Cited by 291Adipokines, Inflammation, and Metabolic DiseasesFatty Acid Research and HealthLipid metabolism and biosynthesis

The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.

A saturated fatty acid–rich diet induces an obesity-linked proinflammatory gene expression profile in adipose tissue of subjects at risk of metabolic syndrome

Open access

van Dijk, Susan J, Feskens, Edith JM, Bos, Marieke B, Hoelen, Dianne WM, Heijligenberg, Rik, Bromhaar, Mechteld Grootte, de Groot, Lisette CPGM, de Vries, Jeanne HM, Müller, Michael, Afman, Lydia A·2009·The American Journal of Clinical Nutrition

DOI 10.3945/ajcn.2009.27792

Open this paper in CoChat — free account

Abstract

Background Changes in dietary fat composition could lower the risk of developing metabolic syndrome. Adipose tissue is an interesting tissue in this respect because of its role in lipid metabolism and inflammation.Objective Our objective was to investigate the effect of a saturated fatty acid (SFA)- and a monounsaturated fatty acid (MUFA)-rich diet on insulin sensitivity, serum lipids, and gene expression profiles of adipose tissue in subjects at risk of metabolic syndrome.Design A parallel controlled-feeding trial was conducted in 20 abdominally overweight subjects. Subjects received an SFA diet or a MUFA diet for 8 wk. Plasma and subcutaneous adipose tissue samples were obtained, and insulin sensitivity was measured by using a hyperinsulinemic-euglycemic clamp. Adipose tissue samples underwent whole-genome microarray and histologic analysis. Plasma and adipose tissue fatty acid composition and concentrations of serum cholesterol and plasma cytokine were determined.Results Consumption of the SFA diet resulted in increased expression of genes involved in inflammation processes in adipose tissue, without changes in morphology or insulin sensitivity. The MUFA diet led to a more antiinflammatory gene expression profile, which was accompanied by a decrease in serum LDL-cholesterol concentrations and an increase in plasma and adipose tissue oleic acid content.Conclusions Consumption of an SFA diet resulted in a proinflammatory "obesity-linked" gene expression profile, whereas consumption of a MUFA diet caused a more antiinflammatory profile. This suggests that replacement of dietary SFA with MUFA could prevent adipose tissue inflammation and may reduce the risk of inflammation-related diseases such as metabolic syndrome. This trial was registered at clinicaltrials.gov as NCT00405197.

