Check biochemistry, genetics and molecular biology papers: citations, claims and retractions

Single-cell transcriptomic analysis of Alzheimer’s disease

Mathys, H., Davila-Velderrain, J., Peng, Z., Gao, F., Mohammadi, S., Young, J. Z., Menon, M., He, L., Abdurrob, F., Jiang, X., et al. (2019) · Nature

Single-cell and spatial transcriptomicsAlzheimer's disease research and treatments

Cited by 2,568

Design and development of polymers for gene delivery

Pack, D. W., Hoffman, A. S., Pun, S., & Stayton, P. S. (2005) · Nature Reviews Drug Discovery

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 2,568

Wnt signaling: a common theme in animal development

Cadigan, K. M., & Nusse, R. (1997) · Genes & Development

Wnt/β-catenin signaling in development and cancerDevelopmental Biology and Gene Regulation

Cited by 2,567

Causal Relationship Between Stressful Life Events and the Onset of Major Depression

Kendler, K. S., Karkowski, L. M., & Prescott, C. A. (1999) · American Journal of Psychiatry

Genetic Associations and EpidemiologyChild and Adolescent Psychosocial and Emotional Development

Cited by 2,566

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions

Howard, D. M., Adams, M. J., Clarke, T.-K., Hafferty, J. D., Gibson, J., Shirali, M., Coleman, J. R. I., Hagenaars, S. P., Ward, J., Wigmore, E. M., et al. (2019) · Nature Neuroscience

Genetic Associations and EpidemiologyNeurotransmitter Receptor Influence on Behavior

Cited by 2,565

HiC-Pro: an optimized and flexible pipeline for Hi-C data processing.

Servant, N., Varoquaux, N., Lajoie, B. R., Viara, E., Chen, C.-J., Vert, J.-P., Heard, E., Dekker, J., & Barillot, E. (2015) · Genome Biology

Genomics and Chromatin DynamicsGenomics and Phylogenetic Studies

Cited by 2,565

CRISPR RNA Maturation by Trans-Encoded Small RNA and Host Factor RNase III

Deltcheva, E., Chylinski, K., Sharma, C. M., Gonzales, K., Chao, Y., Pirzada, Z. A., Eckert, M. R., Vogel, J., & Charpentier, E. (2011) · Nature

CRISPR and Genetic EngineeringBacterial Genetics and Biotechnology

Cited by 2,563

mTOR Inhibition Induces Upstream Receptor Tyrosine Kinase Signaling and Activates Akt

O'Reilly, K. E., Rojo, F., She, Q.-B., Solit, D., Mills, G. B., Smith, D., Lane, H., Hofmann, F., Hicklin, D. J., Ludwig, D. L., et al. (2006) · Cancer Research

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 2,561

Fast and effective prediction of microRNA/target duplexes

REHMSMEIER, M., STEFFEN, P., HÖCHSMANN, M., & GIEGERICH, R. (2004) · RNA

MicroRNA in disease regulationRNA and protein synthesis mechanisms

Cited by 2,560

Molecular mechanisms of mTOR-mediated translational control

Ma, X. M., & Blenis, J. (2009) · Nature Reviews Molecular Cell Biology

PI3K/AKT/mTOR signaling in cancerRNA and protein synthesis mechanisms

Cited by 2,558

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

Bennett, B. L., Sasaki, D. T., Murray, B. W., O'Leary, E. C., Sakata, S. T., Xu, W., Leisten, J. C., Motiwala, A., Pierce, S., Satoh, Y., et al. (2001) · Proceedings of the National Academy of Sciences

Protein Kinase Regulation and GTPase SignalingNF-κB Signaling Pathways

Cited by 2,558

Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer

Puram, S. V., Tirosh, I., Parikh, A. S., Patel, A. P., Yizhak, K., Gillespie, S., Rodman, C., Luo, C. L., Mroz, E. A., Emerick, K. S., et al. (2017) · Cell

