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Cited by 57Multiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanismsMitochondrial Function and Pathology

Oligodendroglial Energy Metabolism and (re)Myelination

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Tepavčević, Vanja·2021·Life
DOI 10.3390/life11030238PMC PMC7998845

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Abstract

Central nervous system (CNS) myelin has a crucial role in accelerating the propagation of action potentials and providing trophic support to the axons. Defective myelination and lack of myelin regeneration following demyelination can both lead to axonal pathology and neurodegeneration. Energy deficit has been evoked as an important contributor to various CNS disorders, including multiple sclerosis (MS). Thus, dysregulation of energy homeostasis in oligodendroglia may be an important contributor to myelin dysfunction and lack of repair observed in the disease. This article will focus on energy metabolism pathways in oligodendroglial cells and highlight differences dependent on the maturation stage of the cell. In addition, it will emphasize that the use of alternative energy sources by oligodendroglia may be required to save glucose for functions that cannot be fulfilled by other metabolites, thus ensuring sufficient energy input for both myelin synthesis and trophic support to the axons. Finally, it will point out that neuropathological findings in a subtype of MS lesions likely reflect defective oligodendroglial energy homeostasis in the disease.

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Cited by

Sorted by citations

Authors
Tepavčević, V.
Affiliations
University of the Basque Country (ES)
Corresponding author
Tepavčević, Vanja
ORCID
Tepavčević, Vanja
Venue
Life
Publisher
MDPI AG
Published
2021-03-13
Volume
11
Issue
3
Pages
238
ISSN
2075-1729 (ISSN-L)
DOI
10.3390/life11030238
PMC
PMC7998845
OpenAlex
W3127974202
Cited by
57
References
11
Citations by year
2026: 12 · 2025: 19 · 2024: 9 · 2023: 5 · 2022: 9 · 2021: 3
FWCI
1.14
Type
journal article
Language
en
Open access
Licence
Locations
  • Life (publishedVersion, cc-by)
  • Preprints.org (acceptedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Communities in ADDI (University of the Basque Country) (submittedVersion, cc-by)
  • Communities in ADDI (Universidad del Pais Vasco) (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Hispana (submittedVersion, cc-by)
Funders
Ministerio de Economía, Industria y Competitividad, Gobierno de España (SAF2015-74332-JIN)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords
remyelination, demyelination, multiple sclerosis, myelin synthesis, oligodendrocyte maturation, alternative energy, energy homeostasis

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