Inducing partner preference in mice by chemogenetic stimulation of CA2 hippocampal subfield
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Social recognition is fundamental for social decision making and the establishment of long-lasting affiliative behaviors in behaviorally complex social groups. It is a critical step in establishing a selective preference for a social partner or group member. C57BL/6J lab mice do not form monogamous relationships, and typically do not show prolonged social preferences for familiar mice. The CA2 hippocampal subfield plays a crucial role in social memory and optogenetic stimulation of inputs to the dorsal CA2 field during a short memory acquisition period can enhance and extend social memories in mice. Here, we show that partner preference in mice can be induced by chemogenetic selective stimulation of the monosynaptic projections from the hypothalamic paraventricular nucleus (PVN) to the CA2 during the cohabitation period. Specifically, male mice spend more time in social contact, grooming and huddling with the partner compared to a novel female. Preference was not induced by prolonging the cohabitation period and allowing more time for social interactions and males to sire pups with the familiar female. These results suggest that PVN-to-CA2 projections are part of an evolutionarily conserved neural circuitry underlying the formation of social preference and may promote behavioral changes with appropriate stimulation.
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When the paraventricular nucleus to CA2 pathway is activated chemogenetically, nonmonogamous C57Bl6 mice form partner preferences in a species-atypical way.
“Further, when the PVN to CA2 pathway is activated chemogenetically, nonmonogamous C57Bl6 mice form partner preferences in a species-atypical way (103).”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [103]
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“…first-order neuromodulation and depolarization of principal neurons has been identified in rodent hippocampal area CA2, which is important for social recognition memory (Hitti & Siegelbaum 2014, Raam et al. 2017, Leroy et al. 2018, Lin et al. 2018, Cymerblit-Sabba et al. 2020, Donegan et al. 2020).”
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- Authors
- Cymerblit-Sabba, A., Smith, A. S., Williams Avram, S. K., Stackmann, M., Korgan, A. C., Tickerhoof, M. C., & Young, W. S.
- Affiliations
- National Institutes of Health (US)
- University of Kansas (US)
- Corresponding author
- Smith, Adam S.
- Venue
- Frontiers in Molecular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2020-04-23
- Volume
- 13
- Pages
- 61-61
- ISSN
- 1662-5099 (ISSN-L)
- PMC
- PMC7192236
- OpenAlex
- W3019822529
- Cited by
- 14
- References
- 36
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 6
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Molecular Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- KU ScholarWorks (The University of Kansas) (submittedVersion, cc-by)
- The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
- Funders
- National Institute of Mental Health
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- mate preferences, paraventricular nucleus, hypothalamus, social recognition, social memory, monogamy, cohabitation, chemogenetic stimulation, social behavior, neural circuits
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