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Cited by 1,926

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Acetaminophen‐induced acute liver failure: Results of a United States multicenter, prospective study†‡

Larson, Anne M., Polson, Julie, Fontana, Robert J., Davern, Timothy J., Lalani, Ezmina, Hynan, Linda S., Reisch, Joan S., Schiødt, Frank V., Ostapowicz, George, Shakil, A. Obaid, Lee, William M.·2005·Hepatology
DOI 10.1002/hep.20948
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Abstract

Severe acetaminophen hepatotoxicity frequently leads to acute liver failure (ALF). We determined the incidence, risk factors, and outcomes of acetaminophen-induced ALF at 22 tertiary care centers in the United States. Detailed prospective data were gathered on 662 consecutive patients over a 6-year period fulfilling standard criteria for ALF (coagulopathy and encephalopathy), from which 275 (42%) were determined to result from acetaminophen liver injury. The annual percentage of acetaminophen-related ALF rose during the study from 28% in 1998 to 51% in 2003. Median dose ingested was 24 g (equivalent to 48 extra-strength tablets). Unintentional overdoses accounted for 131 (48%) cases, intentional (suicide attempts) 122 (44%), and 22 (8%) were of unknown intent. In the unintentional group, 38% took two or more acetaminophen preparations simultaneously, and 63% used narcotic-containing compounds. Eighty-one percent of unintentional patients reported taking acetaminophen and/or other analgesics for acute or chronic pain syndromes. Overall, 178 subjects (65%) survived, 74 (27%) died without transplantation, and 23 subjects (8%) underwent liver transplantation; 71% were alive at 3 weeks. Transplant-free survival rate and rate of liver transplantation were similar between intentional and unintentional groups. In conclusion, acetaminophen hepatotoxicity far exceeds other causes of acute liver failure in the United States. Susceptible patients have concomitant depression, chronic pain, alcohol or narcotic use, and/or take several preparations simultaneously. Education of patients, physicians, and pharmacies to limit high-risk use settings is recommended.

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Metadata

Authors
Larson, A. M., Polson, J., Fontana, R. J., Davern, T. J., Lalani, E., Hynan, L. S., Reisch, J. S., Schiødt, F. V., Ostapowicz, G., Shakil, A. O., & Lee, W. M.
Venue
Hepatology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2005-12
Volume
42
Issue
6
Pages
1364-1372
ISSN
0270-9139 (ISSN-L)
DOI
10.1002/hep.20948
OpenAlex
W2163790438
Cited by
1,926
References
4
FWCI
43.52
Type
journal article
Language
en
Open access
closed

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