Contribution of Inhibitory Metabolites and Competition for Nutrients to Colonization Resistance against Clostridioides difficile by Commensal Clostridium
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Clostridioides difficile is an anaerobic pathogen that causes significant morbidity and mortality. Understanding the mechanisms of colonization resistance against C. difficile is important for elucidating the mechanisms by which C. difficile is able to colonize the gut after antibiotics. Commensal Clostridium play a key role in colonization resistance. They are able to modify bile acids which alter the C. difficile life cycle. Commensal Clostridium also produce other inhibitory metabolites including antimicrobials and short chain fatty acids. They also compete with C. difficile for vital nutrients such as proline. Understanding the mechanistic effects that these metabolites have on C. difficile and other gut pathogens is important for the development of new therapeutics against C. difficile infection (CDI), which are urgently needed.
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Microbial BA metabolism is an important mechanism of colonization resistance against C. difficile.
“microbial BA metabolism is an important mechanism of colonization resistance against C. difficile”
From Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut (2023) · cites this paper as [25]
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BaiCD gene cluster abundance is negatively correlated with Clostridium difficile infection
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Self-citationPhysiological Role of Bile Acids Modified by the Gut Microbiome
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- Authors
- Reed, A. D., & Theriot, C. M.
- Affiliations
- North Carolina State University (US)
- Corresponding author
- Theriot, Casey M.
- Venue
- Microorganisms
- Publisher
- MDPI AG
- Published
- 2021-02-12
- Volume
- 9
- Issue
- 2
- Pages
- 371
- ISSN
- 2076-2607 (ISSN-L)
- PMC
- PMC7918557
- OpenAlex
- W3131092505
- Cited by
- 39
- References
- 100
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 13 · 2023: 9 · 2022: 3 · 2021: 2
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Microorganisms (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institute of General Medical Sciences of the National Institutes of Health (R35GM119438)
- NCSU Molecular Biology Training Program T32 GM008776 through NIH (T32 GM008776)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- Clostridium difficile, colonization resistance, inhibitory metabolites, short-chain fatty acids, antimicrobial agents, nutrient competition, Clostridium difficile infection, gut microbiota, antibiotic-associated diarrhea
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