The effects of dietary protein intake on appendicular lean mass and muscle function in elderly men: A 10-wk randomized controlled trial
Open accessAbstract
Background: The Recommended Daily Allowance (RDA) for protein intake in the adult population is widely promoted as 0.8 g · kg-1 · d-1 Aging may increase protein requirements, particularly to maintain muscle mass.Objective: We investigated whether controlled protein consumption at the current RDA or twice the RDA (2RDA) affects skeletal muscle mass and physical function in elderly men.Design: In this parallel-group randomized trial, 29 men aged >70 y [mean ± SD body mass index (in kg/m 2): 28.3 ± 4.2] were provided with a complete diet containing either 0.8 (RDA) or 1.6 (2RDA) g protein · kg-1 · d-1, aimed to balance energy needs. Before treatment and after 10 wk of intervention, whole-body and appendicular lean mass were measured by using dual-energy X-ray absorptiometry. Knee-extension peak power was measured with dynamometry.Results: Both groups were found to have been in a moderate negative energy balance (mean ± SD RDA: 209 ± 213 kcal/d; 2RDA 145 ± 214 kcal/d; P= 0.427 for difference between the groups). In comparison with RDA, whole-body lean mass increased in 2RDA (P = 0.001; 1.49 ± 1.30 kg, P < 0.001 compared with -0.55 ± 1.49 kg, P = 0.149). This difference was mostly accounted for by an increase in trunk lean mass found in 2RDA (+1.39 ± 1.09 kg, P < 0.001). Appendicular lean mass also decreased in RDA compared with 2RDA (P = 0.022), driven by a reduction in RDA (-0.64 ± 0.91 kg, P = 0.005 compared with 0.11 ± 0.57 kg, P = 0.592). Adjusting for energy imbalances did not alter these findings. Knee-extension peak power was also differently affected (P = 0.012; 26.6 ± 47.7 W, P = 0.015 in 2RDA compared with -11.7 ± 31.0 W, P = 0.180 in RDA).Conclusions: Consumption of a diet providing 2RDA for protein compared with the current guidelines was found to have beneficial effects on lean body mass and leg power in elderly men. These effects were not explained by differences in energy balance. This trial was registered at the Australia New Zealand Clinical Trial Registry (www.anzctr.org.au) as ACTRN12616000310460.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Timed “Up & Go”: A Test of Basic Functional Mobility for Frail Elderly Persons
Podsiadlo, D., & Richardson, S. (1991) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1991.tb01616.x · Cited by 14,418 · see citing works
Sarcopenia: European consensus on definition and diagnosis
Cruz-Jentoft, A. J., Baeyens, J. P., Bauer, J. M., Boirie, Y., Cederholm, T., Landi, F., Martin, F. C., Michel, J.-P., Rolland, Y., Schneider, S. M., et al. (2010) · Age and Ageing · doi:10.1093/ageing/afq034 · Cited by 11,601 · see citing works
Janssen, I., Heymsfield, S. B., & Ross, R. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50216.x · Cited by 3,139 · see citing works
Goodpaster, B. H., Park, S. W., Harris, T. B., Kritchevsky, S. B., Nevitt, M., Schwartz, A. V., Simonsick, E. M., Tylavsky, F. A., Visser, M., Newman, A. B., et al. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.10.1059 · Cited by 3,083 · see citing works
Walston, J., Hadley, E. C., Ferrucci, L., Guralnik, J. M., Newman, A. B., Studenski, S. A., Ershler, W. B., Harris, T., & Fried, L. P. (2006) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2006.00745.x · Cited by 1,605 · see citing works
Houston, D. K., Nicklas, B. J., Ding, J., Harris, T. B., Tylavsky, F. A., Newman, A. B., Lee, J. S., Sahyoun, N. R., Visser, M., & Kritchevsky, S. B. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.1.150 · Cited by 1,214 · see citing works
Morton, R. W., Murphy, K. T., McKellar, S. R., Schoenfeld, B. J., Henselmans, M., Helms, E., Aragon, A. A., Devries, M. C., Banfield, L., Krieger, J. W., et al. (2018) · British Journal of Sports Medicine · doi:10.1136/bjsports-2017-097608 · Cited by 1,154 · see citing works
An overview of sarcopenia: facts and numbers on prevalence and clinical impact
von Haehling, S., Morley, J. E., & Anker, S. D. (2010) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1007/s13539-010-0014-2 · Cited by 888 · see citing works
Reid, K. F., & Fielding, R. A. (2012) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e31823b5f13 · Cited by 858 · see citing works
The Harris Benedict equation reevaluated: resting energy requirements and the body cell mass
Roza, A. M., & Shizgal, H. M. (1984) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/40.1.168 · Cited by 824 · see citing works
Dietary protein recommendations and the prevention of sarcopenia
Paddon-Jones, D., & Rasmussen, B. B. (2009) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32831cef8b · Cited by 823 · see citing works
Srikanthan, P., & Karlamangla, A. S. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0435 · Cited by 785 · see citing works
Moore, D. R., Churchward-Venne, T. A., Witard, O., Breen, L., Burd, N. A., Tipton, K. D., & Phillips, S. M. (2015) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glu103 · Cited by 770 · see citing works
