Impact of Acute and Chronic Cannabis Use on Stress Response Regulation: Challenging the Belief That Cannabis Is an Effective Method for Coping
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Although research has only recently started to examine the impact of cannabis use on stress response, there is some evidence that indicates acute and chronic impacts of cannabis on these processes. In this paper, we review processes involved in regulating the stress response and we review the influence of acute and chronic exposure to cannabis on patterns and regulation of the stress response. We also highlight the role of stress as a risk factor for initiation and maintenance of cannabis use. In this context, we examine moderating variables, including sex and life adversity. In light of recent observations indicating increasing prevalence of cannabis use during pregnancy, we provide additional focus on cannabis use in this vulnerable population, including how acute and chronic stress may predispose some individuals to use cannabis during pregnancy. While this line of research is in its infancy, we review available articles that focus on the perinatal period and that examined the association between cannabis use and various life stressors, including partner violence, job loss, and lack of housing. We also review psychiatric co-morbidities (e.g., post-traumatic stress disorder, anxiety). A better understanding of the way stress and cannabis use relate within the general population, as well as within certain subgroups that may be at a greater risk of using and/or at greater risk for adverse outcomes of use, may lead to the development of novel prevention and intervention approaches.
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Drugs of abuse, such as opioids, psychostimulants, and alcohol, can induce neuroinflammatory mediators like IL-1β, which modulate drug reward, dependence, and tolerance.
“Drugs of abuse, such as opioids, psychostimulants, and alcohol, can induce neuroinflammatory mediators like interleukin-1β (IL-1β), which modulate the drug reward, dependence, and tolerance.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [86]
These substances may directly activate microglial and astroglial cells via Toll-like receptors, contributing to neuroinflammation and the addictive process.
“These substances may directly activate microglial and astroglial cells via Toll-like receptors (TLRs), contributing to neuroinflammation and the addictive process.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [86]
Stress is a significant risk factor for the initiation and maintenance of cannabis use.
“Stress is also a significant risk factor for the initiation and maintenance of cannabis use [86,87].”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [86]
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- Antinori S. Fattore L. (2017). “How CB1 receptor activity and distribution contribute to make the male and female brain different toward cannabinoid-induced effects,” in Endocannabinoids and Lipid Mediators in Brain Functions, ed Melis M. (Cham: Springer), 27– 51. 10.1007/978-3-319-57371-7_2 · DOI
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Shchaslyvyi, A. Y., Antonenko, S. V., & Telegeev, G. D. (2024) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph21081077 · Cited by 73 · see citing works
- Authors
- al'Absi, M., & Allen, A. M.
- Affiliations
- University of Arizona (US)
- ORCID
- Allen, Alicia M.
- Venue
- Frontiers in Psychology
- Publisher
- Frontiers Media SA
- Published
- 2021-07-01
- Volume
- 12
- Pages
- 687106-687106
- ISSN
- 1664-1078 (ISSN-L)
- PMC
- PMC8283823
- OpenAlex
- W3186779297
- Cited by
- 34
- References
- 169
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 13 · 2023: 3 · 2022: 3
- FWCI
- 0.60
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Psychology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health
- National Institute on Drug Abuse (R01DA016351, R01DA027232)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- cannabis use, stress response regulation, chronic cannabis use, sex differences, life adversity, cannabis use during pregnancy, perinatal period, intimate partner violence, job loss, housing insecurity, post-traumatic stress disorder, anxiety, psychiatric comorbidity, coping
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