Cited by 423Diabetes, Cardiovascular Risks, and LipoproteinsCardiovascular Disease and AdiposityAdipokines, Inflammation, and Metabolic Diseases

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Adiposity, Fat Distribution, and Cardiovascular Risk

Peiris, Alan N., Sothmann, Mark S., Hoffmann, Raymond G., Hennes, Magda I., Wilson, Charles R., Gustafson, Anthony B., Kissebah, Ahmed H.·1989·Annals of Internal Medicine

DOI 10.7326/0003-4819-110-11-867

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Abstract

STUDY OBJECTIVE: To determine the relative importance of adiposity and fat distribution to cardiovascular risk profile. DESIGN: A cross-sectional study. SETTING: Clinical research center funded by the National Institutes of Health. PATIENTS: Convenience sample of 33 healthy premenopausal women with a wide range of body weight who did not have diabetes mellitus, hirsutism and virilism, gynecologic disorder, cardiac disease, or hypertension. Women participating in exercise or dietary programs or taking medication were excluded. All subjects completed the study. INTERVENTIONS: Total body fat mass was determined by hydrostatic weighting, and fat distribution was assessed by subscapular skinfold thickness, subscapular-to-triceps skinfold ratio, the waist-to-hip ratio, and computed tomography. Cardiovascular risk was assessed by the serum insulin response during oral glucose stimulation; levels of triglycerides and total cholesterol; high-density lipoprotein cholesterol to total cholesterol concentrations; and systolic and diastolic blood pressures. MEASUREMENTS AND MAIN RESULTS: The anthropometric parameters chosen were significantly associated with the cardiovascular risk profile (P less than 0.001). Visceral fat distribution assessed by computed tomography accounted for a significantly greater degree of variance in the cardiovascular risk factors than the total body fat mass (P less than 0.05). The cumulative insulin response was the primary metabolic variable relating the anthropometric indices to cardiovascular risk. CONCLUSIONS: Intra-abdominal fat deposition constitutes a greater cardiovascular risk than obesity alone. Hyperinsulinemia may constitute an important component of the increased cardiovascular risk of abdominal obesity.

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Authors: Peiris, A. N., Sothmann, M. S., Hoffmann, R. G., Hennes, M. I., Wilson, C. R., Gustafson, A. B., & Kissebah, A. H.
Affiliations: Medical College of Wisconsin (US)
ORCID: Peiris, Alan N.
Wilson, Charles R.
Venue: Annals of Internal Medicine
Publisher: American College of Physicians
Published: 1989-06-01
Volume: 110
Issue: 11
Pages: 867-872
ISSN: 0003-4819 (ISSN-L)
1539-3704
DOI: 10.7326/0003-4819-110-11-867
OpenAlex: W2022094463
Cited by: 423
References: 47
Citations by year: 2025: 2 · 2024: 5 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 7 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 2 · 2015: 9 · 2014: 8 · 2013: 9 · 2012: 16
FWCI: 11.27
Type: journal article
Language: en
Open access: closed
Licence: www.acpjournals.org/journal/aim/text-and-data-mining (tdm)
Locations: Annals of Internal Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (HL 34989)
National Center for Research Resources (RR00058)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: adiposity, body fat distribution, cardiovascular risk, abdominal obesity, visceral fat, hyperinsulinemia, insulin resistance, waist-to-hip ratio, subscapular skinfold, fat mass, premenopausal women, dyslipidemia, blood pressure
MeSH terms: Adipose Tissue, Adult, Anthropometry, Blood Pressure, Body Composition, Body Constitution, Cardiovascular Diseases, Cross-Sectional Studies, Female, Glucose Tolerance Test, Humans, Insulin, Lipids, Obesity, Risk Factors, Tomography, X-Ray Computed

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Adiposity, Fat Distribution, and Cardiovascular Risk

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