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Cited by 720

The DOI matches its Crossref record; 92 of the 92 references it cites were found in a registry or an index.

Contemporary Management of Acute Right Ventricular Failure: A Statement from the Heart Failure Association and the Working Group on Pulmonary Circulation and Right Ventricular Function of the European Society of Cardiology

Harjola, Veli-Pekka, Mebazaa, Alexandre, Čelutkienė, Jelena, Bettex, Dominique, Bueno, Hector, Chioncel, Ovidiu, Crespo-Leiro, Maria G., Falk, Volkmar, Filippatos, Gerasimos, Gibbs, Simon, Leite-Moreira, Adelino, Lassus, Johan, Masip, Josep, Mueller, Christian, Mullens, Wilfried, Naeije, Robert, Nordegraaf, Anton Vonk, Parissis, John, Riley, Jillian P., Ristic, Arsen, Rosano, Giuseppe, Rudiger, Alain, Ruschitzka, Frank, Seferovic, Petar, Sztrymf, Benjamin, Vieillard-Baron, Antoine, Yilmaz, Mehmet Birhan, Konstantinides, Stavros·2016·European Journal of Heart Failure
DOI 10.1002/ejhf.478
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Abstract

Acute right ventricular (RV) failure is a complex clinical syndrome that results from many causes. Research efforts have disproportionately focused on the failing left ventricle, but recently the need has been recognized to achieve a more comprehensive understanding of RV anatomy, physiology, and pathophysiology, and of management approaches. Right ventricular mechanics and function are altered in the setting of either pressure overload or volume overload. Failure may also result from a primary reduction of myocardial contractility owing to ischaemia, cardiomyopathy, or arrhythmia. Dysfunction leads to impaired RV filling and increased right atrial pressures. As dysfunction progresses to overt RV failure, the RV chamber becomes more spherical and tricuspid regurgitation is aggravated, a cascade leading to increasing venous congestion. Ventricular interdependence results in impaired left ventricular filling, a decrease in left ventricular stroke volume, and ultimately low cardiac output and cardiogenic shock. Identification and treatment of the underlying cause of RV failure, such as acute pulmonary embolism, acute respiratory distress syndrome, acute decompensation of chronic pulmonary hypertension, RV infarction, or arrhythmia, is the primary management strategy. Judicious fluid management, use of inotropes and vasopressors, assist devices, and a strategy focusing on RV protection for mechanical ventilation if required all play a role in the clinical care of these patients. Future research should aim to address the remaining areas of uncertainty which result from the complexity of RV haemodynamics and lack of conclusive evidence regarding RV-specific treatment approaches.

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Metadata

Authors
Harjola, V.-P., Mebazaa, A., Čelutkienė, J., Bettex, D., Bueno, H., Chioncel, O., Crespo-Leiro, M. G., Falk, V., Filippatos, G., Gibbs, S., Leite-Moreira, A., Lassus, J., Masip, J., Mueller, C., Mullens, W., Naeije, R., Nordegraaf, A. V., Parissis, J., Riley, J. P., Ristic, A., Rosano, G., Rudiger, A., Ruschitzka, F., Seferovic, P., Sztrymf, B., Vieillard-Baron, A., Yilmaz, M. B., & Konstantinides, S.
Venue
European Journal of Heart Failure
Publisher
Oxford University Press (OUP)
Published
2016-03-01
Volume
18
Issue
3
Pages
226-241
ISSN
  • 1388-9842 (ISSN-L)
  • 1879-0844
DOI
10.1002/ejhf.478
OpenAlex
W2301761598
Cited by
720
References
92
FWCI
51.91
Type
journal article
Language
en
Open access
closed

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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