Kidney and eye diseases: Common risk factors, etiological mechanisms, and pathways
Open accessAbstract
Chronic kidney disease is an emerging health problem worldwide. The eye shares striking structural, developmental, and genetic pathways with the kidney, suggesting that kidney disease and ocular disease may be closely linked. A growing number of studies have found associations of chronic kidney disease with age-related macular degeneration, diabetic retinopathy, glaucoma, and cataract. In addition, retinal microvascular parameters have been shown to be predictive of chronic kidney disease. Chronic kidney disease shares common vascular risk factors including diabetes, hypertension, smoking, and obesity, and pathogenetic mechanisms including inflammation, oxidative stress, endothelial dysfunction, and microvascular dysfunction, with ocular diseases supporting the 'Common Soil Hypothesis.' In this review, we present major epidemiological evidence for these associations and explore underlying pathogenic mechanisms and common risk factors for kidney and ocular disease. Understanding the link between kidney and ocular disease can lead to the development of new treatment and screening strategies for both diseases.
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The kidney and eye have structural and developmental similarities.
“both of which have structural and developmental similarities [208]”
From Bruch’s Membrane: A Key Consideration with Complement-Based Therapies for Age-Related Macular Degeneration (2023) · cites this paper as [208]
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Sabanayagam, C., Xu, D., Ting, D. S. W., Nusinovici, S., Banu, R., Hamzah, H., Lim, C., Tham, Y.-C., Cheung, C. Y., Tai, E. S., et al. (2020) · The Lancet Digital Health · doi:10.1016/s2589-7500(20)30063-7 · Cited by 279 · see citing works
Self-citationHammadi, S., Tzoumas, N., Ferrara, M., Meschede, I. P., Lo, K., Harris, C., Lako, M., & Steel, D. H. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12082870 · Cited by 44 · see citing works
Betzler, B. K., Chee, E. Y. L., He, F., Lim, C. C., Ho, J., Hamzah, H., Tan, N. C., Liew, G., McKay, G. J., Hogg, R. E., et al. (2023) · Journal of the American Medical Informatics Association · doi:10.1093/jamia/ocad179 · Cited by 42 · see citing works
Self-citation
- Authors
- Wong, C. W., Wong, T. Y., Cheng, C.-Y., & Sabanayagam, C.
- Affiliations
- Singapore National Eye Center (SG)
- National University of Singapore (SG)
- Corresponding author
- Sabanayagam, Charumathi
- Venue
- Kidney International
- Publisher
- Elsevier BV
- Published
- 2014-06
- Volume
- 85
- Issue
- 6
- Pages
- 1290-1302
- ISSN
- 0085-2538 (ISSN-L)
- OpenAlex
- W2053650049
- Cited by
- 276
- References
- 165
- Citations by year
- 2026: 25 · 2025: 43 · 2024: 34 · 2023: 42 · 2022: 33 · 2021: 16 · 2020: 23 · 2019: 16 · 2018: 4 · 2017: 13 · 2016: 13 · 2015: 10 · 2014: 4
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Kidney International (publishedVersion)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
- Keywords
- chronic kidney disease, eye diseases, age-related macular degeneration, diabetic retinopathy, glaucoma, cataract, vascular risk factors, diabetes mellitus, hypertension, smoking, obesity, inflammation, oxidative stress, endothelial dysfunction, microvascular dysfunction, pathogenesis
- MeSH terms
- Eye Diseases, Humans, Kidney Diseases, Phenotype, Predictive Value of Tests, Prognosis, Risk Factors, Signal Transduction, Risk Assessment, Genetic Predisposition to Disease
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