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Arginase-1 and Ym1 Are Markers for Murine, but Not Human, Alternatively Activated Myeloid Cells
Abstract
In an interesting paper, Scotton et al. ([1][1]) reported the effects of IL-13 on the transcriptional profile of human monocytes. Comparing their results with studies analyzing the profile induced by IL-4 in murine macrophages ([2][2], [3][3]), the authors notice some differences, giving as examples
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“Finally and perhaps most importantly, rodent and human Mp do not exhibit entirely similar responses to in vitro activation [9,34,66,80], and it remains to be determined whether there are also species-dependent differences in Mp function during in vivo tissue repair.”
From Macrophage phenotypes during tissue repair (2013) · cites this paper as [80]
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Transcriptional Profiling Reveals Complex Regulation of the Monocyte IL-1β System by IL-13
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Metadata
- Authors
- Raes, G., Van den Bergh, R., De Baetselier, P., & Ghassabeh, G. H.
- Affiliations
- Vrije Universiteit Brussel (BE)
- Laboratory of Cellular and Molecular Immunology, Department of Molecular and Cellular Interactions, Vlaams Interuniversitair Instituut voor Biotechnologie, Vrije Universiteit Brussel , Brussels ,
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-06-01
- Volume
- 174
- Issue
- 11
- Pages
- 6561-6562
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1667820694
- Cited by
- 302
- References
- 12
- Citations by year
- 2026: 2 · 2025: 12 · 2024: 14 · 2023: 10 · 2022: 15 · 2021: 17 · 2020: 27 · 2019: 10 · 2018: 22 · 2017: 18 · 2016: 13 · 2015: 18 · 2014: 25 · 2013: 18 · 2012: 17
- FWCI
- 2.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- VUBIR (Vrije Universiteit Brussel) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Keywords
- arginase-1, Ym1, M2 macrophages, myeloid cells, IL-13, IL-4, monocytes, macrophages, species differences, gene expression profiling
- MeSH terms
- Animals, Arginase, beta-N-Acetylhexosaminidases, Humans, Macrophage Activation, Monocytes, Biomarkers, Myeloid Cells, Lectins, Mice
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