Tunable Narrow Band Emissions from Dye-Sensitized Core/Shell/Shell Nanocrystals in the Second Near-Infrared Biological Window
Open accessAbstract
We introduce a hybrid organic–inorganic system consisting of epitaxial NaYF 4:Yb 3+ /X 3+ @NaYbF 4 @NaYF 4:Nd 3+ (X = null, Er, Ho, Tm, or Pr) core/shell/shell (CSS) nanocrystal with organic dye, indocyanine green (ICG) on the nanocrystal surface. This system is able to produce a set of narrow band emissions with a large Stokes-shift (>200 nm) in the second biological window of optical transparency (NIR-II, 1000–1700 nm), by directional energy transfer from light-harvesting surface ICG, via lanthanide ions in the shells, to the emitter X 3+ in the core. Surface ICG not only increases the NIR-II emission intensity of inorganic CSS nanocrystals by ∼4-fold but also provides a broadly excitable spectral range (700–860 nm) that facilitates their use in bioapplications. We show that the NIR-II emission from ICG-sensitized Er 3+ -doped CSS nanocrystals allows clear observation of a sharp image through 9 mm thick chicken breast tissue, and emission signal detection through 22 mm thick tissue yielding a better imaging profile than from typically used Yb/Tm-codoped upconverting nanocrystals imaged in the NIR-I region (700–950 nm). Our result on in vivo imaging suggests that these ICG-sensitized CSS nanocrystals are suitable for deep optical imaging in the NIR-II region.
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Organic dye-coated RENPs provide tunable excitation and increased SWIR luminescence with up to 40-fold enhancement.
“The high durability of such systems has been demonstrated in J-aggregate-based photosensibilization and photoluminescence amplification in SWNTs and NIR emitting PbS quantum dots,228,229 organic dye-coated RENPs providing a tunable excitation, and increased SWIR luminescence with up to 40-fold enhancement.230,231”
From The Pursuit of Shortwave Infrared-Emitting Nanoparticles with Bright Fluorescence through Molecular Design and Excited-State Engineering of Molecular Aggregates (2022) · cites this paper as [230]
The paper reports that surface-attached ICG broadens excitation to about 700–870 nm and increases NIR-II emission from the nanocrystals. Its reported enhancement is approximately 4-fold (3.7–4.2-fold for the tested emitters), not up to 40-fold. The supplied copy labels these passages “Abstract” and provides no page number. (LLM, conf=0.92)
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Cites
Second window for in vivo imaging
Smith, A. M., Mancini, M. C., & Nie, S. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.326 · Cited by 2,848 · see citing works
Upconversion Nanoparticles: Design, Nanochemistry, and Applications in Theranostics
Chen, G., Qiu, H., Prasad, P. N., & Chen, X. S. (2014) · Chemical Reviews · doi:10.1021/cr400425h · Cited by 2,704 · see citing works
Self-citationA small-molecule dye for NIR-II imaging
Antaris, A. L., Chen, H., Cheng, K., Sun, Y., Hong, G., Qu, C., Diao, S., Deng, Z., Hu, X., Zhang, B., et al. (2016) · Nature Materials · doi:10.1038/nmat4476 · Cited by 1,778 · see citing works
Bashkatov, A. N., Genina, E. A., Kochubey, V. I., & Tuchin, V. V. (2005) · Journal of Physics D: Applied Physics · doi:10.1088/0022-3727/38/15/004 · Cited by 1,720 · see citing works
Looking and listening to light: the evolution of whole-body photonic imaging
Ntziachristos, V., Ripoll, J., Wang, L. V., & Weissleder, R. (2005) · Nature Biotechnology · doi:10.1038/nbt1074 · Cited by 1,557 · see citing works
The Spectra of the Doubly and Triply Ionized Rare Earths
Dieke, G. H., & Crosswhite, H. M. (1963) · Applied Optics · doi:10.1364/ao.2.000675 · Cited by 1,113 · see citing works
Through-skull fluorescence imaging of the brain in a new near-infrared window
Hong, G., Diao, S., Chang, J., Antaris, A. L., Chen, C., Zhang, B., Zhao, S., Atochin, D. N., Huang, P. L., Andreasson, K. I., et al. (2014) · Nature Photonics · doi:10.1038/nphoton.2014.166 · Cited by 1,052 · see citing works
Near-infrared fluorescence: application to in vivo molecular imaging
