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Keeping Older Muscle “Young” through Dietary Protein and Physical Activity
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“Decline in muscle mass is markedly influenced by physical activity, with inactive and sedentary individuals experiencing a more rapid decline that is generally preceded by the development of “anabolic resistance” (i.e., a reduced ability to utilize dietary amino acids for muscle protein synthesis; Moore, 2014;Witard et al., 2018).”
From Nutrition for Special Populations: Young, Female, and Masters Athletes (2019) · cites this paper as Moore, 2014
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Fielding, R. A., Vellas, B., Evans, W. J., Bhasin, S., Morley, J. E., Newman, A. B., Abellan van Kan, G., Andrieu, S., Bauer, J., Breuille, D., et al. (2011) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2011.01.003 · Cited by 3,256
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“3 g/d) (11), even slight differences in the rates of protein synthesis and breakdown could translate into meaningful differences in net protein balance that, over time, could contribute to the risk of developing sarcopenia.”
BackgroundBauer, J., Biolo, G., Cederholm, T., Cesari, M., Cruz-Jentoft, A. J., Morley, J. E., Phillips, S., Sieber, C., Stehle, P., Teta, D., et al. (2013) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.05.021 · Cited by 2,553 · cited 7×
“” Although some evidence suggests that older adults may have an attenuated capacity for insulin-induced suppression of muscle protein breakdown (22), the anabolic resistance of muscle protein synthesis is believed to be the major underlying mechanism of the normal loss of muscle mass with advancing age (8).”
BackgroundMethodInfluentialMuscaritoli, M., Anker, S. D., Argilés, J., Aversa, Z., Bauer, J. M., Biolo, G., Boirie, Y., Bosaeus, I., Cederholm, T., Costelli, P., et al. (2010) · Clinical Nutrition · doi:10.1016/j.clnu.2009.12.004 · Cited by 1,732
Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle
Cuthbertson, D., Smith, K., Babraj, J., Leese, G., Waddell, T., Atherton, P., Wackerhage, H., Taylor, P. M., & Rennie, M. J. (2005) · The FASEB Journal · doi:10.1096/fj.04-2640fje · Cited by 1,211 · cited 2×
“muscle may have a reduced capacity for and/or sensitivity to amino acids, as suggested by observations of a reduced ribosomal protein content (15) and/or dysregulated mTOR (or 1 of its primary downstream effectors ribosomal protein S6 kinase) signaling in response to exogenous amino acids and/or insulin in older muscl…”
BackgroundEffect of 10 Days of Bed Rest on Skeletal Muscle in Healthy Older Adults
Kortebein, P., Ferrando, A., Lombeida, J., Wolfe, R., & Evans, W. J. (2007) · JAMA · doi:10.1001/jama.297.16.1772-b · Cited by 933
Katsanos, C. S., Kobayashi, H., Sheffield-Moore, M., Aarsland, A., & Wolfe, R. R. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00488.2005 · Cited by 923
Volpi, E., Kobayashi, H., Sheffield-Moore, M., Mittendorfer, B., & Wolfe, R. R. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.2.250 · Cited by 846
Cermak, N. M., Res, P. T., de Groot, L. C., Saris, W. H., & van Loon, L. J. (2012) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.037556 · Cited by 827
Resistance exercise for muscular strength in older adults: a meta-analysis
Peterson, M. D., Rhea, M. R., Sen, A., & Gordon, P. M. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.03.004 · Cited by 808
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Cited by
Reduced physical activity in young and older adults: Metabolic and musculoskeletal implications
Bowden Davies, K. A., Pickles, S., Sprung, V. S., Kemp, G. J., Alam, U., Moore, D. R., Tahrani, A. A., & Cuthbertson, D. J. (2019) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018819888824 · Cited by 278
Self-citationGielen, E., Beckwée, D., Delaere, A., De Breucker, S., Vandewoude, M., Bautmans, I., the Sarcopenia Guidelines Development Group of the Belgian Society of Gerontology and Geriatrics (BSGG), Bautmans, I., Beaudart, C., Beckwée, D., et al. (2021) · Nutrition Reviews · doi:10.1093/nutrit/nuaa011 · Cited by 269
Dietary protein, aging and nutritional geometry
Simpson, S. J., Le Couteur, D. G., Raubenheimer, D., Solon-Biet, S. M., Cooney, G. J., Cogger, V. C., & Fontana, L. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.03.001 · Cited by 169
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ten Haaf, D. S. M., Nuijten, M. A. H., Maessen, M. F. H., Horstman, A. M. H., Eijsvogels, T. M. H., & Hopman, M. T. (2018) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqy192 · Cited by 152
Metadata
- Authors
- Moore, D. R.
- Venue
- Advances in Nutrition
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 5
- Issue
- 5
- Pages
- 599S-607S
- ISSN
- 2161-8313
- Cited by
- 80
- References
- 39
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2705 d)
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