Integrity signals

Registry

Crossref · 10.3945/ajcn.2009.27792

Cites

46 of 46 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge
Friedewald, W. T., Levy, R. I., & Fredrickson, D. S. (1972) · Clinical Chemistry · doi:10.1093/clinchem/18.6.499 · Cited by 32,423
Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments
Smyth, G. K. (2004) · Statistical Applications in Genetics and Molecular Biology · doi:10.2202/1544-6115.1027 · Cited by 11,829
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
A comparison of normalization methods for high density oligonucleotide array data based on variance and bias
Bolstad, B. M., Irizarry, R. A., Åstrand, M., & Speed, T. P. (2003) · Bioinformatics · doi:10.1093/bioinformatics/19.2.185 · Cited by 8,328
Glucose clamp technique: a method for quantifying insulin secretion and resistance.
DeFronzo, R. A., Tobin, J. D., & Andres, R. (1979) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1979.237.3.e214 · Cited by 7,425
Summaries of Affymetrix GeneChip probe level data
Irizarry, R. A. (2003) · Nucleic Acids Research · doi:10.1093/nar/gng015 · Cited by 4,837
Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.
Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., & Spiegelman, B. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117936 · Cited by 3,543
Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans
Cinti, S., Mitchell, G., Barbatelli, G., Murano, I., Ceresi, E., Faloia, E., Wang, S., Fortier, M., Greenberg, A. S., & Obin, M. S. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500294-jlr200 · Cited by 2,529
Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes.
Guilherme, A., Virbasius, J. V., Puri, V., & Czech, M. P. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2391 · Cited by 2,292
Adipokines: inflammation and the pleiotropic role of white adipose tissue
Trayhurn, P., & Wood, I. S. (2004) · British Journal of Nutrition · doi:10.1079/bjn20041213 · Cited by 2,210
Effect of a Mediterranean-Style Diet on Endothelial Dysfunction and Markers of Vascular Inflammation in the Metabolic Syndrome: A Randomized Trial
Esposito, K., Marfella, R., Ciotola, M., Di Palo, C., Giugliano, F., Giugliano, G., D'Armiento, M., D'Andrea, F., & Giugliano, D. (2004) · JAMA · doi:10.1001/jama.292.12.1440 · Cited by 2,126
Metabolic Syndrome and Risk of Incident Cardiovascular Events and Death
Gami, A. S., Witt, B. J., Howard, D. E., Erwin, P. J., Gami, L. A., Somers, V. K., & Montori, V. M. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.09.032 · Cited by 1,888
Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data
Dai, M. (2005) · Nucleic Acids Research · doi:10.1093/nar/gni179 · Cited by 1,807
Adiponectin and Metabolic Syndrome
Matsuzawa, Y., Funahashi, T., Kihara, S., & Shimomura, I. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000099786.99623.ef · Cited by 1,203
Molecular recognition of fatty acids by peroxisome proliferator-activated receptors
Xu, H. E., Lambert, M. H., Montana, V. G., Parks, D. J., Blanchard, S. G., Brown, P. J., Sternbach, D. D., Lehmann, J. M., Wisely, G. B., Willson, T. M., et al. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80467-0 · Cited by 1,169
Reduction of Macrophage Infiltration and Chemoattractant Gene Expression Changes in White Adipose Tissue of Morbidly Obese Subjects After Surgery-Induced Weight Loss
Cancello, R., Henegar, C., Viguerie, N., Taleb, S., Poitou, C., Rouault, C., Coupaye, M., Pelloux, V., Hugol, D., Bouillot, J.-L., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.8.2277 · Cited by 1,164
Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: the KANWU Study
Vessby, B., Uusitupa, M., Hermansen, K., Riccardi, G., Rivellese, A. A., Tapsell, L. C., Nälsén, C., Berglund, L., Louheranta, A., Rasmussen, B. M., et al. (2001) · Diabetologia · doi:10.1007/s001250051620 · Cited by 1,119
The Metabolic Syndrome as Predictor of Type 2 Diabetes
Lorenzo, C., Okoloise, M., Williams, K., Stern, M. P., & Haffner, S. M. (2003) · Diabetes Care · doi:10.2337/diacare.26.11.3153 · Cited by 800
The relation of body fat mass and distribution to markers of chronic inflammation
Festa, A., D'Agostino, R., Jr., Williams, K. M., Aj, K., Mayer-Davis, E., Tracy, R. P., & Haffner, S. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801792 · Cited by 722
T-Cell Accumulation and Regulated on Activation, Normal T Cell Expressed and Secreted Upregulation in Adipose Tissue in Obesity
Wu, H., Ghosh, S., Perrard, X. D., Feng, L., García, G., Perrard, J. L., Sweeney, J. F., Peterson, L. E., Chan, L., Smith, C. W., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.638379 · Cited by 696
T-lymphocyte Infiltration in Visceral Adipose Tissue: A Primary Event in Adipose Tissue Inflammation and the Development of Obesity-Mediated Insulin Resistance
Kintscher, U., Hartge, M., Hess, K., Foryst-Ludwig, A., Clemenz, M., Wabitsch, M., Fischer-Posovszky, P., Barth, T. F. E., Dragun, D., Skurk, T., et al. (2008) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.165100 · Cited by 692
Weight loss regulates inflammation‐related genes in white adipose tissue of obese subjects
ClÉment, K., Viguerie, N., Poitou, C., Carette, C., Pelloux, V., Curat, C. A., Sicard, A., Rome, S., Benis, A., Zucker, J., et al. (2004) · The FASEB Journal · doi:10.1096/fj.04-2204com · Cited by 640
Body-composition assessment via air-displacement plethysmography in adults and children: a review
Fields, D. A., Goran, M. I., & McCrory, M. A. (2002) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/75.3.453 · Cited by 638
Saturated Fatty Acid-Mediated Inflammation and Insulin Resistance in Adipose Tissue: Mechanisms of Action and Implications
