Harmine and Imipramine Promote Antioxidant Activities in Prefrontal Cortex and Hippocampus
Open accessAbstract
A growing body of evidence has suggested that reactive oxygen species (ROS) may play an important role in the physiopathology of depression. Evidence has pointed to the β‐carboline harmine as a potential therapeutic target for the treatment of depression. The present study we evaluated the effects of acute and chronic administration of harmine (5, 10 and 15 mg/kg) and imipramine (10, 20 and 30 mg/kg) or saline in lipid and protein oxidation levels and superoxide dismutase (SOD) and catalase (CAT) activities in rat prefrontal cortex and hippocampus. Acute and chronic treatments with imipramine and harmine reduced lipid and protein oxidation, compared to control group in prefrontal cortex and hippocampus. The SOD and CAT activities increased with acute and chronic treatments with imipramine and harmine, compared to control group in prefrontal cortex and hippocampus. In conclusion, our results indicate positive effects of imipramine antidepressant and β‐carboline harmine of oxidative stress parameters, increasing SOD and CAT activities and decreasing lipid and protein oxidation.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Imipramine treatment increases SOD and CAT activity and decreases lipid and protein damage in male rat prefrontal cortex and hippocampus after both acute and chronic treatment.
“Réus et al. (2010) reported increased SOD and CAT activity and decreased lipid and protein damage in male rat prefrontal cortex and hippocampus after both acute and chronic treatment with imipramine [17].”
From Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder (2012) · cites this paper as [17]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 315,771 · see citing works
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
Aebi, H. (1984) · Methods in Enzymology · doi:10.1016/s0076-6879(84)05016-3 · Cited by 25,696 · see citing works
The Neuroendocrinology of Stress: A Never Ending Story
Lightman, S. L. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01711.x · Cited by 3,570 · see citing works
A Neurotrophic Model for Stress-Related Mood Disorders
Duman, R. S., & Monteggia, L. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.013 · Cited by 3,375 · see citing works
[42] Determination of aldehydic lipid peroxidation products: Malonaldehyde and 4-hydroxynonenal
Esterbauer, H., & Cheeseman, K. H. (1990) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(90)86134-h · Cited by 3,365 · see citing works
Nestler, E. J., Barrot, M., DiLeone, R. J., Eisch, A. J., Gold, S. J., & Monteggia, L. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00653-0 · Cited by 3,217 · see citing works
[37] Carbonyl assays for determination of oxidatively modified proteins
Levine, R. L., Williams, J. A., Stadtman, E. R., & Shacter, E. B. (1994) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(94)33040-9 · Cited by 2,707 · see citing works
A molecular and cellular theory of depression
Duman, R. S. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830190015002 · Cited by 2,129 · see citing works
New approaches to antidepressant drug discovery: beyond monoamines
Berton, O., & Nestler, E. J. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1846 · Cited by 1,589 · see citing works
Oxidative stress in psychiatric disorders: evidence base and therapeutic implications
Ng, F., Berk, M., Dean, O., & Bush, A. I. (2008) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145707008401 · Cited by 1,069 · see citing works
Antioxidants, Oxidative Stress, and Degenerative Neurological Disorders
Floyd, R. A. (1999) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1046/j.1525-1373.1999.d01-140.x · Cited by 824 · see citing works
Bilici, M., Efe, H., Köroğlu, M. A., Uydu, H. A., Bekaroğlu, M., & Değer, O. (2001) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00199-3 · Cited by 718 · see citing works
Castrén, E. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1629 · Cited by 563 · see citing works
Assays for Superoxide Dismutase
Bannister, J. V., & Calabrese, L. (1987) · Methods of biochemical analysis · doi:10.1002/9780470110539.ch5 · Cited by 551 · see citing works
Preskorn, S., Baker, B., Kolluri, S., Menniti, F. S., Krams, M., & Landen, J. W. (2008) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e31818a6cea · Cited by 522 · see citing works
Oxidative Stress and Anxiety: Relationship and Cellular Pathways
Bouayed, J., Rammal, H., & Soulimani, R. (2009) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.2.2.7944 · Cited by 517 · see citing works
Garcia, L. S. B., Comim, C. M., Valvassori, S. S., Réus, G. Z., Barbosa, L. M., Andreazza, A. C., Stertz, L., Fries, G. R., Gavioli, E. C., Kapczinski, F., et al. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.07.027 · Cited by 454 · see citing works
