The Gut-Brain Axis: The Missing Link in Depression

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Normal gut microbiota modulates brain development and behavior

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The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner

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Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders

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From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways

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The Gut Microbiota and Alzheimer’s Disease

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Human gut microbiota in health and disease: Unveiling the relationship

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A Comprehensive Review on the Role of the Gut Microbiome in Human Neurological Disorders

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Effect of probiotics on depression: a systematic review and meta-analysis of randomized controlled trials

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Altered Composition of Gut Microbiota in Depression: A Systematic Review

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The progress of gut microbiome research related to brain disorders

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Gut microbiome and depression: what we know and what we need to know

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Recognizing Depression from the Microbiota–Gut–Brain Axis

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Relationship between the gut microbiome and brain function

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Variations in gut microbiota and fecal metabolic phenotype associated with depression by 16S rRNA gene sequencing and LC/MS-based metabolomics

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Absolute quantitation of microbiota abundance in environmental samples

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The Gut-Brain Axis: Influence of Microbiota on Mood and Mental Health.

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Tryptophan Metabolism by Gut Microbiome and Gut-Brain-Axis: An in silico Analysis

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Microglia: An Interface between the Loss of Neuroplasticity and Depression

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Impact of Edible Cricket Consumption on Gut Microbiota in Healthy Adults, a Double-blind, Randomized Crossover Trial

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Gut microbiota–brain axis in depression: the role of neuroinflammation

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Reductions in anti-inflammatory gut bacteria are associated with depression in a sample of young adults

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Guts Imbalance Imbalances the Brain: A Review of Gut Microbiota Association With Neurological and Psychiatric Disorders

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The function of gut microbiota in immune-related neurological disorders: a review

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Neural networks and the anti-inflammatory effect of transcutaneous auricular vagus nerve stimulation in depression

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Crosstalk between the microbiota-gut-brain axis and depression

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Similarly in depression, nuances of gut microbiota: Evidences from a shotgun metagenomics sequencing study on major depressive disorder versus bipolar disorder with current major depressive episode patients

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Leaky gut biomarkers in depression and suicidal behavior

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Impact of dietary fats on brain functions

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Clostridium butyricum Attenuates Chronic Unpredictable Mild Stress-Induced Depressive-Like Behavior in Mice via the Gut-Brain Axis

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PROVIT: Supplementary Probiotic Treatment and Vitamin B7 in Depression—A Randomized Controlled Trial

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Probiotic consumption relieved human stress and anxiety symptoms possibly via modulating the neuroactive potential of the gut microbiota

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Fecal Microbiota Transplantation and Its Usage in Neuropsychiatric Disorders

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Parkinson’s Disease: The Emerging Role of Gut Dysbiosis, Antibiotics, Probiotics, and Fecal Microbiota Transplantation

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Human Gut Microbiota: Toward an Ecology of Disease

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Gut microbiota in various childhood disorders: Implication and indications

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The Microbiota-Inflammasome Hypothesis of Major Depression

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Single-Shot 10K Proteome Approach: Over 10,000 Protein Identifications by Data-Independent Acquisition-Based Single-Shot Proteomics with Ion Mobility Spectrometry

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Altered gut metabolome contributes to depression-like behaviors in rats exposed to chronic unpredictable mild stress

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The Therapeutic Potential of Plant Polysaccharides in Metabolic Diseases

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Gut-brain axis metabolic pathway regulates antidepressant efficacy of albiflorin

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The Role of Nutrition and the Gut-Brain Axis in Psychiatry: A Review of the Literature

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Serotonin as a link between the gut-brain-microbiome axis in autism spectrum disorders

Israelyan, N., & Margolis, K. G. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.03.020 · Cited by 122

Prophylactic Effects of Bifidobacterium adolescentis on Anxiety and Depression-Like Phenotypes After Chronic Stress: A Role of the Gut Microbiota-Inflammation Axis

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Gut microbiota composition is associated with newborn functional brain connectivity and behavioral temperament

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The role of the gut-brain axis in depression: endocrine, neural, and immune pathways

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Associations of neurotransmitters and the gut microbiome with emotional distress in mixed type of irritable bowel syndrome

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Probiotics ameliorate intestinal pathophysiology in a mouse model of Alzheimer’s disease

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Identification of a Signaling Mechanism by Which the Microbiome Regulates Th17 Cell-Mediated Depressive-Like Behaviors in Mice