Jančeková, K., Ruprich, J., de Vries, J. H. M., Jakubiková, M., & Veer, P. V. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509990602 · Cited by 695 · see citing works
Nutritional recommendations for the management of sarcopenia
Morley, J. E., Argiles, J. M., Evans, W. J., Bhasin, S., Cella, D., Deutz, N. E. P., Doehner, W., Fearon, K. C. H., Ferrucci, L., Hellerstein, M. K., et al. (2010) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2010.04.014 · Cited by 664 · see citing works
The LIFE Study Investigators* [*See Appendix for List of LIFE Study Investigators] (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.11.1157 · Cited by 661 · see citing works
Association of Muscle Power With Functional Status in Community-Dwelling Elderly Women
Foldvari, M., Clark, M., Laviolette, L. C., Bernstein, M. A., Kaliton, D., Castaneda, C., Pu, C. T., Hausdorff, J. M., Fielding, R. A., & Singh, M. A. F. (2000) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/55.4.m192 · Cited by 653 · see citing works
The Skeletal Muscle Anabolic Response to Plant- versus Animal-Based Protein Consumption
van Vliet, S., Burd, N. A., & van Loon, L. J. (2015) · The Journal of Nutrition · doi:10.3945/jn.114.204305 · Cited by 651 · see citing works
Resistance exercise load does not determine training-mediated hypertrophic gains in young men
Mitchell, C. J., Churchward-Venne, T. A., West, D. W. D., Burd, N. A., Breen, L., Baker, S. K., & Phillips, S. M. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00307.2012 · Cited by 627 · see citing works
Self-citationVillareal, D. T., Apovian, C. M., Kushner, R. F., & Klein, S. (2005) · Obesity Research · doi:10.1038/oby.2005.228 · Cited by 579 · see citing works
Ello-Martin, J. A., Ledikwe, J. H., & Rolls, B. J. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.1.236s · Cited by 513 · see citing works
Meta-analysis of nitrogen balance studies for estimating protein requirements in healthy adults
Rand, W. M., Pellett, P. L., & Young, V. R. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.1.109 · Cited by 506 · see citing works
Tieland, M., van de Rest, O., Dirks, M. L., van der Zwaluw, N., Mensink, M., van Loon, L. J. C., & de Groot, L. C. P. G. M. (2012) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2012.07.005 · Cited by 446 · see citing works
Dietary protein distribution positively influences 24-h muscle protein synthesis in healthy adults
Mamerow, M. M., Mettler, J. A., English, K. L., Casperson, S. L., Arentson-Lantz, E., Sheffield-Moore, M., Layman, D. K., & Paddon-Jones, D. (2014) · The Journal of Nutrition · doi:10.3945/jn.113.185280 · Cited by 438 · see citing works
Cawthon, P. M., Peters, K. W., Shardell, M. D., McLean, R. R., Dam, T.-T. L., Kenny, A. M., Fragala, M. S., Harris, T. B., Kiel, D. P., Guralnik, J. M., et al. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu023 · Cited by 388 · see citing works
Vasunilashorn, S. M., Coppin, A. K., Patel, K. V., Lauretani, F., Ferrucci, L., Bandinelli, S., & Guralnik, J. M. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/gln022 · Cited by 383 · see citing works
Aging is accompanied by a blunted muscle protein synthetic response to protein ingestion
Wall, B. T., Gorissen, S. H., Pennings, B., Koopman, R., Groen, B. B. L., Verdijk, L. B., & van Loon, L. J. C. (2015) · PLOS ONE · doi:10.1371/journal.pone.0140903 · Cited by 352 · see citing works
Elia, M., & Livesey, G. (2015) · World review of nutrition and dietetics · doi:10.1159/000421672 · Cited by 332 · see citing works
A Brief Review of Critical Processes in Exercise-Induced Muscular Hypertrophy
Phillips, S. M. (2014) · Sports Medicine · doi:10.1007/s40279-014-0152-3 · Cited by 281 · see citing works
Relation of muscle mass and fat mass to cardiovascular disease mortality
Srikanthan, P., Horwich, T. B., & Tseng, C. H. (2016) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2016.01.033 · Cited by 260 · see citing works
Reid, K. F., Pasha, E., Doros, G., Clark, D. J., Patten, C., Phillips, E. M., Frontera, W. R., & Fielding, R. A. (2014) · European Journal of Applied Physiology · doi:10.1007/s00421-013-2728-2 · Cited by 246 · see citing works
Dietary protein and muscle in older persons
Paddon‐Jones, D., & Leidy, H. J. (2013) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000011 · Cited by 203 · see citing works
Churchward-Venne, T. A., Burd, N. A., & Phillips, S. M. (2012) · Nutrition & Metabolism · doi:10.1186/1743-7075-9-40 · Cited by 186 · see citing works
Kelley, D. S., Taylor, P. C., Nelson, G. J., & Mackey, B. E. (1998) · Lipids · doi:10.1007/s11745-998-0187-9 · Cited by 143 · see citing works
Bosy-Westphal, A., & Müller, M. J. (2015) · International Journal of Obesity · doi:10.1038/ijo.2014.161 · Cited by 133 · see citing works
Fluharty, F. L., & McClure, K. E. (1997) · Journal of Animal Science · doi:10.2527/1997.753604x · Cited by 130 · see citing works
An easy approach to calculating estimated energy requirements.
Gerrior, S., Juan, W., & Peter, B. (2006) · PubMed · Cited by 129 · see citing works
Shad, B. J., Thompson, J. L., & Breen, L. (2016) · American Journal of Physiology. Endocrinology and Metabolism · doi:10.1152/ajpendo.00213.2016 · Cited by 125 · see citing works
Murphy, C. H., Churchward-Venne, T. A., Mitchell, C. J., Kolar, N. M., Kassis, A., Karagounis, L. G., Burke, L. M., Hawley, J. A., & Phillips, S. M. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00550.2014 · Cited by 124 · see citing works
Self-citationChowdhury, E. A., Western, M. J., Nightingale, T. E., Peacock, O. J., & Thompson, D. (2017) · PLOS ONE · doi:10.1371/journal.pone.0171720 · Cited by 118 · see citing works
The Effects of Increased Protein Intake on Kidney Size and Function
Hammond, K. A., & Janes, D. N. (1998) · Journal of Experimental Biology · doi:10.1242/jeb.201.13.2081 · Cited by 105 · see citing works
Voluntary weight loss: systematic review of early phase body composition changes
Heymsfield, S. B., Thomas, D. M., Nguyen, A. M., Peng, J. Z., Martin, C. K., Shen, W., Strauss, B. J., Bosy‐Westphal, A., & Müller, M. J. (2010) · Obesity Reviews · doi:10.1111/j.1467-789x.2010.00767.x · Cited by 103 · see citing works
Dietary Protein to Maintain Muscle Mass in Aging: A Case for Per-meal Protein Recommendations.
Murphy, C., Oikawa, S., & Phillips, S. M. (2016) · The Journal of frailty & aging · doi:10.14283/jfa.2016.80 · Cited by 96 · see citing works
Tang, M., McCabe, G. P., Elango, R., Pencharz, P. B., Ball, R. O., & Campbell, W. W. (2014) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.042325 · Cited by 92 · see citing works
Rafii, M., Chapman, K., Elango, R., Campbell, W. W., Ball, R. O., Pencharz, P. B., & Courtney-Martin, G. (2016) · The Journal of Nutrition · doi:10.3945/jn.115.225631 · Cited by 87 · see citing works
Eating and activity guidelines for New Zealand adults
McIntyre, L., & Dutton, M. V. (2015) · Cited by 79 · see citing works
Protein requirements of elderly people.
Campbell, W. W., & Evans, W. J. (1996) · PubMed · Cited by 75 · see citing works
Xu, Z.-R., Tan, Z., Zhang, Q., Gui, Q.-F., & Yang, Y.-M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109141 · Cited by 61 · see citing works
Mackenzie, T., Clark, N. G., Bistrian, B., Flatt, J., Hallowell, E., & Blackburn, G. (1985) · Journal of the American College of Nutrition · doi:10.1080/07315724.1985.10720100 · Cited by 61 · see citing works
Amigues, I., Schott, A., Amine, M., Gelas‐Dore, B., Veerabudun, K., Paillaud, É., Beauchet, O., Rolland, Y., Canouï‐Poitrine, F., & Bonnefoy, M. (2013) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2012.12.002 · Cited by 48 · see citing works
Accuracy of handsv. household measures as portion size estimation aids
Gibson, A. A., Hsu, M. S. H., Rangan, A., Seimon, R. V., Lee, C., Das, A., Finch, C. H., & Sainsbury, A. (2016) · Journal of Nutritional Science · doi:10.1017/jns.2016.22 · Cited by 44 · see citing works
Possibility of leg muscle hypertrophy by ambulation in older adults: a brief review
Abe, T., Ozaki, Loenneke, Thiebaud, Stager, & Stager (2013) · Clinical Interventions in Aging · doi:10.2147/cia.s43837 · Cited by 37 · see citing works
Farooqi, N., Sandström, T., Slinde, F., Håglin, L., & Carlsson, M. (2015) · International Journal of COPD · doi:10.2147/copd.s80616 · Cited by 12 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Plant Proteins: Assessing Their Nutritional Quality and Effects on Health and Physical Function
Hertzler, S. R., Lieblein-Boff, J. C., Weiler, M., & Allgeier, C. (2020) · Nutrients · doi:10.3390/nu12123704 · Cited by 594 · see citing works
Traylor, D. A., Gorissen, S., & Phillips, S. M. (2018) · Advances in Nutrition · doi:10.1093/advances/nmy003 · Cited by 208 · see citing works
Dietary Protein and Muscle Mass: Translating Science to Application and Health Benefit
Carbone, J. W., & Pasiakos, S. M. (2019) · Nutrients · doi:10.3390/nu11051136 · Cited by 210 · see citing works
Strategies to Prevent Sarcopenia in the Aging Process: Role of Protein Intake and Exercise
Rogeri, P. S., Zanella, R., Martins, G. L., Garcia, M. D. A., Leite, G., Lugaresi, R., Gasparini, S. O., Sperandio, G. A., Ferreira, L. H. B., Souza-Junior, T. P., et al. (2021) · Nutrients · doi:10.3390/nu14010052 · Cited by 181 · see citing works
Strasser, B., Wolters, M., Weyh, C., Krüger, K., & Ticinesi, A. (2021) · Nutrients · doi:10.3390/nu13062045 · Cited by 181 · see citing works
Cancer-associated malnutrition
Baracos, V. E. (2018) · European Journal of Clinical Nutrition · doi:10.1038/s41430-018-0245-4 · Cited by 175 · see citing works
ten Haaf, D. S. M., Nuijten, M. A. H., Maessen, M. F. H., Horstman, A. M. H., Eijsvogels, T. M. H., & Hopman, M. T. (2018) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqy192 · Cited by 152 · see citing works
Dietary Protein and Muscle in Aging People: The Potential Role of the Gut Microbiome
Lochlainn, M. N., Bowyer, R. C. E., & Steves, C. J. (2018) · Nutrients · doi:10.3390/nu10070929 · Cited by 138 · see citing works
Tessier, A., & Chevalier, S. (2018) · Nutrients · doi:10.3390/nu10081099 · Cited by 132 · see citing works
A word of caution against excessive protein intake
Mittendorfer, B., Klein, S., & Fontana, L. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0274-7 · Cited by 122 · see citing works
Gut microbiota as a promising therapeutic target for age-related sarcopenia
Zhang, T., Cheng, J.-K., & Hu, Y. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101739 · Cited by 102 · see citing works
ten Haaf, D. S. M., Eijsvogels, T. M. H., Bongers, C. C. W. G., Horstman, A. M. H., Timmers, S., de Groot, C. P. G. M., & Hopman, M. T. E. (2019) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12394 · Cited by 102 · see citing works
Schiessel, D. L., & Baracos, V. E. (2018) · Proceedings of The Nutrition Society · doi:10.1017/s0029665118000186 · Cited by 91 · see citing works
Kirwan, R., Mazidi, M., Rodríguez‐García, C., Lane, K. E., Jafari, A., Butler, T., de Heredia, F. P., & Davies, I. G. (2021) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqab355 · Cited by 93 · see citing works
Mertz, K. H., Reitelseder, S., Bechshoeft, R. L., Bülow, J., Højfeldt, G. W., Jensen, M., Schacht, S. R., Lind, M. V., Rasmussen, M. A., Mikkelsen, U. R., et al. (2020) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqaa372 · Cited by 91 · see citing works
Gut microbiota and physical frailty through the mediation of sarcopenia
Casati, M., Ferri, E., Azzolino, D., Cesari, M., & Arosio, B. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.110639 · Cited by 75 · see citing works
Dietary Protein, Muscle and Physical Function in the Very Old
Franzke, B., Neubauer, O., Cameron‐Smith, D., & Wagner, K. (2018) · Nutrients · doi:10.3390/nu10070935 · Cited by 74 · see citing works
Self-citationProtein Intake and Functional Integrity in Aging: The Framingham Heart Study Offspring
Hruby, A., Sahni, S., Bolster, D. R., & Jacques, P. F. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly201 · Cited by 66 · see citing works
Optimizing Adult Protein Intake During Catabolic Health Conditions
Phillips, S. M., Paddon-Jones, D., & Layman, D. K. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa047 · Cited by 65 · see citing works
Mathewson, S. L., Azevedo, P. S., Gordon, A. L., Phillips, B. E., & Greig, C. A. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101401 · Cited by 60 · see citing works
Phillips, S. M., & Martinson, W. (2018) · Nutrition reviews · doi:10.1093/nutrit/nuy062 · Cited by 64 · see citing works
Griffen, C., Duncan, M. J., Hattersley, J. G., Weickert, M. O., Dallaway, A., & Renshaw, D. W. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111651 · Cited by 57 · see citing works
Is It Time to Reconsider the U.S. Recommendations for Dietary Protein and Amino Acid Intake?
Weiler, M. D., Hertzler, S. R., & Dvoretskiy, S. (2023) · Nutrients · doi:10.3390/nu15040838 · Cited by 55 · see citing works
Galbreath, M., Campbell, B. I., Bounty, P. L., Bunn, J. A., Dove, J., Harvey, T. M., Hudson, G. M., Gutierrez, J. L., Levers, K. S., Galvan, E., et al. (2018) · Nutrients · doi:10.3390/nu10081070 · Cited by 54 · see citing works
Pathways in formulating foods for the elderly
Qin, Y., Pillidge, C. J., Harrison, B., & Adhikari, B. (2024) · Food Research International · doi:10.1016/j.foodres.2024.114324 · Cited by 52 · see citing works
Ispoglou, T., Witard, O. C., Duckworth, L. C., & Lees, M. J. (2020) · Proceedings of The Nutrition Society · doi:10.1017/s0029665120008010 · Cited by 53 · see citing works
Nishimura, Y., Højfeldt, G. W., Breen, L., Tetens, I., & Holm, L. (2021) · Nutrition Research Reviews · doi:10.1017/s0954422421000329 · Cited by 51 · see citing works
A Review of Nutritional Requirements of Adults Aged ≥65 Years in the UK
Dorrington, N., Fallaize, R., Hobbs, D. A., Weech, M., & Lovegrove, J. A. (2020) · Journal of Nutrition · doi:10.1093/jn/nxaa153 · Cited by 48 · see citing works
Verreijen, A. M., Engberink, M. F., Houston, D. K., Brouwer, I. A., Cawthon, P. M., Newman, A. B., Tylavsky, F. A., Harris, T. B., Weijs, P. J. M., & Visser, M. (2019) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqy341 · Cited by 45 · see citing works
Alternative dietary protein sources to support healthy and active skeletal muscle aging
van der Heijden, I., Monteyne, A. J., Stephens, F. B., & Wall, B. T. (2023) · Nutrition Reviews · doi:10.1093/nutrit/nuac049 · Cited by 45 · see citing works
Li, C.-Y., Fang, A.-P., Ma, W.-J., Wu, S.-L., Li, C.-L., Chen, Y.-M., & Zhu, H.-L. (2019) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2019.03.010 · Cited by 44 · see citing works
Liao, C.-D., Huang, S.-W., Chen, H.-C., Huang, M.-H., Liou, T.-H., & Lin, C.-L. (2024) · Nutrients · doi:10.3390/nu16070941 · Cited by 45 · see citing works
Hudson, J. L., Wang, Y., Bergia III, R. E., & Campbell, W. W. (2020) · Advances in Nutrition · doi:10.1093/advances/nmz106 · Cited by 41 · see citing works
Zeng, N., D’Souza, R. F., Mitchell, C. J., & Cameron‐Smith, D. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.05.006 · Cited by 41 · see citing works
Self-citationExploring the Preventive Effect and Mechanism of Senile Sarcopenia Based on “Gut–Muscle Axis”
Liao, X., Wu, M., Hao, Y., & Hong, D. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.590869 · Cited by 44 · see citing works
Verzola, D., Picciotto, D., Saio, M., Aimasso, F., Bruzzone, F., Sukkar, S. G., Massarino, F., Esposito, P. B., Viazzi, F. C., & Garibotto, G. (2020) · Nutrients · doi:10.3390/nu13010083 · Cited by 41 · see citing works
Liao, C., Liao, Y., Liou, T., Hsieh, C.-Y., Kuo, Y., & Chen, H. (2021) · Nutrients · doi:10.3390/nu13082487 · Cited by 41 · see citing works
Yasuda, J., Tomita, T., Arimitsu, T., & Fujita, S. (2020) · The Journal of Nutrition · doi:10.1093/jn/nxaa101 · Cited by 41 · see citing works
Mitchell, S. M., Milan, A. M., Mitchell, C. J., Gillies, N. A., D’Souza, R. F., Zeng, N., Ramzan, F., Sharma, P., Knowles, S. O., Roy, N. C., et al. (2019) · Nutrients · doi:10.3390/nu11092207 · Cited by 40 · see citing works
Self-citationKang, Y., Kim, N. H., Choi, Y. J., Lee, Y., Yun, J., Park, S. J., Park, H. S., Chung, Y., & Park, Y. K. (2020) · Nutrients · doi:10.3390/nu12061816 · Cited by 40 · see citing works
A Calorie-Restricted DASH Diet Reduces Body Fat and Maintains Muscle Strength in Obese Older Adults
Perry, C. A., Guilder, G. P. V., Kauffman, A., & Hossain, M. (2019) · Nutrients · doi:10.3390/nu12010102 · Cited by 39 · see citing works
Muscle protein turnover and low-protein diets in patients with chronic kidney disease
Garibotto, G., Picciotto, D., Saio, M., Esposito, P. B., & Verzola, D. (2020) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfaa072 · Cited by 34 · see citing works
Hengeveld, L. M., de Goede, J., Afman, L. A., Bakker, S. J. L., Beulens, J. W. J., Blaak, E. E., Boersma, E. H., Geleijnse, J. M., van Goudoever, J. B., Hopman, M. T. E., et al. (2021) · Advances in Nutrition · doi:10.1093/advances/nmab140 · Cited by 35 · see citing works
Dietary Protein and Muscle in Aging People: The Potential Role of the Gut Microbiome
Ni Lochlainn, M., Bowyer, R. C. E., & Steves, C. J. (2018) · doi:10.20944/preprints201806.0152.v1 · Cited by 138 · see citing works
Gut-muscle axis mechanism of exercise prevention of sarcopenia
Li, T., Yin, D., & Shi, R. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1418778 · Cited by 37 · see citing works
Targeting the Gut Microbiota to Improve Dietary Protein Efficacy to Mitigate Sarcopenia
Castro, E. D. M., Murphy, C. H., & Roche, H. M. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.656730 · Cited by 31 · see citing works
Devries, M. C., & Giangregorio, L. (2022) · Bone · doi:10.1016/j.bone.2022.116573 · Cited by 29 · see citing works
Protein Intake and Human Health: Implications of Units of Protein Intake
Hruby, A., & Jacques, P. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa097 · Cited by 26 · see citing works
Nakayama, K., Saito, Y., Sanbongi, C., Murata, K., & Urashima, T. (2021) · European Journal of Nutrition · doi:10.1007/s00394-020-02302-4 · Cited by 27 · see citing works
Yasuda, J., Asako, M., Arimitsu, T., & Fujita, S. (2019) · Nutrients · doi:10.3390/nu11030612 · Cited by 26 · see citing works
Novel dietary strategies to manage sarcopenia
Cailleaux, P., Déchelotte, P., & Coëffier, M. (2024) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000001023 · Cited by 24 · see citing works
Jun, S., Cowan, A., Dwyer, J. T., Campbell, W. W., Thalacker‐Mercer, A. E., Gahche, J. J., & Bailey, R. L. (2021) · Journal of Nutrition · doi:10.1093/jn/nxab288 · Cited by 26 · see citing works
Role of Cachexia and Fragility in the Patient Candidate for Cardiac Surgery
Pisano, C., Polisano, D., Balistreri, C. R., Altieri, C., Nardi, P., Bertoldo, F., Trombetti, D., Asta, L., Ferrante, M. S., Buioni, D., et al. (2021) · Nutrients · doi:10.3390/nu13020517 · Cited by 23 · see citing works
Buckinx, F., Gaudreau, P., Marcangeli, V., Boutros, G. E. H., Dulac, M., Morais, J. A., & Aubertin‐Leheudre, M. (2019) · Aging Clinical and Experimental Research · doi:10.1007/s40520-019-01149-y · Cited by 21 · see citing works
Mitchell, S. M., McKenzie, E. J., Mitchell, C. J., Milan, A. M., Zeng, N., D’Souza, R. F., Ramzan, F., Sharma, P., Rettedal, E. A., Knowles, S. O., et al. (2020) · Journal of Nutritional Science · doi:10.1017/jns.2020.15 · Cited by 20 · see citing works
Self-citationUnterberger, S., Aschauer, R., Zöhrer, P. A., Draxler, A., Franzke, B., Strasser, E.-M., Wagner, K., & Wessner, B. (2022) · Clinical Nutrition · doi:10.1016/j.clnu.2022.02.017 · Cited by 20 · see citing works
Self-citationFranzke, B., Bileck, A., Unterberger, S., Aschauer, R., Zöhrer, P. A., Draxler, A., Strasser, E.-M., Wessner, B., Gerner, C., & Wagner, K. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.925450 · Cited by 20 · see citing works
Self-citationKim, E., Chung, S., Hwang, J., & Park, Y. J. (2022) · Journal of Nutrition and Health · doi:10.4163/jnh.2022.55.1.10 · Cited by 19 · see citing works
Hawley, A., Liang, X., Børsheim, E., Wolfe, R., Salisbury, L., Hendy, E. B., Wu, H., Walker, S., Tacinelli, A. M., & Baum, J. (2022) · Meat Science · doi:10.1016/j.meatsci.2022.108830 · Cited by 17 · see citing works
Şimşek, H., & Uçar, A. (2022) · Nutrition Research · doi:10.1016/j.nutres.2022.02.002 · Cited by 18 · see citing works
Nunes, E. A., Currier, B. S., Lim, C., & Phillips, S. M. (2021) · Proceedings of the Nutrition Society · doi:10.1017/s0029665120007892 · Cited by 19 · see citing works
Otsuka, Y., Miyamoto, N., Nagai, A., Izumo, T., Nakai, M., Fukuda, M., Arimitsu, T., Yamada, Y., & Hashimoto, T. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.912217 · Cited by 17 · see citing works
Targeting cancer via ribosome biogenesis: the cachexia perspective
Figueiredo, V., & McCarthy, J. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03888-6 · Cited by 15 · see citing works
Bell, K. E., Brook, M. S., Snijders, T., Kumbhare, D. A., Parise, G., Smith, K., Atherton, P. J., & Phillips, S. M. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00040 · Cited by 16 · see citing works
Association of Dietary Protein Intake with Muscle Mass in Elderly Chinese: A Cross-Sectional Study
Ouyang, Y., Huang, F., Zhang, X., Li, L., Zhang, B., Wang, Z., & Wang, H. (2022) · Nutrients · doi:10.3390/nu14235130 · Cited by 16 · see citing works
Granic, A., Hurst, C., Dismore, L. L., Stevenson, E., Sayer, A. A., & Aspray, T. (2020) · PLoS ONE · doi:10.1371/journal.pone.0235952 · Cited by 17 · see citing works
Nabuco, H. C. G., Tomeleri, C. M., Sugihara, P., Fernandes, R. R., Cavalcante, E. F., Nunes, J. P., Cunha, P. M., dos Santos, L., & Cyrino, E. S. (2019) · Nutrition and Health · doi:10.1177/0260106019838365 · Cited by 16 · see citing works
Wright, C. S., Li, J., & Campbell, W. W. (2019) · Advances in Nutrition · doi:10.1093/advances/nmz058 · Cited by 15 · see citing works
Nutrition and physical activity countermeasures for sarcopenia: Time to get personal?