Self-citationImmobilization stress causes oxidative damage to lipid, protein, and DNA in the brain of rats
Liu, J., Wang, X., Shigenaga, M. K., Yeo, H. C. H., Mori, A., & Ames, B. N. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.13.8940299 · Cited by 383 · see citing works
Effects of chronic mild stress on the oxidative parameters in the rat brain
Lucca, G., Comim, C. M., Valvassori, S. S., Réus, G. Z., Vuolo, F. S., Petronilho, F. C., Dal‐Pizzol, F., Gavioli, E. C., & Quevedo, J. (2009) · Neurochemistry International · doi:10.1016/j.neuint.2009.01.001 · Cited by 265 · see citing works
Self-citationInhibition of Monoamine Oxidase A by β-Carboline Derivatives
Kim, H., Sablin, S. O., & Ramsay, R. R. (1997) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1996.9771 · Cited by 252 · see citing works
Kunz, M., Gama, C. S., Andreazza, A. C., Salvador, M. M., Ceresér, K. M., Gomes, F. A., Belmonte-de-Abreu, P. S., Berk, M., & Kapczinski, F. P. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.07.001 · Cited by 241 · see citing works
Frey, B. N., Valvassori, S. S., Réus, G. Z., Martins, M. R., Petronilho, F. C., Bardini, K., Dal‐Pizzol, F., Kapczinski, F. P., & Quevedo, J. (2006) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0637 · Cited by 238 · see citing works
Self-citationMichel, T. M., Frangou, S., Thiemeyer, D., Camara, S., Jecel, J., Nara, K., Brunklaus, A., Zoechling, R., & Riederer, P. (2007) · Psychiatry Research · doi:10.1016/j.psychres.2006.04.013 · Cited by 218 · see citing works
Glennon, R. A., Dukat, M., Grella, B. S., Hong, S., Costantino, L., Teitler, M., Smith, C., Egan, C., Davis, K., & Mattson, M. V. (2000) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(99)00148-9 · Cited by 210 · see citing works
Antioxidative enzymes and increased oxidative stress in depressive women
Kodydková, J., Vávrová, L., Zeman, M., Jirák, R., Macášek, J., Staňková, B., Tvrzická, E., & Žák, A. (2009) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2009.06.006 · Cited by 197 · see citing works
Repeated Restraint Stress Induces Oxidative Damage in Rat Hippocampus
Fontella, F. U., Siqueira, I. R., de Vasconcellos, A. P. S., Tabajara, Â. S., Netto, C. A., & Dalmaz, C. (2005) · Neurochemical Research · doi:10.1007/s11064-004-9691-6 · Cited by 195 · see citing works
In vivo antioxidant status: A putative target of antidepressant action
Zafir, A., Ara, A., & Banu, N. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.11.010 · Cited by 183 · see citing works
Antidepressant-like effect of harmane and other β-carbolines in the mouse forced swim test
Farzin, D., & Mansouri, N. (2006) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2005.08.005 · Cited by 171 · see citing works
Venlafaxine Modulates Depression-Induced Oxidative Stress in Brain and Medulla of Rat
Eren, İ., Nazıroğlu, M., Demirdaş, A., Çelik, Ö., Uğuz, A. C., Altunbaşak, A., Özmen, İ., & Uz, E. (2007) · Neurochemical Research · doi:10.1007/s11064-006-9258-9 · Cited by 161 · see citing works
Fortunato, J. J., Réus, G. Z., Kirsch, T. R., Stringari, R. B., Stertz, L., Kapczinski, F., Pinto, J. P., Hallak, J. E., Zuardi, A. W., Crippa, J. A., et al. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.07.021 · Cited by 150 · see citing works
Self-citationLucca, G., Comim, C. M., Valvassori, S. S., Réus, G. Z., Vuolo, F. S., Petronilho, F. C., Gavioli, E. C., Dal‐Pizzol, F., & Quevedo, J. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2008.11.002 · Cited by 137 · see citing works
Self-citationKim, Y. K. (2003) · Journal of the Korean Medical Association · doi:10.5124/jkma.2003.46.9.783 · Cited by 128 · see citing works
Neurobiology of Schizophrenia Spectrum Disorders: The Role of Oxidative Stress
Wood, S. J., Yücel, M., Pantelis, C., & Berk, M. (2009) · Annals of the Academy of Medicine Singapore · doi:10.47102/annals-acadmedsg.v38n5p396 · Cited by 127 · see citing works
Gałecki, P., Szemraj, J., Bieńkiewicz, M., Zboralski, K., & Gałecka, E. (2009) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.1014 · Cited by 124 · see citing works
Fortunato, J. J., Réus, G. Z., Kirsch, T. R., Stringari, R. B., Fries, G. R., Kapczinski, F. P., Hallak, J. E. C., Zuardi, A. W., Crippa, J. A. S., & Quevedo, J. (2009) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2009.09.008 · Cited by 99 · see citing works
Self-citationFrey, B. N., Valvassori, S. S., Réus, G. Z., Martins, M. R., Petronilho, F. C., Bardini, K., Dal‐Pizzol, F., Kapczinski, F. P., & Quevedo, J. (2006) · Neurochemical Research · doi:10.1007/s11064-006-9070-6 · Cited by 98 · see citing works
Self-citationRiegel, R. E., Valvassori, S. S., Elias, G. A., Réus, G. Z., Steckert, A. V., de Souza, B., Petronilho, F. C., Gavioli, E. C., Dal‐Pizzol, F., & Quevedo, J. (2009) · Neurochemistry International · doi:10.1016/j.neuint.2009.05.003 · Cited by 75 · see citing works