Hilderbrand, S. A., & Weissleder, R. (2009) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2009.09.029 · Cited by 1,026 · see citing works
Multifunctional in vivo vascular imaging using near-infrared II fluorescence
Hong, G., Lee, J. C., Robinson, J. T., Raaz, U., Xie, L., Huang, N. F., Cooke, J. P., & Dai, H. (2012) · Nature Medicine · doi:10.1038/nm.2995 · Cited by 995 · see citing works
Welsher, K., Sherlock, S. P., & Dai, H. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014501108 · Cited by 958 · see citing works
Wang, Y., Liu, G.-Y., Sun, L., et al. (2013) · ACS Nano · doi:10.1021/nn402601d · Cited by 884 · see citing works
Liu, Q., Sun, Y., Yang, T., Feng, W., Li, C., & Li, F. (2011) · Journal of the American Chemical Society · doi:10.1021/ja207078s · Cited by 798 · see citing works
Zhang, Y., Hong, G., Zhang, Y., Chen, G., Li, F., Dai, H., & Wang, Q. (2012) · ACS Nano · doi:10.1021/nn301218z · Cited by 765 · see citing works
Self-citationLi, Z., & Zhang, Y. (2008) · Nanotechnology · doi:10.1088/0957-4484/19/34/345606 · Cited by 762 · see citing works
Rare-earth-doped biological composites as in vivo shortwave infrared reporters
Naczynski, D. J., Tan, M. C., Zevon, M., Wall, B., Kohl, J., Kulesa, A. B., Chen, S., Roth, C. M., Riman, R. E., & Moghe, P. V. (2013) · Nature Communications · doi:10.1038/ncomms3199 · Cited by 757 · see citing works
Mechanistic Investigation of Photon Upconversion in Nd 3+ -Sensitized Core–Shell Nanoparticles
Xie, X., Gao, N., Deng, R., Sun, Q., Xu, Q., & Liu, X. (2013) · Journal of the American Chemical Society · doi:10.1021/ja4075002 · Cited by 743 · see citing works
In Vivo Fluorescence Imaging with Ag 2 S Quantum Dots in the Second Near‐Infrared Region
Hong, G., Robinson, J. T., Zhang, Y., Diao, S., Antaris, A. L., Wang, Q., & Dai, H. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201206059 · Cited by 742 · see citing works
Hemmer, E., Benayas, A., Légaré, F., & Vetrone, F. (2016) · Nanoscale Horizons · doi:10.1039/c5nh00073d · Cited by 732 · see citing works
Chen, G., Shen, J., Ohulchanskyy, T. Y., Patel, N. J., Kutikov, A. B., Li, Z., Song, J., Pandey, R. K., Ågren, H., Prasad, P. N., et al. (2012) · ACS Nano · doi:10.1021/nn302972r · Cited by 719 · see citing works
Self-citationNear-Infrared Luminescent Lanthanide MOF Barcodes
White, K. A., Chengelis, D. A., Gogick, K. A., et al. (2009) · Journal of the American Chemical Society · doi:10.1021/ja907885m · Cited by 492 · see citing works
Chen, G., Ohulchanskyy, T. Y., Liu, S., Law, W., Wu, F. P., Swihart, M. T., Ågren, H., & Prasad, P. N. (2012) · ACS Nano · doi:10.1021/nn2042362 · Cited by 453 · see citing works
Self-citationFluorescence Imaging In Vivo at Wavelengths beyond 1500 nm
Diao, S., Blackburn, J. L., Hong, G., Antaris, A. L., Chang, J., Wu, J. Z., Zhang, B., Cheng, K., Kuo, C. J., & Dai, H. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201507473 · Cited by 417 · see citing works
Energy-Cascaded Upconversion in an Organic Dye-Sensitized Core/Shell Fluoride Nanocrystal
Chen, G., Damasco, J. A., Qiu, H., et al. (2015) · Nano Letters · doi:10.1021/acs.nanolett.5b02830 · Cited by 412 · see citing works
Self-citationWang, R., Li, X., Zhou, L., & Zhang, F. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201407420 · Cited by 365 · see citing works
Upconverting Near‐Infrared Light through Energy Management in Core–Shell–Shell Nanoparticles
Wen, H., Zhu, H., Chen, X., et al. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201306811 · Cited by 345 · see citing works
Liu, J., Liu, Y., Bu, W., Bu, J., Sun, Y., Du, J., & Shi, J. (2014) · Journal of the American Chemical Society · doi:10.1021/ja5042989 · Cited by 332 · see citing works
Kraft, J. C., & Ho, R. J. Y. (2014) · Biochemistry · doi:10.1021/bi500021j · Cited by 161 · see citing works
In Vivo Fluorescence Imaging with Ag2S Quantum Dots in the Second Near‐Infrared Region
Hong, G., Robinson, J. T., Zhang, Y., Diao, S., Antaris, A. L., Wang, Q., & Dai, H. (2012) · Angewandte Chemie · doi:10.1002/ange.201206059 · Cited by 128 · see citing works
Fluorescence Imaging In Vivo at Wavelengths beyond 1500 nm
