Telomerase activity in human germline and embryonic tissues and cells

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

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Telomeres shorten during ageing of human fibroblasts

Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750

Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

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Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age.

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Activation of telomerase in human lymphocytes and hematopoietic progenitor cells

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Yeast heat shock factor is an essential DNA-binding protein that exhibits temperature-dependent phosphorylation

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The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation

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Telomerase activity in human ovarian carcinoma.

Counter, C. M., Hirte, H. W., Bacchetti, S., & Harley, C. B. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.8.2900 · Cited by 677

Correlating telomerase activity levels with human neuroblastoma outcomes

Hiyama, E., Hiyama, K., Yokoyama, T., Matsuura, Y., Piatyszek, M. A., & Shay, J. W. (1995) · Nature Medicine · doi:10.1038/nm0395-249 · Cited by 611

Altered regulation of G1 cyclins in senescent human diploid fibroblasts: accumulation of inactive cyclin E-Cdk2 and cyclin D1-Cdk2 complexes.

Dulić, V, Drullinger, L. F., Lees, E., Reed, S. I., & Stein, G. H. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.23.11034 · Cited by 279

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C.-P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., & Wright, W. E. (1998) · Science · doi:10.1126/science.279.5349.349 · Cited by 4,975

A survey of telomerase activity in human cancer

Shay, J. W., & Bacchetti, S. (1997) · European Journal of Cancer · doi:10.1016/s0959-8049(97)00062-2 · Cited by 2,794

The essence of senescence: Figure 1.

Kuilman, T., Michaloglou, C., Mooi, W. J., & Peeper, D. S. (2010) · Genes & Development · doi:10.1101/gad.1971610 · Cited by 2,038

hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization

Meyerson, M., Counter, C. M., Eaton, E. N., Ellisen, L. W., Steiner, P., Caddle, S. D., Ziaugra, L., Beijersbergen, R. L., Davidoff, M. J., Liu, Q., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80538-3 · Cited by 1,784

Reversal of human cellular senescence: roles of the p53 and p16 pathways

Beauséjour, C. M., Krtolica, A., Galimi, F., Narita, M., Lowe, S. W., Yaswen, P., & Campisi, J. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg417 · Cited by 1,457

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

Rudolph, K. L., Chang, S., Lee, H.-W., Blasco, M., Gottlieb, G. J., Greider, C., & DePinho, R. A. (1999) · Cell · doi:10.1016/s0092-8674(00)80580-2 · Cited by 1,349

The telomere syndromes

Armanios, M., & Blackburn, E. H. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3246 · Cited by 982

Human Telomerase and Its Regulation

Cong, Y.-S., Wright, W. E., & Shay, J. W. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.3.407-425.2002 · Cited by 898

Body size, energy metabolism and lifespan

Speakman, J. R. (2005) · Journal of Experimental Biology · doi:10.1242/jeb.01556 · Cited by 914

Adult-onset pulmonary fibrosis caused by mutations in telomerase

Tsakiri, K. D., Cronkhite, J. T., Kuan, P. J., Xing, C., Raghu, G., Weissler, J. C., Rosenblatt, R. L., Shay, J. W., & Garcia, C. K. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701009104 · Cited by 894

Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts.

Stein, G. H., Drullinger, L. F., Soulard, A., & Dulić, V. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.3.2109 · Cited by 868

Control of Human Telomere Length by TRF1 and TRF2

Smogorzewska, A., van Steensel, B., Bianchi, A., Oelmann, S., Schaefer, M. R., Schnapp, G., & de Lange, T. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.5.1659-1668.2000 · Cited by 768

Telomerase and cancer therapeutics

Harley, C. B. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2275 · Cited by 728

Role of Telomeres and Telomerase in Aging and Cancer

Shay, J. W. (2016) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-0062 · Cited by 668

Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence

Ohtani, N., Zebedee, Z., Huot, T. J. G., Stinson, J. A., Sugimoto, M., Ohashi, Y., Sharrocks, A. D., Peters, G., & Hara, E. (2001) · Nature · doi:10.1038/35059131 · Cited by 654

Telomeres: history, health, and hallmarks of aging

Chakravarti, D., LaBella, K. A., & DePinho, R. A. (2021) · Cell · doi:10.1016/j.cell.2020.12.028 · Cited by 637

Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence

Coppé, J.-P., Kauser, K., Campisi, J., & Beauséjour, C. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603307200 · Cited by 604

Microbial Cell Individuality and the Underlying Sources of Heterogeneity

Avery, S. V. (2006) · Nature Reviews Microbiology · doi:10.1038/nrmicro1460 · Cited by 521

Hallmarks of senescence in carcinogenesis and cancer therapy

Shay, J. W., & Roninson, I. B. (2004) · Oncogene · doi:10.1038/sj.onc.1207518 · Cited by 502

Comparative biology of mammalian telomeres: hypotheses on ancestral states and the roles of telomeres in longevity determination

Gomes, N. M. V., Ryder, O. A., Houck, M. L., Charter, S. J., Walker, W., Forsyth, N. R., Austad, S. N., Venditti, C., Pagel, M., Shay, J. W., et al. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00718.x · Cited by 464

Preferential Accumulation of Single-Stranded Regions in Telomeres of Human Fibroblasts

Petersen, S., Saretzki, G., & Zglinicki, T. V. (1998) · Experimental Cell Research · doi:10.1006/excr.1997.3893 · Cited by 427

Telomere dysfunction and tumour suppression: the senescence connection

Deng, Y., Chan, S. S., & Chang, S. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2393 · Cited by 411

Telomere Lengths, Pulmonary Fibrosis and Telomerase (TERT) Mutations

Diaz de Leon, A., Cronkhite, J. T., Katzenstein, A.-L. A., Godwin, J. D., Raghu, G., Glazer, C. S., Rosenblatt, R. L., Girod, C. E., Garrity, E. R., Xing, C., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010680 · Cited by 377

Bet Hedging in Yeast by Heterogeneous, Age-Correlated Expression of a Stress Protectant

Levy, S. F., Ziv, N., & Siegal, M. L. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001325 · Cited by 371

Telomerase and differentiation in multicellular organisms: Turn it off, turn it on, and turn it off again

Forsyth, N. R., Wright, W. E., & Shay, J. W. (2002) · Differentiation · doi:10.1046/j.1432-0436.2002.690412.x · Cited by 345

Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae

Kirchman, P. A., Kim, S., Lai, C.-Y., & Jazwinski, S. M. (1999) · Genetics · doi:10.1093/genetics/152.1.179 · Cited by 328

Dietary deprivation extends lifespan in Caenorhabditis elegans

Lee, G. D., Wilson, M. A., Zhu, M., Wolkow, C. A., De Cabo, R., Ingram, D. K., & Zou, S. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00241.x · Cited by 307

Cellular senescence as a tumor-protection mechanism: the essential role of counting

Wright, W. E., & Shay, J. W. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00163-5 · Cited by 306

Allele-Specific Chromosome Removal after Cas9 Cleavage in Human Embryos

Zuccaro, M. V., Xu, J., Mitchell, C., Marin, D., Zimmerman, R., Rana, B., Weinstein, E., King, R. T., Palmerola, K. L., Smith, M. E., et al. (2020) · Cell · doi:10.1016/j.cell.2020.10.025 · Cited by 303

Normal Aging Induces Changes in the Brain and Neurodegeneration Progress: Review of the Structural, Biochemical, Metabolic, Cellular, and Molecular Changes

Lee, J., & Kim, H.-J. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.931536 · Cited by 310

Revenge of the “Sit”: How lifestyle impacts neuronal and cognitive health through molecular systems that interface energy metabolism with neuronal plasticity

Vaynman, S., & Gomez‐Pinilla, F. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20979 · Cited by 299

Immune aging and autoimmunity

Goronzy, J. J., & Weyand, C. M. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-0970-0 · Cited by 292

TERT promoter mutations in cancer development

Heidenreich, B., Rachakonda, P. S., Hemminki, K., & Kumar, R. (2014) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2013.11.005 · Cited by 238

Telomere length in leukocyte subpopulations of patients with aplastic anemia

Brümmendorf, T. H., Maciejewski, J. P., Mak, J., Young, N. S., & Lansdorp, P. M. (2001) · Blood · doi:10.1182/blood.v97.4.895 · Cited by 233

Meiosis in oocytes: predisposition to aneuploidy and its increased incidence with age

Jones, K. T. (2008) · Human Reproduction Update · doi:10.1093/humupd/dmm043 · Cited by 228

Lgr5 intestinal stem cells have high telomerase activity and randomly segregate their chromosomes

Schepers, A. G., Vries, R., van den Born, M., van de Wetering, M., & Clevers, H. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.26 · Cited by 217

Inflammation and DNA damage: cause, effect or both

Pezone, A., Olivieri, F., Napoli, M. V., Procopio, A., Avvedimento, E. V., & Gabrielli, A. (2023) · Nature Reviews Rheumatology · doi:10.1038/s41584-022-00905-1 · Cited by 212

Telomerase Activity in Candidate Stem Cells From Fetal Liver and Adult Bone Marrow

Yui, J., Chiu, C.-P., & Lansdorp, P. M. (1998) · Blood · doi:10.1182/blood.v91.9.3255 · Cited by 216

Dietary Restriction Stimulates BDNF Production in the Brain and Thereby Protects Neurons Against Excitotoxic Injury

Duan, W., Lee, J., Guo, Z., & Mattson, M. P. (2001) · Journal of Molecular Neuroscience · doi:10.1385/jmn:16:1:1 · Cited by 183

Telomeropathies: An emerging spectrum disorder

Holohan, B., Wright, W. E., & Shay, J. W. (2014) · Journal of Cell Biology · doi:10.1083/jcb.201401012 · Cited by 175

Telomeres and aging

Shay, J. W. (2018) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2017.12.001 · Cited by 174

Targeting telomerase for cancer therapeutics

Shay, J. W., & Keith, W. N. (2008) · British Journal of Cancer · doi:10.1038/sj.bjc.6604209 · Cited by 171

Mitochondrial DNA deletion mutations are concomitant with ragged red regions of individual, aged muscle fibers: Analysis by laser-capture microdissection

Cao, Z. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.21.4502 · Cited by 170

Reinitiation of DNA Synthesis and Cell Division in Senescent Human Fibroblasts by Microinjection of Anti-p53 Antibodies

Gire, V., & Wynford-Thomas, D. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.3.1611 · Cited by 161

TERC and TERT gene mutations in patients with bone marrow failure and the significance of telomere length measurements

Du, H.-Y., Pumbo, E., Ivanovich, J., An, P., Maziarz, R. T., Reiss, U. M., Chirnomas, D., Shimamura, A., Vlachos, A., Lipton, J. M., et al. (2009) · Blood · doi:10.1182/blood-2008-07-166421 · Cited by 158

An Essential Role for Functional Telomeres in Mouse Germ Cells during Fertilization and Early Development

Liu, L., Blasco, M. A., Trimarchi, J. R., & Keefe, D. L. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0735 · Cited by 157

Overexpression of Telomerase Confers Growth Advantage, Stress Resistance, and Enhanced Differentiation of ESCs Toward the Hematopoietic Lineage

Armstrong, L., Saretzki, G., Peters, H., Wappler, I., Evans, J., Hole, N., von Zglinicki, T., & Lako, M. (2005) · Stem Cells · doi:10.1634/stemcells.2004-0269 · Cited by 153

Telomere shortening in mTR−/− embryos is associated with failure to close the neural tube

Herrera, E., Samper, E., & Blasco, M. A. (1999) · The EMBO Journal · doi:10.1093/emboj/18.5.1172 · Cited by 147

Histone deacetylase inhibitors induce a senescence-like state in human cells by a p16-dependent mechanism that is independent of a mitotic clock

Munro, J., Barr, N. I., Ireland, H., Morrison, V., & Parkinson, E. K. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.01.017 · Cited by 141

Genetics of leukocyte telomere length and its role in atherosclerosis

Aviv, A. (2012) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2011.05.001 · Cited by 143

Telomeres, sex, reactive oxygen species, and human cardiovascular aging

Aviv, A. (2002) · Journal of Molecular Medicine · doi:10.1007/s00109-002-0377-8 · Cited by 138

Synchrony in telomere length of the human fetus

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Telomere and adaptive immunity

Weng, N.-P. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.11.005 · Cited by 99

The role of telomeres in the ageing of human skin: Telomeres and skin ageing

Buckingham, E. M., & Klingelhutz, A. J. (2011) · Experimental Dermatology · doi:10.1111/j.1600-0625.2010.01242.x · Cited by 109

The mitotic clock in skeletal muscle regeneration, disease and cell mediated gene therapy

Mouly, V., Aamiri, A., Bigot, A., Cooper, R. N., Di Donna, S., Furling, D., Gidaro, T., Jacquemin, V., Mamchaoui, K., Negroni, E., et al. (2005) · Acta Physiologica Scandinavica · doi:10.1111/j.1365-201x.2005.01417.x · Cited by 106

Senescence-associated genes in normal human oral keratinocytes

Kang, M. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(03)00061-2 · Cited by 89

No decline in skeletal muscle oxidative capacity with aging in long-term calorically restricted rats: Effects are independent of mitochondrial DNA integrity

Baker, D. J., Betik, A. C., Krause, D. J., & Hepple, R. T. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.7.675 · Cited by 89

Mitochondrial DNA deletion mutations and sarcopenia

AIKEN, J., BUA, E., CAO, Z., LOPEZ, M., WANAGAT, J., McKENZIE, D., & McKIERNAN, S. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02111.x · Cited by 85

Telomere length correlations among somatic tissues in adult zebra finches

Reichert, S., Criscuolo, F., Verinaud, E., Zahn, S., & Massemin, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081496 · Cited by 81

Reprogramming of Telomerase by Expression of Mutant Telomerase RNA Template in Human Cells Leads to Altered Telomeres That Correlate with Reduced Cell Viability

Marušić, L., Anton, M., Tidy, A., Wang, P., Villeponteau, B., & Bacchetti, S. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.11.6394 · Cited by 74

Telomerase is active in normal gastrointestinal mucosa and not up-regulated in precancerous lesions

Bachor, C., Bachor, O. A., & Boukamp, P. (1999) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s004320050302 · Cited by 68

Telomeres as Therapeutic Targets in Heart Disease

Yeh, J.-K., Lin, M.-H., & Wang, C.-Y. (2019) · JACC: Basic to Translational Science · doi:10.1016/j.jacbts.2019.05.009 · Cited by 49

The Role of Telomerase Expression and Telomere Length Maintenance in Human and Mouse

Nan-PIng, W., & Hodes, R. J. (2000) · Journal of Clinical Immunology · doi:10.1023/a:1017223602293 · Cited by 49

The Geroscience Hypothesis: Is It Possible to Change the Rate of Aging?

Austad, S. N. (2016) · Advances in Geroscience · doi:10.1007/978-3-319-23246-1_1 · Cited by 43

Reproductive aging and telomeres: Are women and men equally affected?

Chico-Sordo, L., Córdova-Oriz, I., Polonio, A. M., S-Mellado, L. S., Medrano, M., García-Velasco, J. A., & Varela, E. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111541 · Cited by 27