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Cited by 266Retinal Diseases and TreatmentsNutritional Studies and DietAntioxidant Activity and Oxidative Stress

The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.

Prospective Study of Intake of Fruits, Vegetables, Vitamins, and Carotenoidsand Risk of Age-Related Maculopathy

Cho, Eunyoung·2004·Archives of Ophthalmology
DOI 10.1001/archopht.122.6.883
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Abstract

OBJECTIVE: To examine the intake of antioxidant vitamins and carotenoids as well as fruits and vegetables in relation to the development of age-related maculopathy (ARM). METHODS: We conducted a prospective follow-up study of women in the Nurses' Health Study and men in the Health Professionals Follow-up Study. We followed 77 562 women and 40 866 men who were at least 50 years of age and had no diagnosis of ARM or cancer at baseline for up to 18 years for women and up to 12 years for men. Fruit and vegetable intakes were assessed with a validated semiquantitative food-frequency questionnaire up to 5 times for women and up to 3 times for men during follow-up. RESULTS: A total of 464 (329 women and 135 men) incident cases of early ARM and 316 (217 women and 99men) cases of neovascular ARM, all with visual loss of 20/30 or worse due primarily to ARM, were diagnosed during follow-up. Fruit intake was inversely associated with the risk of neovascular ARM. Participants who consumed 3 or more servings per day of fruits had a pooled multivariate relative risk of 0.64 (95% confidence interval, 0.44-0.93; P value for trend =.004) compared with those who consumed less than 1.5 servings per day. The results were similar in women and men. However, intakes of vegetables, antioxidant vitamins, or carotenoids were not strongly related to either early or neovascular ARM. CONCLUSION: These data suggest a protective role for fruit intake on the risk of neovascular ARM.

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Metadata

Authors
Cho, E.
Affiliations
Brigham and Women's Hospital (US)
Corresponding author
Cho, Eunyoung
ORCID
Cho, Eunyoung
Venue
Archives of Ophthalmology
Publisher
American Medical Association (AMA)
Published
2004-06-01
Volume
122
Issue
6
Pages
883
ISSN
0003-9950 (ISSN-L)
DOI
10.1001/archopht.122.6.883
OpenAlex
W2149867743
Cited by
266
References
55
Citations by year
2025: 4 · 2024: 6 · 2023: 9 · 2022: 13 · 2021: 9 · 2020: 10 · 2019: 9 · 2018: 10 · 2017: 13 · 2016: 14 · 2015: 14 · 2014: 12 · 2013: 15 · 2012: 21
FWCI
22.49
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of Ophthalmology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Heart, Lung, and Blood Institute (R01HL035464, HL35464)
  • National Eye Institute (R01EY009611, EY09611)
  • National Cancer Institute (CA-87969, CA-55075, P01CA087969)
Topics
  • Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords
age-related maculopathy, fruit consumption, vegetable consumption, antioxidant vitamins, carotenoids, dietary intake, vision loss, disease risk factors, Nurses' Health Study, Health Professionals Follow-up Study
MeSH terms
Adult, Aged, Antioxidants, Carotenoids, Diet, Feeding Behavior, Female, Follow-Up Studies, Fruit, Humans, Macular Degeneration, Male, Middle Aged, Prospective Studies, Risk Factors, United States, Vegetables, Vitamins, Diet Records, Incidence

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