Kennedy, A. J., Martinez, K., Chuang, C., LaPoint, K., & McIntosh, M. (2008) · Journal of Nutrition · doi:10.3945/jn.108.098269 · Cited by 579
Peroxisome Proliferator-Activated Receptor γ and Adipose Tissue—Understanding Obesity-Related Changes in Regulation of Lipid and Glucose Metabolism
Sharma, A. M., & Staels, B. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1268 · Cited by 483
Dietary fatty acids affect plasma markers of inflammation in healthy men fed controlled diets: a randomized crossover study
Baer, D. J., Judd, J. T., Clevidence, B. A., & Tracy, R. P. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.6.969 · Cited by 476
Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity
Henegar, C., Tordjman, J., Achard, V., Lacasa, D., Cremer, I., Guerre-Millo, M., Poitou, C., Basdevant, A., Stich, V., Viguerie, N., et al. (2008) · Genome Biology · doi:10.1186/gb-2008-9-1-r14 · Cited by 471
Inflamed Adipose Tissue
Gustafson, B., Hammarstedt, A., Andersson, C. X., & Smith, U. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.147835 · Cited by 447
Relation of dietary fat and fiber to elevation of C-reactive protein
King, D. E., Egan, B. M., & Geesey, M. E. (2003) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2003.08.020 · Cited by 303
Microarray profiling of isolated abdominal subcutaneous adipocytes from obese vs non-obese Pima Indians: increased expression of inflammation-related genes
Lee, Y. H., Nair, S., Rousseau, E., Allison, D. B., Page, G. P., Tataranni, P. A., Bogardus, C., & Permana, P. A. (2005) · Diabetologia · doi:10.1007/s00125-005-1867-3 · Cited by 265
Plasma fatty acid composition is associated with the metabolic syndrome and low-grade inflammation in overweight adolescents
Platat, C., Drai, J., Oujaa, M., Schlienger, J.-L., & Simon, C. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.6.1178 · Cited by 263
A Mediterranean and a high-carbohydrate diet improve glucose metabolism in healthy young persons
P�rez-Jim�nez, F., L�pez-Miranda, J., Pinillos, M. D., Paz-Rojas, E., Montilla, P., Mar�n, C., Velasco, M. J., Blanco-Molina, A., Jim�nez Perep�rez, J. A., G�mez, P., et al. (2001) · Diabetologia · doi:10.1007/s001250100009 · Cited by 236
Dietary Factors That Promote or Retard Inflammation
Basu, A., Devaraj, S., & Jialal, I. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000214295.86079.d1 · Cited by 222
Expression profiling — best practices for data generation and interpretation in clinical trials
The Tumor Analysis Best Practices Working Group (2004) · Nature Reviews Genetics · doi:10.1038/nrg1297 · Cited by 203
The Modulation of Inflammatory Gene Expression by Lipids: Mediation through Toll-like Receptors
Lee, J. Y., & Hwang, D. H. (2006) · Molecules and Cells · doi:10.1016/s1016-8478(23)12877-9 · Cited by 196
Abdominal adipose tissue cytokine gene expression: relationship to obesity and metabolic risk factors
You, T., Yang, R., Lyles, M. F., Gong, D., & Nicklas, B. J. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00419.2004 · Cited by 173
Increased expression of inflammation-related genes in cultured preadipocytes/stromal vascular cells from obese compared with non-obese Pima Indians
Nair, S., Lee, Y. H., Rousseau, E., Cam, M. C., Tataranni, P. A., Baier, L. J., Bogardus, C., & Permana, P. A. (2005) · Diabetologia · doi:10.1007/s00125-005-1868-2 · Cited by 141
Effect of a high monounsaturated fatty acids diet and a Mediterranean diet on serum lipids and insulin sensitivity in adults with mild abdominal obesity
Bos, M. B., de Vries, J. H. M., Feskens, E. J. M., van Dijk, S. J., Hoelen, D. W. M., Siebelink, E., Heijligenberg, R., & de Groot, C. P. G. M. (2009) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2009.05.008 · Cited by 137
Fasting induces changes in peripheral blood mononuclear cell gene expression profiles related to increases in fatty acid β-oxidation: functional role of peroxisome proliferator–activated receptor α in human peripheral blood mononuclear cells
Bouwens, M., Afman, L. A., & Müller, M. M. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.5.1515 · Cited by 129
Effect of Synthetic Dietary Triglycerides: A Novel Research Paradigm for Nutrigenomics
Sanderson, L. M., de Groot, P. J., Hooiveld, G. J. E. J., Koppen, A., Kalkhoven, E., Müller, M. M., & Kersten, S. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001681 · Cited by 126
Effects of monounsaturated fatty acids ν complex carbohydrates on serum lipoproteins and apoproteins in healthy men and women
Mensink, R. P., de Groot, M. J. M., van den Broeke, L. T., Severijnen-Nobels, A. P., Demacker, P. N. M., & Katan, M. (1989) · Metabolism · doi:10.1016/0026-0495(89)90258-8 · Cited by 100
Are there specific treatments for the metabolic syndrome?
Giugliano, D., Ceriello, A., & Esposito, K. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.1.8 · Cited by 75
Activation of peroxisome proliferator-activated receptor alpha in human peripheral blood mononuclear cells reveals an individual gene expression profile response
Bouwens, M., Afman, L. A., & Müller, M. M. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-262 · Cited by 39
Stability of n−3 fatty acids in human fat tissue aspirates during storage
Deslypère, J. P., van de Bovenkamp, P., Harryvan, J. L., & Katan, M. (1993) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/57.6.884 · Cited by 16
Clustering of metabolic risk factors in young adults: Genes and environment
Peeters, M., Thomis, M. A., Loos, R. J. F., Derom, C. A., Fagard, R., VLIETINCK, R. F., & Beunen, G. P. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.11.024 · Cited by 12
Untitled work
Alberti (1998) · doi:10.1002/(sici)1096-9136(199807)15:7

