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The Rich World of p53 DNA Binding Targets: The Role of DNA Structure

Brázda, Václav, Fojta, Miroslav·2019·International Journal of Molecular Sciences
DOI 10.3390/ijms20225605
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Abstract

The tumor suppressor functions of p53 and its roles in regulating the cell cycle, apoptosis, senescence, and metabolism are accomplished mainly by its interactions with DNA. p53 works as a transcription factor for a significant number of genes. Most p53 target genes contain so-called p53 response elements in their promoters, consisting of 20 bp long canonical consensus sequences. Compared to other transcription factors, which usually bind to one concrete and clearly defined DNA target, the p53 consensus sequence is not strict, but contains two repeats of a 5′RRRCWWGYYY3′ sequence; therefore it varies remarkably among target genes. Moreover, p53 binds also to DNA fragments that at least partially and often completely lack this consensus sequence. p53 also binds with high affinity to a variety of non-B DNA structures including Holliday junctions, cruciform structures, quadruplex DNA, triplex DNA, DNA loops, bulged DNA, and hemicatenane DNA. In this review, we summarize information of the interactions of p53 with various DNA targets and discuss the functional consequences of the rich world of p53 DNA binding targets for its complex regulatory functions.

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Cited by

See all 55

Metadata

Authors
Brázda, V., & Fojta, M.
Affiliations
Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 612 65 Brno, Czech Republic
ORCID
Brázda, Václav
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2019-11-09
Volume
20
Issue
22
Pages
5605
ISSN
1422-0067
DOI
10.3390/ijms20225605
Cited by
55
References
17
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
  • Grantová Agentura České Republiky (18-15548S)
  • European Regional Development Fund (CZ.02.1.01/0.0/0.0/15 003/0000477)

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CoChat. (2026). Citation check: The Rich World of p53 DNA Binding Targets: The Role of DNA Structure. https://app.cochat.ai/papers/10.3390/ijms20225605
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Brázda, V., & Fojta, M. (2019). The Rich World of p53 DNA Binding Targets: The Role of DNA Structure. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms20225605

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