Cited by 89Per- and polyfluoroalkyl substances researchEnvironmental Toxicology and EcotoxicologyToxic Organic Pollutants Impact

Per- and Polyfluoroalkyl Substances (PFAS) in Surface Water Near US Air Force Bases: Prioritizing Individual Chemicals and Mixtures for Toxicity Testing and Risk Assessment

East, Andrew, Anderson, Richard H., Salice, Christopher J.·2020·Environmental Toxicology and Chemistry

Abstract

Per- and polyfluoroalkyl substances (PFAS) are a large class of persistent chemicals used for decades in industrial and commercial applications. A key challenge with regard to estimating potential risk to ecological (and human) receptors associated with PFAS exposure lies in the fact that there are many different PFAS compounds and several to many can co-occur in any given environmental sample. We applied a data science approach to characterize and prioritize PFAS and PFAS mixtures from a large dataset of PFAS measurements in surface waters associated with US Air Force Installations with a history of the use of aqueous film-forming foams (AFFFs). Several iterations of stakeholder feedback culminated in a few main points that advanced our understanding of a complex dataset and the larger ecotoxicological problem. First, perfluorooctane sulfonate (PFOS) was often a dominant PFAS in a given surface water sample, frequently followed by perfluorohexane sulfonate (PFHxS). Second, a 4-chemical mixture generally accounted for >80% of the sum of all routinely reported PFAS in a sample, and the most representative 4-chemical mixture was composed of PFOS, PFHxS, perfluorohexanoic acid (PFHxA), and perfluorooctanoic acid (PFOA). We suggest that these results demonstrate the utility of formalized data science analysis and assessment frameworks to address complex ecotoxicological problems. Specifically, our example dataset results can be used to provide perspective on toxicity testing, eco…

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Crossref · 10.1002/etc.4893

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Authors
East, A., Anderson, R. H., & Salice, C. J.
Affiliations
  • Towson University (US)
  • United States Air Force (US)
Corresponding author
Salice, Christopher J.
Venue
Environmental Toxicology and Chemistry
Published
2020-10-07
Volume
40
Issue
3
Pages
871-882
ISSN
  • 0730-7268 (ISSN-L)
  • 1552-8618
OpenAlex
W3092309423
Cited by
89
References
36
Citations by year
2026: 14 · 2025: 15 · 2024: 18 · 2023: 12 · 2022: 16 · 2021: 12 · 2020: 2
FWCI
3.89
Type
journal article
Language
en
Open access
closed
Locations
  • Environmental Toxicology and Chemistry (publishedVersion)
  • PubMed (publishedVersion)
Funders
Strategic Environmental Research and Development Program (ER-2627, ER‐2627)
Topics
  • Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Environmental Toxicology and Ecotoxicology
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
Keywords
per- and polyfluoroalkyl substances, PFAS mixtures, surface water contamination, aqueous film-forming foam, PFOS, PFHxS, perfluorohexanoic acid, perfluorooctanoic acid, chemical prioritization, toxicity testing, environmental risk assessment, military base environmental contamination
MeSH terms
Fluorocarbons, Humans, Water, Water Pollutants, Chemical, Alkanesulfonic Acids, Risk Assessment, Toxicity Tests

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