Medina-Rodriguez, E. M., Madorma, D., O’Connor, G., Mason, B. L., Han, D., Deo, S. K., Oppenheimer, M., Nemeroff, C. B., Trivedi, M. H., Daunert, S., et al. (2020) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2020.19090960 · Cited by 110

Alleviation of depression by glucagon-like peptide 1 through the regulation of Neuroinflammation, neurotransmitters, neurogenesis, and synaptic function

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Effects of long-term administration of Multi-Strain Probiotic on circulating levels of BDNF, NGF, IL-6 and mental health in patients with multiple sclerosis: a randomized, double-blind, placebo-controlled trial

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Maternal gut and fetal brain connection: Increased anxiety and reduced social interactions in Wistar rat offspring following peri-conceptional antibiotic exposure

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The Microbiota–Gut–Brain Axis: Psychoneuroimmunological Insights

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Variations in the oral microbiome are associated with depression in young adults

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Sodium butyrate triggers a functional elongation of microglial process via akt-small RhoGTPase activation and HDACs inhibition

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Can psychobiotics “mood” ify gut? An update systematic review of randomized controlled trials in healthy and clinical subjects, on anti-depressant effects of probiotics, prebiotics, and synbiotics

Vaghef‐Mehrabany, E., Maleki, V., Behrooz, M., Ranjbar, F., & Ebrahimi‐Mameghani, M. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2019.06.004 · Cited by 96

The gut microbiome correlates with conspecific aggression in a small population of rescued dogs(Canis familiaris)

Kirchoff, N. S., Udell, M. A. R., & Sharpton, T. J. (2019) · PeerJ · doi:10.7717/peerj.6103 · Cited by 88

Reprint of: Serotonin as a link between the gut-brain-microbiome axis in autism spectrum disorders

Israelyan, N., & Margolis, K. G. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2018.12.023 · Cited by 87

The mechanism of electroacupuncture for depression on basic research: a systematic review

Han, X., Gao, Y., Yin, X., Zhang, Z., Lao, L., Chen, Q., & Xu, S. (2021) · Chinese Medicine · doi:10.1186/s13020-020-00421-y · Cited by 87

Bacteriome Structure, Function, and Probiotics in Fish Larviculture: The Good, the Bad, and the Gaps

Borges, N., Keller‐Costa, T., Sanches‐Fernandes, G. M. M., Louvado, A., Gomes, N. C. M., & Costa, R. (2020) · Annual Review of Animal Biosciences · doi:10.1146/annurev-animal-062920-113114 · Cited by 87

Microbiome and metabolome data integration provides insight into health and disease

Shaffer, M., Armstrong, A. J. S., Phelan, V. V., Reisdorph, N. A., & Lozupone, C. (2017) · Translational research · doi:10.1016/j.trsl.2017.07.001 · Cited by 86

Gut-brain axis: A matter of concern in neuropsychiatric disorders…!

Naveed, M., Zhou, Q.-G., Chu, X., Taleb, A., Meng, F. J., Ahmed, B., Zhang, Y., Fukunaga, K., & Han, F. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110051 · Cited by 82

Human Intestinal Enteroids With Inducible Neurogenin-3 Expression as a Novel Model of Gut Hormone Secretion

Chang‐Graham, A. L., Danhof, H. A., Engevik, M. A., Tomaro-Duchesneau, C., Karandikar, U. C., Estes, M. K., Versalovic, J. A., Britton, R. A., & Hyser, J. M. (2019) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2019.04.010 · Cited by 79

The Human Gut Microbiome in Health and Disease

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A Gut-Brain Axis-on-a-Chip for studying transport across epithelial and endothelial barriers

Kim, M., Kim, D., & Sung, J. H. (2021) · Journal of Industrial and Engineering Chemistry · doi:10.1016/j.jiec.2021.06.021 · Cited by 79

Effect of combined chronic predictable and unpredictable stress on depression-like symptoms in mice

Qiao, Y., Zhao, J., Li, C., Zhang, M., Wei, L., Zhang, X., Kurskaia, O. V., Bi, H., & Gao, T. (2020) · Annals of Translational Medicine · doi:10.21037/atm-20-5168 · Cited by 80

