal directed behaviour (Janelle et al., 2022; Walther et al., 2012; Wang et al., 2016).”
Lim, S., Kim, H., Lee, Y., & Initiative, A. D. N. (2025) · PLoS ONE · doi:10.1371/journal.pone.0329893 · Cited by 5
Deferm, W., Tang, T., Moerkerke, M., Daniëls, N., Steyaert, J. G., Alaerts, K., Ortibus, E., Naulaers, G., & Boets, B. (2024) · NeuroImage Clinical · doi:10.1016/j.nicl.2024.103580 · Cited by 4
“…design and Figure puzzles) and verbal (VIQ; Similarities and Vocabulary) intelligence were collected for all participants at the moment of visit using an abbreviated version of the WISC-V (WISC-V-NL | Wechsler Intelligence Scale for Children-V, 2018) with the norms for Dutch-speaking children.”
MethodA multisite validation of brain white matter pathways of resilience to chronic back painPreprint
Mišić, M., Lee, N., Zidda, F., Sohn, K., Usai, K., Löffler, M., Uddin, M. N., Farooqi, A., Schifitto, G., Zhang, Z., et al. (2024) · eLife · doi:10.7554/elife.96312.3 · Cited by 7
Alves, R. L., Zortéa, M., Mayor, D. F., Watson, T., & Steffert, T. (2025) · Brain Sciences · doi:10.3390/brainsci15030270 · Cited by 5
“These functions were correlated with the connectivity patterns of the IPG that occur via the superior longitudinal fasciculus [77].”
Lavrador, J. P., García, V. E., Marchi, F., Rajwani, K., Kalyal, N., Perera, A. P., Prakashvel, S., Chowdhury, Y. A., Elhag, A., Ferrari, L. D., et al. (2025) · Brain Structure and Function · doi:10.1007/s00429-025-02963-z · Cited by 4
“Sensory integration and motor planning occur via the previously described short association and long association fibers (Catani et al. 2017; Janelle et al. 2022).”
Chen, W., Xie, G., Xu, C., Zhang, C., & Liang, J. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120027 · Cited by 4
Lu, Y.-Q., Liu, Y.-S., Zhou, X., Wu, H., Zhou, Y., Hu, L.-Y., Zhang, H., Long, Y., Pang, C., Xi, J., et al. (2025) · Journal of Alzheimer's Disease · doi:10.1177/13872877251372953 · Cited by 3
“53 Due to the extensive reach of ATR, some researchers have proposed that its regulatory function may also be distributed across different subdivisions.”
Smullen, D., Bagshaw, A. P., Shalev, L., Tsafrir, S., Kolodny, T., & Mevorach, C. (2025) · Scientific Reports · doi:10.1038/s41598-025-02326-y · Cited by 4
Ma, H., Xie, Z., Huang, L., Gao, Y., Zhan, L., Hu, S., Zhang, J., & Ding, Q. (2022) · Neural Plasticity · doi:10.1155/2022/1478048 · Cited by 5
“Anatomical studies have shown that the superior longitudinal fasciculus is the biggest associative fiber bundle system in the brain and is connected to the superior frontal gyrus and supplementary motor areas [82].”
