A review of the explainability and safety of conversational agents for mental health to identify avenues for improvement
Open accessAbstract
Virtual Mental Health Assistants (VMHAs) continuously evolve to support the overloaded global healthcare system, which receives approximately 60 million primary care visits and 6 million emergency room visits annually. These systems, developed by clinical psychologists, psychiatrists, and AI researchers, are designed to aid in Cognitive Behavioral Therapy (CBT). The main focus of VMHAs is to provide relevant information to mental health professionals (MHPs) and engage in meaningful conversations to support individuals with mental health conditions. However, certain gaps prevent VMHAs from fully delivering on their promise during active communications. One of the gaps is their inability to explain their decisions to patients and MHPs, making conversations less trustworthy. Additionally, VMHAs can be vulnerable in providing unsafe responses to patient queries, further undermining their reliability. In this review, we assess the current state of VMHAs on the grounds of user-level explainability and safety, a set of desired properties for the broader adoption of VMHAs. This includes the examination of ChatGPT, a conversation agent developed on AI-driven models: GPT3.5 and GPT-4, that has been proposed for use in providing mental health services. By harnessing the collaborative and impactful contributions of AI, natural language processing, and the mental health professionals (MHPs) community, the review identifies opportunities for technological progress in VMHAs to ensure their capabilities include explainable and safe behaviors. It also emphasizes the importance of measures to guarantee that these advancements align with the promise of fostering trustworthy conversations.
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Written from the paper’s full text.
TL;DR
This review assesses explainability and safety in virtual mental health assistants (VMHAs), including ChatGPT, Woebot, Wysa, Limbic, and ALLEVIATE, and argues that current systems often lack user-level explainability and clinically grounded safe responses. It proposes knowledge-infused learning with clinical guidelines such as PHQ-9 and GAD-7, plus new qualitative and knowledge-infusion evaluation metrics, to improve trustworthiness.
Key findings
- The review reports that existing VMHAs such as Woebot, Wysa, and ChatGPT generated assumptive questions or responses with no association to a clinical reference or clinical support in a real-world unemployment-related query.
- It cites evidence that safety lexicons from PHQ-9 and GAD-7 produced an 85% improvement in safety across sequence-to-sequence and attention-based language models, with explainability showing a 23% uptake in terms of safety across the same models.
- Approximately 70% of attendees at the inaugural safety for conversational AI workshop doubted the ability of present-day conversational systems relying on language models to produce safe responses.
- Table 2 contrasts existing VMHAs with a desired system: Woebot, Wysa, Limbic, and ALLEVIATE mostly lack user-level explainability, while the desired system is marked for screening, triaging, motivational interviewing, safety, user-level explainability, and qualitative metrics of harmlessness, adherence, and transparency.
Methods
- Narrative review organized around five research questions on defining explainability and safety in VMHAs, assessing current capabilities and limitations, analyzing AI challenges, exploring desired functionalities, and identifying evaluation changes.
- Evidence includes examination of ChatGPT/GPT-3.5/GPT-4, Woebot, Wysa, Limbic, and ALLEVIATE, conversational datasets, and a high-level analysis of publicly available user reviews on forums such as WebMD, AskaPatient, MedicineNet, and Reddit; Table 2 notes a survey of 40 participants at Prisma Health for Woebot, Wysa, and Alleviate.
- Main analysis is qualitative synthesis and taxonomy development, proposing qualitative metrics (adherence, harmlessness, transparency) and knowledge-infusion metrics (safety, logical coherence, semantic relations).
Limitations
- The paper states that there currently exists no mental health-specific dataset or established method rooted in clinical principles for refining LLMs to ensure safety, and that rule-based and data-driven safety methods are limited by size and context.
- The paper states that VMHAs may not fully understand behavioral and emotional instability, self-harm tendencies, and the user’s underlying psychological state.
- Evident from the text: as a narrative review, no systematic search strategy, inclusion/exclusion criteria, or risk-of-bias assessment is reported, and the proposed evaluation metrics are not empirically validated in the paper.
Model-written summary. Check it against the paper before relying on it.
Integrity signals
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Cites
Statistics
Claims the paper makes
0 of 33 cited sources checked · 0 supported · 0 flagged
- Findingown data
GPT 3.5 provides user-level explainability when prompted with clinically-relevant words and keyphrases such as pregnancy, morning sickness, vomiting, nausea, and anxiety caused by tranquilizers during pregnancy.
“Figure 4 GPT 3.5 provides user-level explainability when prompted with clinically-relevant words and keyphrases such as pregnancy, morning sickness, vomiting, nausea, and anxiety caused by tranquilizers during pregnancy.”
Quote in the paperNot a substantial claim- Rests on an assumption: The clinical knowledge bases UMLS and RxNorm contain accurate and sufficient relationships between pregnancy, symptoms, and causes for generating symbolic questions.
- Findingnone given
Current datasets typically have a foundation in psychology but are crowd-sourced rather than explicitly derived from clinically grounded guidelines of psychiatrists.