Multi-strain Probiotic Formulation Reverses Maternal Separation and Chronic Unpredictable Mild Stress-Generated Anxiety- and Depression-like Phenotypes by Modulating Gut Microbiome–Brain Activity in Rats

Dandekar, M. P., Palepu, M. S. K., Satti, S., Jaiswal, Y., Singh, A. A., Dash, S. P., Gajula, S. N. R., & Sonti, R. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00143 · Cited by 75

Unraveling the Role of the Human Gut Microbiome in Health and Diseases

Khalil, M., Ciaula, A. D., Mahdi, L., Jaber, N., Palo, D. M. D., Graziani, A., Baffy, G., & Portincasa, P. (2024) · Microorganisms · doi:10.3390/microorganisms12112333 · Cited by 100

Effect of the probiotic Lactobacillus plantarum IS-10506 on BDNF and 5HT stimulation: role of intestinal microbiota on the gut-brain axis

Ranuh, R. G., Athiyyah, A. F., Darma, A., Risky, V. P., Riawan, W., SURONO, I. S., & Sudarmo, S. M. (2019) · Iranian Journal of Microbiology · doi:10.18502/ijm.v11i2.1077 · Cited by 75

Correction: Altered gut metabolome contributes to depression-like behaviors in rats exposed to chronic unpredictable mild stress

Li, J., Xueyang, J., Cui, W., Wu, C., & Xue-mei, Q. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0645-9 · Cited by 72

New Insights Into the Comorbidity of Coronary Heart Disease and Depression

Wu, Y., Zhu, B., Chen, Z., Duan, J., Luo, A., Yang, L., & Yang, C. (2019) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2019.03.002 · Cited by 72

The role of the brain–gut–microbiota axis in psychology: The importance of considering gut microbiota in the development, perpetuation, and treatment of psychological disorders

Ganci, M., Suleyman, E., Butt, H., & Ball, M. (2019) · Brain and Behavior · doi:10.1002/brb3.1408 · Cited by 75

Dairy probiotics: Beyond the role of promoting gut and immune health

Ζουμποπούλου, Γ., Pot, B., Tsakalidou, E., & Papadimitriou, K. (2016) · International Dairy Journal · doi:10.1016/j.idairyj.2016.09.010 · Cited by 74

Neuroinflammation, Gut-Brain Axis and Depression

Evrensel, A., Ünsalver, B. Ö., & Ceylan, M. E. (2019) · Psychiatry Investigation · doi:10.30773/pi.2019.08.09 · Cited by 73

Targeting the Microbiota in Pharmacology of Psychiatric Disorders

Pascale, A., Marchesi, N., Govoni, S., & Barbieri, A. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104856 · Cited by 67

Interpersonal Variations in Gut Microbiota Profiles Supersedes the Effects of Differing Fecal Storage Conditions

Bundgaard‐Nielsen, C., Hagstrøm, S., & Sørensen, S. (2018) · Scientific Reports · doi:10.1038/s41598-018-35843-0 · Cited by 65

Global research trends in microbiome-gut-brain axis during 2009–2018: a bibliometric and visualized study

Zyoud, S. H., Smale, S., Waring, W. S., Sweileh, W. M., & Al‐Jabi, S. W. (2019) · BMC Gastroenterology · doi:10.1186/s12876-019-1076-z · Cited by 70

The Role of the Gut-Brain Axis in Attention-Deficit/Hyperactivity Disorder

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Lactobacillus delbrueckii alleviates depression-like behavior through inhibiting toll-like receptor 4 (TLR4) signaling in mice

Qiu, X., Wu, G., Wang, L., Tan, Y., & Song, Z. Q. (2021) · Annals of Translational Medicine · doi:10.21037/atm-20-4411 · Cited by 63

Does the microbiome and virome contribute to myalgic encephalomyelitis/chronic fatigue syndrome?

Newberry, F., Hsieh, S.-Y., Wileman, T., & Carding, S. R. (2018) · Clinical Science · doi:10.1042/cs20171330 · Cited by 63

Effect of probiotic interventions on depressive symptoms: A narrative review evaluating systematic reviews

Ibrahim, N., Rahman, M. Z., Ad-Dab’bagh, Y., & Akhtar, M. (2018) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12804 · Cited by 63

Major Depressive Disorder and gut microbiota – Association not causation. A scoping review

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A review on preventive role of ketogenic diet (KD) in CNS disorders from the gut microbiota perspective

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