BackgroundCoccaro, A., Bono, M. G. D., Maffei, A., Orefice, C., Lievore, R., Mammarella, I. C., & Mario Liotti, A. (2023) · Brain Sciences · doi:10.3390/brainsci13050731 · Cited by 4
Dewan, M. V., Jungilligens, J., Kobus, S., Diezel, M., Dathe, A.-K., Schweiger, B., Hüning, B. M., Felderhoff‐Müser, U., & Bruns, N. (2024) · European Journal of Paediatric Neurology · doi:10.1016/j.ejpn.2024.06.009 · Cited by 5
Asymmetries in the human brain
Dulyan, L., Bortolami, C., & Forkel, S. J. (2025) · Handbook of clinical neurology · doi:10.1016/b978-0-443-15646-5.00030-0 · Cited by 3
Podwalski, P., Dawidowski, B., Lipinski, K. A., Franczak, Ł., Wysocki, P., Jabłoński, M., Jędrzejewski, A., Plichta, P., Tyburski, E. M., Zwarzany, Ł., et al. (2025) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2025.111987 · Cited by 3
Structural and functional connectomic analysis of high-grade gliomas: A systematic review
Burrington, L. R., Smith, A. D., Lauinger, A. R., et al. (2025) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2025.111415 · Cited by 3
Chen, S. N., Yang, S., Li, J., et al. (2026) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2026.110615 · Cited by 3
Hsu, P.-S., Cheng, C.-M., Chao, H., Lin, M., Li, W., Lee, L., Liu, C., Chen, L., & Hsieh, J. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1179851 · Cited by 4
Aljuhani, T., Coker‐Bolt, P., Katikaneni, L., Ramakrishnan, V., Brennan, A., George, M. S., Badran, B. W., & Jenkins, D. (2023) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2023.1297325 · Cited by 4
Amandola, M., Farber, K., Kidambi, R., & Leung, H. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.0821-24.2025 · Cited by 3
Baj, J., Forma, A., Karakuła, K. H., Flieger, W., Flieger, M., Kowalska, B., Kamińska, I., Majerek, D., Teresiński, G., Maciejewski, R., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-03283-2 · Cited by 4
“The SLF, in turn, is part of the system of longitudinal association fibres connecting the frontal and parietal lobes, with a clear asymmetry between the two hemispheres 127 .”
Kawata, N. Y. S., Fujisawa, T. X., Makita, K., Yao, A., Okazawa, H., & Tomoda, A. (2025) · Scientific Reports · doi:10.1038/s41598-025-13363-y · Cited by 3
“The SLF is a major WM tract that connects the frontal and parietal regions of the brain, playing a crucial role in cognitive functions such as attention, language, and executive functions 28 .”
Right hemisphere and metaphor comprehension: A connectionist perspective
Duque, A. C. M., Cuesta, T. A. C., Melo, A. D. S., & Maldonado, I. L. (2023) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2023.108618 · Cited by 3
Wu, Y.-Y., Chen, K., Chu, Y.-C., et al. (2023) · Journal of Neuro-Oncology · doi:10.1007/s11060-023-04431-2 · Cited by 3
Zhang, W., Gorelik, A. J., Wang, Q., Norton, S. A., Hershey, T. G., Arpana Agrawal, A., Bijsterbosch, J. D., & Bogdan, R. (2023) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2023.100722 · Cited by 3
Naveed, K., Rashidi‐Ranjbar, N., Kumar, S., Zomorrodi, R., Blumberger, D. M., Fischer, C. E., Sanches, M., Mulsant, B. H., Pollock, B. G., Voineskos, A. N., et al. (2024) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2023.0233 · Cited by 3
Lehman, C., & Peebles, R. S. (2025) · doi:10.37349/eaa.2025.100967 · Cited by 2
“…an extensive fiber bundle system, acting as a communication bridge linking regions involved in language, spatial awareness, and cognitive control [52]; corticospinal tract which is a major neural pathway responsible for facilitating voluntary movement [53]; the corona radiata serves as an…”
Nitto, K., Abe, H., Hashimoto, Y., et al. (2025) · Journal of Rehabilitation Medicine · doi:10.2340/jrm.v57.42782 · Cited by 2
“The SLF is an associated fibre tract between the frontal lobe and the ipsilateral parietal and temporal regions (31), playing a crucial role in motor control, including information transmission for motor planning and integration of visuomotor information (32).”