“The current datasets typically have a foundation in psychology but are crowd-sourced rather than explicitly derived from clinically grounded guidelines of psychiatrists.”
Quote in the paperNot a substantial claim - Findingown data
Without specific keyphrases, GPT 3.5 may produce incorrect inferences.
“Without these specific keyphrases, GPT 3.5 may produce incorrect inferences [shown in (b)].”
Quote in the paperSubstantial claim - Findingnone given
VMHAs generate incoherent and unsafe responses when a user tries to seek a response for clinically relevant questions or vice-versa.
“VMHAs (as exemplified in Figures 2, 3) generate incoherent and unsafe responses when a user tries to seek a response for clinically relevant questions or vice-versa.”
Quote in the paperSubstantial claim- Rests on an assumption: The examples in Figures 2, 3, and 4 are representative of how VMHAs generally behave.
- Findingnone given
VMHAs may not fully understand issues related to behavioral and emotional instability, self-harm tendencies, and the user's underlying psychological state.
“our observations suggest that VMHAs may not fully understand issues related to behavioral and emotional instability, self-harm tendencies, and the user's underlying psychological state.”
Quote in the paperSubstantial claim- Rests on an assumption: The examples in Figures 2, 3, and 4 are representative of how VMHAs generally behave.
- Findingown data
When keyphrases are used as prompts, the explanation provided by GPT 3.5 becomes more concise compared with the explanation generated without such prompting.
“When these keyphrases are used as prompts, the explanation provided by GPT 3.5 in (a) becomes more concise compared with the explanation in (b) generated without such prompting.”
Quote in the paperNot a substantial claim - Premisecitation
ChatGPT use in mental health for personalized advice without clinical explanation can hurt user safety and trust.
“A recent surge in the use of ChatGPT, in particular for mental health, is emergent for providing crucial personalized advice without clinical explanation, which can hurt user's safety, and thus trust (Sallam, 2023).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Sallam, 2023 source
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- Premisecitation
Bommasani et al. (2021) reports hallucination and harmful question generations as unexpected behaviors shown by large language models.
“To this end, Bommasani et al. (2021) reports hallucination and harmful question generations as unexpected behaviors shown by such LLMs and are referred to as black box models by other authors (Rai, 2020).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Bommasani et al. (2021)
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- Premisecitation
The study by Roy et al. (2022a) showed an 85% improvement in safety across sequence-to-sequence and attention-based language models.
“The study showed an 85% improvement in safety across sequence-to-sequence and attention-based language models.”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Roy et al., 2022a
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- Premisecitation
Replika, a VMHA augmented with GPT-3, provides meditative suggestions to a user expressing self-harm tendencies.
“Recently, Replika, a VMHA, augmented with a GPT-3, provides meditative suggestions to a user expressing self-harm tendencies (Ineqe, 2022).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Ineqe, 2022
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- Premisecitation
The study by Roy et al. (2022a) showed an uptake of 23% in explainability in terms of safety across the same language models.
“In addition, explainability saw an uptake of 23% in terms of safety across the same language models.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Roy et al., 2022a
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- Premisecitation
Roy et al. (2022a) developed safety lexicons from PHQ-9 and GAD-7 for safe and explainable functioning of language models.
“Roy et al. (2022a) develop safety lexicons from PHQ-9 and GAD-7 for safe and explainable functioning of language models.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Roy et al., 2022a
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- Premisecitation
ALLEVIATE implements safety through the use of clinical knowledge.
“On the other hand, ALLEVIATE implements safety through the use of clinical knowledge.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Roy et al., 2023
Not checked in the free run.
- Rests on an assumption: The survey of 40 participants at Prisma Health provides a valid basis for the high-level analysis of Woebot, Wysa, and Alleviate.
- Interpretationreasoning
VMHAs can efficiently integrate with clinical practice guidelines such as PHQ-9 and GAD-7, utilizing reinforcement learning.
“Given these circumstances, VMHAs can efficiently integrate with clinical practice guidelines such as PHQ-9 and GAD-7, utilizing reinforcement learning.”
Quote in the paperNot a substantial claim- Rests on an assumption: Clinical specification questions are safe and medically adapted.
- Interpretationreasoning
Techniques such as policy gradient-based learning can enhance the capability of chat systems in ensuring safe message generation.
“Techniques such as policy gradient-based learning can enhance the capability of chat systems in ensuring safe message generation.”
Quote in the paperSubstantial claim- Rests on an assumption: Clinical specification questions are safe and medically adapted.
- Interpretationcitation
Using DiG, a VMHA can rephrase its questions to obtain a meaningful response from the user while maintaining engagement.
“Using DiG, a VMHA can rephrase its questions to obtain a meaningful response from the user while maintaining engagement.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Roy et al., 2022a
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- Premisecitation
Similar results were noticed when PHQ-9 was used in explainable training of language models.
