Cited by 60Exercise and Physiological ResponsesRedox biology and oxidative stressMuscle Physiology and Disorders

Redox Characterization of Functioning Skeletal Muscle

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Zuo, Li, Pannell, Benjamin K.·2015·Frontiers in Physiology

Abstract

Skeletal muscle physiology is influenced by the presence of chemically reactive molecules such as reactive oxygen species (ROS). These molecules regulate multiple redox-sensitive signaling pathways that play a critical role in cellular processes including gene expression and protein modification. While ROS have gained much attention for their harmful effects in muscle fatigue and dysfunction, research has also shown ROS to facilitate muscle adaptation after stressors such as physical exercise. This manuscript aims to provide a comprehensive review of the current understanding of redox signaling in skeletal muscle. ROS-induced oxidative stress and its role in the aging process are discussed. Mitochondria have been shown to generate large amounts of ROS during muscular contractions, and thus are susceptible to oxidative stress. ROS can modify proteins located in the mitochondrial membrane leading to cell death and osmotic swelling. ROS also contribute to the necrosis and inflammation of muscle fibers that is associated with muscular diseases including Duchenne muscular dystrophy. It is imperative that future research continues to investigate the exact role of ROS in normal skeletal muscle function as well as muscular dysfunction and disease.

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Crossref · 10.3389/fphys.2015.00338

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  • Oxidative stress is a major trigger of imbalance between protein synthesis and degradation leading to muscle atrophy.

    “Oxidative stress, characterized by increased reactive oxygen species (ROS) production and impairment of antioxidant defense systems, is also a major trigger of imbalance between protein synthesis and degradation leading to muscle atrophy [10,11].”

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Authors
Zuo, L., & Pannell, B. K.
Affiliations
The Ohio State University (US)
Corresponding author
Zuo, Li
ORCID
Zuo, Li
Venue
Frontiers in Physiology
Published
2015-11-18
Volume
6
Pages
338-338
ISSN
1664-042X (ISSN-L)
OpenAlex
W2160351118
Cited by
60
References
118
Citations by year
2026: 3 · 2025: 5 · 2024: 3 · 2023: 6 · 2022: 5 · 2021: 4 · 2020: 5 · 2019: 6 · 2018: 7 · 2017: 10 · 2016: 6
FWCI
1.06
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Physiology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
OSUCOM-HRS (013000)
Topics
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords
reactive oxygen species, skeletal muscle, redox signaling, oxidative stress, mitochondria, muscle fatigue, exercise adaptation, aging, Duchenne muscular dystrophy, muscle inflammation, protein oxidation

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