l-Carnitine Supplementation in Older Women. A Pilot Study on Aging Skeletal Muscle Mass and Function
Open accessAbstract
Skeletal muscle wasting, associated with aging, may be regulated by the inflammatory cytokines as well as by insulin-like growth factor 1 (IGF-1). l-carnitine possesses anti-inflammatory properties and increases plasma IGF-1 concentration, leading to the regulation of the genes responsible for protein catabolism and anabolism. The purpose of the present study was to evaluate the effect of a 24-week l-carnitine supplementation on serum inflammatory markers, IGF-1, body composition and skeletal muscle strength in healthy human subjects over 65 years of age. Women between 65 and 70 years of age were supplemented for 24 weeks with either 1500 mg l-carnitine-l-tartrate or an isonitrogenous placebo per day in a double-blind fashion. Before and after the supplementation protocol, body mass and composition, as well as knee extensor and flexor muscle strength were determined. In the blood samples, free carnitine, interleukin-6, tumor necrosis factor-α, C-reactive protein and IGF-1 were determined. A marked increase in free plasma carnitine concentration was observed due to l-carnitine supplementation. No substantial changes in other parameters were noted. In the current study, supplementation for 24 weeks affected neither the skeletal muscle strength nor circulating markers in healthy women over 65 years of age. Positive and negative aspects of l-carnitine supplementation need to be clarified.
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L-carnitine exerts an anti-inflammatory effect in several disease settings.
“L-carnitine exerts an anti-inflammatory effect in several disease settings”
From Novel Insights on Intake of Fish and Prevention of Sarcopenia: All Reasons for an Adequate Consumption (2020) · cites this paper as [96]
In healthy aged women, 24 weeks of 1500 mg l-carnitine-l-tartrate supplementation is associated with a better preservation of lean mass.
“Sawicka et al. [96] demonstrated that 24 weeks of 1500 mg l-carnitine-l-tartrate supplementation is associated with a better preservation of lean mass in healthy aged women.”
From Novel Insights on Intake of Fish and Prevention of Sarcopenia: All Reasons for an Adequate Consumption (2020) · cites this paper as [96]
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- Authors
- Sawicka, A., Hartmane, D., Lipinska, P., Wojtowicz, E., Lysiak-Szydlowska, W., & Olek, R.
- Affiliations
- Gdansk University of Physical Education and Sport (PL)
- Latvijas Organiskās Sintēzes Institūts (LV)
- Institute of Physical Culture, Kazimierz Wielki University, 85-091 Bydgoszcz, Poland
- Department of Anatomy and Anthropology, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland
- Department of Health Sciences, Powislanski College, 82-500 Kwidzyn, Poland
- Corresponding author
- Olek, Robert
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2018-02-23
- Volume
- 10
- Issue
- 2
- Pages
- 255
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC5852831
- OpenAlex
- W2791466668
- Cited by
- 49
- References
- 62
- Citations by year
- 2025: 6 · 2024: 5 · 2023: 8 · 2022: 10 · 2021: 3 · 2020: 7 · 2019: 6 · 2018: 3 · 2016: 1
- FWCI
- 3.27
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Science Centre in Poland (2014/15/B/NZ7/00893)
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- carnitine supplementation, sarcopenia, skeletal muscle mass, muscle strength, older women, aging, insulin-like growth factor I, inflammatory cytokines, interleukin-6, TNF-α, C-reactive protein, free carnitine, body composition, quadriceps strength, hamstring strength
- MeSH terms
- Aged, Anti-Inflammatory Agents, Body Composition, C-Reactive Protein, Carnitine, Double-Blind Method, Female, Humans, Insulin-Like Growth Factor I, Pilot Projects, Tumor Necrosis Factor-alpha, Biomarkers, Interleukin-6, Body Mass Index, Muscle, Skeletal, Dietary Supplements, Muscle Strength
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