Most cited biochemistry, genetics and molecular biology papers
- Verified
MicroRNA biogenesis: coordinated cropping and dicing
Kim, V. N. (2005) · Nature Reviews Molecular Cell Biology
MicroRNA in disease regulationPlant Molecular Biology Research
Cited by 2,546
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Transient Regenerative Potential of the Neonatal Mouse Heart
Porrello, E. R., Mahmoud, A. I., Simpson, E., Hill, J. A., Richardson, J. A., Olson, E. N., & Sadek, H. A. (2011) · Science
Congenital heart defects researchTissue Engineering and Regenerative Medicine
Cited by 2,545
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Dynamic personalities of proteins
Henzler-Wildman, K., & Kern, D. (2007) · Nature
Protein Structure and DynamicsEnzyme Structure and Function
Cited by 2,545
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A Gene Network Regulating Lysosomal Biogenesis and Function
Sardiello, M., Palmieri, M., di Ronza, A., Medina, D. L., Valenza, M., Gennarino, V. A., Di Malta, C., Donaudy, F., Embrione, V., Polishchuk, R. S., et al. (2009) · Science
Autophagy in Disease and TherapyCellular transport and secretion
Cited by 2,543
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Combination therapy in combating cancer
Mokhtari, R. B., Homayouni, T. S., Baluch, N., Morgatskaya, E., Kumar, S., Das, B., & Yeger, H. (2017) · Oncotarget
Cancer, Hypoxia, and MetabolismEnzyme function and inhibition
Cited by 2,543
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Environmental sensing through focal adhesions
Geiger, B., Spatz, J. P., & Bershadsky, A. D. (2009) · Nature Reviews Molecular Cell Biology
Cellular Mechanics and InteractionsCell Adhesion Molecules Research
Cited by 2,543
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Nile red: a selective fluorescent stain for intracellular lipid droplets.
Greenspan, P., Mayer, E. P., & Fowler, S. D. (1985) · The Journal of cell biology
Lipid metabolism and biosynthesisBiological Stains and Phytochemicals
Cited by 2,543
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Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases
Allard, W. J., Matera, J., Miller, M. C., Repollet, M., Connelly, M. C., Rao, C., Tibbe, A. G. J., Uhr, J. W., & Terstappen, L. W. M. M. (2004) · Clinical Cancer Research
Cancer Genomics and DiagnosticsCancer Cells and Metastasis
Cited by 2,542
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DNA methylation GrimAge strongly predicts lifespan and healthspan
Lu, A. T., Quach, A., Wilson, J. G., Reiner, A. P., Aviv, A., Raj, K., Hou, L., Baccarelli, A. A., Li, Y., Stewart, J. D., et al. (2019) · Aging
Epigenetics and DNA MethylationGenetics, Aging, and Longevity in Model Organisms
Cited by 2,540
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Succession of microbial consortia in the developing infant gut microbiome
Koenig, J. E., Spor, A., Scalfone, N., Fricker, A. D., Stombaugh, J., Knight, R., Angenent, L. T., & Ley, R. E. (2011) · Proceedings of the National Academy of Sciences
Gut microbiota and healthInfant Nutrition and Health
Cited by 2,540
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UniProt: the Universal Protein Knowledgebase in 2025
The UniProt Consortium, Bateman, A., Martin, M.-J., Orchard, S., Magrane, M., Adesina, A., Ahmad, S., Bowler-Barnett, E. H., Bye-A-Jee, H., Carpentier, D., et al. (2025) · Nucleic Acids Research
Genomics and Phylogenetic StudiesBioinformatics and Genomic Networks
Cited by 2,537
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Initiation of biofilm formation in Pseudomonas fluorescens WCS365 proceeds via multiple, convergent signalling pathways: a genetic analysis
O'Toole, G. A., & Kolter, R. (1998) · Molecular Microbiology
Bacterial biofilms and quorum sensingBacterial Genetics and Biotechnology
Cited by 2,537
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Genome-scale DNA methylation maps of pluripotent and differentiated cells
Meissner, A., Mikkelsen, T. S., Gu, H., Wernig, M., Hanna, J., Sivachenko, A., Zhang, X., Bernstein, B. E., Nusbaum, C., Jaffe, D. B., et al. (2008) · Nature
Epigenetics and DNA MethylationGenomics and Chromatin Dynamics
Cited by 2,536
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Gut biogeography of the bacterial microbiota
Donaldson, G. P., Lee, S. M., & Mazmanian, S. K. (2016) · Nature Reviews Microbiology
Gut microbiota and healthOral microbiology and periodontitis research
Cited by 2,535
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The structure and function of G-protein-coupled receptors
Rosenbaum, D. M., Rasmussen, S. G. F., & Kobilka, B. K. (2009) · Nature
Receptor Mechanisms and SignalingProtein Kinase Regulation and GTPase Signaling
Cited by 2,534
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Histone modifications at human enhancers reflect global cell-type-specific gene expression
Heintzman, N. D., Hon, G. C., Hawkins, R. D., Kheradpour, P., Stark, A., Harp, L. F., Ye, Z., Lee, L. K., Stuart, R. K., Ching, C. W., et al. (2009) · Nature
Genomics and Chromatin DynamicsEpigenetics and DNA Methylation
Cited by 2,533
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Long Noncoding RNAs: Cellular Address Codes in Development and Disease
Batista, P. J., & Chang, H. Y. (2013) · Cell
Cancer-related molecular mechanisms researchGenomics and Chromatin Dynamics
Cited by 2,531
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Quartet Puzzling: A Quartet Maximum-Likelihood Method for Reconstructing Tree Topologies
Strimmer, K., & von Haeseler, A. (1996) · Molecular Biology and Evolution
Genomics and Phylogenetic StudiesRNA and protein synthesis mechanisms
Cited by 2,531
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Deep generative modeling for single-cell transcriptomics
Lopez, R., Regier, J., Cole, M. B., Jordan, M. I., & Yosef, N. (2018) · Nature Methods
Single-cell and spatial transcriptomicsGene expression and cancer classification
Cited by 2,530
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Opportunities and challenges in long-read sequencing data analysis
Amarasinghe, S. L., Su, S., Dong, X., Zappia, L., Ritchie, M. E., & Gouil, Q. (2020) · Genome Biology
Genomics and Phylogenetic StudiesSingle-cell and spatial transcriptomics
Cited by 2,530
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Non-canonical inflammasome activation targets caspase-11
Kayagaki, N., Warming, S., Lamkanfi, M., Walle, L. V., Louie, S., Dong, J., Newton, K., Qu, Y., Liu, J., Heldens, S., et al. (2011) · Nature
Inflammasome and immune disordersImmune Response and Inflammation
Cited by 2,530
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Targeting Autophagy in Cancer
Levy, J. M. M., Towers, C. G., & Thorburn, A. (2017) · Nature Reviews Cancer
Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolism
Cited by 2,526
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Reactive oxygen species have a causal role in multiple forms of insulin resistance
Houstis, N., Rosen, E. D., & Lander, E. S. (2006) · Nature
Redox biology and oxidative stressMetabolism, Diabetes, and Cancer
Cited by 2,525
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Oxidative stress shortens telomeres
von Zglinicki, T. (2002) · Trends in Biochemical Sciences
Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms
Cited by 2,524
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