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Cited by 116Traumatic Brain Injury ResearchAlzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Neurofibrillary tangles, but not Alzheimer‐type pathology, in a young boxer

Geddes, J. F., Vowles, G. H., Robinson, S. F. D., Sutcliffe, J. C.·1996·Neuropathology and Applied Neurobiology
DOI 10.1111/j.1365-2990.1996.tb00840.x
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Abstract

The chronic neurological sequelae of boxing are well described, but there have been few neuropathological studies of boxers dying early in their career. We report the case of a 23‐year‐old boxer, whose brain showed neurofibrillary tangles in all neocortical areas, but remarkable sparing of medial temporal lobe structures. These tangles, assumed to be the result of repetitive head injury, were the only detectable abnormality: none of the other changes previously described in the brains of retired boxers were seen. The distribution and features of the neuropathological findings in this case suggest that the mechanism of tangle formation induced by repetitive head trauma may be different from that in Alzheimer's disease.

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Crossref · 10.1111/j.1365-2990.1996.tb00840.x

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  • The conspicuous perivascular nature of neurofibrillary pathology and its tendency to be irregularly concentrated at the sulcal depths of the cortex in CTE were first noted by Geddes.

    “The conspicuous perivascular nature of the neurofibrillary pathology and its tendency to be irregularly concentrated at the sulcal depths of the cortex in CTE were first noted by Geddes in her description of the neuropathological alterations of five young men, 23– 28 years old, including two boxers, one soccer player, one developmentally challenged individual with a long history of head banging, a”

    From The neuropathology of sport (2014) · cites this paper as [66]

  • Despite evidence for Ab deposition in moderate to severe TBI, Ab plaques have not been found in early or mild stages of CTE in young individuals, but occur in older subjects with CTE in association with increased age at death.

    “However, despite evidence for Ab deposition in moderate to severe TBI [94], Ab plaques have not been found in early or mild stages of CTE in young individuals [65, 66, 72, 91, 126] but occur in older subjects with CTE in association with increased age at death [128].”

    From The neuropathology of sport (2014) · cites this paper as [66]

  • CTE has been diagnosed neuropathologically in American football players, professional and amateur boxers, ice hockey players, professional wrestlers, soccer players, rugby players, and a professional baseball player.

    “Although CTE was first identified in association with boxing, CTE has been diagnosed neuropathologically in American football players, professional and amateur boxers, ice hockey players, professional wrestlers, soccer players, rugby players, and a professional baseball player (Figs. 3, 4, 5, 6) [38, 65, 66, 88, 91, 127, 128, 146–148].”

    From The neuropathology of sport (2014) · cites this paper as [66]

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Authors
Geddes, J. F., Vowles, G. H., Robinson, S. F. D., & Sutcliffe, J. C.
Venue
Neuropathology and Applied Neurobiology
Publisher
Wiley
Published
1996-02
Volume
22
Issue
1
Pages
12-16
ISSN
  • 0305-1846 (ISSN-L)
  • 1365-2990
DOI
10.1111/j.1365-2990.1996.tb00840.x
OpenAlex
W2033273505
Cited by
116
References
10
Citations by year
2025: 2 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 5 · 2019: 8 · 2018: 5 · 2017: 6 · 2016: 7 · 2015: 10 · 2014: 7 · 2013: 5 · 2012: 3
FWCI
5.10
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 4484 d)
Locations
  • Neuropathology and Applied Neurobiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
neurofibrillary tangles, boxing, repetitive head injury, chronic traumatic encephalopathy, Alzheimer's disease pathology, neuropathology
MeSH terms
Adult, Boxing, Brain Injuries, Humans, Immunohistochemistry, Male, Temporal Lobe, Neurofibrillary Tangles

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