Diao, S., Blackburn, J. L., Hong, G., Antaris, A. L., Chang, J., Wu, J. Z., Zhang, B., Cheng, K., Kuo, C. J., & Dai, H. (2015) · Angewandte Chemie · doi:10.1002/ange.201507473 · Cited by 122 · see citing works
Kamimura, M., Kanayama, N., Tokuzen, K., et al. (2011) · Nanoscale · doi:10.1039/c1nr10466g · Cited by 111 · see citing works
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Research works printed but not linked: 1
- [4]Prasad PN Introduction to Biophotonics John Wiley& Sons Hoboken, NJ 2003 633
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Advanced Fluorescence Imaging Technology in the Near-Infrared-II Window for Biomedical Applications
Li, C., Chen, G., Zhang, Y., Wu, F., & Wang, Q. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.0c07022 · Cited by 1,037 · see citing works
Self-citationHe, S., Song, J., Qu, J., & Cheng, Z. (2018) · Chemical Society Reviews · doi:10.1039/c8cs00234g · Cited by 1,021 · see citing works
Zhong, Y., Ma, Z., Wang, F., Wang, X., Yang, Y., Liu, Y., Zhao, X., Li, J., Du, H., Zhang, M., et al. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0262-4 · Cited by 575 · see citing works
In vivo NIR-II fluorescence imaging for biology and medicine
Wang, F., Zhong, Y., Bruns, O., Liang, Y., & Dai, H. (2024) · Nature Photonics · doi:10.1038/s41566-024-01391-5 · Cited by 564 · see citing works
Qi, J., Sun, C., Zebibula, A., Zhang, H., Kwok, R. T. K., Zhao, X., Xi, W., Lam, J. W. Y., Qian, J., & Tang, B. Z. (2018) · Advanced Materials · doi:10.1002/adma.201706856 · Cited by 418 · see citing works
Qi, J., Sun, C., Li, D., Zhang, H., Yu, W., Zebibula, A., Lam, J. W. Y., Xi, W., Zhu, L., Cai, F., et al. (2018) · ACS Nano · doi:10.1021/acsnano.8b02452 · Cited by 226 · see citing works
Piwoński, H., Nozue, S., & Habuchi, S. (2022) · ACS Nanoscience Au · doi:10.1021/acsnanoscienceau.1c00038 · Cited by 39 · see citing works
Piwoński, H., Li, W., Wang, Y., Michinobu, T., & Habuchi, S. (2020) · ACS Applied Polymer Materials · doi:10.1021/acsapm.9b00967 · Cited by 36 · see citing works
Koralli, P., D. Nega, A., Vagiaki, L. E., Pavlou, A., Siskos, M. G., Dimitrakopoulou-Strauss, A., Gregoriou, V. G., & Chochos, C. L. (2020) · Materials Chemistry Frontiers · doi:10.1039/d0qm00195c · Cited by 37 · see citing works
Second Near‐Infrared Window Fluorescence Materials for In Vivo Dynamic Multiplexed Imaging
Fan, F., Zeng, K., Zhu, Y., Zhang, Y., Chen, Y., Lv, D., Jia, D., Chai, Y., Chen, X., & Li, Q. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202422693 · Cited by 33 · see citing works
- Authors
- Shao, W., Chen, G., Kuzmin, A., Kutscher, H. L., Pliss, A., Ohulchanskyy, T. Y., & Prasad, P. N.
- Affiliations
- Harbin Institute of Technology (CN)
- University at Buffalo, State University of New York (US)
- Shenzhen University (CN)
- Corresponding author
- Chen, Guanying
- Prasad, Paras N.
- ORCID
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2016-12-09
- Volume
- 138
- Issue
- 50
- Pages
- 16192-16195
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- PMC
- PMC5474680
- OpenAlex
- W2559550576
- Cited by
- 386
- References
- 30
- Citations by year
- 2026: 22 · 2025: 20 · 2024: 34 · 2023: 25 · 2022: 51 · 2021: 53 · 2020: 54 · 2019: 56 · 2018: 43 · 2017: 28
- FWCI
- 18.86
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of the American Chemical Society (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Ministry of Education of the People's Republic of China (AUGA5710052614, AUGA8880100415)
- Air Force Office of Scientific Research (FA9550-15-1-0358)
- National Natural Science Foundation of China (51672061)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence Properties of Advanced Materials
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Solid State Laser Technologies
- Physical Sciences › Materials Science › Materials Chemistry › Lanthanide and Transition Metal Complexes
- Keywords
- indocyanine green, dye sensitization, NIR-II emission, deep tissue imaging, upconversion nanoparticles, erbium doping, Stokes shift, in vivo imaging
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