“Similar results were noticed when PHQ-9 was used in explainable training of language models (Zirikly and Dredze, 2022).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Zirikly and Dredze, 2022
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- Interpretationcitation
Semantic enhancements in VMHA with clinical knowledge and associated guidelines, if they remain under-explored, may miss the hidden mental states in a given narrative, which is an essential component of question generation.
“We argue that semantic enhancements in VMHA with clinical knowledge and associated guidelines, if they remain under-explored, may miss the hidden mental states in a given narrative which is an essential component of question generation (Gaur et al., 2022a; Gupta et al., 2022).”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites Gaur et al., 2022a
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- cites Gupta et al., 2022 source
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- Premisecitation
The absence of ethical considerations in WoeBot and Wysa becomes evident in their responses to emergencies such as immediate harm or suicidal ideation, where they lack clinical grounding and contextual awareness.
“The absence of ethical considerations in WoeBot and Wysa becomes evident in their responses to emergencies such as immediate harm or suicidal ideation, where they lack clinical grounding and contextual awareness (Koutsouleris et al., 2022).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Koutsouleris et al., 2022 source
Not checked in the free run.
- Rests on an assumption: The survey of 40 participants at Prisma Health provides a valid basis for the high-level analysis of Woebot, Wysa, and Alleviate.
- May combine two claims. 23
- Classified as probably not a substantial claim. 31
- The quote only partly states this claim. 1
May combine two claims.
FindingcitationExisting VMHAs Woebot, Wysa, and ChatGPT initiated responsive conversation without focusing on context, producing assumptive questions and responses with no association with a clinical reference or clinical support.
“As a result, we found assumptive questions (e.g., anxiety) and responses from Wysa, Woebot, and ChatGPT with no association with a clinical reference or clinical support.”
Quote in the paperSubstantial claim0 of 3 sources checkedMay combine two claims.
FindingreasoningBoth Limbic and ALLEVIATE incorporate safety measures, but they do so with a nuanced distinction in their implementation approaches.
“Table 2 illustrates that both Limbic and ALLEVIATE incorporate safety measures, but they do so with a nuanced distinction in their implementation approaches.”
Quote in the paperNot a substantial claim- Rests on an assumption: The survey of 40 participants at Prisma Health provides a valid basis for the high-level analysis of Woebot, Wysa, and Alleviate.
Probably not a substantial claim: may not pass S3 (load-bearing), S4 (based). May combine two claims.
Findingown dataThe next word prediction strategy of the generative AI within the VMHA suggesting that "the fact that you are using tranquilizer medication is a step in the right direction, but it is essential to address the root cause of your anxiety as well" is a harmful statement, because tranquilizers cause anxiety during pregnancy.
“The next word prediction strategy of the generative AI within the VMHA suggests that “the fact that you are using tranquilizer medication is a step in the right direction, but it is essential to address the root cause of your anxiety as well”. is a harmful statement, because tranquilizers cause anxiety during pregnancy (as shown Figure 4).”
Quote in the paperNot a substantial claim- Rests on an assumption: The examples in Figures 2, 3, and 4 are representative of how VMHAs generally behave.
- Rests on an assumption: The clinical knowledge bases UMLS and RxNorm contain accurate and sufficient relationships between pregnancy, symptoms, and causes for generating symbolic questions.
Classified as probably not a substantial claim.
FindingreasoningThere was not a pursuit of grounding datasets with clinical knowledge and clinical practice guidelines and use in training VMHAs.
“As such, there was not a pursuit of grounding datasets with clinical knowledge and clinical practice guidelines and use in training VMHAs.”
Quote in the paperSubstantial claim- Rests on an assumption: The examples in Figures 2, 3, and 4 are representative of how VMHAs generally behave.
May combine two claims.
Findingnone givenCurrently, there exists no mental health-specific datasets or established method rooted in clinical principles for refining LLMs to ensure their safety.
“Nonetheless, currently, there exists no mental health-specific datasets or established method rooted in clinical principles for refining LLMs to ensure their safety.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S2 (checkable).
Findingnone givenVMHAs remain distant from translational research.
“However, VMHAs remain distant from such translational research.”
Quote in the paperNot a substantial claim- Rests on an assumption: The examples in Figures 2, 3, and 4 are representative of how VMHAs generally behave.
Probably not a substantial claim: may not pass S4 (based).
Interpretationnone givenVMHAs' inability to explain their decisions to patients and MHPs makes conversations less trustworthy.
“One of the gaps is their inability to explain their decisions to patients and MHPs, making conversations less trustworthy.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S4 (based). May combine two claims.
Interpretationnone givenVMHAs can be vulnerable to providing unsafe responses to patient queries, which undermines their reliability.
“Additionally, VMHAs can be vulnerable in providing unsafe responses to patient queries, further undermining their reliability.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
PremisereasoningLexicons in mental health resolve ambiguities in human language.
“Lexicons in mental health resolve ambiguities in human language.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
InterpretationreasoningClinical practice guidelines such as PHQ-9 enable VMHAs to exercise control over content generation, preventing the generation of false or unsafe information.