Flagged first, then by citations

Sorted by citations

Chronic Inflammation in Obesity and the Metabolic Syndrome
Monteiro, R., & Azevedo, I. (2010) · Mediators of Inflammation · doi:10.1155/2010/289645 · Cited by 1,186
“Consumption of a saturated fatty acid-rich diet resulted in a proinflammatory “obesity-linked” gene expression profile, whereas consumption of a monounsaturated fatty acid-rich diet caused a more anti-inflammatory profile [99].”
Background
Western Diet and the Immune System: An Inflammatory Connection
Christ, A., Lauterbach, M., & Latz, E. (2019) · Immunity · doi:10.1016/j.immuni.2019.09.020 · Cited by 907
Gut-liver axis: Pathophysiological concepts and clinical implications
Tilg, H., Adolph, T. E., & Trauner, M. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.09.017 · Cited by 843
Diet and Inflammation
Galland, L. (2010) · Nutrition in Clinical Practice · doi:10.1177/0884533610385703 · Cited by 715
“Consumption of the SFA diet resulted in increased expression of adipose tissue genes promoting inflammation whereas the MUFA diet led to an anti-inflammatory gene expression profile, associated with an increase in plasma and adipose tissue oleic acid content.(31)”
Background
A Consideration of Biomarkers to be Used for Evaluation of Inflammation in Human Nutritional Studies
Calder, P. C., Ahluwalia, N., Albers, R., Bosco, N., Bourdet-Sicard, R., Haller, D., Holgate, S. T., Jönsson, L. S., Latulippe, M. E., Marcos, A., et al. (2013) · British Journal of Nutrition · doi:10.1017/s0007114512005119 · Cited by 425

See all 291

Authors: van Dijk, S. J., Feskens, E. J., Bos, M. B., Hoelen, D. W., Heijligenberg, R., Bromhaar, M. G., de Groot, L. C., de Vries, J. H., Müller, M., & Afman, L. A.
Affiliations: TiFN (NL)
Corresponding author: Afman, Lydia A
ORCID: Feskens, Edith JM
Müller, Michael
Afman, Lydia A
Venue: The American Journal of Clinical Nutrition
Publisher: Elsevier BV
Published: 2009-12
Volume: 90
Issue: 6
Pages: 1656-1664
ISSN: 0002-9165 (ISSN-L)
DOI: 10.3945/ajcn.2009.27792
OpenAlex: W2113492975
Cited by: 291
References: 46
Citations by year: 2026: 5 · 2025: 12 · 2024: 11 · 2023: 11 · 2022: 10 · 2021: 12 · 2020: 14 · 2019: 24 · 2018: 11 · 2017: 25 · 2016: 14 · 2015: 19 · 2014: 18 · 2013: 35 · 2012: 26
FWCI: 15.41
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4842 d)
Locations: American Journal of Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
Socio-Environmental Systems Modeling (acceptedVersion)
UEA Digital Repository (University of East Anglia) (acceptedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Funders: Dutch Diabetes Research Foundation (20060052)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords: saturated fatty acids, monounsaturated fatty acids, dietary fat composition, adipose tissue inflammation, metabolic syndrome, insulin sensitivity, gene expression profiles, oleic acid, LDL cholesterol, overweight, hyperinsulinemic-euglycemic clamp, cytokines
MeSH terms: Adipose Tissue, Adult, Aged, Complement C3, Fatty Acids, Female, Humans, Immunohistochemistry, Insulin Resistance, Lipids, Male, Middle Aged, Chemokine CCL5, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Metabolic Syndrome, PPAR gamma, Adiponectin

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A saturated fatty acid–rich diet induces an obesity-linked proinflammatory gene expression profile in adipose tissue of subjects at risk of metabolic syndrome

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks