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Cited by 265

The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.

Reduced GABA and altered somatosensory function in children with autism spectrum disorder

Open access
Puts, Nicolaas A.J., Wodka, Ericka L., Harris, Ashley D., Crocetti, Deana, Tommerdahl, Mark, Mostofsky, Stewart H., Edden, Richard A.E.·2017·Autism Research
DOI 10.1002/aur.1691
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Abstract

Background: Abnormal responses to tactile stimuli are a common feature of autism spectrum disorder (ASD). Several lines of evidence suggest that GABAergic function, which has a crucial role in tactile processing, is altered in ASD. In this study, we determine whether in vivo GABA levels are altered in children with ASD, and whether alterations in GABA levels are associated with abnormal tactile function in these children. Methods: GABA‐edited magnetic resonance spectroscopy was acquired in 37 children with Autism and 35 typically developing children (TDC) from voxels over primary sensorimotor and occipital cortices. Children performed tactile tasks previously shown to be altered in ASD, linked to inhibitory mechanisms. Detection threshold was measured with‐ and without the presence of a slowly increasing sub‐threshold stimulus. Amplitude discrimination was measured with‐ and without the presence of an adapting stimulus, and frequency discrimination was measured. Results: Sensorimotor GABA levels were significantly reduced in children with autism compared to healthy controls. Occipital GABA levels were normal. Sensorimotor GABA levels correlated with dynamic detection threshold as well as with the effect of sub‐threshold stimulation. Sensorimotor GABA levels also correlated with amplitude discrimination after adaptation (an effect absent in autism) and frequency discrimination in controls, but not in children with autism. Conclusions: GABA levels correlate with behavioral measures of inhibition. Children with autism have reduced GABA, associated with abnormalities in tactile performance. We show here that altered in vivo GABA levels might predict abnormal tactile information processing in ASD and that the GABA system may be a future target for therapies. Autism Res 2016. © 2016 International Society for Autism Research, Wiley Periodicals, Inc.

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Research works printed but not linked: 1

  1. Whitsel B.L., 1989, Sensory Processing in the Mammalian Brain: Neural substrates and experimental strategies

Cited by

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Metadata

Authors
Puts, N. A. J., Wodka, E. L., Harris, A. D., Crocetti, D., Tommerdahl, M., Mostofsky, S. H., & Edden, R. A. E.
Venue
Autism Research
Publisher
Wiley
Published
2016-09-09
Volume
10
Issue
4
Pages
608-619
ISSN
  • 1939-3792 (ISSN-L)
  • 1939-3806
DOI
10.1002/aur.1691
OpenAlex
W2520088250
Cited by
265
References
58
FWCI
9.01
Type
journal article
Language
en
Open access
green
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Funders
National Institutes of Health (P41 EB015909, R21 MH098228, R01 MH078160, R01 EB016089)

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