“Such guidelines act as standards that enable VMHAs to exercise control over content generation, preventing generating false or unsafe information.”
Quote in the paperNot a substantial claim- Rests on an assumption: Clinical specification questions are safe and medically adapted.
Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Premisenone givenKIL involves injecting external knowledge into the learning process to enhance the AI model's performance and achieve user-level explainability and safety.
“The concept of KIL involves injecting external knowledge, such as domain-specific rules, ontologies, or expert knowledge, into the learning process to enhance the AI model's performance and achieve USEx and safety.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
InterpretationreasoningEnsuring diversity in generation poses a natural challenge in open-domain conversations, but it becomes an unavoidable aspect in domain-specific conversations for VMHAs.
“Ensuring diversity in generation poses a natural challenge in open-domain conversations, but it becomes an unavoidable aspect in domain-specific conversations for VMHAs.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
PremisecitationClinical specifications include questionnaires such as PHQ-9, C-SSRS, and GAD-7, and provide a sequence of questions clinicians follow to interview individuals with mental health conditions.
“Clinical specifications1 include questionnaires such as PHQ-9 (depression), Columbia Suicide Severity Rating Scale [C-SSRS; suicide (Posner et al., 2008)], Generalized Anxiety Disorder (GAD-7) (Coda-Forno et al., 2023). It provides a sequence of questions clinicians follow to interview individuals with mental health conditions.”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites Posner et al., 2008
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- cites Coda-Forno et al., 2023
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Probably not a substantial claim: may not pass S2 (checkable).
InterpretationreasoningTo ensure that VMHAs are both safe and understandable, datasets need to be semantically enhanced with clinically grounded knowledge or clinical practice guidelines.
“To ensure that VMHAs are both safe and understandable, these datasets need to be semantically enhanced with clinically grounded knowledge [e.g., MedChatbot (Kazi et al., 2012)] or clinical practice guidelines [e.g., Patient Health Questionnaire (PHQ-9) (Kroenke et al., 2001)].”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites Kazi et al., 2012
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- cites Kroenke et al., 2001 source
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- Rests on an assumption: Clinical specification questions are safe and medically adapted.
Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
InterpretationcitationBy incorporating such knowledge, the decision-making ability of AI can be enhanced and better equipped to generate explanations that are more comprehensible to humans.
“By incorporating such knowledge, the decision-making ability of AI can be enhanced and better equipped to generate explanations that are more comprehensible to humans (Joyce et al., 2023).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Joyce et al., 2023
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- Rests on an assumption: Clinical specification questions are safe and medically adapted.
Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
PremisecitationWoebot is an Automated Coach designed to provide a coach-like experience without human intervention, promoting good thinking hygiene through lessons, exercises, and videos rooted in CBT.
“Woebot is an Automated Coach designed to provide a coach-like experience without human intervention, promoting good thinking hygiene through lessons, exercises, and videos rooted in Cognitive Behavioral Therapy (CBT) (Fitzpatrick et al., 2017; Grigoruta, 2018).”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites Fitzpatrick et al., 2017 source
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- cites Grigoruta, 2018
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- Rests on an assumption: The survey of 40 participants at Prisma Health provides a valid basis for the high-level analysis of Woebot, Wysa, and Alleviate.
Probably not a substantial claim: may not pass S2 (checkable).
InterpretationreasoningThe above analysis supports the critical need for an explainable approach to the decision-making mechanism of VMHAs.
“The above analysis supports the critical need for an explainable approach to the decision-making mechanism of VMHAs.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationApproximately 70% of workshop attendees doubted the ability of present-day conversational systems that rely on language models to produce safe responses.
“Approximately 70% of workshop attendees doubted the ability of present-day conversational systems that rely on language models to produce safe responses (Dinan, 2020).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Dinan, 2020
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Classified as probably not a substantial claim.
InterpretationreasoningThe risk of user disengagement arises if the chatbot asks redundant questions or provides repetitive responses.
“The risk of user disengagement arises if the chatbot asks redundant questions or provides repetitive responses.”
Quote in the paperSubstantial claimClassified as probably not a substantial claim.
PremisecitationThe absence of any link to a factual knowledge source that can help LLMs reason on their generation introduces the black box effect.
“The absence of any link to a factual knowledge source that can help LLMs reason on their generation introduce what is known as the “black box” effect (Rudin, 2019).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Rudin, 2019 source
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PremisecitationWysa uses a CBT conversational agent to engage in empathetic and therapeutic conversations and activities, aiming to help users with various mental health problems.
“Wysa uses a CBT conversational agent to engage in empathetic and therapeutic conversations and activities, aiming to help users with various mental health problems (Inkster et al., 2018).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Inkster et al., 2018 source
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- Rests on an assumption: The survey of 40 participants at Prisma Health provides a valid basis for the high-level analysis of Woebot, Wysa, and Alleviate.
Classified as probably not a substantial claim. May combine two claims. The quote only partly states this claim.
