Oxidative stress parameters after combined fluoxetine and acetylsalicylic acid therapy in depressive patients
Abstract
Objective: There are numerous reports indicating disturbed equilibrium between oxidative processes and antioxidative defense in patients with depression. Moreover, depressive patients are characterized by the presence of elements of an inflammatory process, which is one of the sources of reactive oxygen species (ROS). In view of the above, it was decided to study both the effect of fluoxetine monotherapy and that of fluoxetine co‐administered with acetylsalicylic acid on lipid peroxidation and antioxidative defense in patients with the first depressive episode in their life. Method: Seventy seven patients with major depressive disorder (MDD), divided into two groups were included in the study. The first group, consisting of 52 patients, received fluoxetine 20 mg, and the second one, in addition to fluoxetine 20 mg, received 150 mg of acetylsalicylic acid. The activity of antioxidative enzymes, copper‐zinc superoxide dismutase (CuZnSOD, SOD1), catalase (CAT), glutathione peroxidase (GPSH‐x) and the concentration of malonyldialdehyde (MDA) was determined in erythrocytes, whereas the total antioxidant status (TAS) was determined in the plasma. All parameters were measured before and after three month therapy. Results: The obtained results indicate a significant decrease in the activity of SOD1, CAT and GSHP‐x, as well as in MDA concentration after the combined therapy. Also a significant TAS increase was observed after the combined therapy. The study demonstrated that combined therapy with fluoxetine and ASA is characterized by the same efficacy and clinical safety as fluoxetine monotherapy, resulting additionally in improvement of oxidative stress parameters in the patients treated for depression. Copyright © 2009 John Wiley & Sons, Ltd.
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The Gałecki group demonstrated that fluoxetine given together with acetylsalicylic acid decreases oxidative stress levels in patients with major depressive disorder.
“the Gałecki group, which demonstrated that fluoxetine given together with acetylsalicylic acid is decreasing the oxidative stress levels in patients with major depression disorder (MDD) [122]”
From Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches (2016) · cites this paper as [122]
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Psychological stress impairs ischemia-induced neovascularization: Protective effect of fluoxetine
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Oxidative Stress in Depression
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- Authors
- Gałecki, P., Szemraj, J., Bieńkiewicz, M., Zboralski, K., & Gałecka, E.
- Affiliations
- Medical University of Lodz (PL)
- Corresponding author
- Gałecki, Piotr
- Venue
- Human Psychopharmacology: Clinical and Experimental
- Publisher
- Wiley
- Published
- 2009-03-24
- Volume
- 24
- Issue
- 4
- Pages
- 277-286
- ISSN
- 0885-6222 (ISSN-L)
- 1099-1077
- OpenAlex
- W2097745840
- Cited by
- 124
- References
- 116
- Citations by year
- 2024: 5 · 2023: 6 · 2022: 8 · 2021: 6 · 2020: 7 · 2019: 7 · 2018: 6 · 2017: 11 · 2016: 6 · 2015: 16 · 2014: 7 · 2013: 8 · 2012: 16
- FWCI
- 7.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Psychopharmacology Clinical and Experimental (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Uniwersytet Łódzki
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- major depressive disorder, fluoxetine, aspirin, oxidative stress, lipid peroxidation, antioxidant enzymes, superoxide dismutase, catalase, glutathione peroxidase, malondialdehyde, total antioxidant status, combination therapy, first-episode depression, erythrocytes
- MeSH terms
- Adult, Anti-Inflammatory Agents, Non-Steroidal, Antioxidants, Aspirin, Major Depressive Disorder, Drug Therapy, Combination, Fluoxetine, Humans, Psychiatric Status Rating Scales, Lipid Peroxidation, Oxidative Stress, Antidepressive Agents, Second-Generation
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