Beucler, N., Sellier, A., Almairac, F., Tran, A. D., Guyot, B., Mouramba, M., Robert, P., Fawaz, R., Fouet, M., Maison, F.-L., et al. (2025) · Neurosurgical Review · doi:10.1007/s10143-025-03827-0 · Cited by 4
MRI ‐ DTI Biomarkers Along the Continuum of Behavioral Variant Frontotemporal Dementia
Michelutti, M., Huppertz, H., Anderl‐Straub, S., Volkmann, H., Urso, D., Tafuri, B., Nigro, S. L., Manganotti, P., Rosenbohm, A., Ludolph, A. C., et al. (2025) · European Journal of Neurology · doi:10.1111/ene.70438 · Cited by 2
“…linking frontal and temporal cortices with limbic hubs [53], while showing relatively milder changes in the SLF (trend-level significance in the bvFTD group; nonsignificant for the ALS-FTD group) as a tract that connects anterior regions with more posterior parietal and occipital cortices [54].”
The white matter of Aha! moments
Salvi, C., Luchini, S. A., Pestilli, F., Hanekamp, S., Hope, T., Parrish, T. B., Beeman, M., & Grafman, J. H. (2026) · BMC Psychology · doi:10.1186/s40359-025-03593-0 · Cited by 2
“Notably, the left SLF III supports speech processing, whereas the right SLF III facilitates visuospatial functions [110].”
Diaz‐Fong, J. P., McGough, J. J., McCracken, J. T., et al. (2026) · Scientific Reports · doi:10.1038/s41598-026-40086-5 · Cited by 2
Podwalski, P., Dawidowski, B., Lipinski, K. A., Franczak, Ł., Wysocki, P., Jabłoński, M., Wietrzyński, K., Plichta, P., Tyburski, E. M., Zwarzany, Ł., et al. (2026) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2026.107816 · Cited by 2
Preuilh, A., Lackmy‐Vallée, A., Béranger, B., et al. (2026) · Clinical Neurophysiology · doi:10.1016/j.clinph.2026.2111864 · Cited by 2
Ravestyn, C. V., Riga, A., Bihin, B., Dricot, L., Dessain, Q., Delinte, N., Devis, L., Herman, B., Coene, B. D., Deltombe, T., et al. (2026) · Neuroscience · doi:10.1016/j.neuroscience.2026.04.018 · Cited by 2
Saito, J., Katagiri, N., Tagata, H., et al. (2024) · Journal of Personalized Medicine · doi:10.3390/jpm14030228 · Cited by 2
“The SLF III is suggested to play a role in speech in the left hemisphere and in spatial recognition in the right hemisphere [7].”
BackgroundXu, X., Song, X., Lin, L., Pan, N., Jin, Y., Tan, S., Cao, M., Chen, Y., Zhao, J., Su, X., et al. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.111083 · Cited by 2
Chen, W., Deng, S., Li, H., et al. (2025) · International Journal of General Medicine · doi:10.2147/ijgm.s499346 · Cited by 2
“40 SLF.”
Tilwani, D., O’Reilly, C., Riccardi, N., Shalin, V. L., den Ouden, D., Shinkareva, S. V., Fridriksson, J., Sheth, A., & Desai, R. H. (2025) · Frontiers in Neuroimaging · doi:10.3389/fnimg.2025.1573816 · Cited by 3
Ikemizu, Y., Isobe, Y., Sudo, Y., Ota, J., Chhatkuli, R. B., Sasaki, T., Kurita, K., Yoshida, T., Matsumoto, K., Kuno, M., et al. (2025) · Neuroimage Reports · doi:10.1016/j.ynirp.2025.100275 · Cited by 3
“It plays a key role in visual attention and spatial orientation by integrating perceptual input with executive control (Janelle et al., 2022).”
Associations between negative symptoms and thermal pain perception in bipolar I disorder
Vrolix, L., Legarreta, J. H., van der Heijden, H. C., van Gool, R., Ray, A., Golden, E., Cay, M., Yogesh Rathi, A., Gonzalez–Heydrich, J., O’Donnell, L. J., et al. (2025) · International Journal of Bipolar Disorders · doi:10.1186/s40345-025-00403-9 · Cited by 2
Taçyıldız, A. E., Barut, O., Üçer, M., et al. (2024) · World Neurosurgery · doi:10.1016/j.wneu.2024.03.038 · Cited by 2
Hartnett, P., Zomorodi, N., Goodkin, H. P., et al. (2024) · Epilepsia Open · doi:10.1002/epi4.13000 · Cited by 2
“…lobe, likely facilitated through the superior longitudinal fasciculus, the largest associative fiber bundle connecting superior parietal lobule to frontal lobe, 9,10 which was consistent with findings of VBM and other presurgical modalities including PET scan and MEG, and phase II evaluation.”