InterpretationreasoningAs a conversation unfolds, it becomes necessary to continually update the knowledge graph to ensure safety, because patients may experience varying levels of mental health conditions due to comorbidities and evolving severity, and contextual dynamics may shift.
“As the conversation unfolds, it becomes necessary to continually update the KG to ensure safety, which holds particular significance in VMHA.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
PremisecitationIn Limbic, patient safety is considered to be a spontaneous assessment of the severity of the mental health condition of the user (a classification problem), and it prioritizes patients seeking in-person clinical care.
“In Limbic, patient safety is considered to be a spontaneous assessment of the severity of the mental health condition of the user (a classification problem). It prioritizes patients seeking in-person clinical care (Sohail, 2023).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Sohail, 2023
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May combine two claims.
PremisecitationPeople are particularly forthcoming about their mental health problems while interacting with conversational agents, which may increase the danger of agreeing with user utterances that imply self-harm.
“People have been proven to be particularly forthcoming about their mental health problems while interacting with conversational agents, which may increase the danger of “agreeing with those user utterances that imply self-harm”.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Dinan et al., 2022 source
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Probably not a substantial claim: may not pass S3 (load-bearing), S4 (based).
InterpretationreasoningIn mental health, clinical specifications can serve as a substitute for rules to confirm that the AI model is functioning within safe limits.
“In mental health, clinical specifications can serve as a substitute for rules to confirm that the AI model is functioning within safe limits.”
Quote in the paperNot a substantial claim- Rests on an assumption: Clinical specification questions are safe and medically adapted.
May combine two claims.
PremisecitationThe component can generate false information or inference upon personally identifiable information, thus sacrificing user privacy.
“The component can generate false information or inference upon personally identifiable information, thus sacrificing user privacy (Coghlan et al., 2023).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Coghlan et al., 2023
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Probably not a substantial claim: may not pass S3 (load-bearing), S4 (based). May combine two claims.
Interpretationnone givenAdherence to guidelines helps VMHA maintain context and ensure safe conversation.
“Adherence to guidelines helps VMHA maintain context and ensure safe conversation.”
Quote in the paperNot a substantial claimMay combine two claims.
PremisecitationMost traditional quantitative metrics are reference-based, which are limited in availability and make it very difficult to ensure the quality of the human-written references.
“In addition, most of these traditional quantitative metrics are reference-based, which are limited in availability and make it very difficult to ensure the quality of the human-written references (Bao et al., 2022).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Bao et al., 2022
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Probably not a substantial claim: may not pass S3 (load-bearing), S4 (based). May combine two claims.
InterpretationreasoningThe question generation and response generation in ALLEVIATE are bound by the subgraph and information in the backend knowledge bases, thus ensuring accountable, transparent, and safe conversation.
“The question generation and response generation in ALLEVIATE are bound by the subgraph and information in the backend knowledge bases, thus ensuring accountable, transparent, and safe conversation.”
Quote in the paperNot a substantial claim- Rests on an assumption: The survey of 40 participants at Prisma Health provides a valid basis for the high-level analysis of Woebot, Wysa, and Alleviate.
May combine two claims.
PremisecitationThe conversational agents generate harmful, unsafe, and sometimes incoherent information, which are the negative effects of generative AI.
“The conversational agents generate harmful, unsafe, and sometimes incoherent information, which are the negative effects of generative AI (Welbl et al., 2021).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Welbl et al., 2021
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- Rests on an assumption: The examples in Figures 2, 3, and 4 are representative of how VMHAs generally behave.
Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
PremisecitationPeople perceive the quality of a service based on the price paid for it and the word of mouth buzz around it.
“A well-understood result in marketing is that people perceive the quality of a service based on the price paid for it and the word of mouth buzz around it (Liu and Lee, 2016).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Liu and Lee, 2016
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Premisenone givenObtaining training data from real conversations can be challenging due to privacy concerns.
“While obtaining training data from real conversations can be challenging due to privacy concerns, some approaches can help address these issues and still provide valuable and useful outputs.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing), S4 (based).
InterpretationreasoningTransparency can be achieved by either augmenting or incorporating external knowledge.
“Transparency can be achieved by either augmenting or incorporating external knowledge.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing), S4 (based). May combine two claims.
InterpretationreasoningIn contrast to the in-person sessions, the conversational agents miss the personalized and contextual information from non-verbal communication hindering the efficacy of VMHAs.
“In contrast to the in-person sessions (leveraged on both verbal and non-verbal communication), the conversational agents miss the personalized and contextual information from non-verbal communication hindering the efficacy of VMHAs.”
Quote in the paperNot a substantial claim- Rests on an assumption: The examples in Figures 2, 3, and 4 are representative of how VMHAs generally behave.
Probably not a substantial claim: may not pass S2 (checkable), S3 (load-bearing), S4 (based).
Interpretationnone givenCreating a realistic conversational experience for VMHAs is important for user acceptance.
“Creating a realistic conversational experience for VMHAs is important for user acceptance.”
