The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
HMGB1 Develops Enhanced Proinflammatory Activity by Binding to Cytokines
Abstract
High mobility group box 1 protein (HMGB1), originally characterized as a nuclear DNA-binding protein, has also been described to have an extracellular role when it is involved in cellular activation and proinflammatory responses. In this study, FLAG-tagged HMGB1 was inducibly expressed in the presence of culture media with or without added IL-1β, IFN-γ, or TNF-α. HMGB1 purified from cells grown in culture media alone only minimally increased cytokine production by MH-S macrophages and had no effect on murine neutrophils. In contrast, HMGB1 isolated from cells cultured in the presence of IL-1β, IFN-γ, and TNF-α had enhanced proinflammatory activity, resulting in increased production of MIP-2 and TNF-α by exposed cells. IL-1β was bound to HMGB1 isolated from cells cultured with this cytokine, and purified HMGB1 incubated with recombinant IL-1β acquired proinflammatory activity. Addition of anti-IL-1β Abs or the IL-1 receptor antagonist to cell cultures blocked the proinflammatory activity of HMGB1 purified from IL-1β-exposed cells, indicating that such activity was dependent on interaction with the IL-1 receptor. These results demonstrate that HMGB1 acquires proinflammatory activity through binding to proinflammatory mediators, such as IL-1β.
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Citations
Cites
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“However, other reports suggest that HMGB-1 does not always induce proinflammatory cytokines (Rouhiainen et al., 2007; Sha et al., 2008; Cassetta et al., 2009).”
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Metadata
- Authors
- Sha, Y., Zmijewski, J., Xu, Z., & Abraham, E.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-02
- Volume
- 180
- Issue
- 4
- Pages
- 2531-2537
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1490007860
- Cited by
- 393
- References
- 5
- FWCI
- 25.86
- Type
- journal article
- Language
- en
- Open access
- closed
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