Murphy, C. H., & Roche, H. M. (2018) · Nutrition Bulletin · doi:10.1111/nbu.12351 · Cited by 15 · see citing works
Ramzan, F., Mitchell, C. J., Milan, A. M., Schierding, W. S., Zeng, N., Sharma, P., Mitchell, S. M., D’Souza, R. F., Knowles, S. O., Roy, N. C., et al. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201800811 · Cited by 14 · see citing works
Self-citationSchacht, S. R., Lind, M. V., Bechshøft, R. L., Højfeldt, G. W., Reitelseder, S., Jensen, T., Jespersen, A. P., Nielsen, D. S., Holm, L., & Tetens, I. (2019) · Nutrients · doi:10.3390/nu11040795 · Cited by 13 · see citing works
Okada, C., Okada, E., & Takimoto, H. (2020) · Public Health Nutrition · doi:10.1017/s1368980020000415 · Cited by 13 · see citing works
Wu, X. S., Miles, A., & Braakhuis, A. J. (2022) · Foods · doi:10.3390/foods11142157 · Cited by 13 · see citing works
Khani, Y., Salmani, A. S., Elahi, M., Vahed, I. E., Rad, E. S., Samani, A. B., Karami, S., Nouroozi, M., & Mehrvar, A. (2025) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-025-05847-4 · Cited by 13 · see citing works
Chen, Y., Liang, Y., Guo, H., Meng, K., Qiu, J., & Benardot, D. (2022) · Nutrients · doi:10.3390/nu14112289 · Cited by 13 · see citing works
Sica, P., Galvao, A., Scariolo, F., Maucieri, C., Nicoletto, C., Pilon, C., Sambo, P., Barcaccia, G., Borin, M., Cabrera, M. L., et al. (2021) · Horticulturae · doi:10.3390/horticulturae7020017 · Cited by 12 · see citing works
Amount of Protein Required to Improve Muscle Mass in Older Adults
Kim, D., & Park, Y. (2020) · Nutrients · doi:10.3390/nu12061700 · Cited by 12 · see citing works
A review of recent evidence of dietary protein intake and health
Park, Y. J., Chung, S., Hwang, J., Shon, J., & Kim, E. (2022) · Nutrition Research and Practice · doi:10.4162/nrp.2022.16.s1.s37 · Cited by 12 · see citing works
Kavanaugh, M., Rodgers, D., Rodriguez, N. R., & Leroy, F. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1525011 · Cited by 11 · see citing works
Macpherson, H., Brownell, S., Duckham, R. L., Meyer, B. J., Mirzaee, S., & Daly, R. M. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-024145 · Cited by 12 · see citing works
Silva, T. R., Lago, S. C., Yavorivski, A., Ferreira, L. L., Fighera, T. M., & Spritzer, P. M. (2020) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000001692 · Cited by 11 · see citing works
Hawley, A. L., & Baum, J. (2023) · Nutrition Reviews · doi:10.1093/nutrit/nuad061 · Cited by 11 · see citing works
Kouw, I. W. K., Parr, E. B., Wheeler, M. J., Radford, B. E., Hall, R. C., Senden, J. M., Goessens, J. P. B., van Loon, L. J. C., & Hawley, J. A. (2024) · Clinical Nutrition · doi:10.1016/j.clnu.2024.09.034 · Cited by 13 · see citing works
Buckinx, F., Marcangeli, V., Carvalho, L. P., Dulac, M., Boutros, G. H., Gouspillou, G., Gaudreau, P., Morais, J. A., Noirez, P., & Aubertin‐Leheudre, M. (2019) · Nutrients · doi:10.3390/nu11071685 · Cited by 10 · see citing works
Durainayagam, B. R., Mitchell, C. J., Milan, A. M., Zeng, N., Sharma, P., Mitchell, S. M., Ramzan, F., Knowles, S. O., Sjödin, A. M., Wagner, K., et al. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00180 · Cited by 10 · see citing works
Self-citationTherapeutic strategies to modulate gut microbial health: Approaches for sarcopenia management.