Quote in the paperNot a substantial claim- Rests on an assumption: The examples in Figures 2, 3, and 4 are representative of how VMHAs generally behave.
May combine two claims.
InterpretationreasoningDespite the efforts, VMHA is still susceptible to generating harmful and untrustworthy content, as these methods are limited by size and context.
“Despite the efforts, VMHA is still susceptible to generating harmful and untrustworthy content, as these methods are limited by size and context.”
Quote in the paperNot a substantial claim- Rests on an assumption: The examples in Figures 2, 3, and 4 are representative of how VMHAs generally behave.
Probably not a substantial claim: may not pass S2 (checkable), S4 (based).
InterpretationreasoningTraditional metrics such as accuracy, precision, and recall may not be sufficient to capture the nuances of these complex requirements.
“Traditional metrics such as accuracy, precision, and recall may not be sufficient to capture the nuances of these complex requirements.”
Quote in the paperNot a substantial claimMay combine two claims.
PremisecitationThe lack of safe responses, DiG, and UsEx within VMHAs has drawn criticism and raised concerns about the impact on adherence.
“Despite the AI community's considerable interest in evaluating health assistants' adherence to user needs (Davis et al., 2020), the lack of safe responses, DiG, and UsEx within VMHAs has drawn criticism and raised concerns about the impact on adherence.”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Davis et al., 2020
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- Rests on an assumption: The examples in Figures 2, 3, and 4 are representative of how VMHAs generally behave.
Probably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationALLEVIATE creates a subgraph from the user's utterances and chatbot questions during the conversation, constructed by actively querying UMLS for disorders and symptoms and Rx-NORM for medicine.
“ALLEVIATE creates a subgraph from the user's utterances and chatbot questions during the conversation. This subgraph is constructed by actively querying two knowledge bases: UMLS, for disorders and symptoms and Rx-NORM for medicine (Liu et al., 2005).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Liu et al., 2005
Not checked in the free run.
- Rests on an assumption: The survey of 40 participants at Prisma Health provides a valid basis for the high-level analysis of Woebot, Wysa, and Alleviate.
Probably not a substantial claim: may not pass S2 (checkable), S4 (based).
Interpretationnone givenKnowledge in various human-curated knowledge bases (both online and offline) is more exhaustive in terms of context.
“In contrast, knowledge in various human-curated knowledge bases (both online and offline) is more exhaustive in terms of context.”
Quote in the paperNot a substantial claim
The paper relies on this without support.
Fabrication and hallucination problems already exist in smaller language models and are even more pronounced in larger ones.
“While these problems already exist in smaller language models, they are even more pronounced in larger ones.”
The paper relies on this without support.
Clinical specification questions are safe and medically adapted.
“Such questions are safe and medically adapted.”
The paper relies on this without support.
The examples in Figures 2, 3, and 4 are representative of how VMHAs generally behave.
“VMHAs (as exemplified in Figures 2, 3) generate incoherent and unsafe responses when a user tries to seek a response for clinically relevant questions or vice-versa.”
“Without these specific keyphrases, GPT 3.5 may produce incorrect inferences [shown in (b)].”
The paper relies on this without support.
The survey of 40 participants at Prisma Health provides a valid basis for the high-level analysis of Woebot, Wysa, and Alleviate.
“For Woebot, Wysa, and Alleviate, a survey of 40 participants was carried out at Prisma Health.”
The paper relies on this without support.
The clinical knowledge bases UMLS and RxNorm contain accurate and sufficient relationships between pregnancy, symptoms, and causes for generating symbolic questions.
“In Figure 4(a), the process generates two symbolic questions based on the relationship between pregnancy, symptoms, and causes found in clinical knowledge sources UMLS and RxNorm.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
AI systems introduce novel stressors that are continuous, personally salient, and socially immersive, thereby functioning as 24-hour contextual stimuli capable of modulating arousal, perception, and belief formation.
“These systems introduce novel stressors that are continuous, personally salient, and socially immersive, thereby functioning as 24-hour contextual stimuli capable of modulating arousal, perception, and belief formation [19].”
From Delusional Experiences Emerging From AI Chatbot Interactions or “AI Psychosis” (2025) · cites this paper as [19]
Section 5.1 (page unavailable) says Woebot and Wysa track mood changes throughout the day and warns that discussing certain topics could exacerbate a user's mental health condition. It does not characterize these systems as continuous, socially immersive stressors or 24-hour stimuli, or say they modulate arousal, perception, and belief formation. (LLM, conf=0.77)
Experimental — accuracy not yet measuredSystematic and scoping reviews show that LLM-CB risks (e.g., consistencies, hallucinations, ethical risks) may outweigh potential benefits.
“Systematic and scoping reviews show that LLM-CB risks (e.g., consistencies, hallucinations, ethical risks) may outweigh potential benefits33,76,77.”
