A Diet High in Resistant Starch Modulates Microbiota Composition, SCFA Concentrations, and Gene Expression in Pig Intestine
Open accessAbstract
Resistant starch (RS) is highly fermentable by microbiota in the colon, resulting in the production of SCFAs. RS is thought to mediate a large proportion of its health benefits, including increased satiety, through the actions of SCFAs. The aim of this study was to investigate the effects of a diet high in RS on luminal microbiota composition, luminal SCFA concentrations, and the expression of host genes involved in SCFA uptake, SCFA signaling, and satiety regulation in mucosal tissue obtained from small intestine, cecum, and colon. Twenty adult female pigs were either assigned to a digestible starch (DS) diet or a diet high in RS (34%) for a period of 2 wk. After the intervention, luminal content and mucosal scrapings were obtained for detailed molecular analysis. RS was completely degraded in the cecum. In both the cecum and colon, differences in microbiota composition were observed between DS- and RS-fed pigs. In the colon these included the stimulation of the healthy gut-associated butyrate-producing Faecalibacterium prausnitzii, whereas potentially pathogenic members of the Gammaproteobacteria, including Escherichia coli and Pseudomonas spp., were reduced in relative abundance. Cecal and colonic SCFA concentrations were significantly greater in RS-fed pigs, and cecal gene expression of monocarboxylate transporter 1 (SLC16A1) and glucagon (GCG) was induced by RS. In conclusion, our data show that RS modulates microbiota composition, SCFA concentrations, and host gene expression in pig intestine. Combined, our data provide an enhanced understanding of the interaction between diet, microbiota, and host.
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SCFAs such as acetate, propionate, and butyrate are water-soluble and diffusible gut-microbiota-derived metabolites reaching peak concentrations in the caecum and decrease from the proximal to the distal colon.
“SCFAs such as acetate, propionate, and butyrate are water-soluble and diffusible gut-microbiota-derived metabolites reaching their peak concentrations in the caecum and decrease from the proximal to the distal colon36.”
From Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer (2021) · cites this paper as [36]
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- Authors
- Haenen, D., Zhang, J., Souza da Silva, C., Bosch, G., van der Meer, I. M., van Arkel, J., van den Borne, J. J. G. C., Pérez Gutiérrez, O., Smidt, H., Kemp, B., Müller, M., & Hooiveld, G. J. E. J.
- Affiliations
- Wageningen University & Research (NL)
- Corresponding author
- Haenen, Daniëlle
- Hooiveld, Guido J.E.J.
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 2013-03
- Volume
- 143
- Issue
- 3
- Pages
- 274-283
- ISSN
- 0022-3166 (ISSN-L)
- OpenAlex
- W2142537875
- Cited by
- 341
- References
- 64
- Citations by year
- 2026: 7 · 2025: 24 · 2024: 19 · 2023: 21 · 2022: 33 · 2021: 35 · 2020: 24 · 2019: 39 · 2018: 20 · 2017: 20 · 2016: 29 · 2015: 35 · 2014: 27 · 2013: 8
- FWCI
- 14.70
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Wageningen University and Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
- Keywords
- resistant starch, gut microbiota, short-chain fatty acids, butyrate, Faecalibacterium prausnitzii, Escherichia coli, Pseudomonas, MCT1, glucagon, satiety regulation, intestinal gene expression, cecum, colon, small intestine, pigs, dietary intervention
- MeSH terms
- Animals, Bacteria, Cecum, Colon, Diet, Dietary Carbohydrates, Fatty Acids, Volatile, Female, Glucagon, Intestinal Mucosa, Intestine, Large, Starch, Swine, Gene Expression, Monocarboxylic Acid Transporters, Lipid Metabolism, Metagenome
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