Self-citationKim, D. H., Jang, Y. Y., Han, E. S., & Lee, C. S. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01563.x · Cited by 71 · see citing works
Hippocampal function in schizophrenia and bipolar disorder
Hall, J., Whalley, H. C., Marwick, K. F. M., McKirdy, J. W., Sussmann, J. E., Romaniuk, L., Johnstone, E. C., Wan, H. I., McIntosh, A. M., & Lawrie, S. M. (2009) · Psychological Medicine · doi:10.1017/s0033291709991000 · Cited by 66 · see citing works
Role of serotonin in cerebral oxidative stress in rat
Muñoz-Castañeda, J. R., Montilla, P., Padillo, F., Bujalance, I., Muñoz, M. C., Muntané, J., & Tunez, A. (2006) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2006-1581 · Cited by 63 · see citing works
Júnior, H. V. N., Fonteles, M. M. D. F., & de Freitas, R. M. (2009) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.2.3.8488 · Cited by 48 · see citing works
Tretter, L., Chinopoulos, C., & Ádám‐Vizi, V. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69062529.x · Cited by 42 · see citing works
Kumar, A., Garg, R., Gaur, V., & Kumar, P. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.10.004 · Cited by 35 · see citing works
Mokoena, M. L., Harvey, B. H., Oliver, D. W., & Brink, C. B. (2010) · Metabolic Brain Disease · doi:10.1007/s11011-010-9189-7 · Cited by 34 · see citing works
Kumar, A., & Garg, R. (2009) · Methods and Findings in Experimental and Clinical Pharmacology · doi:10.1358/mf.2009.31.6.1386992 · Cited by 17 · see citing works
High Anxiety: Recognizing Stress As the Stressor
Maiese, K. (2009) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.2.2.8842 · Cited by 10 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Osório, F. D. L., Sanches, R. F., Macedo, L. R., dos Santos, R. G., Maia-de-Oliveira, J. P., Wichert-Ana, L., de Araujo, D. B., Riba, J., Crippa, J. A., & Hallak, J. E. (2015) · Revista Brasileira de Psiquiatria · doi:10.1590/1516-4446-2014-1496 · Cited by 488 · see citing works
Self-citationInsulin resistance in brain alters dopamine turnover and causes behavioral disorders
Kleinridders, A., Cai, W., Cappellucci, L., Ghazarian, A., Collins, W. R., Vienberg, S. G., Pothos, E. N., & Kahn, C. R. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1500877112 · Cited by 486 · see citing works
dos Santos, R. G., Osório, F. L., Crippa, J. A. S., Riba, J., Zuardi, A. W., & Hallak, J. E. C. (2016) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125316638008 · Cited by 306 · see citing works
Self-citationAyahuasca: pharmacology, neuroscience and therapeutic potential
Domínguez-Clavé, E., Soler, J., Elices, M., Pascual, J. C., Álvarez, E., de la Fuente Revenga, M., Friedlander, P., Feilding, A., & Riba, J. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.03.002 · Cited by 226 · see citing works
Behr, G. A., Moreira, J. C. F., & Frey, B. N. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/609421 · Cited by 205 · see citing works
Brito-da-Costa, A. M., Dias-da-Silva, D., Gomes, N. G. M., Dinis-Oliveira, R. J., & Madureira-Carvalho, Á. (2020) · Pharmaceuticals · doi:10.3390/ph13110334 · Cited by 117 · see citing works
de Morais, H., de Souza, C. P., da Silva, L. M., Ferreira, D. M., Werner, M. F., Andreatini, R., da Cunha, J. M., & Zanoveli, J. M. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.10.011 · Cited by 111 · see citing works
Hassan, W., Barroso Silva, C., Mohammadzai, I. U., Teixeira da Rocha, J., & Landeira-Fernandez, J. (2014) · Current Neuropharmacology · doi:10.2174/1570159x11666131120232135 · Cited by 100 · see citing works
Aboul-Fotouh, S. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.12.027 · Cited by 97 · see citing works
- Authors
- Réus, G. Z., Stringari, R. B., de Souza, B., Petronilho, F., Dal-Pizzol, F., Hallak, J. E., Zuardi, A. W., Crippa, J. A., & Quevedo, J.
- Affiliations
- Universidade de São Paulo (BR)
- Corresponding author
- Quevedo, João
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Wiley
- Published
- 2010-01
- Volume
- 3
- Issue
- 5
- Pages
- 325-331
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- PMC
- PMC3154037
- OpenAlex
- W2058072416
- Cited by
- 110
- References
- 47
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 8 · 2023: 2 · 2022: 7 · 2021: 11 · 2020: 10 · 2019: 1 · 2018: 5 · 2017: 5 · 2016: 8 · 2015: 13 · 2014: 11 · 2013: 7 · 2012: 7
- FWCI
- 4.23
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Synthesis and bioactivity of alkaloids
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- harmine, imipramine, depression, oxidative stress, reactive oxygen species, lipid peroxidation, protein oxidation, superoxide dismutase, catalase, prefrontal cortex, hippocampus, β-carbolines, antidepressant effects
- MeSH terms
- Animals, Antidepressive Agents, Catalase, Depression, Harmine, Hippocampus, Imipramine, Male, Superoxide Dismutase, Rats, Wistar, Prefrontal Cortex, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