From A scoping review on the mental health harms of LLM-based chatbots (2026) · cites this paper as [77]
Section 2.1 says the consequences of LLMs’ black-box behavior are more concerning than their utility, particularly in mental health. Sections 5 and 6.1 describe incoherent, hallucinated, and unsafe responses from virtual mental health assistants. The source supports the risk–benefit concern in that setting, but it does not identify itself as a systematic or scoping review or establish the claim for LLM chatbots generally. (LLM, conf=0.85)
Experimental — accuracy not yet measured
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Gupta, S., Agarwal, A., Gaur, M., Roy, K., Narayanan, V., Kumaraguru, P., & Sheth, A. (2022) · Proceedings of the Eighth Workshop on Computational Linguistics and Clinical Psychology · doi:10.18653/v1/2022.clpsych-1.12 · Cited by 27 · see citing works
Self-citationInterdisciplinary IoT and Emotion Knowledge Graph-Based Recommendation System to Boost Mental Health
Gyrard, A., & Boudaoud, K. (2022) · Applied Sciences · doi:10.3390/app12199712 · Cited by 24 · see citing works
Adapting and Implementing Apps for Mental Healthcare
Zielasek, J., Reinhardt, I., Schmidt, L., & Gouzoulis‐Mayfrank, E. (2022) · Current Psychiatry Reports · doi:10.1007/s11920-022-01350-3 · Cited by 23 · see citing works
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DeMasi, O., Hearst, M. A., & Recht, B. (2019) · Workshop on Computational Linguistics and Clinical Psychology (CLPsych) · doi:10.18653/v1/w19-3001 · Cited by 18 · see citing works
Srivastava, B. (2021) · Patterns · doi:10.1016/j.patter.2021.100308 · Cited by 18 · see citing works
Self-citationHEAL: A Knowledge Graph for Distress Management Conversations
Welivita, A., & Pu, P. (2022) · Proceedings of the AAAI Conference on Artificial Intelligence · doi:10.1609/aaai.v36i10.21398 · Cited by 18 · see citing works
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Self-citationSemantic Diversity in Dialogue with Natural Language Inference
Stasaski, K., & Hearst, M. A. (2022) · Conference of the North American Chapter of the Association for Computational Linguistics: Human Language Technologies (NAACL-HLT) · doi:10.18653/v1/2022.naacl-main.6 · Cited by 17 · see citing works
Explaining Models of Mental Health via Clinically Grounded Auxiliary Tasks
Zirikly, A., & Dredze, M. H. (2022) · Workshop on Computational Linguistics and Clinical Psychology (CLPsych) · doi:10.18653/v1/2022.clpsych-1.3 · Cited by 16 · see citing works
Evaluating Superhuman Models with Consistency Checks
Fluri, L., Paleka, D., & Tramèr, F. (2024) · IEEE Conference on Secure and Trustworthy Machine Learning (SaTML) · doi:10.1109/satml59370.2024.00017 · Cited by 14 · see citing works
Ghosh, S. K., Ekbal, A., & Bhattacharyya, P. (2022) · International Joint Conference on Artificial Intelligence · doi:10.24963/ijcai.2022/704 · Cited by 13 · see citing works
A Study of Automatic Metrics for the Evaluation of Natural Language Explanations
Clinciu, M., Eshghi, A., & Hastie, H. (2021) · Conference of the European Chapter of the Association for Computational Linguistics · doi:10.18653/v1/2021.eacl-main.202 · Cited by 13 · see citing works
Evaluation of In-Person Counseling Strategies To Develop Physical Activity Chatbot for Women
Liang, K.-H., Lange, P. L., Oh, Y. J., Zhang, J., Fukuoka, Y., & Yu, Z. (2021) · Annual Meeting of the Special Interest Group on Discourse and Dialogue · doi:10.18653/v1/2021.sigdial-1.5 · Cited by 12 · see citing works
Towards Detecting Need for Empathetic Response in Motivational Interviewing
Wu, Z., Helaoui, R., Kumar, V., Recupero, D. R., & Riboni, D. (2020) · Companion Publication of the International Conference on Multimodal Interaction (ICMI Companion) · doi:10.1145/3395035.3425228 · Cited by 12 · see citing works
AttViz: Online exploration of self-attention for transparent neural language modelingPreprint
Škrlj, B., Eržen, N., Sheehan, S., Luz, S. F., Robnik‐Šikonja, M., & Pollak, S. (2020) · arXiv (Cornell University) · doi:10.48550/arxiv.2005.05716 · Cited by 9 · see citing works
Functional Transparency for Structured Data: a Game-Theoretic ApproachPreprint
Lee, G.-H., Jin, W., Alvarez-Melis, D., & Jaakkola, T. (2019) · arXiv (Cornell University) · doi:10.48550/arxiv.1902.09737 · Cited by 9 · see citing works
Process Knowledge-infused Learning for Suicidality Assessment on Social MediaPreprint
Roy, K., Gaur, M., Zhang, Q., & Sheth, A. (2022) · arXiv (Cornell University) · doi:10.48550/arxiv.2204.12560 · Cited by 7 · see citing works
Self-citationChatGPT and Medicine: Fears, Fantasy, and the Future of Physicians
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Using In-Context Learning to Improve Dialogue SafetyPreprint
Meade, N., Gella, S., Hazarika, D., Gupta, P., Jin, D., Reddy, S., Liu, Y., & Hakkani-Tür, D. Z. (2023) · arXiv (Cornell University) · doi:10.48550/arxiv.2302.00871 · Cited by 1 · see citing works
Evaluating Superhuman Models with Consistency ChecksPreprint
Fluri, L., Paleka, D., & Tramèr, F. (2023) · arXiv (Cornell University) · doi:10.48550/arxiv.2306.09983 · Cited by 1 · see citing works
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“These systems introduce novel stressors that are continuous, personally salient, and socially immersive, thereby functioning as 24-hour contextual stimuli capable of modulating arousal, perception, and belief formation [19].”