Single-cell and spatial transcriptomicsCancer Cells and Metastasis

Cited by 2,557

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

Ostrem, J. M., Peters, U., Sos, M. L., Wells, J. A., & Shokat, K. M. (2013) · Nature

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 2,557

Large-scale copy number polymorphism in the human genome

Sebat, J., Lakshmi, B., Troge, J., Alexander, J., Young, J., Lundin, P., Månér, S., Massa, H., Walker, M., Chi, M., et al. (2004) · Science

Genomic variations and chromosomal abnormalitiesGenome Rearrangement Algorithms

Cited by 2,557

MicroRNA-21 Is an Antiapoptotic Factor in Human Glioblastoma Cells

Chan, J. A., Krichevsky, A. M., & Kosik, K. S. (2005) · Cancer Research

MicroRNA in disease regulationCancer-related molecular mechanisms research

Cited by 2,557

Recombinant protein expression in Escherichia coli: advances and challenges

Rosano, G. L., & Ceccarelli, E. A. (2014) · Frontiers in Microbiology

Bacterial Genetics and BiotechnologyProtein purification and stability

Cited by 2,556

Endocrine regulation of energy metabolism by the skeleton

Lee, N. K., Sowa, H., Hinoi, E., Ferron, M., Ahn, J. D., Confavreux, C., Dacquin, R., Mee, P. J., McKee, M. D., Jung, D. Y., et al. (2007) · Cell

Bone Metabolism and DiseasesAdipokines, Inflammation, and Metabolic Diseases

Cited by 2,554

A Long Noncoding RNA Controls Muscle Differentiation by Functioning as a Competing Endogenous RNA

Cesana, M., Cacchiarelli, D., Legnini, I., Santini, T., Sthandier, O., Chinappi, M., Tramontano, A., & Bozzoni, I. (2011) · Cell

Cancer-related molecular mechanisms researchMuscle Physiology and Disorders

Cited by 2,554

Molecular Architecture of the Mouse Nervous System

Zeisel, A., Hochgerner, H., Lönnerberg, P., Johnsson, A., Memic, F., van der Zwan, J., Häring, M., Braun, E., Borm, L. E., La Manno, G., et al. (2018) · Cell

Single-cell and spatial transcriptomicsNeurogenesis and neuroplasticity mechanisms

Cited by 2,552

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

Stambolic, V., Suzuki, A., de la Pompa, J. L., Brothers, G. M., Mirtsos, C., Sasaki, T., Ruland, J., Penninger, J. M., Siderovski, D. P., & Mak, T. W. (1998) · Cell

PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase Signaling

Cited by 2,551

An atlas of active enhancers across human cell types and tissues

The FANTOM Consortium, Andersson, R., Gebhard, C., Miguel-Escalada, I., Hoof, I., Bornholdt, J., Boyd, M., Chen, Y., Zhao, X., Schmidl, C., et al. (2014) · Nature

Genomics and Chromatin DynamicsCancer-related molecular mechanisms research

Cited by 2,550

A conserved family of prolyl-4-hydroxylases that modify HIF

Bruick, R. K., & McKnight, S. L. (2001) · Science

Cancer, Hypoxia, and MetabolismErythropoietin and Anemia Treatment

Cited by 2,549

Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres

Lin, J., Wu, H., Tarr, P. T., Zhang, C.-Y., Wu, Z., Boss, O., Michael, L. F., Puigserver, P., Isotani, E., Olson, E. N., et al. (2002) · Nature

Muscle Physiology and DisordersAdipose Tissue and Metabolism

Cited by 2,546

Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer

Hoadley, K. A., Yau, C., Hinoue, T., Wolf, D. M., Lazar, A. J., Drill, E., Shen, R., Taylor, A. M., Cherniack, A. D., Thorsson, V., et al. (2018) · Cell

Cancer Genomics and DiagnosticsGene expression and cancer classification

Cited by 2,546