Cited by 276Chronic Kidney Disease and DiabetesRetinal Diseases and TreatmentsGlaucoma and retinal disorders

Kidney and eye diseases: Common risk factors, etiological mechanisms, and pathways

Open access
Wong, Chee Wai, Wong, Tien Yin, Cheng, Ching-Yu, Sabanayagam, Charumathi·2014·Kidney International

Abstract

Chronic kidney disease is an emerging health problem worldwide. The eye shares striking structural, developmental, and genetic pathways with the kidney, suggesting that kidney disease and ocular disease may be closely linked. A growing number of studies have found associations of chronic kidney disease with age-related macular degeneration, diabetic retinopathy, glaucoma, and cataract. In addition, retinal microvascular parameters have been shown to be predictive of chronic kidney disease. Chronic kidney disease shares common vascular risk factors including diabetes, hypertension, smoking, and obesity, and pathogenetic mechanisms including inflammation, oxidative stress, endothelial dysfunction, and microvascular dysfunction, with ocular diseases supporting the 'Common Soil Hypothesis.' In this review, we present major epidemiological evidence for these associations and explore underlying pathogenic mechanisms and common risk factors for kidney and ocular disease. Understanding the link between kidney and ocular disease can lead to the development of new treatment and screening strategies for both diseases.

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Crossref · 10.1038/ki.2013.491

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Authors
Wong, C. W., Wong, T. Y., Cheng, C.-Y., & Sabanayagam, C.
Affiliations
  • Singapore National Eye Center (SG)
  • National University of Singapore (SG)
Corresponding author
Sabanayagam, Charumathi
Venue
Kidney International
Publisher
Elsevier BV
Published
2014-06
Volume
85
Issue
6
Pages
1290-1302
ISSN
0085-2538 (ISSN-L)
OpenAlex
W2053650049
Cited by
276
References
165
Citations by year
2026: 25 · 2025: 43 · 2024: 34 · 2023: 42 · 2022: 33 · 2021: 16 · 2020: 23 · 2019: 16 · 2018: 4 · 2017: 13 · 2016: 13 · 2015: 10 · 2014: 4
FWCI
1.18
Type
journal article
Language
en
Open access
Locations
  • Kidney International (publishedVersion)
  • PubMed (publishedVersion)
  • National University of Singapore (submittedVersion)
Topics
  • Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
  • Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
  • Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
Keywords
chronic kidney disease, eye diseases, age-related macular degeneration, diabetic retinopathy, glaucoma, cataract, vascular risk factors, diabetes mellitus, hypertension, smoking, obesity, inflammation, oxidative stress, endothelial dysfunction, microvascular dysfunction, pathogenesis
MeSH terms
Eye Diseases, Humans, Kidney Diseases, Phenotype, Predictive Value of Tests, Prognosis, Risk Factors, Signal Transduction, Risk Assessment, Genetic Predisposition to Disease

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