Effects of Healthy Aging on Hippocampal and Rhinal Memory Functions: An Event-Related fMRI Study
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Event-related functional magnetic resonance imaging was used to study the effects of healthy aging on hippocampal and rhinal memory functions. Memory for past events can be based on retrieval accompanied by specific contextual details (recollection) or on the feeling that an event is old or new without the recovery of contextual details (familiarity). There is evidence that recollection is more dependent on hippocampus, whereas familiarity is more dependent on the rhinal cortex, and that healthy aging has greater effects on recollection than on familiarity. However, little evidence is available about the neural correlates of these effects. Here, we isolated activity associated with recollection and familiarity by distinguishing between linear and quasi-exponential "perceived oldness" functions derived from recognition confidence levels. The main finding was a double dissociation within the medial temporal lobes between recollection-related activity in hippocampus, which was reduced by aging, and familiarity-related activity in rhinal cortex, which was increased by aging. In addition, age dissociations were found within parietal and posterior midline regions. Finally, aging reduced functional connectivity within a hippocampal-retrosplenial/parietotemporal network but increased connectivity within a rhinal-frontal network. These findings indicate that older adults compensate for hippocampal deficits by relying more on rhinal cortex, possibly through a top-down frontal modulation. This finding has important clinical implications because early Alzheimer's disease impairs both hippocampus and rhinal cortex.
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Cognitive decline, primarily in executive functioning and memory formation, is one of the most pronounced consequences of aging.
“Cognitive decline, primarily in executive functioning and memory formation, is one of the most pronounced consequences of aging (Daselaar et al, 2006;Hedden and Gabrieli, 2004;Townsend et al, 2006).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Daselaar et al, 2006
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- Authors
- Daselaar, S. M., Fleck, M. S., Dobbins, I. G., Madden, D. J., & Cabeza, R.
- Affiliations
- University of Amsterdam (NL)
- Duke University (US)
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-12-28
- Volume
- 16
- Issue
- 12
- Pages
- 1771-1782
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- PMC
- PMC1810232
- OpenAlex
- W2162654011
- Cited by
- 392
- References
- 67
- Citations by year
- 2026: 9 · 2025: 5 · 2024: 8 · 2023: 17 · 2022: 14 · 2021: 13 · 2020: 11 · 2019: 16 · 2018: 14 · 2017: 19 · 2016: 18 · 2015: 29 · 2014: 22 · 2013: 24 · 2012: 26
- FWCI
- 11.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cerebral Cortex (publishedVersion)
- PubMed (publishedVersion)
- UvA-DARE (University of Amsterdam) (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- National Institute on Aging (R01AG019731, AG 19731, AG 11622, R01AG011622, R37AG002163)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Keywords
- healthy aging, hippocampus, rhinal cortex, recollection, familiarity, recognition memory, recognition confidence, medial temporal lobe, functional connectivity, Alzheimer's disease, older adults
- MeSH terms
- Adult, Aged, Aging, Behavior, Brain Mapping, Hippocampus, Humans, Magnetic Resonance Imaging, Memory, Neuropsychological Tests, ROC Curve, Entorhinal Cortex, Recognition, Psychology
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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