Das, S., Preethi, B., Kushwaha, S., & Shrivastava, R. (2024) · PubMed · doi:10.14670/hh-18-730 · Cited by 12 · see citing works
Exploring nutritional quality and bioactive compounds in Mediterranean bean landraces
Gorbe, E., Morard, M., Rausell‐Moreno, A., Calatayud, Á., & Penella, C. (2025) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2025.107433 · Cited by 9 · see citing works
Functional Nutrients to Ameliorate Neurogenic Muscle Atrophy
Moresi, V., Renzini, A., Cavioli, G., Seelaender, M. C. L., Coletti, D., Gigli, G., & Cedola, A. (2022) · Metabolites · doi:10.3390/metabo12111149 · Cited by 9 · see citing works
Naclerio, F., Larumbe‐Zabala, E., Larrosa, M., Centeno, A., Esteve-Lanao, J., & Moreno‐Pérez, D. (2019) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2018-0359 · Cited by 8 · see citing works
Zeng, N., Prodhan, U., D'Souza, R., Ramzan, F., Mitchell, S., Sharma, P., Knowles, S., Roy, N. C., Sjödin, A., Wagner, K., et al. (2019) · The Journal of Nutrition, Health & Aging · doi:10.1007/s12603-019-1171-4 · Cited by 6 · see citing works
Self-citationDedeyne, L., Dupont, J., Verschueren, S., Koppo, K., Tournoy, J., Matthys, C., & Gielen, E. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.672971 · Cited by 8 · see citing works
Jackson, K. L., Gropper, S. S., Hunt, D., D’Avolio, D., & Newman, D. (2022) · Nutrients · doi:10.3390/nu14020375 · Cited by 8 · see citing works
Draxler, A., Franzke, B., Cortolezis, J. T., Gillies, N. A., Unterberger, S., Aschauer, R., Zöhrer, P. A., Bragagna, L., Kodnar, J., Strasser, E.-M., et al. (2021) · Nutrients · doi:10.3390/nu13103479 · Cited by 7 · see citing works
Self-citationGriffen, C., Renshaw, D. W., Duncan, M. J., Weickert, M. O., & Hattersley, J. G. (2022) · Physiological Reports · doi:10.14814/phy2.15268 · Cited by 6 · see citing works
Sarcopenia in Aging: Pathogenesis, Diagnosis, and Emerging Therapeutic Frontiers
Jeyaraman, M., Jeyaraman, N., Nallakumarasamy, A., Ramasubramanian, S., Muthu, S., Murugan, S., Rajendran, S. N. S., Rajendran, R. L., Ahn, B., & Gangadaran, P. (2025) · Molecular Imaging and Biology · doi:10.1007/s11307-025-02071-8 · Cited by 6 · see citing works
Gathercole, J. L., Grosvenor, A. J., Lee, E., Thomas, A., Mitchell, C. J., Zeng, N., D’Souza, R. F., Ramzan, F., Sharma, P., Knowles, S. O., et al. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2020.595905 · Cited by 6 · see citing works
Self-citationAssociation between dietary protein intake and skeletal muscle mass in older Korean adults
Kim, H., & Song, S.-W. (2021) · European Geriatric Medicine · doi:10.1007/s41999-021-00530-3 · Cited by 5 · see citing works
Yang, H., Jiang, Y., Luo, Y., Qin, K., Yang, C. Q., Liang, D., Xie, Y., Cui, X., Ju, W., Tang, P., et al. (2025) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2025.105805 · Cited by 5 · see citing works
Gillies, N. A., Milan, A. M., Chia, P., Sharma, P., Mitchell, S. M., Zeng, N., Ramzan, F., D’Souza, R. F., Mitchell, C. J., Knowles, S. O., et al. (2021) · Nutrition · doi:10.1016/j.nut.2021.111231 · Cited by 4 · see citing works
Self-citationAssociation between protein intake and lean body mass in a group of Masters Athletes
Stanzione, J. R., Boullata, J. I., Bruneau, M. L., & Volpe, S. L. (2022) · Journal of Nutritional Science · doi:10.1017/jns.2022.10 · Cited by 4 · see citing works
- Authors
- Mitchell, C. J., Milan, A. M., Mitchell, S. M., Zeng, N., Ramzan, F., Sharma, P., Knowles, S. O., Roy, N. C., Sjödin, A., Wagner, K.-H., & Cameron-Smith, D.
- Affiliations
- University of Auckland (NZ)
- AgResearch (NZ)
- University of Copenhagen (DK)
- University of Vienna (AT)
- ORCID
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2017-12
- Volume
- 106
- Issue
- 6
- Pages
- 1375-1383
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2765197935
- Cited by
- 132
- References
- 53
- Citations by year
- 2026: 2 · 2025: 13 · 2024: 12 · 2023: 8 · 2022: 20 · 2021: 20 · 2020: 19 · 2019: 25 · 2018: 13
- FWCI
- 11.52
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Figshare (submittedVersion, cc-by)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- ResearchSpace (University of Auckland) (submittedVersion)
- Funders
- AgResearch
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- protein intake, protein requirements, recommended daily allowance, appendicular lean mass, skeletal muscle mass, muscle function, older men, sarcopenia, energy balance, aging, muscle strength, trunk lean mass, protein supplementation, physical function decline, muscle protein synthesis, muscle protein degradation, muscle fiber cross-sectional area, muscle fiber hypertrophy
- MeSH terms
- Aged, Aged, 80 and over, Aging, Body Composition, Body Fluid Compartments, Energy Intake, Diet, Dietary Proteins, Energy Metabolism, Feeding Behavior, Humans, Leg, Male, Nutritional Requirements, Organ Size, Absorptiometry, Photon, Body Mass Index, Muscle, Skeletal, Muscle Strength, Recommended Dietary Allowances
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