Safety of Large Language Models in Addressing Depression
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Mental Health Applications of Generative AI and Large Language Modeling in the United States
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Chen, K., Xu, W., & Li, X. (2024) · Academic Radiology · doi:10.1016/j.acra.2024.08.052 · Cited by 22 · see citing works
Tilton, A. K., Caplan, B. E., & Cole, B. J. (2025) · Frontiers in Digital Health · doi:10.3389/fdgth.2025.1616488 · Cited by 21 · see citing works
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Vairamani, A. D. (2024) · The Springer series in applied machine learning · doi:10.1007/978-3-031-63821-3_12 · Cited by 6 · see citing works
The dangers of AI friendship: Adolescent mental health and ethical oversight
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Predicting Digital Addiction Patterns with Machine Learning for Personalised Mental Health Support
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A scoping review on the mental health harms of LLM-based chatbots
Diel, A., Torous, J., Cuijpers, P., Kleesiek, J., Nensa, F., Weber, N., Faust, F., Lalgi, T. J., Mellis, F. S., Teufel, M., et al. (2026) · npj Digital Medicine · doi:10.1038/s41746-026-03054-x · Cited by 4 · see citing works
“Systematic and scoping reviews show that LLM-CB risks (e.g., consistencies, hallucinations, ethical risks) may outweigh potential bene fi ts 33,76,77 .”
Generative AI Health Assistants in Modern Healthcare: Drivers and Barriers to Adoption
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How explanatory features of AI and time frame reshape adolescents’ decision-making
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Digital Psychiatry: Opportunities, Challenges, and Future Directions
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Recommendation endpoints and safety of an online self-triage for depression symptoms
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A bibliometric analysis of large language models in mental health research
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Using Explainable AI for Assessment of Depression: A Systematic Literature Review
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Dalal, S., Tilwani, D., Gaur, M., Jain, S., Shalin, V. L., & Sheth, A. P. (2024) · Maryland Shared Open Access Repository (USMAI Consortium) · doi:10.13016/m2e7io-a2k6
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Erdem, G., Kafesçioğlu, N., & Başer, G. (2026) · Journal of Marital and Family Therapy · doi:10.1111/jmft.70168
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Salinas-Layana, A., Jiménez-Molina, Á., Lira, D., Montoya, F. V., Venegas, A., Muñoz, N., Chandía, M., Rojas, R., & Martínez, V. (2026) · JMIR Research Protocols · doi:10.2196/91677
- Authors
- Sarkar, S., Gaur, M., Chen, L. K., Garg, M., & Srivastava, B.
- Affiliations
- University of Maryland, Baltimore County (US)
- Mayo Clinic (US)
- University of South Carolina (US)
- Corresponding author
- Sarkar, Surjodeep
- Venue
- Frontiers in Artificial Intelligence
- Publisher
- Frontiers Media SA
- Published
- 2023-10-12
- Volume
- 6
- Pages
- 1229805-1229805
- ISSN
- 2624-8212 (ISSN-L)
- PMC
- PMC10601652
- OpenAlex
- W4387578765
- Semantic Scholar
- 6f542f60a5d4f540d056bb49d47f89f1035ad0cf
- Cited by
- 38
- References
- 121
- Citations by year
- 2026: 10 · 2025: 16 · 2024: 11 · 2023: 1
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Artificial Intelligence (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Maryland Shared Open Access Repository (USMAI Consortium) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Digital Repository at the University of Maryland (University of Maryland College Park) (cc-by)
- Topics
- Physical Sciences › Computer Science › Artificial Intelligence › Explainable Artificial Intelligence (XAI)
- Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
- Health Sciences › Medicine › Health Informatics › Artificial Intelligence in Healthcare and Education
- Keywords
- chatbots, explainability, AI safety, ChatGPT, GPT-4, cognitive behavioral therapy, mental health professionals, trust in AI, large language models
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Claims read by deepseek-v4.1-flash under definition version 3 (extract-v3) on 2026-10-09.
Classified by jev-1.13-20260917 (gold-guideline-v0.2) on 2026-10-09.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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