Gut Microbiota and Type 1 Diabetes
Open accessAbstract
Recently, the onset of type 1 diabetes (T1D) has increased rapidly and became a major public health concern worldwide. Various factors are associated with the development of T1D, such as diet, genome, and intestinal microbiota. The gastrointestinal (GI) tract harbors a complex and dynamic population of microorganisms, the gut microbiota, which exert a marked influence on the host homeostasis and metabolic diseases. Recent evidence shows that altered gut bacterial composition (dysbiosis) is highly associated with the pathogenesis of insulin dysfunction and T1D and, thus, targeting gut microbiota may serve as a therapeutic potential for T1D patients. In this study, we updated the effect of gut microbiota on T1D and potential mechanisms were discussed.
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Patients with type 1 diabetes mellitus have an altered intestinal flora compared to healthy individuals.
“Studies have shown that patients with T1DM have an altered intestinal flora compared to healthy individuals [104].”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [104]
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Bell, V., Ferrão, J., Pimentel, L., Pintado, M., & Fernandes, T. (2018) · Foods · doi:10.3390/foods7120195 · Cited by 188 · see citing works
- Authors
- Han, H., Li, Y., Fang, J., Liu, G., Yin, J., Li, T., & Yin, Y.
- Affiliations
- Chinese Academy of Sciences (CN)
- Hunan Agricultural University (CN)
- Corresponding author
- Yin, Jie
- Li, Tiejun
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2018-03-27
- Volume
- 19
- Issue
- 4
- Pages
- 995
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC5979537
- OpenAlex
- W2795138078
- Cited by
- 206
- References
- 87
- Citations by year
- 2026: 5 · 2025: 20 · 2024: 14 · 2023: 46 · 2022: 44 · 2021: 33 · 2020: 22 · 2019: 18 · 2018: 4
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Basic Research Program of China (973) (2013CB127301)
- National Natural Science Foundation of China (31772642, 31672457, 31472106)
- Hunan Key Research Program (2017NK2321, 2017NK2322)
- China Agriculture Research System (CARS-35)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- gut microbiota, type 1 diabetes, dysbiosis, diabetes pathogenesis, host-microbe interactions, diet and microbiome
- MeSH terms
- Gastrointestinal Microbiome, Animals, Diabetes Mellitus, Type 1, Diet, Homeostasis, Humans, Dysbiosis
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