ResultLanguage Environment and Infants' Brain Structure
Lawton, W., Araujo, O., & Kufaishi, Y. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.0787-23.2023 · Cited by 1
Yang, A., Yang, Y., & Zhao, X. (2023) · PLoS Genetics · doi:10.1371/journal.pgen.1011112 · Cited by 1
Kaltsouni, E., Gu, X., Wikström, J., Hahn, A., Lanzenberger, R. R., Poromaa, I. S., & Comasco, E. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.111179 · Cited by 1
“…differences between treatment groups were identified in the superior longitudinal fasciculus, involved in attentional and somatosensory processes (Janelle et al., 2022), and the inferior fronto-occipital fasciculus, crucial for goal-oriented processing and visual recognition (Conner et al.,…”
BackgroundKrammer, W., Missimer, J. H., Vallesi, V., Pastore‐Wapp, M., Kägi, G., Wiest, R., & Weder, B. (2025) · Scientific Reports · doi:10.1038/s41598-025-86157-x · Cited by 1
Right-Hemispheric White Matter Organization Is Associated With Speech Timing in Autistic Children
Davison, K. E., Liu, T., Belisle, R. M., Perrachione, T. K., Qi, Z., Gabrieli, J. D. E., Tager-Flusberg, H. B., & Zuk, J. (2025) · Journal of Speech Language and Hearing Research · doi:10.1044/2025_jslhr-24-00548 · Cited by 1
“As part of this stream, the SLF plays a prominent role in mapping phonemic representations to motor representations important for speech (Hickok & Poeppel, 2007; Janelle et al., 2022).”
White Matter Correlates of Psychopathic Traits in a Japanese Community Sample: Sex Matters!
Chester, S. C., Rogers, J. C., Ogawa, T., Terao, M., Nakai, R., Abe, N., & Brito, S. A. D. (2025) · European Journal of Neuroscience · doi:10.1111/ejn.70177 · Cited by 1
Sun, Q., Fan, W., Liu, Y., Kou, Z., & Han, P. (2025) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2025.1600100 · Cited by 1
“It is a part of the longitudinal association fiber system, which lays connections between the frontal lobe and other areas, such as temporal and parietal (Ayy ı ld ı z et al., 2023; Janelle et al., 2022).”
Jung, J., Rajwani, K., Mirallave-Pescador, A., et al. (2025) · Clinical Neurophysiology · doi:10.1016/j.clinph.2025.2110995 · Cited by 1
Metadata
- Authors
- Janelle, F., Iorio-Morin, C., D'amour, S., & Fortin, D.
- Affiliations
- Université de Sherbrooke (CA)
- Corresponding author
- Fortin, David
- ORCID
- Fortin, David
- Venue
- Frontiers in Neurology
- Publisher
- Frontiers Media SA
- Published
- 2022-04-27
- Volume
- 13
- Pages
- 794618-794618
- ISSN
- 1664-2295 (ISSN-L)
- PMC
- PMC9093186
- OpenAlex
- W4224927688
- Semantic Scholar
- 24b650219ef5424d102e7ef0e0af039754115939
- Cited by
- 189
- References
- 81
- Citations by year
- 2026: 57 · 2025: 61 · 2024: 45 · 2023: 25 · 2022: 1
- FWCI
- 16.98
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Neurology (publishedVersion, cc-by)
- PubMed (publishedVersion)
- PubMed Central (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Anatomy › Classical Anatomy and Histology
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- superior longitudinal fasciculus, arcuate fasciculus, frontal lobe, anatomical landmarks, hemispheric lateralization, interindividual variability, diffusion MRI, postmortem dissection, functional correlates, white matter tracts, nomenclature
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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