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Cited by 228Seaweed-derived Bioactive CompoundsAntioxidant Activity and Oxidative StressAlgal biology and biofuel production

The DOI matches its Crossref record; 168 of the 170 references it cites were found in a registry or an index, and 1 are not checked yet.

Carotenoids from Marine Microalgae: A Valuable Natural Source for the Prevention of Chronic Diseases

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Raposo, Maria, De Morais, Alcina, De Morais, Rui·2015·Marine Drugs
DOI 10.3390/md13085128PMC PMC4557017
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Abstract

Epidemiological studies have shown a relation between antioxidants and the prevention of several chronic diseases. Microalgae are a potential novel source of bioactive molecules, including a wide range of different carotenoids that can be used as nutraceuticals, food supplements and novel food products. The objective of this review is (i) to update the research that has been carried out on the most known carotenoids produced by marine microalgae, including reporting on their high potentialities to produce other less known important compounds; (ii) to compile the work that has been done in order to establish some relationship between carotenoids and oxidative protection and treatment; (iii) to summarize the association of oxidative stress and the various reactive species including free radicals with several human diseases; and (iv) to provide evidence of the potential of carotenoids from marine microalgae to be used as therapeutics to treat or prevent these oxidative stress-related diseases.

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Figure 1 Pathways for the carotenogenesis and biosynthesis of astaxanthin, based on Han et al. [27], Dambek et al. [48] and Takaichi [29], and the synthesis of fucoxanthin and diadinoxanthin in diatoms [61], including P. tricornutum, proposed by Dambek and colleagues [48]. The genes and enzymes involved in the process and already identified in some microalgae are evidenced; the underlined ones were reported by Bertrand [61].
Figure 1 Pathways for the carotenogenesis and biosynthesis of astaxanthin, based on Han et al. [27], Dambek et al. [48] and Takaichi [29], and the synthesis of fucoxanthin and diadinoxanthin in diatoms [61], including P. tricornutum, proposed by Dambek and colleagues [48]. The genes and enzymes involved in the process and already identified in some microalgae are evidenced; the underlined ones were reported by Bertrand [61].CC BY · PubMed Central
Figure 2 Cascade triggered within a cell by O2•− (superoxide radical) generated mainly by NADPH oxidase. Some reactions with lipid hydroperoxides (LOOH) are also included (dashed arrows; M = transition metal) [58,63,64,65].
Figure 2 Cascade triggered within a cell by O2•− (superoxide radical) generated mainly by NADPH oxidase. Some reactions with lipid hydroperoxides (LOOH) are also included (dashed arrows; M = transition metal) [58,63,64,65].CC BY · PubMed Central

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  1. FitzGerald, 1996, Generation of 8-epi prostaglandin F2α by human monocytes: Discriminate production by reactive oxygen species and prostaglandin endoperoxide synthase-2, J. Biol. Chem., 271, 8919

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Metadata

Authors
Raposo, M., De Morais, A., & De Morais, R.
Affiliations
  • Universidade Católica Portuguesa (PT)
  • CBQF—Centro de Biotecnologia e Química Fina—Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa/Porto, Rua Arquiteto Lobão Vital, Porto 4202-401, Portugal
ORCID
Venue
Marine Drugs
Publisher
MDPI AG
Published
2015-08-14
Volume
13
Issue
8
Pages
5128-5155
ISSN
1660-3397 (ISSN-L)
DOI
10.3390/md13085128
PMC
PMC4557017
OpenAlex
W1495693701
Cited by
228
References
170
Citations by year
2026: 12 · 2025: 26 · 2024: 23 · 2023: 25 · 2022: 29 · 2021: 31 · 2020: 23 · 2019: 26 · 2018: 18 · 2017: 11 · 2016: 4
FWCI
1.38
Type
journal article
Language
en
Open access
Licence
Locations
  • Marine Drugs (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, cc-by)
Funders
Fundação para a Ciência e a Tecnologia (OE/EQB/LA0016/2013, PEst-OE/EQB/LA0016/2013)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
  • Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
  • Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
Keywords
carotenoids, marine microalgae, antioxidants, oxidative stress, free radicals, reactive oxygen species, chronic disease prevention, nutraceuticals, dietary supplements, novel foods
MeSH terms
Animals, Antioxidants, Biological Products, Carotenoids, Chronic Disease, Humans, Oxidative Stress, Microalgae

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